Factor X Human prevents bleeding during and after surgery of Factor X deficit patients. This condition is inherited or caused by vitamin K deficiency. It is administered in the body by injection depending on the patient's bodyweight and extent of bleeding. It has active substances that control pain, swelling and internal bleeding that result when the blood cannot clot normally. However, Coagadex is contraindicated in patients with hypersensitivity to any of the drug's components.
The most common side effects experienced by factor X Human users are blurred vision, difficulty when swallowing, redness and pain at the injection site, confusion, pulse or irregular heartbeat, fever, itching, and restlessness. Sweating, chest tightness, vomiting and unusual tiredness have been reported as well.
Other side effects do not commonly appear but are worth mentioning. Back pain, skin rash, nausea, cough, puffiness around the tongue or eyelids, and faintness when getting up from a sitting or lying position are some of them.
Emergency medical help is required when the patient experiences continued bleeding, new or worse. Allergic reaction symptoms like wheezing and tingling, swelling of the lips, throat, tongue, and face should also not be ignored. Typically, minimal side effects are experienced by patients taking Coagadex.
Some of the side effects do not need medical attention as they tend to go away with time. Your doctor may inform you of ways to reduce or prevent some of the side effects. However, it's important to seek medical attention when the symptoms persist or become bothersome.
Just like the other medication, Factor X Human should only be taken under a doctor's prescription. It is infused to the blood veins directly by a health practitioner. The dosage may slightly differ in different patients since it depends on one's condition and the level of Factor X deficit. The drug's frequency depends on the reaction shown after the first dose. Adjustment is needed for the elderly, hepatic and renal impaired patients. Both children and adults are given the same dosage. However, do not use more than 60 IU/kg per day. The infusion formula used is:
Dosage (IU) = the anticipated factor X rise (IU/Dl) Ã— the body weight (kg) x 0.5 (IU/kg)
For on-demand therapy and prevention of bleeding instances - Inject about 24-25 IU/kilogram of Factor X Human when the initial bleeding sign occurs or before the onset of menstruation. Repeat in 24hr intervals until the bleeding stops completely.
For perioperative bleeding management ' measure the levels of post-infusion Factor X plasma to 80-90 IU/Dl utilizing the infusion formula. Careful dosage control and treatment duration are essential, especially for major surgeries.
For post-surgery 're-do the dose to maintain the Factor X levels of plasma at 50 IU/Dl minimum until the bleeding stops. It is advisable to measure the post-infusion plasma after the surgery to ensure that the homeostatic level has been maintained.
For intravenous administration, reconstitute and draw up the solution into a single syringe. Visually inspect the solution for discoloration and particulate matter before administration. Do not use the drug if you notice any form of discoloration. Attach the suitable needle into the syringe and then administer by intravenous injection at the rate of 10 ml/min. Do not exceed 20 ml/min.
Before receiving the medicine, inform the doctor if you are allergic to any Factor X Human ingredients, if you are currently taking anticoagulation drugs, if you have any medical problems, if you are breastfeeding or pregnant. Keep the doctor informed of any vitamins, herbal supplements or non-prescribed medicines that you might be taking.
It is not known if the drug is passed through human milk. Since many medications are crossed to human milk, a choice can be made either to stop the medicine or the nursing. Your health provider will weigh the risks and benefits of using Factor X Human. The drug should not be used either in smaller or more significant amounts than the recommended ones. Gentle swirling is required before taking the drug but do not shake. Ideally, the drug should slightly pearl-like or clear. The injection should be done within one hour after mixing.
Most patients learn to inject themselves or with assistance from a family member. The infusion should, however, be strictly done as per the doctor's prescription. Avoid injecting yourself if you do not fully understand how to inject yourself or how to dispose of the used needles and IV tubing. Seek medical attention immediately if the bleeding does not stop after the frequent infusions.
Drugs interact with others in the human body making them less effective, hence it's vital for a patient to keep a good record of the medications they are taking. The doctor should be made aware of these drugs to avoid such reactions.
Below is a list of some medications that are known to interact with Factor X Human.
Based on the mechanism of action, Factor X Human is mostly counteracted directly or indirectly by Factor X inhibitors. These antithrombotic elements should be avoided in the patients. Additionally, the doctor should be informed when the patient is taking substances like marijuana or alcohol.
The patient should discuss their medical history as well as any allergies. Coagadex has been known to cause hypersensitive reactions like anaphylaxis. The early signs of these responses are inflammation, hypertension, musculoskeletal pains, and restlessness, flushing, tingling, pruritus, lethargy, hives and vomiting. Visit your medical practitioner when the hypersensitive reactions persist. The drug can be discontinued if the neurotic results do not stop.
Human blood makes factor X Human, hence it carries a risk of infectious agent transmissions like viruses. Although testing is always done after the blood is donated, there is a possibility that some infectious agents may be in the drug, making it a potential agent for transmitting diseases.
There may be the formation of neutralizing inhibitors (antibodies) to Factor X. patients treated using this drug need close monitoring and clinical observations for any growth. If the bleeding continues or the plasma X levels of activity are not attained, an assay is performed on the factor X inhibitor to measure its concentration.
The patients should be cautious on the color of the drug. It should not be taken if it contains some particles or if it looks cloudy. Also, the medical needle and syringe should only be used once and disposed of. Use a "sharps" disposal container to keep them away from children. Read the medication guide, instruction sheets and the patient information provided and ask your pharmacist about anything that you do not understand.
Patients are not allowed to drive or operate machinery after taking the drug since it causes drowsiness. This implies that the patients should not engage themselves in complex activities after its consumption as this may result in accidents.
Do not share the drug with other patients or infuse yourself with anyone else's drugs. It's important to check with your physician since some medications may contain another patient's information leaflet. In case of an overdose, contact your medical care provider or the poison control center immediately. Be honest in explaining how much, how and the time it was taken.
Factor X human should be stored in the original container at room temperature, or preferably inside a refrigerator. However, it should not freeze. It should be kept away from light and out of reach of both children and pets. Also, it should not be exposed to moisture and heat. Keep it in either a medicine cabinet or cupboard.
If the medication is past the expiration dates indicated on the carton and vial labels, dispose of the container as directed by your physician.
Factor X Human is an essential injection that controls bleeding in patients suffering from mild Factor X deficit. It's injected into the veins only under the doctor's instruction and supervision. However, some medicines and food can affect how this drug works hence the patient should inform their doctor if they are currently taking other products that contain Factor X (like prothrombin complex concentrate or fresh frozen plasma). This drug is highly contraindicated in patients who have a history of severe hypersensitivity reactions.
Precaution is needed because the medicine is made from blood donated by humans. Viruses can easily be transmitted although the risk is relatively low. Inform your doctor when the bleeding does not stop or in case of allergic reactions like breathing trouble or a pounding heartbeat. It's not advisable to use Factor X human on children below the age of 12.
A patient needs frequent blood testing while on this medication. Any food, beverages and activity restrictions should be followed as per the doctor's instructions. For best results, transparent communication should exist between the patient and the doctor. The amount and frequency of the dosage should also be well observed.