Estazolam (Oral)

Estazolam is a treatment used on patients suffering from insomnia and works by depressing the central nervous system.

Overview

Estazolam is a part of the medicine group known as benzodiazepines. This treatment works on the central nervous system of the patient to slow down the nervous system, enabling the patient to become tired and drowsy.

Estazolam is used in the treatment of patients who are suffering from insomnia and are unable to sleep. The treatment is a short-term medication that is usually only used for a period of between 7-10 days.

Estazolam is only available under prescription in the form of Prosom tablets.

Condition treated

  • Insomnia

Type Of Medicine

  • Benzodiazepine

Side Effects

In addition to helping patients suffering from insomnia to sleep, Estazolam can also cause unwanted side effects in the patient. While not all of the following side effects may occur, in some cases the patient will need to seek medical attention for treatment of them.

Patients experiencing any of the following side effects from the use of Estazolam should contact their doctor immediately:

Occurring more commonly:

  • Absence of body movement
  • Clumsiness
  • Decrease in body movement
  • Dizziness
  • Sleepiness
  • Unsteadiness
  • Unusual drowsiness

Occurring less commonly:

  • Delusions
  • Dementia
  • Dryness of the mouth
  • Headaches
  • Mental changes
  • Mood changes
  • Nausea
  • Tiredness
  • Vomiting

Occurring only rarely:

  • Aggressive behavior
  • Becoming uncaring
  • Black stools with a tarry appearance
  • Bleeding nose
  • Blood appearing in the urine
  • Bloody stool
  • Burning, itching, numbness or tingling feelings of the skin
  • Chest pains
  • Chills
  • Convulsions or seizures
  • Coughing
  • Crying without cause
  • Decreased awareness
  • Decreased responsiveness
  • Decreased speed of reflexes
  • Decreased urine output
  • Deep or fast breathing that causes dizziness
  • Depersonalization
  • Difficulty breathing
  • Difficulty during urination or dribbling
  • Difficulty in breathing
  • Difficulty with muscle control or coordination
  • Dryness of the throat
  • Dysphoria
  • Fainting or faintness
  • Feeling of warmth when cool
  • Feverishness
  • Hoarseness
  • Increased urge to urinate
  • Increased urge to urinate at night
  • Irrational fear or nervousness
  • Irregular heartbeat or pulse
  • Irritability
  • Labored breathing
  • Lack of emotion
  • Loss of control of the bladder
  • Loss of memory quality
  • Mouth sores or ulcers
  • Muscle spasms or jerking of extremities
  • Numbness of the feet, hands and area around the mouth
  • Paranoia
  • Perceiving or feeling things that are not perceived by others
  • Problems with memory
  • Quickness to anger
  • Quickness to react or overreact emotionally
  • Rapidly changed moods
  • Reddening of the face, neck, arms and/or upper chest
  • Restlessness
  • Severe sleepiness
  • Severe stomach pains
  • Shakiness in the legs, arms, hands or feet
  • Shakiness on feet
  • Shortness of breath without exertion
  • Skin rash
  • Soreness of throat
  • Sores and/or ulcers on lip or in the mouth
  • Sudden loss of consciousness
  • Swelling
  • Swelling of glands
  • Swelling of lymph nodes
  • Tightness across the chest
  • Trouble in swallowing
  • Trouble with sleeping
  • Uncontrolled eye movements
  • Unsteady walk
  • Unusual bleeding
  • Unusual bruising
  • Unusual or false sense of well-being
  • Unusual tiredness
  • Unusual weakness
  • Unusually audible breathing
  • Voice changes
  • Waking to urinate at night
  • Wheezing
  • White spots on the lips or in mouth

Frequency of incidence not known:

  • Blistering or peeling of skin
  • Diarrhea
  • Fever with or without chills
  • General feeling of tiredness
  • General feeling of weakness
  • Inability to sleep
  • Itching
  • Joint pains
  • Loosening of the skin
  • Lower back pain
  • Muscle cramping
  • Muscle pain
  • Red and/or irritated eyes
  • Side pain
  • Skin lesions that may have a purple center
  • Sleeplessness
  • Sweating when cool

Other side effects may also occur that would not normally necessitate that the patient seeks medical attention. The following side effects will usually be mild, will abate over time and are not generally an indication of wider medical complications.

Occurring more commonly:

  • Lack of strength
  • Loss of strength

Occurring less commonly:

  • Pain in the feet
  • Pain in the legs

Occurring only rarely:

  • Bad, unusual or unpleasant aftertaste
  • Blemishing of the skin
  • Bloated feeling
  • Blurring of vision
  • Brownish vaginal discharge
  • Build up of excess gas in the stomach or intestines
  • Burning feeling in the chest
  • Burning feeling in the stomach
  • Changed color vision
  • Changed sense of taste
  • Changes in vision
  • Continued ringing or unexplained noise not heard by others
  • Cramping of the lower abdomen, back or legs
  • Decrease in interest in sexual intercourse
  • Difficulty passing a bowel movement
  • Difficulty seeing in the dark
  • Difficulty with moving
  • Doubling of vision
  • Ear pain
  • Eye pain
  • Feeling of fullness
  • Glaring caused by bright lights
  • Hives
  • Inability to get or maintain an erection
  • Increase or decrease in appetite
  • Increased eye sensitivity to sunlight
  • Indigestion
  • Loss of sexual ability or performance
  • Loss of sexual desire or drive
  • Loss of hearing quality
  • Muscle pains
  • Muscle stiffness
  • Night blindness
  • Pain in the arms, jaw or neck
  • Pain or tenderness around cheekbones and/or eyes
  • Passing of gas
  • Pimples
  • Reddening of the skin
  • Runny nose
  • Seeing double
  • Sneezing
  • Soreness or redness of the eyes
  • Stomach upset
  • Stuffy nose
  • Swelling of the breasts
  • Swelling or redness of the joints with pain
  • Tenderness of the stomach area
  • Weight gain
  • Weight loss
  • Welts
  • White vaginal discharge

Frequency of incidence not known:

  • Discoloration of skin
  • Increased skin sensitivity to sunlight
  • Severe sunburn

Estazolam may also cause other side effects that have not been listed herein. In this case you should contact your doctor for advice. If you believe that your immediate health is in danger, however, then you should always contact the emergency services.

Dosage

This medication should only ever be used as directed by your doctor. Misuse can make the medication habit forming and can expose you to risks of serious side effects developing. You should never take a higher dose than prescribed, take it more frequently than prescribed, nor take it for longer than your doctor has instructed you to.

Estazolam tablets should be taken just before bed when you are ready to fall asleep.

Estazolam will be provided with a medication guide in all cases. You should ask your doctor if you have any questions once you have read through this thoroughly.

The dose of this treatment will differ between patients and you should only ever take it as prescribed. You should not adjust your dose without discussing this with your doctor and should not change the frequency of use. The following information is a guideline only:

For the treatment of insomnia with oral dosage by tablet:

  • In Adults ' Initially the patient should take 1mg before bed. The doctor may increase this dose as required.
  • In Older Adults ' Initially the patient should take 0.5mg before bed. The doctor may increase this dose as required.
  • In Children ' Use in children must be determined in each individual case by the prescribing doctor.

If a dose of this treatment is missed then you should take it as soon as possible unless the night has passed. You should never take double doses of this treatment and should not take it unless you are ready and able to sleep at that time.

Interactions

Estazolam can interact with other medications in your body with serious consequences. Before using this treatment you should inform your doctor of all other medication that you are taking whether it is available over the counter or has been prescribed to you by another medical professional. In the most serious cases medications can react violently in the patient and cause life-threatening problems. In other cases medications used together may stop one another from working or may expose the patient to far greater risks of severe side effects.

The use of the following medication in conjunction with Estazolam is not recommended and your doctor may choose not to prescribe this treatment:

  • Flumazenil

The use of Estazolam with the following treatments is not normally recommended, but it may be the best course of action in some cases. If your doctor prescribes both treatments then the dose or frequency of use may be adjusted:

  • Zolpidem
  • Tramadol
  • Thiopental
  • Tapentadol
  • Sufentanil
  • Sodium Oxybate
  • Secobarbital
  • Remifentanil
  • Propoxyphene
  • Propofol
  • Primidone
  • Phenobarbital
  • Periciazine
  • Pentobarbital
  • Pentazocine
  • Oxymorphone
  • Oxycodone
  • Morphine Sulfate Liposome
  • Morphine
  • Mirtazapine
  • Methohexital
  • Methocarbamol
  • Methadone
  • Metaxalone
  • Meprobamate
  • Mephobarbital
  • Mephenesin
  • Meperidine
  • Meclizine
  • Levorphanol
  • Hydromorphone
  • Hydrocodone
  • Fospropofol
  • Flibanserin
  • Fentanyl
  • Ethchlorvynol
  • Doxylamine
  • Dihydrocodeine
  • Dantrolene
  • Codeine
  • Clarithromycin
  • Chlorzoxazone
  • Chloral Hydrate
  • Carisoprodol
  • Carbinoxamine
  • Butorphanol
  • Butalbital
  • Butabarbital
  • Buprenorphine
  • Bromopride
  • Bromazepam
  • Anileridine
  • Amobarbital
  • Alfentanil

Using Estazolam in conjunction with the following medication can increase the risk of certain side effects occurring. Use together is not normally recommended but may be required in some cases. The doctor may make adjustments to the doses given or to the frequency of use:

  • Theophylline

Interactions between Estazolam and other medications may also occur that have not been listed herein. You should ensure your doctor is aware of all substances you are taking before use.

Other medical problems from which you suffer can also affect the use of this treatment. You should share your full medical history with your doctor and be particularly clear if you have any of the following conditions

Dependence on Estazolam may develop in patients with the following:

  • A history of or ongoing alcohol abuse
  • A history of or ongoing drug abuse or dependency

The following conditions may be worsened by the use of Estazolam:

  • Breathing problems
  • History of depression
  • Lung disease

The effects of Estazolam may be increased in patients with the following conditions:

Other medical problems from which you suffer can also affect the use of Estazolam that may not be listed herein. Ensure your doctor is fully aware of your conditions before beginning treatment.

Warnings

Before beginning use of any medication it is important that you understand the risks of taking the medication and weigh these in relation to the benefits. The decision to take any medication should be made with your doctor having considered all of the following:

Allergies' Allergies can prohibit the use of certain medications. Share any allergies from which you suffer with your doctor, especially if you have ever reacted badly to any medications taken in the past.

Pediatric'The safety and use of Estazolam has not been established in children. Discuss use with your doctor.

Geriatric' The initial dose given to the elderly should be reduced as drowsiness, confusion, clumsiness, dizziness and unsteadiness appear more commonly as a result of use. Elderly patients are also more likely to suffer from other conditions that may limit or prohibit the use of Estazolam.

Pregnancy 'This medication should not be prescribed to pregnant women. You should inform your doctor if you are pregnant and should use effective birth control both before use and during use of this treatment. Studies have demonstrated fetal abnormalities that have occurred from the use of this treatment during pregnancy. You should inform your doctor immediately if you believe you have become pregnant during your treatment.

Breastfeeding 'Do not breastfeed your child while taking this treatment. Discuss this with your doctor before beginning use.

Your doctor will need to examine your regularly during treatment to ensure that it is working as desired and to check for unwanted side effects. In some cases blood tests and urine samples may be required for this.

The use of this medication can reduce reaction times, make people dizzy and make people drowsy. These effects can continue into the next day after taking the tablet at night. Remember that it is your legal responsibility to ensure that you are safe to drive and safe to operate machinery before doing so. If you have any doubt that you are fully alert then you should not carry out such tasks following the treatment.

Changes in both mood and behavior may occur during the use of this treatment and you should be alert to this. Any changes should be reported to your doctor. In some cases these changes can be similar to the changes in people who drink too much alcohol but may also include increased nervousness, unusual excitement, suicidal thoughts and increased irritability.

The use of this treatment can also increase the occurrence of sleep-related activities. These can include sleep-driving, sleep-walking, making phone calls, preparing meals, eating and having sex during sleep. If any of these reactions do occur then you should inform your doctor immediately. The occurrence of these actions during sleep can be very dangerous and can expose you and others to serious risks. Ensure that you report such occurrences straight away even if they are mild cases.

The use of this medication may add to the effects of other depressants of the central nervous system so these must be avoided during use. These CNS depressants include:

  • Alcohol
  • Hay fever tablets
  • Antihistamines
  • Tranquilizers
  • Sedatives
  • Narcotics
  • Barbiturates
  • Anesthetics

You should check with your doctor before taking any of the medications that are listed above. You should not take any other medications in conjunction with Estazolam without first discussing the use with your doctor.

You should not stop the use of Estazolam without first checking with your doctor. The treatment may need to be reduced gradually instead of being stopped abruptly as this medication can be habit-forming. Reducing the dose gradually as directed by a doctor will help to prevent withdrawal symptoms including the following from occurring:

  • Muscle cramping
  • Tremors
  • Unusual behavior
  • Hallucinations
  • Convulsions
  • Stomach cramps

Patients using this treatment should avoid smoking tobacco products during treatment.

If your condition does not improve within a period of 7-10 days then you should consult your doctor for further advice. You should not continue taking the medication after this period unless you are directed to by your doctor.

Storage

This medication should be stored in the provided packaging at room temperature.

You should always keep this medication out of the reach of children.

Keep the Estazolam tablets out of direct sunlight, away from moisture and away from heat.

Unused medication should be disposed of properly and safely as directed by your healthcare professional.

Summary

Estazolam is a treatment used in patients who are suffering from insomnia. Insomnia is a sleeping disorder wherein patients are unable to get to sleep at night with a resulting impact on their health and happiness.

Estazolam is a benzodiazepine medication that affects the central nervous system. By depressing the central nervous system, Estazolam enables the patient to get to sleep.

Estazolam is a short-term medication that should only be used for 7-10 days to help the patient sleep and reset their normal sleeping pattern. Use for longer than this can result in dependency on the medication and the development of severe side effects. This also prohibits the use of this treatment in patients who have a history of abuse or dependency on either drugs or alcohol.

Patients taking Estazolam should avoid the use of both tobacco and alcohol during the period of use.

This medication should not be taken during any stage of pregnancy and nor should it be taken when breastfeeding. There have been demonstrated fetal abnormalities occurring from the use of this treatment during all trimesters of pregnancy. Patients using this treatment should use effective contraception to prevent pregnancy from occurring during use.

Estazolam can cause a wide range of unwanted side effects to occur in the patient. Before use the patient should seriously consider the risks of using this medication in relation to the benefits of use. This consideration should be made with the prescribing doctor and should take into account everything listed herein.

Patients must also inform their doctor of all other medical conditions from which they suffer and of all other medications that they are taking. Estazolam can interact with a range of other medications in the body and cause severe effects. It can also cause a worsening of certain medical conditions.

Behavioural changes may occur when taking Estazolam. You should be alert to these and should report any changes to your doctor. In some cases these changes may include the occurrence of suicidal thoughts and changes to treatment may need to be made.