Factor IX (injection, intravenous)

Factor IX injection and intravenous medication is used to boost a blood protein that may be deficient in patients who suffer from hemophilia.

Overview

What is Factor IX for injection or intravenous?

This drug may be more familiar to patients under one of its brand names, including:

  • Alprolix
  • Benefix
  • Bebulin
  • Alphanine SD
  • Bebulin VH
  • Benefix
  • Ixinity
  • Idelvion
  • Mononine
  • Proplex T
  • Profilnine SD
  • Rixubis

Factor IX for injection or intravenous administration is available only through a doctor and is used to increase the level of clotting protein not found in great amounts in patients who have been diagnosed with hemophilia B.

Factor IX injection or intravenous is a filtered and treated preparation of a protein extracted from human blood. This medication may also be made synthetically.

What is hemophilia B?

Sometimes referred to as Christmas disease, hemophilia B patients do not have sufficient amounts of factor IX in their blood. Factor IX, when found naturally in the human body, works with other proteins to stop bleeding by causing the blood to clot. Hemophilia B is a genetic disease that many patients don't know they have and almost exclusively occurs in males. If left untreated, patients could die from this disease due to their inability to stop bleeding either internally or externally.

Hemophilia B patients have no factor IX in their blood or very little of it, but a sterilized form of injection that is derived from other humans is available along with a synthetic version. Both versions are safely injected or administered intravenously. The human-derived version has been screened for viruses and proven safe for medical administration.

Conditions Treated

  • Hemophilia B
  • Factor IX hemophilia
  • Christmas disease

Type Of Medicine

  • Blood coagulation factor
  • Ant hemophilic agent

Side Effects

Patients who receive treatment with Factor IX may experience unexpected, unwanted effects that may be dangerous to their health. Alert your health care provider if you experience:

  • Rapid, shallow breathing
  • Swollen eyes
  • Difficulty breathing
  • Skin color changes
  • Wheezing
  • Rashes or hives on skin
  • Itching
  • Blue feet or hands
  • Convulsions
  • Lightheaded, dizzy feeling when rising
  • Rapid heart rhythm
  • Nausea
  • Vomiting
  • Chest pain
  • Grain or leg pain
  • Pain in calves
  • Bleeding that won't stop
  • Chest pressure or pain
  • Pain in left arm, neck or back
  • Headache
  • Loss of muscle coordination
  • Changes in vision or speech
  • Weak or numb extremities
  • Injection site pain or burning
  • Blood pressure changes
  • Pulse changes
  • Chills
  • Sleepiness
  • Fever
  • Nausea
  • Headache
  • Vomiting
  • Flushed appearance
  • Gasping for breath

You may have other health changes that suddenly appear after being given Factor IX via injection or intravenously. If so, alert your doctor immediately.

Dosage

If you are not hospitalized when requiring this medication, you may be instructed on how to inject yourself at home, giving you a practice session supervised by medical staff. Be sure that you are comfortable with all aspects of preparation and injection, asking any questions you may have during the training provided.

To prepare the powdered medication for injection, first bring the diluent and medicine to room temperature from refrigerated storage. Point the diluent stream at the side of the medicine container to keep it from splashing out and losing any contents. Gently swirl the container so that the medicine dissolves. Shaking the container is not advised. Use the dissolved medication immediately or as soon as three hours after mixing, discarding any older solution after that time.

Use the disposable syringe and needle provided with your medication; do not use other needles or syringes not meant for this medication as they may hold back the necessary product or not filter it properly at the time of injection. The syringes and needles provided to you are disposable and should not be reused. Dispose of sharp objects that have come in contact with your blood properly as instructed by your physician or pharmacist.

Each patient will be prescribed a specific dose based on several factors determined by their doctor. These factors include:

  • Your body's amount of factor IX
  • Quantity, location and amount you are bleeding
  • Your resistance factor to this medication
  • Your health condition
  • Body mass

Take you prescription exactly as instructed, calling your physician with any questions. Do not skip a dose of this medication. If you accidentally miss your scheduled dose, contact your healthcare provider right away.

Interactions

Any hypersensitive reactions you have experienced in the past, including with doses of Factor IX, should be communicated to your physician. Additionally, let your doctor know if you have intolerances to any foods, animals, preservatives or chemicals of any kind including dyes or perfumes.

Disclose your full list of prescribed medications as well as those you take without a prescription including vitamins, herbs or holistic remedies.

Premature and newborn babies are more at risk of developing unwanted blood clots than are adults. Use in this age group should only be done under hospitalization circumstances.

Geriatric patients respond to Factor IX with the same success and risks that adult patients have when being administered a dose of this medication.

Fetal risk with regard to administering Factor IX has not been studied sufficiently in order to advise against use in women who are pregnant or may become pregnant. Use of this medication in this group should be determined on a case-by-case basis.

Women who are breastfeeding may or may not pass a risk on to their children if they are given Factor IX injection or intravenous. Discuss your options with your healthcare provider to determine the best course of treatment for you and your child.

It is up to you and your physician to decide if you should eat prior to being injected or being given intravenous doses of Factor IX. Additionally, you should discuss the use of tobacco products, the consumption of alcoholic beverages and the use of illegal drugs and how these substances affect your drug therapy treatment.

If you have the following medical conditions, make sure your doctor is aware of them prior to giving you a course of Factor IX injection or intravenous medication:

  • Liver disease
  • Blood clotting disorder

These medical conditions could become worsened if you are injected with Factor IX, so your physician will need to discuss an alternate form of treatment with you if you have these disorders. Provide your full medical history before the time of your treatment to avoid any situations that could become dangerous for your health and wellbeing.

Avoid use of Factor IX if you are currently taking Carfilzomib or Kyprolis, as these drugs are known to have dangerous interactivity with regard to Factor IX injections.

Warnings

Your body may build up a defense mechanism in response to injections or intravenous treatment with Factor IX. This defense mechanism is called an antibody. If you notice that your health improvement is decreasing after a few treatments, notify your doctor immediately.

Using Factor IX injection or intravenous route medications to reverse blood thinners such as Warfarin or use to treat other deficiencies in the blood.

Patients with heart disease, immunity conditions, liver or kidney disease or those who have had surgery recently should not use this medication unless they have made their doctor aware of these health factors. Surgeons, dentists and physicians other than the one prescribing Factor IX injection or intravenous should be made aware that you are being treated by this medication.

Factor IX injection and intravenous medication is derived from human plasma, giving you a small chance of contracting a viral infection that was not completely screened out during the purification process. Hemophilia B patients who have been recently diagnosed should receive vaccinations for hepatitis A as well as hepatitis B to reduce the risk of contracting hepatitis A or B from intravenous or injected Factor IX.

This medication should only be used on women who are pregnant or women who are breastfeeding if absolutely necessary to avoid any risk of passing on unwanted health conditions to infants or children.

It is advised that you wear medical certification identification stating your status as a hemophilia patient. Make sure that you consult your health care provider on the correct identification to carry and make sure it is with you at all times. Make family, friends and co-workers aware of your condition in case of emergency.

Storage

Keep the original packaging that Factor IX powder and diluting arrived in and use it to store this medication properly. This medication, as well as others, should be kept out of sight and reach of children and pets. Some Factor IX formulas may be kept at room temperature for short time periods but most must be refrigerated. Keep this medication away from exposure to excessive light, heat or moisture. Do not allow it to freeze and do not use it if it has become frozen.

Expired or unused Factor IX dosages should be disposed of properly according to your physician's instructions for safety. If this is not provided to you by your physician, consult with your pharmacist on safe disposal practices.

As this is an injected medication, special syringes and needles are provided with your prescription, should you be administering this drug in your own home rather than a hospital setting. Make sure that you follow all instructions with regard to safe practices of using these devices including those instructing on their disposal. Keep these implements out of sight and reach of children and pets. Do not substitute other syringes or needles for those provided as they are made specifically for this product. If you have any questions about administering this medication to yourself, contact your health care professional right away.

Summary

Factor IX is a protein found in the blood that provides one of the mechanisms necessary for proper clotting due to injury or other responses. People who have little to no factor IX naturally in their blood are diagnosed as hemophilia B sufferers and need additional means of adding this factor to their blood for their own safety.

Derived from human plasma and screened and purified for use, Factor IX injection and intravenous medication is prescribed to hemophilia B patients to bring this blood clotting factor up to a more normal level. Some hemophilia B sufferers find that their health effects diminish over time with repeated injections of this medication, meaning that their bodies have decided to combat the injection with an antibody. If this happens, alternate treatments must be given.

While being treated with Factor IX, some patients experience unwanted effects that involve the injection site pain, headaches, nausea or vomiting, chills and fever. These effects should be reported to your physician right away. Patients who experience chest pains, difficulty breathing or a blue tinge to their skin should seek emergency medical help.

Though this medication is screened and purified carefully, there is a small chance of viral infections escaping this process and putting patients at risk for infections such as hepatitis A or B. Vaccinations for these infections for newly diagnosed patients prior to an injection or intravenous administration of Factor IX are advised.

Disclose all medical history as well as any medications you currently take to your health care provider and include any over-the-counter, vitamin or herbal supplements or holistic remedies you currently take. If you suffer from a blood clotting disorder or liver disease, make sure your physician is aware of these conditions.