Ezetimibe and Simvastatin (oral)


Vytorin is the brand name for ezetimibe and simvastatin, which is prescription medication belonging to the pharmacologic class of cholesterol inhibitors. The treatment is used together with a proper diet to minimize the amount of bad cholesterol in the blood. Specifically, ezetimibe is the component of the medication that obstructs the absorption of cholesterol from food into the body. On the other hand, simvastatin blocks the liver from making excessive harmful cholesterol.

When you are using ezetimibe and simvastatin, your doctor will recommend that you also eat foods that have low or no fat/cholesterol content. You may even have to adjust other aspects of your lifestyle to enhance the effectiveness of the treatment, including exercising, checking weight, and quitting smoking.

High cholesterol and fat levels in the body are a predisposing factor to the narrowing of blood vessels, which can lead to heart disease, heart attack, or stroke. As such, taking ezetimibe and simvastatin helps minimize the risk of such cardiac or brain complications.

Simvastatin is among a group of statins that the FDA has approved for use in the treatment of both heterozygous and homozygous familial hypercholesterolemia. You may need to use the medication if you have the genetic disorder that causes your system to produce excessive levels of hazardous low-density lipoprotein cholesterol (LDL-C).

Conditions Treated

  • High-fat levels in the blood
  • High cholesterol levels in the blood

Type Of Medicine

  • Cholesterol absorption inhibitor/statin

Side Effects

If you take ezetimibe and simvastatin strictly as your healthcare giver ordered, you may avoid many acute treatment side effects. Typically, the doctor prescribes the medication after assessing your condition and determining that proper use will yield more therapeutic benefits than the likelihood of unfavorable outcomes. Nonetheless, if you are using the drugs to keep the amount of body fat and bad cholesterol in check, you have to keep an eye out for possible side effects and see your healthcare provider immediately when these occur.

There is inadequate documentation for the incidence or prevalence of some ezetimibe and simvastatin side effects that require immediate medical attention. These include problems of the digestive system, such as indigestion, bloating, constipation, and abdominal fullness. Some patients may lose the desire to eat, with others suffering rashes, coldness, breathing complications, nausea and vomiting, joint pain, and stiffness.

It also not known how likely it is for an individual taking ezetimibe and simvastatin to experience pain in the abdomen (which may spread out to the back). The same is true for itching, shortness of breath, swallowing difficulty, dizziness, fast heartbeat, change of skin or eye color to yellow, hives, and dark urine. Some of these side effects are consistent with liver problems and require urgent medical intervention.

Likewise, do not hesitate to check with your doctor if, while using the high cholesterol medication, you start experiencing a feeling of heavy pressure in the chest, loss of desire to eat, or swelling around body parts such as eyelids, face, feet, sex organs, or throat. Some patients using the medication may also suffer hives on the skin or unusual changes in voice.

The occurrence of mild memory problems in patients using simvastatin is almost negligible. Similarly, it is possible, though not usual, for the high cholesterol control medications to cause muscle complications that may result in extremely dangerous disorders such as rhabdomyolysis and autoimmune myopathy. Inform your doctor right away if such rare treatment side effects occur.

Let your doctor know about any unusual fatigue or muscle pain you experience while taking ezetimibe and simvastatin or after your healthcare giver has stopped the medication. Additionally, watch out for and report any signs of kidney complications (for example change in the frequency of urination).

Certain ezetimibe and simvastatin side effects can disappear as the patient continues to use their medication as per their doctor's directives. In that case, medical attention may not be necessary unless the discomfort persists. Nonetheless, you may want to see your healthcare giver if you do not know how to cope with bothersome treatment outcomes even if they pose no perceived danger to your health. Such unfavorable medication results include:

Since you may not envisage all possible ezetimibe and simvastatin side effects, it makes sense that you report to your doctor any feeling of illness you experience but do not understand while using the medicine. Your caregiver may provide an accurate diagnosis and suggest appropriate precautions you can take to control unpleasant treatment outcomes.


The oral ezetimibe and simvastatin medication for controlling the amount of bad cholesterol and fats in the blood is available in the form of tablets. You may take the drugs by mouth after or before meals as your doctor recommended. It is a prescription-only treatment for use strictly according to the instructions your caregiver provided or directives in the patient information leaflet that comes with the product. Treatment results are contingent on the proper utilization of the medicines, so ask your doctor to clarify any confusing dosage information before you start taking it.

Before your physician determines a proper dosing for you, they will look at your specific circumstances, including medical condition, age, and any other drugs you may be already taking. How your system gradually responds to treatment may also inform an adjustment of dosing specifications.

Do not alter the amount or strength of the medication (regarding tablets or milligrams) that your doctor has determined you should take to safely and adequately check bad cholesterol and fat levels in your blood. With that said, the initial daily dose for adults and 10 to 17-year-old children is a single 10-mg ezetimibe tablet and 10-mg simvastatin in the evening. Alternatively, the doctor may order a per-day dose of 10-mg ezetimibe and 20-mg simvastatin.

The doctor may adjust the dosage for simvastatin in the combined medication to a maximum of 40 milligrams per day. Typically, the daily dosing for ezetimibe remains 10mg. Talk to your caregiver if you are worried about the possible health ramifications of taking a higher-than-normal dose.

Due to the lack of in-depth research about the efficacy and safety of ezetimibe and simvastatin in children below ten years, only a qualified caregiver can prescribe the appropriate dosing for this age group.

To make the most out of your cholesterol-control medication, you have to take it daily without fail. Try using it every evening to get the dosing routine in your system and minimize the likelihood of skipping medication. Remember to take any missed dosage of ezetimibe and simvastatin at your earliest convenience provided that your next regular dose is not almost due. Doubling the dosing for this medication is dangerous.

Eating a high-cholesterol diet while taking ezetimibe and simvastatin may defeat the purpose of this treatment. So, it is imperative that you eat well and exercise regularly as your doctor ordered.

Major Drug Interactions:

For the sake of your health, inform your doctor about all other drugs that you are using before you can begin treatment with ezetimibe and simvastatin. It is possible that the anti-bad cholesterol medication may have potentially dangerous interactions with other medicines, substances, or foods. Your healthcare giver will consider any other medical therapies you are using and decide whether and how to prescribe ezetimibe and simvastatin. Some of the other medicines may require stopping or dosing adjustment for the proper working of your entire regimen.

There are potential interactions between ezetimibe and simvastatin and blood thinners such as cyclosporine, warfarin, and gemfibrozil. Amprenavir, lopinavir, boceprevir, fosamprenavir, saquinavir, idelalisib, telithromycin, mifepristone, and cobicistat can also interfere with your medication for treating high blood cholesterol levels.

Patients taking other medication for controlling blood cholesterol levels should let their doctor know beforehand. For example, colestipol or any other bile acid-binding resin may interact with ezetimibe and simvastatin, blocking its proper absorption.

Your doctor will exercise caution before prescribing macrolide antibiotics (such as erythromycin), particular azole antifungal drugs (like ketoconazole and voriconazole), HIV protease inhibitors (for example ritonavir), and any other medicines that may impact the elimination of simvastatin from your system, interfering with the action of your regimen.

Unless necessary, doctors do not readily prescribe ezetimibe and simvastatin to patients that are already taking drugs like acenocoumarol, amlodipine, ciprofibrate, colchicines, dabigatran etexilate, or diltiazem. Others similar medications include fluconazole, tadalafil, fenofibrate, fusidic acid, and lomitapide.

It is also imperative for a healthcare practitioner to assess the risk of side effects that may result from taking ezetimibe and simvastatin and other medication at the same time. If the simultaneous use of such drugs is required, the doctor may work out a formula to prevent or minimize the severity of any likely adverse medicinal interactions. Medicines that may increase the risk of specific treatment side effects include:

  • Clopidogrel
  • Cyclosporine
  • Fosphenytoin
  • Oxcarbazepine
  • St John's Wort
  • Levothyroxine

There are some ezetimibe and simvastatin drug interactions that depend on the ancestry of the patient under treatment. For example, simvastatin may produce unpleasant outcomes in Chinese patients using niacin. The doctor may have to lower the statin dose if both medications are necessary.

A patient on the ezetimibe and simvastatin medication must avoid certain substances, foods, or beverages due to their potential adverse interactions. Alternatively, the doctor may provide appropriate directives for how to consume the items along with the medication without risking significant complications. Additionally, an adjustment of the dosage may be necessary if the individual in question also takes alcohol or tobacco.

Of particular concern is grapefruit or juice from grapefruit or cranberry, which may boost the amount of ezetimibe and simvastatin in the patient's system. It is necessary to inform the doctor about using such drinks or fruits while taking the combined dosage of cholesterol absorption inhibitor and statin.

Beware of potential interactions between ezetimibe and simvastatin and foodstuff that contain red yeast rice. Such products may include lovastatin 'a statin that may expose you to severe muscle and liver complications if you are already taking the anti-cholesterol medication.

Your doctor should review your medical/health history before recommending that you start using ezetimibe and simvastatin. The treatment may produce undesired results or fail to work correctly in patients with specific disorders. For example, chronic excessive alcohol consumption may make it harder to reduce the amount of bad cholesterol in the blood using medication. Though extremely rare, statins, such as simvastatin, may trigger or escalate diabetes.

Ezetimibe and simvastatin may escalate side effects in patients with or that have had liver disease. Also, the medication may trigger kidney or muscle disorders in people with sepsis. Avoid the combined regimen if you have elevated liver enzymes.

Be cautious with the use of ezetimibe and simvastatin if you are still struggling with the symptoms of hypothyroidism. Severe electrolyte disorders, acute metabolic complications, severe endocrine problems, recent major surgery or injury, low blood pressure, and epilepsy also require consultations with the doctor before you can start using the statin and cholesterol absorption inhibitor.


  • Take regular blood tests and keep seeing your doctor for a professional assessment of your response to the ezetimibe and simvastatin medication.
  • While using ezetimibe and simvastatin, avoid taking any other medication (including over-the-counter drugs, herbal therapies, or vitamin supplements) unless your doctor approves it.
  • Avoid pregnancy while using ezetimibe and simvastatin because the drug can harm your unborn child. Consider utilizing effective contraceptives, and if you get pregnant while on this medication, see your doctor right away.
  • The medication may pass into breast milk and harm an infant, so you should avoid it while breastfeeding or stop breastfeeding if you have to use the drug.
  • Do not use ezetimibe and simvastatin along with any other medication that may interact and expose you to muscle injury and kidney complications. Of particular concern are specific antibiotics, HIV/AIDS drugs, or drugs that contain cobicistat.
  • Patients of Chinese ancestry on more than 1 gram of niacin every day may develop muscle injury if they are also taking ezetimibe and simvastatin. The doctor may recommend a lower daily dose of one or both of the medication to protect the patient.
  • Inform your doctor about your allergies to food, medication, or other substances before you can start using ezetimibe and simvastatin. The drug may contain inactive compounds that could trigger allergic reactions or other complications.
  • Do not receive treatment for any other health complication (including dental care) before revealing to your healthcare practitioner that you are taking ezetimibe and simvastatin. The medication may cause devastating effects in a patient who undergoes major surgery or suffers severe physical trauma.
  • Do not hesitate to seek medical attention if you encounter any severe ezetimibe and simvastatin side effects. Watch out for symptoms of liver complications such as change of skin or eye color to yellow, unusual fatigue, darkened urine, loss of appetite, or vomiting.
  • Seek a medical checkup as soon as you notice signs of kidney damage including diarrhea, muscle cramps, high body temperature, or darkened urine.
  • Patients using higher doses of simvastatin (80 milligrams) per day face a higher risk of side effects such as myopathy. Symptoms of such treatment complications include unusual fatigue/weakness, fever, and muscle pain.
  • Patients also taking other medication for the control of cholesterol (such as colestipol or cholestyramine) should use it not less 2 hours after or 4 hours before their scheduled ezetimibe and simvastatin intake.


  • The safety and utility of the cholesterol absorption inhibitor and statin drugs depend on proper storage conditions, such as in a lockable box at room temperature. Do not expose the medication to heat, water/wetness, freezing, or direct light. Always deny children access to the medicines.
  • Dispose of any remaining supplies of ezetimibe and simvastatin if expired, or you are no longer using them. You could use proper directives from your caregiver for how to get rid of unwanted medication safely.


Ezetimibe and simvastatin constitute a regimen that caregivers may prescribe to patients with high levels of fat and bad cholesterol in the blood. By reducing the rate at which the body absorbs LDL-C from food and by limiting the production of the same in the liver, the medication prevents the clogging of blood vessels. In doing so, the treatment minimizes the risk of complications that may result from narrow arteries, such as heart disease, heart attack, or stroke.

The use of ezetimibe and simvastatin does not cause severe side effects in most patients. In isolated cases, however, the medication can lead to complications that require immediate medical intervention, including difficulty breathing, kidney damage, or liver problems. The patient should always inform their doctor once they start experiencing any significant unwanted outcomes while using the treatment.

Always take the recommended ezetimibe and simvastatin dosage no matter your response to the medication unless your doctor suggests otherwise. Changing your dose without proper consultations with your caregiver may affect your treatment or safety.

Let your doctor know about any other treatments you are using and your lifestyle habits as well as medical history to enable them to plan the appropriate ezetimibe and simvastatin dosage for you. In so doing, you may avoid numerous adverse drug interactions.