Etodolac (oral)


Etodolac is used for the treatment of moderate pain in patients suffering from osteoarthritis, rheumatoid arthritis and other arthritic conditions. It is a non-steroidal anti-inflammatory that will help to relieve symptoms such as swelling, stiffness, inflammation and pain of the joints.

Etodolac is not a cure for arthritis. Rather it is a temporary pain reliever that will only continue to work as long as it is taken. The medication needs to be taken regularly and consistently to have full effect. It may also take a week or more to have a noticeable effect on the condition.

Etodolac is only available with a prescription and is administered as a capsule, tablet or extended-release tablet. When taking the extended-release tablet it must be swallowed whole and should not be broken or crushed.

Condition treated

  • Arthritis

Type Of Medicine

  • Non-steroidal anti-inflammatory

Side Effects

In addition to the required effects of Etodolac, it is possible that other unwanted side effects may occur. While not all of these side effects may occur in any patient, in some cases the patient may need to seek urgent medical attention if they do.

Patients should consult their doctor immediately if they experience any of the following conditions:

  • Belching or burping
  • Black stools with a tar-like appearance
  • Bloating, burning, cramping or pain in the abdomen or stomach
  • Bloody stools
  • Blurring of vision
  • Body aches
  • Body pain
  • Changed heartbeat
  • Chills
  • Clouded urine
  • Congestion
  • Constipation
  • Coughing
  • Decrease in the ability to concentrate urine
  • Decreased volume of urine output
  • Diarrhea
  • Dizziness
  • Dryness of the throat
  • Feeling of indigestion
  • Feverishness
  • Headaches
  • Hoarseness
  • Increased duration of bleeding
  • Itching of the skin
  • Loss of appetite
  • Lower back pain
  • Nausea with vomiting
  • Nervousness
  • Pain beneath the breastbone in the chest
  • Pain or difficulty experienced during urination
  • Paleness of the skin
  • Pounding feeling in the ears
  • Rash
  • Running nose
  • Severe stomach pain
  • Side pain
  • Soreness of throat
  • Swelling
  • Swelling or tenderness of the glands in neck
  • Trouble with swallowing
  • Troubled breathing when exerting oneself
  • Unusual bleeding
  • Unusual bruising
  • Unusual tiredness
  • Unusual weakness
  • Voice changes
  • Vomiting of a material that appears similar to coffee grounds
  • Vomiting of blood
  • Weight loss

It is also possible to overdose from the use of Etodolac. Overdosing is very serious and will expose you to more severe side effects and potentially to death. If you believe that you or anyone else has taken an overdose then you should contact the emergency services straight away. Symptoms of overdose include the following:

  • Change level of consciousness
  • Confusion or disorientation
  • Depression or extreme sadness
  • Difficulty with breathing
  • Hives
  • Hostility towards others
  • Increased agitation
  • Irregularity of breathing
  • Irritability or quickness to annoyance
  • Loss of consciousness
  • Muscle twitching
  • Pain and/or discomfort in the chest, upper stomach or throat
  • Paling or bluish tinge to lips, fingernails or skin
  • Puffy or swollen eyelids, area around the eyes, face, lips or tongue
  • Rapid weight gain
  • Seizures or convulsions
  • Shallow breathing
  • Shortness of breath
  • Sleepiness
  • Stupor
  • Swollen face, ankles or hands
  • Tightness in the chest
  • Troubled breathing
  • Unusual drowsiness
  • Unusual dullness
  • Unusual feeling of sluggishness
  • Wheezing

Other side effects from the use of Etodolac can occur that are less serious and do not usually indicate wider medical problems in the patient. These side effects will usually abate over time and are generally mild. If they are ongoing or bothersome then you can contact your doctor for advice but they would not normally necessitate that you visit a medical professional:

  • Bloated feeling
  • Feeling full
  • Continued ringing or buzzing noise in ears that is not heard by others
  • Excess air or gas building up in the stomach or the intestines
  • Loss of hearing
  • Lack of strength
  • Loss of strength
  • Passing of gas
  • Sneezing
  • Stuffy nose

Other side effects that have not been listed herein can also occur. If you experience other side effects then you should consult your doctor for advice. If you believe that your immediate health is at risk, however, then you should contact the emergency services.


This medication should only ever be taken as directed by your doctor. Taking too great a quantity, taking it more frequently than prescribed or taking it for longer than ordered will expose you to greater risks of side effects and to greater severity of side effects too. This especially true in elderly patients.

When the treatment is used for ongoing arthritis conditions the medication needs to be taken regularly and consistently. It will usually begin to work after a period of around a week, but it can take up to two weeks for the patient to begin to feel the full effects of the treatment.

If you are taking the extended-release tablets then these must be swallowed whole. Crushing, breaking, dissolving or in any way damaging these tablets will change the way in which your body absorbs them and may put you at risk. It is common for parts of these tablets to appear in your stool and this is nothing to worry about.

The dose of this medication will vary depending on the patient and their specific conditions. You should always follow the instructions of your doctor. The following information is a guideline only and you should not change your dose without first consulting your doctor.

When treating acute pain with capsules or tablets:

  • Adults ' 200-400mg taken once every 6-8 hours. The dose should not normally exceed 1000mg taken daily.
  • Children ' Individual use and dose must be determined by the doctor.

When treating osteoarthritis and rheumatoid arthritis with capsules or tablets:

  • Adults ' 300mg taken twice or thrice daily. Alternatively 400-500mg taken twice daily. The dose taken should not normally exceed 1000mg taken daily. For long-term use the dose given may be lowered to 600mg taken once daily.
  • Children ' The use of this treatment must be determined by a doctor.

When treating osteoarthritis and rheumatoid arthritis with extended-release tablets:

  • Adults' 400-1000mg taken once daily.
  • Children aged 6-16 ' The dose must be calculated by the prescribing doctor based on the body weight of the patient.
  • Children below the age of 6 'The prescribing doctor must determine the use and dose.

If a dose of this treatment is missed then it should be taken as soon as possible. If it is nearly time for your next dose, however, then you should skip the missed dose and return to your regular dosing schedule. You should never take double doses of this treatment.


Some medications should not be used together because they can interact in the body with severe side effects. In the most serious cases they can cause life-threatening complications and in other cases, drugs may prevent one another from working or may expose you to a greater risk of suffering certain side effects.

Use of Etodolac is not recommended in conjunction with the following treatment. Your doctor may decide to treat you with an alternative medication instead:

  • Ketorolac

The use of Etodolac would not normally be recommended with the following treatments, but use or both may be required in some cases. If both treatments are prescribed together then the dose of one or both may be changed or the frequency of use may be altered.

  • Xipamide
  • Warfarin
  • Vortioxetine
  • Vorapaxar
  • Vilazodone
  • Venlafaxine
  • Valdecoxib
  • Trolamine Salicylate
  • Trimipramine
  • Trichlormethiazide
  • Triamterene
  • Treprostinil
  • Torsemide
  • Tolmetin
  • Tolfenamic Acid
  • Tirofiban
  • Tinzaparin
  • Ticlopidine
  • Ticagrelor
  • Tiaprofenic Acid
  • Tianeptine
  • Tenoxicam
  • Tacrolimus
  • Sulindac
  • Sulfasalazine
  • Spironolactone
  • Sodium Salicylate
  • Sibutramine
  • Sertraline
  • Salsalate
  • Salicylic Acid
  • Salicylamide
  • Rofecoxib
  • Rivaroxaban
  • Reviparin
  • Reboxetine
  • Protriptyline
  • Protein C
  • Proquazone
  • Propyphenazone
  • Proglumetacin
  • Prednisone
  • Prednisolone
  • Prasugrel
  • Pralatrexate
  • Polythiazide
  • Piroxicam
  • Piketoprofen
  • Phenylbutazone
  • Phenyl Salicylate
  • Phenprocoumon
  • Phenindione
  • Pentoxifylline
  • Pentosan Polysulfate Sodium
  • Pemetrexed
  • Paroxetine
  • Parnaparin
  • Parecoxib
  • Paramethasone
  • Oxyphenbutazone
  • Oxaprozin
  • Opipramol
  • Olsalazine
  • Nortriptyline
  • Nimesulide Beta Cyclodextrin
  • Nimesulide
  • Niflumic Acid
  • Nepafenac
  • Nefazodone
  • Naproxen
  • Nadroparin
  • Nabumetone
  • Morniflumate
  • Milnacipran
  • Metolazone
  • Methylprednisolone
  • Methyclothiazide
  • Methotrexate
  • Mesalamine
  • Meloxicam
  • Melitracen
  • Mefenamic Acid
  • Meclofenamate
  • Meadowsweet
  • Magnesium Salicylate
  • Lumiracoxib
  • Loxoprofen
  • Lornoxicam
  • Lofepramine
  • Lithium
  • Levomilnacipran
  • Lepirudin
  • Ketoprofen
  • Indomethacin
  • Indapamide
  • Imipramine
  • Iloprost
  • Ibuprofen
  • Hydroflumethiazide
  • Hydrocortisone
  • Hydrochlorothiazide
  • Heparin
  • Gossypol
  • Ginkgo
  • Furosemide
  • Fondaparinux
  • Fluvoxamine
  • Flurbiprofen
  • Fluoxetine
  • Fluocortolone
  • Flufenamic Acid
  • Floctafenine
  • Feverfew
  • Feprazone
  • Fepradinol
  • Fenoprofen
  • Felbinac
  • Etoricoxib
  • Etofenamate
  • Etodolac
  • Ethacrynic Acid
  • Escitalopram
  • Eptifibatide
  • Epoprostenol
  • Eplerenone
  • Enoxaparin
  • Edoxaban
  • Duloxetine
  • Droxicam
  • Doxepin
  • Dothiepin
  • Dipyrone
  • Dipyridamole
  • Digoxin
  • Diflunisal
  • Diclofenac
  • Dibenzepin
  • Diazoxide
  • Dexketoprofen
  • Dexibuprofen
  • Dexamethasone
  • Desvenlafaxine
  • Desirudin
  • Desipramine
  • Deflazacort
  • Danaparoid
  • Dalteparin
  • Dabigatran Etexilate
  • Cyclosporine
  • Cyclopenthiazide
  • Cortisone
  • Clopidogrel
  • Clopamide
  • Clonixin
  • Clomipramine
  • Citalopram
  • Cilostazol
  • Choline Salicylate
  • Choline Magnesium Trisalicylate
  • Chlorthalidone
  • Chlorothiazide
  • Certoparin
  • Celecoxib
  • Cangrelor
  • Bumetanide
  • Bufexamac
  • Budesonide
  • Bromfenac
  • Bivalirudin
  • Bismuth Subsalicylate
  • Betamethasone
  • Beta Glucan
  • Benzthiazide
  • Bendroflumethiazide
  • Bemiparin
  • Balsalazide
  • Aspirin
  • Argatroban
  • Ardeparin
  • Apixaban
  • Anagrelide
  • Amtolmetin Guacil
  • Amoxapine
  • Amitriptylinoxide
  • Amitriptyline
  • Amineptine
  • Amiloride
  • Acenocoumarol
  • Acemetacin
  • Aceclofenac
  • Abciximab

The use of Etodolac in conjunction with the following treatments can increase the risk of certain side effects occurring. The use of both drugs may still be the best treatment for you, however, and your doctor may still prescribe both. In this case, changes may be made to the frequency of use or to the dose of one or more of the medications.

  • Zofenopril
  • Valsartan
  • Trandolapril
  • Timolol
  • Temocapril
  • Telmisartan
  • Spirapril
  • Sotalol
  • Ramipril
  • Quinapril
  • Propranolol
  • Practolol
  • Pindolol
  • Perindopril
  • Pentopril
  • Penbutolol
  • Oxprenolol
  • Olmesartan
  • Nebivolol
  • Nadolol
  • Moexipril
  • Metoprolol
  • Metipranolol
  • Losartan
  • Lisinopril
  • Levobunolol
  • Labetalol
  • Irbesartan
  • Imidapril
  • Fosinopril
  • Esmolol
  • Eprosartan
  • Enalaprilat
  • Enalapril
  • Dicumarol
  • Delapril
  • Cilazapril
  • Celiprolol
  • Carvedilol
  • Carteolol
  • Captopril
  • Candesartan
  • Bisoprolol
  • Betaxolol
  • Benazepril
  • Azilsartan Medoxomil
  • Azilsartan
  • Atenolol
  • Alacepril
  • Acebutolol

Interactions may also occur with other medications. This list has been compiled for severity and likelihood of occurrence, but it is not all-inclusive. Before beginning treatment with Etodolac, it is vital that you inform your doctor of all medications that you are taking whether they are over-the-counter treatments, prescribed medications or vitamins and herbal remedies.

Other medical conditions from which you suffer can also impact the safe and effective use of this treatment. You should inform your doctor of your full medical history and be especially clear to share if you suffer from any of the following conditions:

The following conditions may be worsened by the use of Etodolac:

  • Anemia
  • Asthma
  • Bleeding problems
  • Blood clots
  • Edema
  • History of heart attack
  • Heart disease
  • High blood pressure
  • Kidney disease
  • Liver disease
  • Ulceration of the stomach or intestines
  • Bleeding from the stomach or intestines
  • History of stroke

Patients with the following condition should not be treated with Etodolac:

  • History of sensitivity to aspirin

This treatment should not be used for the relief of pain before heart surgery.

Other medical conditions not listed herein may also prohibit the use of Etodolac. Ensure that your doctor is fully aware of all conditions from which you suffer or from which you have previously suffered before you begin treatment with this medication.


Before beginning the use of Etodolac you should ensure that you have considered everything herein. You should weigh the benefits of use against the potential risks from use and you should consider these with your doctor. Ensure that you have also discussed all of the following with your doctor before beginning use:

Allergies ' You must inform your doctor of any allergies you have. This is particularly important in cases of allergies to medications. A sensitivity to aspirin would prohibit the use of this treatment completely. Allergies may also affect your ability to use the extended-release tablets or capsules too.

Pediatric' Safety and efficiency of tablets and capsules has not been determined in patients below the age of 18. Use below this age should be avoided where possible and alternative treatments found. The use of the extended-release tablets has been tested to the age of 6+ but should not be used below this age. Safety and efficiency has not been determined below this age.

Geriatric ' No age-related limitations to the use in elderly patients has been demonstrated. Elderly patients are, however, more likely to be more sensitive to the effects of the treatment and prolonged use can have a greater impact in the elderly than in younger patients. Elderly patients are also more likely to suffer from kidney problems that may require dosing adjustments for treatment.

Pregnancy ' The use of this medication when pregnant can harm your baby. Inform your doctor if you are pregnant before you begin taking this treatment. If you become pregnant during use then you should also inform your doctor straight away and if you are planning to become pregnant then you should inform them in advance. There is a potential risk to the use of this treatment during pregnancy that you should discuss with your doctor.

Breastfeeding' There is no adequate information regarding the use of this treatment in nursing mothers. You should discuss the risks in relation to the benefits with your doctor and decide whether to take the treatment during nursing or not.

It is important that you have regular visits with your doctor to check your progress while you taking this medication. Your doctor will use blood and urine tests to determine that the treatment is working properly and make adjustments to the dosing. They will also check for unwanted side effects that may be occurring.

This medication can increase the risk of suffering from a heart attack or stroke. Patients will pre-existing heart disease will be at a further increased risk from this and likewise, patients who take this treatment for a prolonged period will be at greater risk.

Etodolac can cause a condition of bleeding in the stomach or intestines. These conditions may occur without any warning beforehand and is more likely to occur if you have previously suffered from a stomach ulcer. Smokers, heavy drinkers, those using other medications that thin the blood, those aged over 60 and those in poor health will all be at greater risk of bleeding occurring.

Severe skin conditions can develop during the use of this treatment. If the following symptoms of developing skin conditions occur during treatment then you should contact your doctor immediately:

  • Peeling
  • Blistering
  • Loosening of the skin
  • Chills
  • Diarrhea
  • Coughing
  • Fever
  • Itching
  • Muscle pain
  • Joint pain
  • Red lesions
  • Sore ulcers
  • Sore throat
  • White spots around the mouth
  • Unusual weakness
  • Unusual tiredness

Some warning signs of serious problems developing can occur when you are taking this treatment. If you experience any of the following warning signs of severe side effects then you should stop taking the medication and contact your doctor immediately:

  • Swelling
  • Severe pains in the stomach or intestines
  • Weight gain
  • Yellowing of the skin or eyes
  • Black stools
  • Bloody stools
  • Decreased urination
  • Skin rash

These following signs may indicate a developing heart problem:

  • Tightness in the chest
  • Chest pain
  • Irregular heartbeat
  • Unusual flushing
  • Warmth of the skin
  • Slurring of speech

Anaphylaxis, which is a serious allergic reaction, can also occur from the use of this medication. Anaphylaxis can occur at any time and can be a serious and life-threatening condition. If you experience the symptoms of anaphylaxis then you should contact the emergency services straight away. Symptoms include:

  • Irregularity of breathing
  • Wheezing
  • Fainting
  • Discoloration of skin on the face
  • Swelling of the face, eyes and throat
  • Irregularity of heartbeat

Do not use any other medication in conjunction with this treatment without first discussing it with your doctor.

Ensure that you inform all medical professionals that you are taking this medication before having any tests or treatment. This medication may change test results and can prohibit certain procedures.


You should store this medication in a safe place away from heat, moisture and direct light. Always keep Etodolac tablets out of the reach of children. You should dispose of unwanted or outdated medication properly as directed to by your healthcare professional.


Etodolac is a treatment for different forms of arthritis and for acute pain. This treatment is not a cure for pain or arthritis, instead, it is a temporary pain reliever. Etodolac is a non-steroidal anti-inflammatory medication that helps to relieve symptoms such as swelling, joint pains, inflammation and restricted movement.

Etodolac is a prescribed medication that is available as tablets, capsules and as extended-release tablets. The extended-release tablets can be used in children aged 6+, but the tablets and capsules have not been tested for use on children and should not be used below the age of 18.

Etodolac can be harmful to an unborn baby in pregnant women. Ensure that your doctor is aware of pregnancy before beginning treatment and inform your doctor if you may get pregnant during use.

This medication will expose the patient to serious side effects that may become more likely to occur or more severe with prolonged use. Patients should ensure that they understand the risks of use and weigh these risks against the benefits of use before beginning treatment with this medication.

Do not take any other medications in conjunction with this treatment without first discussing this with your doctor. Other medications can have severe interactions with Etodolac and use should in many cases be avoided.