Dronedarone (Oral)

Dronedarone is also known under the US brand name Multaq and is a drug that is used to treat certain types of abnormal heartbeats.

Overview

Dronedarone is a medication that is used to lower the chance of going to the hospital for serious heart rhythm problems in those patients who suffer from persistent atrial fibrillation or paroxysmal. This drug belongs to the group of medications known as antiarrhythmics. They work directly on the heart tissue and slow the hearts nerve impulses which can help keep the heart rhythm normal. This medication is only available via prescription from your doctor and is available in the dosage form of a tablet for oral consumption.

Condition(s) treated?

  • Paroxysmal Atrial Fibrillation

Type of medicine?

  • Oral medication

Side Effects

Along with the intended side effects, some unwanted side effects can occur while taking this drug. Inform your doctor immediately if you suffer from any of the following side effects whilst taking dronedarone.

Less common side effects

Incidence not known

  • Yellow skin or eyes

Some side effects that occur with this drug, may not usually need medical attention. These side effects will usually begin to reduce as your body begins to adjust to the medication. If they are bothersome, you should contact a healthcare professional or local pharmacist for advice on ways to prevent or reduce these side effects. Inform your health care professional if any of these side effects continue or become worse or if you have any questions about them:

More common side effects

  • Loss or lack of strength

Less common side effects

  • Swelling

Rare side effects

  • Increased sensitivity of the skin to sunlight

Not all side effects may be present and if you notice anything strange, then consult advice with a healthcare professional or your doctor.

Remember you can report all side effects to the FDA on 1-800-FDA-1088.

Dosage

The final dose of any medication will depend on individual factors. This includes your age, weight and height, any current and past medications you are taking, any other medical conditions you suffer from and how you react to the first dose for treatment. Do not alter your dose unless your doctor has told you to do so.

Typical Adult Dose for Atrial Fibrillation and Atrial Flutter


400 mg orally twice a day to be taken with a meal.

Children: the use and dose will be determined by your doctor or healthcare professional.

If you miss a dose of this medication, skip the missed dose and revert back to your regular dosing schedule. Under no circumstances should you double dose to make up for a missed dose.

Interactions

Drug interactions can cause severe side effects and reduce the effectiveness of each drug. To help limit the risk of interactions it's important that you give your doctor a full list of all the current medications you are taking and any medication you have taken in the past. You should also let your doctor know if you suffer from any other medical conditions or if any conditions run in your family.

The use of this medication, with any of the following medications, is not recommended. Your doctor may decide to avoid treating you with this drug altogether or alter some of the other medications you are taking.

  • Pimavanserin

The use of this medication alongside any of the following medications is not usually recommended, but in some cases, they may be required. If you are prescribed both medications, your doctor may alter the frequency or dose of one or both medications.

  • Sonidegib

The use of this medication with any of the following medications can cause an increase in your risk of some side effects, but sometimes both medications may be necessary. If you are using both medications together, your doctor may alter the dose or frequency in which you use both or one of the medications.

  • Suvorexant

There are over 550 drugs that are known to have a moderate interaction with this drug. Let your doctor know if you are currently taking any of the following medications.

  • Indacaterol

Other Interactions

Some medications should not be used when eating food or eating certain types of food since it can increase your risk of interactions. Using alcohol or tobacco can also cause interactions.

Using this medication with any of the following is not usually recommended, but in some cases, it may be unavoidable. If used together, your doctor may alter the dose or frequency in which you use this medication or give you specific instructions about the use of tobacco, alcohol or food.

  • Grapefruit Juice

Other Medical Problems

If you suffer from other medical conditions, this can affect the use of this medication. Ensure you tell your doctor if you've got any other medical conditions, especially:

Warnings

Allergies

Let your doctor or healthcare professional know if you have ever suffered from an allergic reaction with this medication or any other medications. You should also let your doctor or healthcare professional know if you suffer from any other allergies including, to preservatives, dyes, foods or animals.

Use in the pediatric population

Studies have not been conducted to date on the relationship of age to the effects of dronedarone in the younger population. Therefore efficacy and safety have not yet been established.

Use in geriatric population

Studies conducted to date have not indicated a geriatric-specific problem that could limit the effectiveness of dronedarone in the older population.

Use in pregnancy and breastfeeding

Dronedarone is under FDA pregnancy category X. You should not use this drug if you are pregnant as to do so could cause birth defects or harm the unborn baby. Use effective birth control to prevent falling pregnant while using this medication and let your doctor know immediately if you fall pregnant.

It's unknown whether this drug passes into breast milk or if it could harm a nursing infant. You should not breast-feed while taking this medication.

It's extremely important that you allow your doctor to monitor your progress at regular appointments to ensure this medication is working popularly. Urine and blood test are useful for checking for unwanted side effects.

Don't use this medication if you are also using cyclosporine ( Sandimmune®, Gengraf®, Neoral®), ritonavir (Norvir®), medication for depression (such as nefazodone, amitriptyline, nortriptyline, Serzone®, Elavil®), medication for heart rhythm problems (such as disopyramide, amiodarone, dofetilide, propafenone, flecainide quinidine, sotalol, Tikosyn®, Cordarone®, Cardioquin®, Norpace®), medication for infections (such as erythromycin, clarithromycin, itraconazole, telithromycin, ketoconazole, voriconazol, Nizoral®, Vfend®, Ery-tab®), or a phenothiazine medication (such as prochlorperazine, chlorpromazine, promethazine, Compazine®, thioridazine, Mellaril®, Thorazine®, Phenergan®, Trilafon®). The use of these medications together could produce serious side effects.

Let your doctor know immediately if you develop any of the following: shortness of breath, chest pain, swelling of your hands, feet or ankles or weight gain. These could show signs of heart failure.

This medication can cause changes in your heart rhythm, such as a prolongation. It can cause fainting or serious side effects in some patients. Inform your doctor right away if you suffer from any symptoms of heart rhythm problems, such as pounding, fast, or irregular heartbeats.

Let your doctor known immediately, if you suffer from pale stools, stomach pain, loss of appetite, unusual tiredness, nausea, or yellow skin or eyes. These could be signs of a serious liver problem.

Inform your doctor immediately if you are having chest tightness, shortness of breath, or any type of breathing problem while being treated with this medication.

This medication may increase your risk of stroke, heart attack, or other serious side effects. Let your doctor know whether you should continue to take this medicine for persistent atrial fibrillation or paroxysmal.

Don't stop taking this medication without first checking with your doctor.

Proper use

>

You should take this medication as directed by your doctor or healthcare professional. You should not take more of it, less, take it more frequently or for a longer period of time that was ordered. If you do so, you could increase your risk of serious side effects.

This medication should come with a Medication Guide. It' s important that you read this information carefully. Ensure you ask your doctor about questions or queries you may have. This medication needs to be taken with food.

Storage

This medication needs to be stored in a closed container and kept away from moisture, heat and direct light. you should not let this medication freeze. Keep this medication out of the reach of children. Do not keep medication that is no longer needed or is out of date. Speak with your healthcare professional about how you should dispose of any medication you have in a safe manner.

Summary

When used correctly, dronedarone is successful in the treatment of a variety of heart rhythm problems. Due to a large number of interactions possible, it's important that you let your doctor know about all the drugs you are currently taking. You should not under any circumstances take this medication while pregnant as it could cause birth defects. You should not use this drug whilst breastfeeding. Check your own pulse often, and seek medical attention right away if you notice an irregular rhythm. Contact your doctor if you begin to suffer from any side effects, even if they are not listed above. Safety and efficacy have not been established for the use of this medication in the use of children.