Fibrin (Topical)


Fibrin consists of two substances derived from human plasma that combine to help blood clot.

Fibrin helps to manage bleeding during an operation when other methods to close an incision or wound (like heat, stitches, or bands) can't be used. Fibrin may also help prevent leaks caused by a stomach tissue wound after a colostomy is done away with.

Fibrin is occasionally used to help stick skin tissues together during cosmetic surgery or skin graft procedures.

Fibrin comes in the form of a topical spray. To use it, you need an absorbable gelatin sponge as well.

Common Fibrin side effects include surgical pain, decreased blood pressure, fever, constipation, and nausea.

Fibrin can also serve other purposes not discussed in this medication guide.

Conditions Treated

  • Bleeding during surgery
  • Bleeding after trauma

Type Of Medicine

  • Hemostatic agent

Side Effects

Along with its useful effects, Fibrin may bring about some undesirable effects. While not all of the side effects mentioned below can occur, those that occur may require medical care.

Check with your nurse or doctor promptly if you develop any of the effects below:

Less common:

  • Collection of fluids or blood under the skin
  • Deep and dark purple bruise
  • Pain, redness, swelling, or itching of the wound, skin, or treated area

Incidence unknown:

  • Confusion
  • Blurred vision
  • Chest pain, tightness, or discomfort
  • Difficulty swallowing
  • Difficulty breathing
  • Cough
  • Redness, flushing of skin
  • Skin rash, itching, hives
  • Slow, fast, irregular, or pounding heartbeat/pulse
  • Lightheadedness, faintness, or dizziness when suddenly rising from a sitting/lying position
  • Huge swelling-like hives on the throat, tongue, lips, eyelids, hands, feet, legs, or genitals
  • Fainting, dizziness, or lightheadedness
  • Tingling or numbness in the legs, arms, or face
  • Sudden severe headache
  • Pain in the groin, chest, or legs (particularly the calves)
  • Swelling or puffiness of eyelids or around eyes, face, tongue, lips
  • Slurred speech
  • Shortness of breath
  • Sweating
  • Sudden failure of coordination
  • Trouble healing
  • Trouble walking or speaking
  • Unusually warm skin
  • Unusual tiredness/weakness
  • Sudden, severe numbness or weakness in the leg or arm

Some Fibrin side effects that normally don't require medical care may occur. These effects may clear during treatment as you get used to Fibrin. In addition, your healthcare giver may help you find ways to relieve or prevent some of the effects. Please consult your healthcare provider if you've got questions about any of the effects below, if they bother you, or if they persist.

Incidence unknown:


Itching, burning, crawling, prickling, numbness, tingling, or 'œpins and needles' feelings

Other Fibrin side effects not named above may occur in some people. If you develop any other effects, see your healthcare professional immediately.


Use Fibrin exactly as indicated.

Your doctor may determine your dose based on these factors:

  • The medical problem being treated
  • Other medical problems you have
  • Your response to Fibrin

The required Fibrin dose is based on the size of the bleeding area that needs treatment.

Normal adult dose for the closure of colostomy and hemostasis:

Before applying Fibrin, make sure that the wound surface is dry as much as possible.

Apply a thin layer of Fibrin. The first amount of Fibrin you apply should be enough to completely cover the targeted area of application. You can repeat the application if necessary.

After you have applied the two components, hold or fix the sealed areas in the position desired for at least 3-5 minutes to make sure that the Fibrin sealant firmly adheres to the tissue nearby.

Fibrin can be dripped or sprayed on the affected surgical or skin area. A healthcare provider in a clinical or surgical environment applies this medicine.

Fibrin is made from a part of blood known as human plasma, which may have viruses as well as other infectious agents. Plasma from donors is examined and treated to lower its risk for contagious agents, but there's still a slight chance it could spread disease. Please talk to your physician about the benefits as well as risks of using Fibrin.

Some people may catch symptoms of a virus infection after receiving Fibrin treatment. Please call up your physician if you develop flu-like symptoms, including chills, fever, runny nose, or drowsiness. You may also develop a skin rash and joint pain around two weeks after the onset of flu symptoms.

Since Fibrin is given by a healthcare provider in a medical facility environment, there's little chance of an overdose happening. However, if you suspect you've overdosed, be sure to get urgent medical attention.

Since you'll receive Fibrin in a medical facility environment, you're not likely to miss a dose.

Don't use Fibrin without talking to your physician first if you're allergic to cow products or cows themselves.

Don't inject Fibrin into one of your veins.

Don't use Fibrin to treat brisk or severe arterial bleeding.

It's not known whether Fibrin will harm an unborn child. Don't use Fibrin without consulting your doctor first if you're pregnant or may get pregnant during treatment.

It's unknown whether Fibrin will harm a breastfeeding infant. However, Fibrin should only be given to an expectant woman if clearly needed. Don't use the medication without consulting your doctor first if you're nursing an infant.

Unless otherwise instructed by your doctor, there aren't any restrictions on food, drinks, or activity after using Fibrin.


It's unknown whether other medicines may interact with Fibrin. Talk to your pharmacist and doctor before using any over-the-counter or prescription medicines, as well as herbal products while you're being treated with Fibrin.

Medicines may interact with some foods. This could be harmful in some cases and your physician may tell you to avoid some foods. When it comes to Fibrin, there aren't specific foods you must avoid while receiving this medication.

Follow your doctor's directions about any limits on food, drinks, or activity.


It's vitally important for you or your child to be checked closely while you're receiving Fibrin to ensure it's working well.

This medication may lead to a serious kind of allergic reaction, such as anaphylaxis, which requires urgent medical attention and may be life-threatening. Tell your doctor straight away if you develop a rash, hives, itching, chest pain, lightheadedness or dizziness, trouble swallowing, trouble breathing, or any kind of swelling on your face, mouth, or hands after receiving Fibrin.

Fibrin is made from blood donated by people. Some blood products have passed on some viruses to recipients, but the risk is minimal. Donated blood and donors are both examined for viruses to minimize the transmission risk. If you're concerned about this risk, consult your healthcare provider.

Some serious effects have occurred after Fibrin use, including the following:

Transmission of serious contagious agents, including viruses as well as Creutzfeldt-Jakob infection agents'make sure to inform your healthcare professional promptly if you develop any of these symptoms of infection: chills, fever, drowsiness, rash, loss of appetite, joint pain, dark urine, abdominal pain, yellowing of eyes or skin.

Thromboembolism'be sure to inform your healthcare professional promptly if you develop any of these thromboembolism symptoms: shortness of breath, difficulty swallowing or speaking, chest pain, leg swelling or tenderness.

Don't take Fibrin if you have these conditions:

  • If you have allergies to Fibrin or some of its ingredients
  • If you have had hypersensitivity (allergic) reactions to any products made from human blood


Keep Fibrin at between 2 degrees Celsius and 25 degrees Celsius.

Do not refrigerate or freeze Fibrin.

Use Fibrin within an hour of opening the vial.

Keep Fibrin and all medications out of children's reach.


Before using Fibrin, let your healthcare professional know about all your medical problems. Especially tell him or her if you:

  • Are breastfeeding or pregnant
  • Have allergies to Fibrin or some of its ingredients or any products made from human blood

Tell your healthcare professional about all the drugs you take, such as prescription and nonprescription drugs, herbal supplements, and vitamins.

You should not receive Fibrin treatment if you have allergies to cow products or cows themselves.

Fibrin shouldn't be used for brisk or very serious arterial bleeding as it'll be washed away before hemostasis is achieved.

Fibrin is made from a part of human blood called plasma and may have contagious agents, like viruses, that may cause disease. While Fibrin is screened, examined, and treated to decrease its risk of carrying a contagious agent, it still can potentially transmit disease. Please discuss with your healthcare professional the benefits and risks of using Fibrin.

Contact your healthcare professional if you develop the following symptoms after receiving Fibrin treatment: chills, fever, drowsiness, runny nose, joint pain, rash, tiredness, poor appetite, vomiting, nausea, dark-colored urine, abdominal pain, or yellowing of the eyes and skin. These could be signs of infections that can occur while using Fibrin.

Fibrin may also serve other purposes not mentioned in this article.

Your pharmacist has extra information about Fibrin written for healthcare providers that you should read.