Domperidone (oral)

Domperidone is a medication that is used to increase the contractions or movements of the bowel or stomach. It is also used to treat the vomiting and nausea caused by drugs taken for Parkinson's Disease.

Overview

Domperidone is a medication that increases the contractions or movements of the stomach and bowels. Domperidone is also used in the treatment of vomiting and nausea that is caused by drugs used to treat Parkinson's Disease. This drug is only to be given under the supervision of a doctor or healthcare professional. This product is available in the dosage form of suspension and tablet.

Condition(s) treated?

  • Symptoms of nausea or vomiting

Type of medicine?

  • Oral tablet

Side Effects

Along with the intended effects of domperidone, this drug can cause a variety of side effects. Not all of these side effects may be present at one time, but if they do occur, you may need medical assistance.

If you suffer from any of the following side effects whilst taking domperidone, contact your doctor or healthcare professional immediately.

Less common side effects

  • Swelling of the mouth

Rare side effects

  • Swelling of the hands, face, lower legs, or feet

Some of the side effects that can occur with this drug do not usually require urgent medical attention. As your body begins to adjust to the medication, these side effects begin to lessen. If they are bothersome, you should contact your doctor or a healthcare professional for advice on ways to reduce or prevent these side effects.

Less common side effects

  • Dry mouth

Rare side effects

  • Change in appetite

Symptoms of overdose

  • Disorientation

Remember you can report any side effects to the FDA.

Dosage

The final dose of any medication will depend on a number of factors. These include your age, weight, height, any current medications you are taking, including those you have taken in the past. Any other medical conditions you suffer from and your reaction to the first dose will also be taken into account when determining your final dose.

For oral dosage form:

Typical adult dose for the treatment of gastrointestinal motility disorders

10 milligrams taken 3-4 times daily. Some patients may need higher doses of up to 20 mg 3-4 times daily.

Typical adult dose for the treatment for nausea and vomiting

20 milligrams taken 3-4 times daily.

If you miss a dose of this medication, take it as soon as you remember. However, if it's close to the scheduled time of your next dose, skip the missed dose and revert back to your original dosing schedule. Under no circumstances should you double doses to make up for a missed dose.

Interactions

Drug interactions can reduce the effectiveness of each drug you are taking and can produce serious side effects. To help limit the risk of these interactions, it's important to inform your doctor or a healthcare professional of all the past and current medications you are taking. This should include all vitamins, herbal products and prescription/nonprescription drugs. You should also make them aware of any other medical conditions you suffer from, including any that run in your family.

The use of domperidone with any of the following medications is not recommended. Your doctor may avoid treating you with this drug or change some of the other medications you are taking.

  • Amifampridine

The use of domperidone alongside any of the following medications is not usually recommended. However, in some cases it may be necessary. If you are prescribed both medications together, your doctor may alter the dose or frequency with which you receive either medication.

  • Abiraterone

Other interactions

The presence of any other medical conditions can affect the use of this medication. You should let your healthcare professional or doctor know if you suffer from any other medical conditions, especially:

  • Medicine sensitivity to domperidone

Interactions with food/alcohol and tobacco

Some medications should not be used at or around the time as eating since it can cause interactions. The use of tobacco or alcohol can also cause interactions. The consumption of grapefruit juice should not be used with this medication. Alcohol intake is not known to affect the workings of domperidone.

Warnings

Use in pediatric patients

Studies of this medication have not been conducted on children, so there is no specific information that compares the use of this medication in children alongside another age group. Safety and efficacy have therefore not been established.

Use in geriatric patients

Many medications have not been specifically studied in older people. Therefore, it is unknown whether they operate the same way they do in younger adults or if they cause different problems or side effects in the older population. There is no information that compares the use of this drug in the elderly with other age groups. Safety and efficacy have not been established.

Use in pregnancy and breastfeeding

If you're pregnant or think you may be pregnant, speak with your doctor or a healthcare professional for advice before taking this medication.

It's always a smart idea to limit the use of this drug whilst pregnant when you are able to do so. However, your doctor may decide that the benefits of this medication outweigh the associated risks. Let your doctor know if you fall pregnant whilst taking this medication.

With regards to breastfeeding, it is not safe to take domperidone if you are breastfeeding.

It is sensible to limit the use of medication during breastfeeding whenever possible.

Allergies

Let your doctor know if you've ever experienced an allergic reaction to this medication or similar medications. You should also inform your doctor or healthcare professional of any other allergic reactions you suffer from, including to animals, dyes, preservatives and foods.

This medication should be taken with water, orally as directed. Domperidone should be used at the lowest dose that is effective for your treatment, for the shortest possible period of time. This medication should be used for the duration you have been advised to get the most benefit from it. Do not alter or change your dose without prior consultation with a doctor or healthcare professional.

Try to take this medication at the same time each day, unless you have been told otherwise. Use an alarm to keep consistency. It can take up to one hour before you feel the full benefit of this medication and some medical conditions may require different dosage requirements. You should seek advice from your doctor. Do not change your doses under any circumstances without speaking with your doctor or a healthcare professional beforehand.

Domperidone should not affect your ability to use machinery or drive. However, you may feel confused, sleepy or have less control of your movements whilst taking this drug. If this does happen, do not use any machinery or drive until you feel better.

Storage

This medication needs to be stored in a closed container at room temperature. It needs to be kept away from moisture, heat and direct light. You should prevent this medication from freezing. Keep this medication out of the reach of children and do not keep medication that is out of date or no longer needed. Contact your local pharmacist for advice on the best way to dispose of this medication.

Summary

When used correctly, domperidone is successful in the treatment of nausea and vomiting as well as increasing bowel and stomach movements. It's important that your doctor monitors your progress at a regularly scheduled visit. This will allow them to check that the medication is working correctly and decide if you need to remain on it. If your symptoms do not improve or if they worsen, then contact your doctor or a healthcare professional immediately. Due to the large amount of interactions possible with this medication, it's important that you let your doctor know about all the medications you are currently taking. Safety and efficacy have not been established for the use of this medication in children or older patients. The maximum duration of this treatment usually does not exceed one week. If you have any questions or require any further information, you should contact your doctor or a healthcare professional for advice.