Esomeprazole (Oral)

Esomeprazole belongs to a group of gastric acid secretion inhibitor, decreasing the amount of acid produced by the stomach.

Overview

Esomeprazole is in a class of drugs called proton pump inhibitors (PPIs), decreasing the supply of acid produced by the stomach. As a PPI, it blocks the enzyme in the wall of the stomach that produces the acid.

Esomeprazole treats conditions caused by too much acid in the stomach. Helicobacter pylori (H.pylori) infection or nonsteroidal anti-inflammatory drugs (NSAIDs) used for pain and arthritis can cause the symptoms. This is not the same as over-the-counter (OTC) heartburn relief, but OTC may have a serious or uncomfortable side effect with this medicine.

  • Duodenal and gastric ulcers
  • Erosive esophagitis
  • Gastroesophageal reflux disease (GERD)
  • Zollinger-Ellison syndrome

Your doctor may not use this medicine for treatment if you suffer from these conditions.

  • Liver disease
  • Lupus
  • Osteoporosis
  • Low levels of Magnesium in your blood

Health Warning

Esomeprazole may increase the risk of bone fracture in the hip, wrist or spine. Incidents happen, more often in individuals taking this medicine for a long time or adults 50 years of age and older. Clinical tests have NOT shown esomeprazole to be the cause. Precautions need to be taken when using this drug therapy to control stomach acid.

Conditions Treated

  • Duodenal
  • Gastric ulcers
  • Erosive esophagitis
  • Gastroesophageal reflux disease (GERD)
  • Zollinger-Ellison syndrome

Type Of Medicine

  • Gastric Acid Secretion Inhibitor, Gastrointestinal Agent

Side Effects

We rely on help from medications to prevent or treat a health condition. Sometimes, introducing medications into our daily routines can cause minor to serious side effects. Esomeprazole offers benefits of easing and healing, health conditions caused by excess stomach acid. If you suffer with gastrointestinal symptoms, this drug may work for you. It's critical that your doctor knows about your past and current medical incidents to prevent any harmful effects.

In most cases, these conditions are discovered in early stages and treatment will help to prevent more damage that is serious and manage the current condition. If you recognize any of these symptoms, it's time to see the doctor.

  • Duodenal and gastric ulcers

O Gastric and duodenal ulcers are peptic ulcers. Peptic ulcers are sores on the inside of the stomach lining (gastric) or the upper part of the small intestine (duodenal). It's possible to have both types of ulcers known as gastroduodenal.

  • Erosive esophagitis

O This condition occurs when the lining of the esophagus is inflamed or eroded as stomach acid backs up into the esophagus.

  • Gastroesophageal reflux disease (GERD)

O ERD causes the injury to the esophagus and heartburn.

  • Zollinger-Ellison syndrome

O One or more tumors form in the pancreas or the upper part of the small intestine. They secrete a peptide hormone causing the stomach to produce excessive amounts of acid. The acid contributes to the peptic ulcers.

There are situations where treatment effects are linked to an existing health condition or your own intolerance to a chemical substance in foods or medicines you are taking now. Allergic reactions are rare with this medicine, but from time to time, they can happen and they can be serious. If you experience any effects while taking esomeprazole contact your doctor. If you have known allergies to foods, dyes, preservatives or animals, tell your doctor. Many times the compounds in medicines contain similar elements that trigger an allergic response.

Your doctor will tell you what side effects are more prevalent with your disorder (s) 'most individuals experience some of these listed, but not all. You may experience a side effect not listed, be sure to tell your doctor if the effect persists or reaches a level of discomfort beyond your tolerance. There are methods to help prevent or relieve the effects. The severity of each effect will vary from person to person depending on your health, the current phase of your disorder and age.

Most Common

  • Change in taste
  • Constipation
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Gas
  • Headache
  • Indigestion
  • Itching
  • Nausea
  • Nervousness
  • Rash
  • Stomach pain

Some side effects do not need medical attention. In most cases, the effects fade during treatment as your body adjusts to the medicine. Your doctor will tell you about ways to prevent or reduce the side effects you're experiencing. It is important to keep your doctor updated on how you feel if any of the side effects continue. Talk with your doctor - they can't help if they don't know. If you have questions about the effects 'ask for information.

It's essential to tell your doctor of the severity and persistence of side effects throughout treatment. The changes may be signs of underlying conditions prompting an unexpected reaction. Since everyone is unique, your doctor will watch for changes gathering more information about your response.

Least Common

  • Cough
  • Darkened urine
  • Jaundice
  • Loss of appetite
  • Mood changes
  • Muscle spasms
  • Red, irritated eyes
  • Sores in the mouth
  • Tightness in the chest
  • Trembling
  • Vomiting

In all health cases, current disorders, diet regimes that include particular foods, health supplements, and herbal remedies can trigger a side effect. Lifestyle choices about alcohol, tobacco, illegal drugs and other medications will instigate side effects that are more serious.

There are situations where this medicine should not be used. If you have allergies, you may have a dangerous allergic response to this medicine depending on the condition. H.pylori infections are treated with multiple medicines' if you are allergic to penicillin, you may have a reaction when treated with amoxicillin and esomeprazole. Tell your doctor, there may be an alternative medicine that works better with esomeprazole.

Medical studies have proven the effectiveness of drugs like esomeprazole to treat health disorders and diseases' yet in some cases, there are side effects that can be detrimental to our health and inconvenient to our lives. The side effects vary depending on your health condition and most are not serious, but if they persist or worsen, you need to talk with your doctor about the symptoms. They may be options to lessen the pain and the frequency of side effects.

If you are receiving treatment for other health conditions, talk to your doctor to avoid unwanted adverse reactions.

Rare, but they can occur.

  • Agitation
  • Allergic reaction
  • Back pain
  • Fever
  • Hair loss or thinning of the hair
  • Hallucinations
  • Irregular heartbeat
  • Joint pain
  • Muscular weakness
  • Seizures
  • Skin rash
  • Swelling or inflammation of the mouth
  • Swollen joints

Precautions

PPIs are associated with increased incidents of the conditions listed. If you recognize unusual effects while taking this medicine ' contact your doctor. DO NOT stop taking this medicine before talking with your doctor. If you have medical appointments or health treatments scheduled, be sure to tell the doctor and the attending physicians that you are taking this drug before proceeding with treatment.

Because there are noted precautions when treating adults with this medicine, regular monitoring by the doctor and follow up with diagnostic testing is recommended. Individuals with below normal responses or symptomatic relapses after completing treatment need to talk with your doctor.

  • Acute Interstitial Nephritis
  • Bone Fracture
  • Clostridium difficile-Associated Diarrhea
  • Cutaneous and Systemic Lupus Erythematosus
  • Cyanocobalamin (Vitamin B-12) Deficiency
  • Hypomagnesemia
  • Neuroendocrine Tumors

Long-term use may develop complications 'not life threatening, but serious enough to monitor for the impacts affecting your health and quality of life.

  • Atrophic gastritis is inflammation in the stomach, caused by long-term use of this medicine. Before starting treatment, it's important that your talk to you doctor to understand the risks associated with this form of therapy compared to the benefits.

Dosage

Take your prescription of esomeprazole as directed by your doctor. DO NOT take more or less than the measured dosage 'exceeding the limit can trigger an overdose reaction. DO NOT extend the duration of taking this medicine without the approval of your doctor.

Doses vary from person to person ' make sure you understand your doctor's instructions for taking this medicine. The doses listed below are averages. Your doctor determines the dose based on your medical condition and response to treatment. In some instances, pediatric doses are based on weight using a single kilogram increment equivalent to slightly over 2 pounds. The amount of medicine taken depends on the strength of the medicine, along with the number of doses you take each day, the time allowed between doses, and the time you take the medicine.

Swallow the entire capsule ' DO NOT chew or crush it. If you have difficulty with swallowing, talk with your doctor ' you may open the capsule and sprinkle the contents onto a spoon of applesauce to help with swallowing. You need to be careful when sprinkling the contents; you want to make sure you are taking a complete dose as instructed.

Oral Dosage' capsules

For NSAID Gastric Ulcer

Adults

  • 40 milligrams (mg), once a day for up to 4 to 8 weeks. Your doctor could extend treatment for 6 months and will adjust the dose as needed.

Children

  • Your doctor will decide on the dose.

For Duodenal Ulcers

  • 20 mg once a day for 4 weeks

For H. pylori infection

Adults

  • 40 mg once a day for 14 days, when taken with clarithromycin
  • 20 mg twice a day for 10 days, when taken with amoxicillin and clarithromycin

Children

  • Your doctor will decide on the dose.

For Erosive Esophagitis

Adults

  • 20 mg once a day 1 hour before meal, from 4 to 8 weeks. To prevent recurrence and maintenance of this condition, your doctor may prescribe 20 mg for 6 months after the first treatment and adjust the dose as needed.

Children

  • 16 to 18 years of age ' treatment duration is 4 to 8 weeks

O 20 mg once a day

  • 1 to 16 years of age' treatment duration is up to 4 weeks

O 5 to less than 10 kg ' 5 mg once a day

O 10 to less than 20 kg ' 10 mg once a day

O 20 kg or more ' 20 mg once a day

  • 1 month to less than 1 year of age ' treatment is up to 6 weeks

O 3 to less than 5kg ' 2.5 mg once a day

O 5 to less than 10 kg ' 5 mg once a day

O 10 kg or more ' 10 mg once a day

Your doctor may prescribe maintenance doses at the same dosage for each age group.

For GERD

Adults

  • 20 mg once a day, 1 hour before meals, up to 4 weeks. Your doctor will adjust the dose as needed.

Children

  • 1 to 16 years of age ' treatment duration is up to 4 weeks

O 5 to less than 10 kg' 5 mg once a day

O 10 to less than 20 kg ' 10 mg once a day

O 20 kg or more '20 mg once a day

  • Less than 1 year of age, the doctor will decide. Starting doses of 0.25 mg up to 1 mg per day used in short-term treatments reported similar results compared to 20 mg used in treating adults with GERD.

For Zollinger-Ellison Syndrome

Adults

  • 40 to 60 mg once a day. Your doctor will adjust the dose as needed and extend treatment to 12 months depending on your response.

Children

  • Your doctor will decide on the dose.

Missed Dose

If you miss a dose of medicine, take it as soon as possible. The only exception to this rule ' if it's near the time for your next dose, skip the missed dose and continue with your normal dosing schedule. DO NOT double the doses under any circumstances ' be sure to tell your doctor about the missed doses. It could have an effect of labs test used to check the condition.

Overdose

If there is an accidental or unintended overdose' contact emergency immediately. If a child is involved in this overdose, contact the pediatric poison information center in your area for instructions.

  • Overdose reactions include headache, nausea, and shortness of breath or loss of coordination.

Interactions

Esomeprazole has worked to help heal and manage the condition. In some situations, different medicines will interact with each other, worsening the condition or prompting serious effects to existing health disorders. Your doctor may change the frequency or the administering time to reduce or prevent the reactions. Sometimes a change of dosage is needed to treat multiple conditions.

There are health situations where using multiple medications are necessary and doctors watch the interactions for any changes in the results or increase the risks. If you look at the names on this list, some share similarities - a sign they also share similar compounds that interact with other drugs or change the outcome of treatment due to the chemical quantities.

Based on a full examination of your health and the condition treated with this medicine, your doctor will decide if any of the medicines you are taking now could cause harm. If you are taking any of these medicines listed or others that may affect your response to this medicine ' tell your doctor.

There are other mediations not listed that interact with this condition. Your doctor will check your medications to be sure the treatment is safe for you. Your doctor may find it necessary to treat this condition with an alternative medicine.

  • Atazanavir
  • Bosutinib
  • Cilostazol
  • Citalopram
  • Clopidogrel
  • Dasatinib
  • Diazepam,
  • Digoxin,
  • Diuretic
  • Erlotinib
  • Erlotinib
  • Escitalopram
  • Gefitinib
  • Iron supplements
  • Ketoconazole
  • Ledipasvir
  • Levothyroxine
  • Methotrexate
  • Mycophenolate Mofetil
  • Nelfinavir
  • Nilotinib
  • Pazopanib
  • Posaconazole
  • Rifampin
  • Rilpivirine
  • Risedronate
  • Saquinavir
  • St John's wort
  • Tacrolimus
  • Thiopental
  • Velpatasvir
  • Vismodegib
  • Voriconazole
  • Warfarin

Other Interactions

This medicine has a medication guide and patient instructions ' you need to read the material. Talk with your doctor so you understand the effects to your health, more important you need to know about the changes you can make to improve your health and life. If you have questions about this medication on how it works and what you need to do to manage your health 'ask your doctor.

Clinical trials and scientific study help to make sure medicines are safe and effective for treating certain conditions. The FDA monitors and post information about public health warnings on all medications used in the medical industry. There are warnings posted on esomeprazole.

Most drugs are listed in interaction categories from mild, moderate to serious. There are over 1800 brand and generic names known to interact with esomeprazole.

  • Serious interactions with at least 21
  • Moderate interactions with at least 64
  • Mild interactions with at least 37

Besides medicines, interactions occur with lifestyle choices about alcohol, tobacco, health supplement, herbal remedies and foods. Food may interfere with the absorption of esomeprazole'for this reason, you should take this medicine at least one hour before a meal, giving your body a chance to process the medicine and heal or prevent an incident.

Additional Health Factors

The presences of other health ailments can affect the outcome of treatment. If you are treated for these conditions tell your doctor. If you experience these effects or notice changes in your body during treatment with esomeprazole 'contact your doctor.

The liver metabolizes esomeprazole; individuals with mild to moderate hepatic impairment may need to start treatment with the lowest effective dose. Talk to your doctor if you suffer from this disorder. If you are diagnosed with osteoporosis, high doses of PPIs have been linked with an increased risk of bone fractures. Your doctor may adjust the dosage and the frequency for treating both conditions.

Magnesium imbalances are rare when treated with this medicine, but incidents have happened when individuals are taking this medicine for 3 to 12 months. Adverse effects associated with this incident include seizures, abnormal heart rhythm and muscular spasms.

Warnings

The FDA has warnings posted for esomeprazole with public health precautions when selecting this medicine for treatment of gastrointestinal disorders. This information is available to the treated individuals' ask your doctor or pharmacist for information if you have questions. The postings provide valuable information for the consumer and the medical professionals when making health decisions for different individuals.

The information collected about medication responses affecting medical conditions substantiates the course of an illness, therapy results and recovery of the patient. During treatment, whether short or long term, the warnings help to recognize the early signs to prevent unwanted health disorders before they develop into conditions that are more serious.

Pregnancy

Pregnancy Category C' there is insufficient data to show this medicine is linked to an increased risk of inherited malformations during pregnancy or adverse outcomes after birth. Limited data and studies show low levels of esomeprazole are present in breast milk with therapy of 20 mg per day.

  • If you are pregnant or plan to conceive, talk to your doctor about the potential effects to you and your child.
  • Caution should be exercised when breast-feeding.

Geriatrics

Few differences between individuals 65 year of age and older compared to younger individuals taking this medicine were noted. One difference was the dose determinations between elderly and younger individuals. Precautions are taken for elderly persons, starting at the lowest dose range, due to existing health conditions or an increased susceptibility as a matter of being older.

Pediatrics

Safety and effectiveness of this prescription in patients younger than 1 month have not been established. Your doctor will make a full assessment of the child's condition and health before prescribing this medicine.

Storage

Keep this medicine out of reach of children and pets. Store it in a closed container at room temperature, away from heat, moisture and direct light.

  • DO NOT freeze this medication.

Dispose of any unused portions or outdated medicines. DO NOT dispose of it by flushing or in the household trash. Your doctor or pharmacist can help you with the disposal to prevent any accidents.

Summary

The effectiveness of this medicine is based on the outcomes for individual patients and their medical needs. Patients taking this medicine in short or long-term durations showed tolerance to the medicine and low effects of allergies or adverse reactions. Based on clinical reports effects were less than one percent. As doctors observe responses and review test data, continuing treatment is subject to measuring the health benefit against the risks of treatment.