Droperidol (Injection)

Droperidol injection is a drug that is used post-surgery and following certain medical tests in order to prevent the feelings of sickness that can sometimes occur.

Overview

Droperidol is usually given to patients who are undergoing certain medical tests, which can leave them feeling nauseous or likely to vomit. The drug is also used following surgery in patients who are made nauseous as a side effect of general anesthesia, and to prevent them from vomiting.

Droperidol is given by injection into a muscle or vein. This drug is only used in a hospital or clinic setting and will be administered by a nurse, doctor, or other trained health professional.

In the US, droperidol is known by the brand name, Inapsine.

Conditions treated

  • Post-surgical nausea and vomiting prevention

Type of medicine

  • Antiemetic
  • Solution
  • Injection

Side effects

In addition to its desired effects, droperidol can cause a few unwanted side effects. Not everyone who is given this drug will notice any of these effects, but if you do, you might need to speak to your doctor for further treatment.

If you experience any of the following effects, tell your doctor or nurse straight away:

  • Unusual tiredness or weakness
  • Tightness of the chest
  • Swelling or puffiness around the eyelids, eyelids, face, tongue, or lips
  • Sweating
  • Slow or irregular heart rate
  • Severe confusion
  • Rapid heartbeat
  • Pounding, or irregular pulse or heartbeat
  • Noisy breathing
  • Low blood pressure
  • Loss of consciousness
  • Hives, skin rash, or itching
  • Feeling faint, dizzy, or lightheaded when getting up suddenly from a prone or seated position
  • Fainting
  • Difficulty with swallowing
  • Cough
  • Confusion
  • Chills
  • Chest pain or discomfort
  • Breathing problems
  • Blurred vision

There are also some effects that may be caused by droperidol that usually resolve themselves, without the need for medical attention, as your body gets used to the new drug. Your doctor or nurse may give you some advice on how to prevent or manage some of these effects. However, if any of these effects become especially troubling or do not go away after a day or two, ask your doctor for more advice.

  • Twisting movements of the body
  • Trouble sitting still
  • Stiffness of the limbs
  • Shuffling walk
  • Restlessness
  • Muscle jerking, trembling, or stiffness
  • Loss of balance
  • Hallucinating
  • Drowsiness
  • Drooling
  • Difficulty speaking
  • Anxiety
  • Uncontrolled movements, especially of the back, neck, and face

You may notice other effects that are not mentioned in this guide. If you do, you should check with your nurse or doctor.

Some patients may notice a skin reaction around the site of the injection. If your skin becomes itchy, reddened, or begins to peel, you should mention this to your nurse immediately. If you experience this reaction following an intramuscular injection, your next dose may be given to you into one of your veins, as you are less likely to suffer this side effect with this site.

Dosage

You will only receive droperidol while you are in a clinic or hospital for diagnostic tests or for a surgical procedure. A trained medical professional will administer this drug if you suffer feelings of nausea or if you are likely to vomit.

The drug is administered via an injection into a vein or muscle.

The dosage rate is calculated according to your body weight, age, and the circumstances of your treatment.

Droperidol is not generally used in the treatment of children under two years of age.

In elderly patients, droperidol will be given at a slightly reduced dosage rate in order to avoid potential side effects that are sometimes associated with certain age-related medical conditions.

Interactions

Some drugs and drug groups should never be used together, as doing so could cause a serious interaction. However, it may be necessary for your doctor to prescribe two drugs together if this is the best treatment for your condition. In this case, your doctor may adjust the dose of one of the drugs or possibly change one for the duration of your treatment with droperidol.

Be sure to tell your treating physician if you are taking any of the drugs listed below, before you are treated with droperidol:

  • Zuclopenthixol
  • Zotepine
  • Zolmitriptan
  • Ziprasidone
  • Zimeldine
  • Xipamide
  • Voriconazole
  • Vinflunine
  • Vemurafenib
  • Vasopressin
  • Vandetanib
  • Urea
  • Triptorelin
  • Trimipramine
  • Trimethoprim
  • Triflupromazine
  • Trifluoperazine
  • Trichlormethiazide
  • Triamterene
  • Trazodone
  • Tranylcypromine
  • Tramadol
  • Torsemide
  • Toremifene
  • Toloxatone
  • Tizanidine
  • Ticrynafen
  • Tiapride
  • Thioridazine
  • Tetrabenazine
  • Terfenadine
  • Telithromycin
  • Telavancin
  • Tedisamil
  • Tapentadol
  • Tacrolimus
  • Sunitinib
  • Sultopride
  • Sulpiride
  • Sulfamethoxazole
  • Sufentanil
  • Spironolactone
  • Spiramycin
  • Sparfloxacin
  • Sotalol
  • Sorbitol
  • Sorafenib
  • Solifenacin
  • Sodium Phosphate, Monobasic
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate
  • Sibutramine
  • Sevoflurane
  • Sertindole
  • Sematilide
  • Selegiline
  • Saquinavir
  • Salmeterol
  • Ritanserin
  • Risperidone
  • Remoxipride
  • Remifentanil
  • Rasagiline
  • Ranolazine
  • Quinine
  • Quinidine
  • Quinethazone
  • Quetiapine
  • Protriptyline
  • Propafenone
  • Promethazine
  • Prochlorperazine
  • Procarbazine
  • Procainamide
  • Probucol
  • Prajmaline
  • Posaconazole
  • Polythiazide
  • Pitolisant
  • Pirmenol
  • Piretanide
  • Piperaquine
  • Pipamperone
  • Pimozide
  • Pimavanserin
  • Phenelzine
  • Perphenazine
  • Periciazine
  • Perflutren Lipid Microsphere
  • Pentazocine
  • Pentamidine
  • Pazopanib
  • Pasireotide
  • Paroxetine
  • Pargyline
  • Panobinostat
  • Paliperidone
  • Oxymorphone
  • Oxycodone
  • Ondansetron
  • Ofloxacin
  • Octreotide
  • Nortriptyline
  • Norfloxacin
  • Nilotinib
  • Nicardipine
  • Nialamide
  • Nefazodone
  • Nafarelin
  • Moxifloxacin
  • Morphine Sulfate Liposome
  • Morphine
  • Molindone
  • Moclobemide
  • Mifepristone
  • Mibefradil
  • Mianserin
  • Metronidazole
  • Metolazone
  • Methadone
  • Mesoridazine
  • Meperidine
  • Mefloquine
  • Mannitol
  • Lumefantrine
  • Lorcainide
  • Lopinavir
  • Lithium
  • Linezolid
  • Lidoflazine
  • Levomethadyl
  • Levofloxacin
  • Leuprolide
  • Lazabemide
  • Lapatinib
  • Lactulose
  • Lacidipine
  • Ketoconazole
  • Ivabradine
  • Isradipine
  • Isoflurane
  • Isocarboxazid
  • Iproniazid
  • Indapamide
  • Imipramine
  • Iloperidone
  • Ibutilide
  • Hydroxyzine
  • Hydroxychloroquine
  • Hydroquinidine
  • Hydroflumethiazide
  • Hydrocodone
  • Hydrochlorothiazide
  • Histrelin
  • Halothane
  • Haloperidol
  • Halofantrine
  • Granisetron
  • Goserelin
  • Gonadorelin
  • Gemifloxacin
  • Gatifloxacin
  • Gallopamil
  • Furosemide
  • Furazolidone
  • Foscarnet
  • Fluvoxamine
  • Fluspirilene
  • Fluoxetine
  • Flunarizine
  • Fluconazole
  • Flibanserin
  • Flecainide
  • Fingolimod
  • Fentanyl
  • Fenquizone
  • Fendiline
  • Felodipine
  • Etozolin
  • Ethacrynic Acid
  • Escitalopram
  • Erythromycin
  • Enflurane
  • Encainide
  • Efavirenz
  • Ebastine
  • Dronedarone
  • Doxylamine
  • Doxepin
  • Donepezil
  • Domperidone
  • Dolasetron
  • Dofetilide
  • Docusate
  • Disopyramide
  • Diltiazem
  • Dihydrocodeine
  • Dibenzepin
  • Deslorelin
  • Desipramine
  • Delamanid
  • Degarelix
  • Dasatinib
  • Dabrafenib
  • Cyclothiazide
  • Cyclobenzaprine
  • Crizotinib
  • Codeine
  • Clozapine
  • Clorgyline
  • Clopamide
  • Clomipramine
  • Clarithromycin
  • Citalopram
  • Cisapride
  • Ciprofloxacin
  • Chlorthalidone
  • Chlorpromazine
  • Chloroquine
  • Chloral Hydrate
  • Castor Oil
  • Canrenoate
  • Butorphanol
  • Buserelin
  • Bupropion
  • Buprenorphine
  • Bumetanide
  • Bromperidol
  • Bromazepam
  • Brofaromine
  • Bretylium
  • Bepridil
  • Benzthiazide
  • Bendroflumethiazide
  • Bemetizide
  • Bedaquiline
  • Azosemide
  • Azithromycin
  • Azimilide
  • Astemizole
  • Asenapine
  • Artemether
  • Arsenic Trioxide
  • Aripiprazole
  • Aranidipine
  • Aprindine
  • Apomorphine
  • Anagrelide
  • Amoxapine
  • Amlodipine
  • Amitriptyline
  • Amisulpride
  • Amiodarone
  • Amiloride
  • Amifampridine
  • Alfuzosin
  • Ajmaline
  • Acetophenazine
  • Acetazolamide
  • Acecainide

This list of possible drug interactions is not necessarily exhaustive. If you are taking any other form of medicine, including over the counter medicines, vitamin supplements, or herbal remedies, be sure to tell your doctor before you begin to receive treatment with droperidol.

Some medications should not be used when you are eating, drinking alcohol, or using tobacco. You should talk to your treating physician about your use of certain foods, tobacco, and alcohol while you are being treated with droperidol.

<Warnings

When you agree to treatment with a drug, you must assess the risks and benefits of doing so. This is a decision that you will arrive at, following discussion with your treating physician. In the case of droperidol, the following should be taken into consideration:

Using droperidol to treat patients with any of the following conditions is not usually recommended as it can make their side effects to become worse:

Patients should be aware that using droperidol with any of the following conditions can make them worse:

  • Cardiac arrhythmias
  • Hypotension

The use of droperidol in patients with the following conditions is not recommended:

  • Congenital long QT syndrome
  • QT prolongation

Droperidol should be used with caution in patients with a history of liver or kidney disease, because these conditions cause the drug to be removed more slowly from the body, potentially increasing its effects.

If you have ever suffered from an allergy to droperidol or to any other medication, you must tell your doctor. You should also mention if you have any other forms of allergies to certain food groups, food colors, preservatives, or animal by-products.

It is not recommended to use this drug in children under two years of age, as there has been insufficient research into the effects it may have.

When using droperidol in elderly patients, it should be taken into account that they may suffer from age-related illnesses such as kidney or heart problems. Dosage levels should therefore be adjusted accordingly.

It is not known whether droperidol causes harm to the unborn baby. Tell your doctor if you are pregnant or if you are intending to become pregnant while you are being treated with this drug. It is also unknown if droperidol passes into breast milk. If you are breastfeeding, you should discuss the safety of doing so while you are being treated with this drug.

You must tell your nurse of doctor immediately if you begin to experience any of the following effects, immediately after receiving droperidol:

  • Feeling faint or dizzy
  • Change in your heart rhythm

Tell your doctor if you or any of your relatives have ever suffered from any form of heart rhythm problems.

Notify your nurse or doctor immediately if you notice that your heart rate has increased, if you develop a high fever, if you have breathing difficulties, if you notice that your blood pressure has changed, if you have stiff muscles, pale skin, an increase in sweating, or a loss of bladder control. All these signs could mean that you have suffering from a serious condition called NMS (neuroleptic malignant syndrome).

Droperidol will exacerbate drugs that make you feel less alert or drowsy, including many over the counter cold medication, hay fever tablets, and sleeping pills. Alcohol will also make these effects worse. You should also mention any herbal sleeping remedies that you use. Be sure to ask your doctor's advice before you take any of these medicines if you are still being treated with droperidol.

Storage

You will not usually be required to store droperidol in your home, as it will generally only be given to you in a hospital setting. However, if you do, you must keep it at a temperature between 68°F to 77°F, in its original container, out of direct sunlight, and away from direct heat sources.

Diluted solution should not be kept for more than seven days.

Summary

Droperidol injection is used in a hospital setting to treat patients who are suffering from feelings of nausea following diagnostic testing or surgery. The drug is administered via injection into a muscle or vein and is always given by a trained medical professional.

There is a wide range of medication that should not be used while a patient is being treated with droperidol, as doing so can cause more side effects and potentially serious interactions. Fortunately, most people who receive droperidol only do so for a short post-operative period, and your treating physician may simply reduce your dose of your usual medicine during this time, returning it to the usual dose once your use of droperidol has ended.

There are a number of serious medical conditions that can be made worse if droperidol is given to patients suffering from these illnesses. For this reason, it is very important that you have a full discussion of your medical history, before you begin treatment with droperidol. You will also have frequent reviews with your medical team while you are taking this drug. This is to make sure that the medicine is working properly and is also your chance to mention any side effects that you have noticed.