Factor XIII (intravenous)


Factor XIII deficiency, or FXIIID, is a congenital disease. It can be treated by replenishing the amount of FXIII in a person's blood. This medication is given intravenously and should only be given under the supervision of your doctor. This drug is made from human blood, so it is manufactured primarily from the blood donations of other people. If you have concerns about being administered this injection, speak to your doctor.

You may need to get your blood tested regularly while being given this medication. This is just to check the quality of your blood and make sure that you are responding to treatment. If you experience troubling changes in your health or serious side effects, speak to your doctor.

A nurse or doctor will prepare and give you this injection. You do not need to go to a pharmacy to get this drug and you do not have to store it in your home. If your child is getting this injection, you will likely be allowed to stay in the room.

Factor XIII helps with blood clotting. If you experience vision changes, a sudden headache or chest pain, notify your doctor immediately. Keep a close eye on your health in the time following this injection, and make sure to monitor your children after they've received this treatment.

Conditions Treated

  • Factor XIII Deficiency

Type Of Medication

  • Synthetic enzyme supplement

Side Effects

You may experience side effects while using this medication. These side effects may lessen over time and they may disappear the more you receive this supplement. Some side effects may be mild, and you can ask your doctor about possible solutions. Changes in your lifestyle, natural remedies and additional medications may help you cope with side effects.

If these side effects persist long after the injection, speak to your doctor. It is also important to remember that you may require this supplement for your safety. While side effects can be unpleasant, they are just a part of receiving treatment for your condition. Over time, they may lessen or become easier to deal with.

Common, harmless side effects include:

  • Mild headache
  • Malaise (feeling of illness or discomfort)
  • Difficulty moving or joint pain
  • Muscle ache

These side effects do not require medical attention. However, if they become troublesome or severe, make sure to mention them to your doctor.

Some side effects may be a sign that the injections are affecting you negatively. If you experience severe side effects, tell your doctor immediately. While rare, this drug can cause complications in certain patients. Tel your doctor if you experience:

  • Sudden, severe headache
  • Chest pain
  • Bloody nose
  • Unexplained bruising

These side effects may be a sign that you should not receive further injections. Talk to your doctor if you experience any of the above, and do not hesitate to let them know if they occur during your treatment. If you feel your life is in danger, contact medical help immediately.

Allergies can also occur. These side effects can lead to a serious medical condition called anaphylaxis, so notify your doctor immediately if they occur. Allergy symptoms include

  • Itching
  • Swelling of the face, tongue or hands
  • Closing of the airways
  • Trouble breathing
  • Unexplained, persistent cough
  • Tightness in the chest
  • Lightheadedness

Be sure to monitor yourself and your children for side effects after the administration of Factor XIII. Children may not be able to tell you that they are experiencing side effects, so check them regularly and ask them how they are feeling. This list is not exhaustive, so if you experience anything strange, talk to your doctor as soon as you can.


This drug is given twice a month on average, but this can change depending on the results of your blood tests. Make sure to show up for all your appointments and get your blood tested regularly. The tests can determine whether or not you are benefiting from your treatment. The exact dosage of Factor XIII will be determined by your doctor and may depend on the severity of your deficiency.

This supplement is given intravenously. If you have a fear of needles or get nervous during injections, you can ask to have a friend or family member present. For parents with children receiving this injection, you will likely be able to stay in the room.


You should tell your doctor if you are taking any additional medications. Even over the counter drugs can cause interactions, so be sure to keep a detailed list of all your medications. This includes herbal remedies, as they can also interact with prescription medications.

Your doctor may lower the doses of the interactive medications, or they may ask that you stop your treatment with that drug. While unpleasant, this is necessary to prevent interactions. Talk to your doctor if you have concerns or questions about how this treatment may interact with your existing medications.

Factor XIII can interact with Coagulation Factor VIIa. If you are receiving treatment with this drug, you may need to stop it before beginning your FXIII injections. Be sure to notify your doctor if this is not already in your file.

Other interactions may not be listed here. Be sure to ask your doctor about interactions, and notify them before beginning any new prescriptions. Your doctor is there to help you, so be sure to keep them in the loop about your health.


This supplement can come with warnings, so be sure that you understand the risks before beginning your injections. You will likely be given an information leaflet before your treatment, so be sure to read it. If you do not understand it, ask your doctor to explain it to you. Ask questions and try to have a good grasp on the information. Further investigation can help you get a better idea, but do not trust all the information you find on the internet.

Talk to your doctor if you've ever experienced blood clots. Factor XIII aids in the clotting of blood, so it can directly affect any existing conditions. If you've ever had a stroke, be sure to mention this before your first injection.

Like all medications, this supplement comes with the risk of allergies. Let your doctor know if you experience allergy symptoms at any point. If you have an allergy to Factor XIII, do not receive any more injections with this supplement. Be sure to inform your doctor if you've reacted adversely to FXIII before.

Because FXIII is made with human blood, it comes with the risk of transmitted diseases. However, all blood donors are thoroughly screened and the risk of this low. Talk to your doctor if you have concerns about this.


Since this drug is stored by medical professionals, there is no need to store this drug yourself. Nurses will prepare the solution and needles and they are trained to handle medications like this one. All you need to do is show up for your appointments. If you have concerns or questions about how this drug is stored, how it works, or what you need to do, talk to your doctor before receiving your first or next injection.

Do not be nervous about getting this injection. Your doctor can reassure you that it is safe, and it can improve your health and prevent bleeding. If you have a deficiency of Factor XIII, this treatment can be valuable in making sure your blood clots properly. Make sure to show up for all of your appointments. If you need to cancel, reschedule for the earliest possible time.


Factor XIII deficiency can affect anyone and it usually occurs congenitally. If you have a family history of this condition, you or your children may require FXIII supplements. This supplement will be given intravenously by a nurse or doctor, so you do not need to worry about preparing or administering this injection.

You may need to get your blood tested regularly while receiving this treatment. Your doctor may schedule the blood tests separately from your FXIII treatments, so be sure to mark down all of your appointments.

Keep an eye on how you or your children react to this treatment. If anything strange or troubling occurs, contact your doctor. Some side effects may disappear over time, but others may require further investigation. Factor XIII has a low rate of complication, but issues have been recorded. Watch out for allergies, blood clots or other issues while receiving this treatment. Contact medical help if you experience anything life-threatening.

This drug has few interactions, but be sure to let your doctor know before you begin taking any new medications. Even if the new medication does not interact directly, it may affect your health in a way that affects your treatment. Communicate with your doctor and talk to them if you have questions or concerns about this supplement.