Dorzolamide and Timolol (Ophthalmic)

Dorzolamide and Timolol is also known under US brand names, Cosopt Ocumeter Plus, Cosopt, Cosopt Ocumeter and Cosopt PF.

Overview

Dorzolamide and timolol ophthalmic are eye drops that are used to treat an increase in pressure in the eye that's caused by a condition called hypertension or open-angle glaucoma. Both eye conditions are caused by increasing pressure in your eye and this can lead to pain your eyes which can eventually harm your vision. This medication can help you retain your eyesight by stopping the pain from reducing the pressure in your eye. This medication is only available via prescription from your doctor and is available in the dosage form of a solution.

Condition(s) treated?

  • Increased pressure in the eye

Type of medicine?

  • Solution

Side Effects

Along with the expected effects of dorzolamide/timolol ophthalmic, the use of this medication can produce some unwanted side effects. whilst not all of these side effects may appear, if they do, you may need medical assistance.

Speak with your doctor or healthcare professional if you suffer from any of the following side effects while taking dorzolamide/timolol ophthalmic:

More common side effects

  • Stinging or burning of the eye (when medication is applied)

Less common

  • Discharge from the eye

Rare side effects

  • Blue lips, fingernails, or skin

Seek emergency help immediately if you experience any of the following signs of overdose when taking dorzolamide/timolol ophthalmic:

Symptoms of overdose

  • Muscle pain or cramps

Some side effects of dorzolamide/timolol ophthalmic that occur usually do not need medical attention. You usually find the intensity of these side effects begins to reduce as your body begins to adjust to the medication. If they are bothersome, you should contact your local pharmacist or healthcare professional for advice on ways to prevent or reduce these side effects.

Check with your health care professional or doctor if any of the following side effects are persistent or you have any questions.

More common side effects

  • Sour, bitter, or unusual taste

Less common side effects

  • Tearing of the eye

Rare side effects

  • Stuffy nose

Dosage

The final dose of any medication will depend on a number of factors. This includes your weight, age and height, your past medical conditions, any current or past medications you are on and your reaction to the first dose. Do not stop or change your dose without prior consultation and advice from your doctor or a healthcare professional. The following doses are only a guideline and your final dose may be different.

Typical Adult Dose for Intraocular Hypertension

One drop of solution into the affected eye or eyes twice a day.

Note:

  • If more than one variety of topical ophthalmic drug is in use, you should administer the drugs 10 minutes apart.
  • The solution from one individual unit needs to be used immediately after it is open, for administration to the eye or eyes.
    Any content that remains should be discarded after administration immediately.

Usual Adult Dose for Glaucoma (Open Angle)

Same dose as above

Typical Pediatric Dose for Intraocular Hypertension

Older than two years old: One drop in the affected eye or eyes twice a day.

TypicalPediatric Dose for Glaucoma (Open Angle)

Same dose as above.

Interactions

Drug interactions can reduce the effectiveness of either drug or increase your risk of unwanted side effects. To limit the risk of these interactions, you should give your doctor or a healthcare professional a full list of the medications you are currently taking. This should include all prescription and nonprescription drugs, all vitamins, and herbal products. You should also mention to your doctor if you suffer from any other medical conditions or if any run in your family.

The use of this medication with any of the following medications is not usually recommended, however in some cases, the combination may be required. If this happens, your doctor may alter or change the frequency in which you use both medications.

  • Memantine

The use of this medication will any of the following medications can increase your risk of some side effects, but both drugs may be necessary for your treatment. If you are prescribed both medications, your doctor may alter the dose or frequency in which you use both drugs.

  • Linagliptin
  • Loxoprofen

There are over 480 drugs that have a moderate reaction to this drug. It's important you let your doctor know if you are taking any of the following medications.

  • Ergonovine
  • Nifedipine

Other Interactions

Some medications should not be used around the time of eating food. This is because it can increase your risk of interactions. Tobacco and alcohol could also react with medications. You should speak with your doctor or healthcare professional about the use of tobacco, food or alcohol with this medication.

Other Medical Problems

If you suffer from any other medical conditions, this could affect the use of this medication. Let your doctor or healthcare professional know if you suffer from any other medical conditions such as:

  • Acute angle-closure glaucoma: The use of this medication has not been studied in patients, so this condition may need other treatment or medication.
  • Asthma, or history of

Warnings

Allergies

Let your doctor know if you have ever suffered from any allergic reactions to this medication or any other medications. You should also let your doctor or healthcare professional know if you suffer from any other allergies such as to animals, preservatives, dyes or foods.

Use in pediatric population

Studies conducted to date have not indicated a pediatric-specific problem that could limit the effectiveness of this drug in children of two years old and above. However, efficacy and safety have not been established in those children younger than two years old.

Use in geriatric population

Studies conducted to date have not indicated a geriatric-specific problem that could limit the effectiveness of this drug in the older population.

Use in pregnancy and breastfeeding

This drug is under FDA pregnancy category C. It is unknown whether dorzolamide and timolol ophthalmic will harm an unborn infant. Let your healthcare professional or doctor know if you are pregnant or intend on falling pregnant while using this drug.

It's unknown whether dorzolamide and timolol ophthalmic can pass into breast milk or if it could harm a baby who is receiving breastmilk. Do not breastfeed whilst using this medication. Speak with your doctor if you have concerns or are currently breastfeeding your baby.

Do not use this medication in a child younger than two years old.

It's extremely important that your doctor monitors the progress of you or your child at regular check-ups to make sure that this medication is working as it should do. Urine and blood test will allow your doctor to test for any unwanted side effects.

If redness, itching, swelling, or other signs of the eyelid or eye irritation occur, then stop using this medication immediately and consult advice from your doctor. These signs could indicate that you or your child is allergic to this medication.

This medication can cause heart failure in some patients. Inform your doctor immediately if you or your child are experiencing chest discomfort or pain, dilated neck veins, irregular breathing, extreme fatigue, an irregular heartbeat, swelling of the fingers, feet, lower legs, shortness of breath, weight gain, or wheezing.

Serious allergic reactions can occur while using this medication. Stop using this medication and inform your doctor urgently if you or your child show any of the following symptoms: tarry, black stools, peeling, blistering, or loosening of the skin, dark urine, chills, muscle or joint pain, rash, sores, red skin lesions, often with a purple center, ulcers, or white spots on the lips or in the mouth, unusual bruising or bleeding, unusual weakness or tiredness, or yellow skin or eyes.

This medication may cause changes in your blood sugar levels and cover up signs of low blood sugar, such as an increased heart rate. Consult your doctor if you or your child experience these problems or if you notice a change in the results of your urine sugar or blood sugar tests.

Before you have any kind of dental treatment, surgery, or emergency treatment, let your dentist or medical doctor aware that you are using this medication. You may need to stop using this medication several days before you have medical tests or surgery.

It's extremely important that you inform your doctor if you get an infection or injury in your eye or if you are scheduled to have eye surgery. Your doctor will let you know whether to keep using the same container of eye drops or if you should start to begin using a fresh bottle of medication.

Do not take other medications unless they have been previously discussed with your doctor.

Proper use

Your eye doctor will let you know how much of this medication to use and the frequency with which to do so. Don't use more medication than you have been told or use it more often than your doctor tells you to.

This medication comes with a patient information insert. Carefully follow and read the instructions. Ask your doctor or healthcare professional for advice if you have any questions.

Use only the brand of this medicine that your doctor has prescribed to you. Do not replace preservative-containing (Cosopt®) with a product without preservative (Cosopt® PF).

Cosopt® PF eye drops is a sterile solution that doesn't contain any preservatives. The solution should be used in the single-unit containers immediately after opening. Dispose of any unused medication.

If you normally wear soft contact lenses, you need to remove them before using Cosopt® eye drops. You should wait at least fifteen minutes before you put your lenses back in.

If you are using Cosopt® PF eye drops, there is a chance you won't need to remove your contact lenses when using this medication, check with your doctor or a healthcare professional.

To use the Cosopt® eye drops:

  • The bottle is only partially full of help provide proper drop control.
  • Next, you need to rip off the safety strip so to break the seal and open the bottle by unscrewing the cap as indicated on the bottle. Don't pull the cap directly up and away from the bottle.
  • Next, drop the medication into the space you have created.
  • Invert the bottle, and gently press the "finger push area" using your index finger or thumb.
  • Let go of the eyelid and then gently close your eyes. Don't blink. Keep your eyes closed and apply pressure to the inner corner of the eye for one to two minutes to let the medication absorb.
  • If you think you were unsuccessful in dropping the medication into your eye, you should replace the cap on the bottle and make it tight. Then remove by turning the cap in the opposite direction as to what is shown in the bottle. Then repeat the process again with another eye drop.
  • You need to replace the cap by turning until firm and touching the bottle. Don't overtighten or you could damage the cap and bottle.
  • After use, immediately, wash your hands to remove any medication that could still remain.
  • To keep the medication germ-free, don't touch the applicator tip to any surface. You should also keep the container closed tightly.
  • Possible loss of vision or serious damage could y result from using contaminated eye drops.

To use the Cosopt® PF eye drops:

  • This medication is packaged in a foil pouch that contains a strip of single-use containers.
  • Begin by washing your hands with water and soap.
  • Pull off one single-use container from the strip. Next, return the remaining strip back in the pouch.
  • Hold the single-use container upright and turn the tab to open the container.
  • Lie down or tilt your head backward and by gently pressing your finger on the skin just beneath the lower eyelid, you should pull the lower eyelid away from your eye to make a small space and use this space to drop the medication into.
  • Ensure you blot any excess solution from around the eye with a tissue.
  • Discard any unused medication from the single-use container.
  • If your doctor ordered two different eye drops to be used in combination, you should wait at least five to ten minutes between applying the medication. This will help to avoid second medication from œwashing out the first one.

Storage

This medication should be kept out of the reach of children. Do not keep any medication that you no longer need or that is out of date. Keep out of the reach of children. Speak with your healthcare professional or doctor about how to dispose of your medication. This medication needs to be kept in a closed container at room temperature away from direct light, heat, and moisture. Keep this medication from freezing.

Keep the Cosopt® PF single-use containers in their original packaging to protect from light. You should write down the date you opened the foil pouch in the space provided in the pouch. Dispose of any unused containers for fifteen days after opening the medication.

Summary

When used correctly, Dorzolamide and Timolol are successful is the treatment of increased pressure in the eye. Due to a large number of interactions, it's important you give your doctor a full list of all the medications you are currently taking. This drug you should not be used when breastfeeding or when pregnant. Let your doctor know if you are pregnant or breastfeeding. Efficacy and safety have not been established for use in those who are aged 2 years or younger. If your symptoms do not improve, contact your doctor as your dose may need to be altered. Do not change or stop your medication without consulting with your doctor or healthcare professional.