Disopyramide (Oral)

Disopyramide is effective in treating heart arrhythmias, but can potentially interact with a number of drugs, as well as cause certain side effects that you should be aware of before taking.


Disopyramide is a drug used on patients who suffer from abnormal heart rhythms. You cannot obtain Disopyramide other than through a prescription from your doctor. Depending on your needs, you may be prescribed a variety of different tablets or capsules depending on your needs. This includes standard a standard capsule or extended-release tablets or capsules.

Condition(is) treated

  • Abnormal heart rhythms

Type of medicine

  • Extended-release capsule

Side Effects

As like all drugs, there are a number of different side effects that could be caused by taking Disopyramide. Some of those side effects may be less pleasant, however, you are not necessarily guaranteed to suffer from such effects. Directly below is a list of side effects which are more serious. If you experience these at all, then you should contact your doctor as soon as you can.

More common

  • Shortness of breath

Less common

  • Itching and/or a rash

Signs and symptoms of hypoglycemia (low blood sugar)

  • Unsteady walk

As well as these, there are other, less serious, side effects which you could experience. Directly below is a list of such effects. You may find that they pass during your treatments. However, if they are worrying you at all, then you can still contact your doctor. They may be able to alter your dosage, or suggest alternative means to reduce the effects.

  • Problems urinating

There is, of course, the chance of experiencing other side effects not listed here. If that is the case, and you would like to discuss any alternate side effects you are having, then do contact your doctor.


Below you can find average doses prescribed to patients suffering from arrhythmias. Be aware that they could differ greatly from what your doctor prescribes you to take. You should not alter your prescription unless told to do so by your doctor. The exact amount you are required to take will depend on a number of personal factors, as well the strength of the medicine and how frequently you need to take it. If you do have any questions about your prescription, you should contact your doctor.

For short-acting capsule dosages:

  • Adults. Take 100 mg to 150 mg every six to eight hours

For extended-release capsules or tablets:

  • Adults. Take 200mg to 400mg every 12 hours.

If you miss a dose for any reason, then you should take it as soon as you remember. However, if it is soon time for you to take the next scheduled dose, you should skip the missed dose. It is important that you never double dose.

You should follow your exact prescription as advised by your doctor. Never take any more than prescribed and, even if you feel better, you should continue taking it for the full course of treatment.

If you are taking the extended-release capsule, then you should swallow them whole Do not chew, crush or break the capsules before swallowing.

If you are taking the extended-release tablets, then you should not chew or crush the tablet before swallowing.

It is important you do not miss any scheduled doses. That is because Disopyramide works best if you have a continual amount of the medicine in your blood. That is also why your doses are evenly spread across each day. If you find that this is difficult as it is disrupting your sleeping patterns, then contact your doctor for any advice.


Disopyramide is known to have interactions with a wide variety of different drugs. Before you are prescribed this medicine, you will be required to tell your doctor about all other drugs you are currently taking. This includes prescription, non-prescription, supplements and herbal remedies. Below is a list of drugs which it is not recommended you take Disopyramide. Your doctor will need to alter one or both of the drugs so that no interactions occur. If you do start taking any new drugs at all, then inform your doctor as they can advise you if any unwanted interactions may take place.

  • Itraconazole

Below here is a list of drugs which it is usually not recommended you take alongside Disopyramide, however, it may be necessary. If prescribed together, it may be your doctor must change the dosage or frequencies so as to avoid unwanted side effects as much as possible.

  • Goserelin

The list below is of drugs which are known to cause an increased chance of side effects from Disopyramide. Again, your doctor may need to alter your dosage if you are to take any of the drugs alongside Disopyramide.

  • Ritonavir

As well as drugs, Disopyramide can potentially interact with a variety of aspects of your diet. This includes the foods you eat, what you drink, as well as how much you smoke. Your doctor may ask you to give them an overview of what you typically consume each day, so as to understand if any interactions may arise. If so, they may ask you to make some alterations to your diet to maximise the benefit of Disopyramide.

Finally, Disopyramide can interact with existing medical problems you have. Be sure to tell your doctor the full extent of your medical condition, and any problems you have. They may need to adjust your dose or choose an alternative form of medication. Below is a list of more serious medical problems that do not interact well with Disopyramide.

  • Sugar diabetes (Diabetes Mellitus). This drug can cause low blood sugars


There is the potential that Disopyramide could react to any allergies you have. You should inform your doctor of all allergies you have, including those to Disopyramide, other drugs, animals, preservatives, foods, and to dyes. They can them come to an educated assessment as to whether this drug is suitable for you to take.

There have been tests carried out on the effects of Disopyramide on younger patients. No increased risk of problems or side effects has been shown, so this drug is suitable for pediatric patients.

Older patients are usually more sensitive to the effects of taking Disopyramide. As such, certain side effects may be more likely to occur. Your doctor is best placed to advise on whether this drug is still suitable for your age. In some cases, they may be required to alter the dosages given.

As of writing, Disopyramide has not been properly tested on pregnant patients. As such, it is not clear as to whether it is a safe and suitable drug to take when pregnant. Your doctor will be up-to-date with ongoing research around this drug. Together you can come to a judgment as to whether there are any extra risks, and whether the benefits outweigh said risks. If at any point whilst taking Disopyramide, you become pregnant, you should inform your doctor right away. They may need to alter your dosage or stop you taking the drug.

Similarly, no adequate studies have taken place on breastfeeding women. Your doctor will be best informed to weigh any risks and benefits that can be obtained.

Your doctor may likely book you in for regular appointments to track your condition whilst taking Disopyramide. It is important you attend all such meeting, as they will be necessary for making any necessary adjustments to your intake.

You should not stop taking Disopyramide unless told to do so by your doctor. By doing this, you could cause a serious change to the functioning of your heart.

When getting up from a sitting or lying position, there is a chance that fainting, dizziness, or lightheadedness could occur. This happens as your blood pressure becomes lower. If this is something you suffer from, then be careful to get up slowly. This doesn't normally happen with standard doses of Disopyramide but is possible. For this reason, you should not drive or perform other dangerous tasks until you are fully aware of all the effects Disopyramide has on your behavior.

As mentioned in the side effects section, Disopyramide can cause some patients to experience low blood sugar levels (hypoglycemia). If this occurs, you should consume a sugary drink, or sugary food, and contact your doctor immediately for further advice.

Disopyramide can also cause problems with your vision. For this reason, as well, you shouldn't drive until you know if you suffer from such problems.

There is the possibility that Disopyramide will cause you to suffer from dry eyes, nose or mouth. To help relieve this you can melt a bit of ice in your mouth, use a saliva substitute, or use sugarless gum or candy. If this problem continues for more than 2 weeks, then you should ask your dentist or doctor for advice. Continual dry mouth can lead to gum disease, dental disease, oral yeast infections, or tooth decay.

Taking Disopyramide can cause you to produce less sweat, which in turn may mean your body temperature often increases. You should exercise caution when performing physical activity to ensure you do not become overheated, as this could then lead to com/health/heat-stroke/">heat stroke.


You should store your Disopyramide in a sealed container, as provided by your chemist. You should keep it safely stored away from the reach of children as it can be dangerous. Be sure to keep it from freezing, and store it at room temperature, away from direct light, moisture and heat. Once you have finished your course of treatment, dispose of any leftover medication in a safe manner as prescribed by your doctor. You should also never take any drugs that are out of date.


If you are suffering from a variety of heart arrhythmias, then Disopyramide can be an extremely useful drug in helping to correct the condition. However, you should be aware that there are a number of different interactions that can occur, and a variety of different side effects are possible. Your doctor can fully assess the risks of you taking Disopyramide, and advise you on means to limit such unwanted effects. You should follow your doctors prescription as accurately as possible, and never make any alterations unless already advised by your doctor.

Disopyramide can cause patients to suffer from a number of problems, like dizziness or blurred vision, which makes dangerous tasks difficult. If you have recently started taking this medication, you should first wait until you are fully aware of any effects it has on your before you perform tasks that are dangerous. If at any time you are worried about the effects it is having, or if you have any questions surrounding your intake, then you should contact your doctor immediately. They are best placed to advise you on any suitable changes you should make. Such alterations can also easily be made at the regularly scheduled appointments you should be making with your doctor.