Eprosartan and Hydrochlorothiazide (Oral)


Eprosartan and Hydrochlorothiazide is used, together with other medicines, as a way to treat patients suffering from hypertension (high blood pressure). If you do suffer from this condition, it's vital you seek a form of medication such as this one. Failure to do so can lead to severe damage to arteries and the heart, as high blood pressure increases the workload they need to perform. This can further lead to damage to the blood vessels in the kidneys, brain, and heart, in turn leading to possible strokes, kidney failure, and heart failure. Taking Eprosartan and Hydrochlorothiazide can, therefore, lower the blood pressure and reduce the risk of heart attacks and strokes.

The Eprosartan portion of this combination is known as an angiotensin II receptor blocker (ARB). Eprosartan is able to relax your blood vessels by blocking a certain substance in your body which is causing the blood vessels to tighten in the first place. In turn, the supply of oxygen and blood to the heart increases, allowing the blood pressure to become lower.

At the same time, the hydrochlorothiazide is known as a water pill (or thiazide diuretic). This increases the flow of urine from your body, and thus reducing the water level you have. In turn, this acts as a means to further reduce blood pressure.

You should never seek to obtain Eprosartan and Hydrochlorothiazide on your own as it is only available via prescription. Your doctor will first need to fully assess the extent of your medical condition and see if this is a suitable drug for you to take. Eprosartan and Hydrochlorothiazide has the potential to cause a number of different side effects, and to interact with many other substances. Your doctor can advise on the best means to reduce the chances of unwanted side effects.

Condition(is) treated

  • High blood pressure

Type of medicine

  • Tablet

Side Effects

As like most other drugs, Eprosartan and Hydrochlorothiazide combination can cause a wide variety of different side effects to occur. Directly below is a list of the most severe side effects that patients may experience. If you are affected by any of the following whilst taking Eprosartan and Hydrochlorothiazide, you should contact your doctor immediately for medical assistance.


  • Increased volume of dilute, pale urine

Incidence not known

  • Thickening of bronchial secretions

As well as these, there are also a large number of other possible side effects which aren't as serious. Instead, these side effects may pass as your treatment continues. Directly below is a list of such side effects. If you do experience any of these and they are overly persistent or are worrying you, then you may still contact your doctor. They may be able to advise you means to reduce these effects and make them more manageable.


  • Feeling unusually cold

Incidence not known

  • Redness of the skin

Though this list is extensive, it is not necessarily complete. You may experience other unwanted side effects as a result of taking Eprosartan and Hydrochlorothiazide combination. If this is the case, and you would like to discuss the effects, then contact your doctor for advice.


Below you can find the average dosages give to patients suffering from high blood pressure. However, do be aware that your dosage may differ due to a number of different factors such as your existing health condition, and other drugs you take. It may also be that you have a higher strength tablet, and need to take it more frequently. Either way, you should stick to your exact prescription as given by your doctor. If you feel it needs altering at all, then you should contact your doctor and discuss it with them.

  • Adults. Take one tablet a day. This dosage may then be increased as treatment progresses.

If you miss a dose for any reason then you should take this missed dose as soon as you remember. However, if it is almost time for your next dose then you should skip the missed dose. This is because it is important you never double dose.

Do be aware that this is not the first drug you should use to treat hypertension. Instead, it should only be taken by patients who have already tried other medicines but found that they either do not work or cause unwanted side effects.

When being prescribed Eprosartan and Hydrochlorothiazide, it is likely your doctor will also recommend other ways in which to help your high blood pressure. Often times this includes changes to your diet, such as reducing foods that are high in salt (sodium). If this is something your doctor has prescribed, then follow these changes in diet alongside taking Eprosartan and Hydrochlorothiazide. However, you should only make such changes if they have been advised by your doctor.

Taking Eprosartan and Hydrochlorothiazide is often a helpful way to better control your high blood pressure, though it is not necessarily a means to treat it. As such, you should continue to take your dosages as prescribed by your doctor, even if you begin to feel better. This will usually mean sticking to a set of regular appointments whereby your doctor can monitor your condition and make any adjustments to your prescriptions as necessary.

You may need to continue to take medicines such as Eprosartan and Hydrochlorothiazide for the rest of your life, as failure to do so could lead to the severe health problems that high blood pressure can cause.

You can take Eprosartan and Hydrochlorothiazide either with or without food.


Interactions can commonly occur between Eprosartan and Hydrochlorothiazide and a number of different things, notably drugs. Sometimes it is possible to avoid such interactions, but in others, they may be expected. Either way, directly below you can find a list of drugs with which it is not recommended you take alongside Eprosartan and Hydrochlorothiazide. The interactions caused can be potentially harmful. Instead, your doctor may need to advise other forms of medication.

  • Dofetilide

As well as this, there are other drugs with which interactions are likely to occur, but it is often still necessary to take both drugs. If you take any of the below, then it is usually not recommended that you continue to take them with Eprosartan and Hydrochlorothiazide. However, in order to limit such interactions your doctor may suggest altering one or more of the dosages.

  • Fenoprofen

Finally, the drugs below are those which are known to cause an increased chance of certain side effects occurring. Your doctor may still require you to take the two, but can advise on ways to limit such unpleasant side effects.

  • Ketorolac

Though this list of drugs is extensive, it does not necessarily include all drugs which could interact with Eprosartan and Hydrochlorothiazide. As such you will need to be open and honest with your doctor about disclosing all drugs you take. This includes all prescription, non-prescription, supplements and herbal remedies.

As well as drugs, there is a chance that Eprosartan and Hydrochlorothiazide could interact with other parts of your dietary intake, including what you eat, drink, smoke, and drink. You should be open in disclosing all aspects of your diet so that your doctor can advise on any such interactions that may occur. They may well advise you on certain dietary adjustments you should make in order to limit interactions from occurring.

Finally, Eprosartan and Hydrochlorothiazide also have the potential of interacting with other existing medical problems you suffer from. As always, be open with all medical problems you have. But also be aware that below are more severe medical problems that are particularly sensitive to interacting with Eprosartan and Hydrochlorothiazide.

  • Myopia, acute (changes in the eyeball leading to vision problems)


As mentioned previously, you will only be prescribed Eprosartan and Hydrochlorothiazide following a full medical consultation with your doctor. They will need to know the chances of any unwanted side effects occurring. A part of this consultation will mean looking into any allergies you have. You will need to disclose any allergies you have to either of these drugs, as well as other drugs, food, animals, dyes, and to preservatives.

As of writing, no efficacy and safety standards have been established for pediatric patients taking Eprosartan and Hydrochlorothiazide. This is because no appropriate studies have yet taken place. Instead, your doctor will need to decide whether this is a suitable drug for your child to take.

The Studies performed on geriatric patients have not shown any signs that this drug combination is any less useful in geriatric patients. However, the prescribing doctor will need to assess any other pre-existing medical conditions that elderly patients are suffering from.

Studies performed including Eprosartan and Hydrochlorothiazide and pregnant patients have identified an increased risk to the fetus. However, if the high blood pressure is life-threatening, it may mean that taking this drug combination is necessary. Your doctor is best placed to weigh the potential risks with any benefits you can expect. If, whilst taking Eprosartan and Hydrochlorothiazide, you become pregnant, then you should inform your doctor immediately as they may need to alter your prescription.

With regards to women who are breastfeeding, no adequate studies have been performed as of yet. Your doctor is most up to date with any such studies and can advise as to whether there is an increased risk of taking this drug combination whilst breastfeeding.

Your doctor will schedule regular appointments whilst you are taking Eprosartan and Hydrochlorothiazide. To check for any unwanted effects they may require you to undertake urine or blood tests. It is important that you attend all scheduled appointments so that they can make any necessary adjustments to your prescription.

It is recommended that you do not try and get pregnant whilst taking Eprosartan and Hydrochlorothiazide. Instead, you should use effective birth control and inform your doctor if you do become pregnant.

When taking a diuretic pill, which the hydrochlorothiazide is, then you may experience fainting, dizziness, or lightheadedness when getting up suddenly from a lying or sitting position. If you do feel dizzy, you should lie down or sit before standing again. Do not attempt to drive, or perform any dangerous tasks before you know how Eprosartan and Hydrochlorothiazide effects you. If you faint at any time whilst taking this drug combination, inform your doctor immediately.

If you get sick whilst taking this medicine then inform your doctor straight away. The associated diarrhea, nausea, or vomiting can cause you to lose too much salt or water, in turn leading to low blood pressure. This could be worsened by any sweating, so drink plenty if you are in the hot or are performing exercise.

If you suffer from eye pain, blurred vision, difficulty reading, or have any other changes in vision whilst taking Eprosartan and Hydrochlorothiazide, then speak to your doctor. It could be that these are indications of a serious eye problem which needs addressing immediately.

Taking Eprosartan and Hydrochlorothiazide combination can cause fluctuations in your blood sugar levels. If you notice changes in your blood or urine tests, then tell your doctor right away.

You should not take any salt substitute, medicines, or supplements that contain potassium without first checking with your doctor that they are suitable.

Similarly, do not take any other medicines unless you have first cleared them with your doctor. In particular, this includes non-prescription medicines designed to help appetite control or to treat sinus problems, coughs, asthma, colds, or hay fever. These drugs tend to increase your blood pressure.


You should store your Eprosartan and Hydrochlorothiazide in a sealed container as given to you upon collecting the prescription. Keep it away from heat, moisture, and direct light. You should store it at room temperature, and keep it from freezing at all times. Once you are done taking the medication, or if you find it goes out of date at any point, then you should dispose of any remaining medication in a safe and sensible manner. For assistance in doing so, contact your doctor.


If you suffer from hypertension, otherwise known as high blood pressure, then taking Eprosartan and Hydrochlorothiazide is a potentially very helpful way of preventing the condition from leading to further health complications. It's usually given after other alternative medicines have been found to not work, or is taken alongside other medicines. You should not seek to obtain this drug on your own, as it is given following a full medical consultation. Above, you can find full details on any potential side effects and interactions that can occur, and your doctor is best placed to minimise the chances of any of these occurring.

As your treatment with Eprosartan and Hydrochlorothiazide continues, you may find that your symptoms of Eprosartan and Hydrochlorothiazide start to subside. This is not a sign you should stop taking your medication, as doing so could lead to your condition getting worse once again. Instead, you should address all questions regarding your prescription to your doctor. Similarly, if you are experiencing any worrying side effects and would like to help relieve these, then speak to your doctor.