Flurbiprofen (Oral)


The prescription drug flurbiprofen is used in the treatment of pain and discomfort caused by osteoarthritis and rheumatoid arthritis. This medication does not cure arthritis and must be taken on a continuous basis in order to be effective. Classed as a nonsteroidal anti-inflammatory medication, commonly referred to as NSAIDs, this medicine can help to relieve joint pain, stiffness. inflammation and swelling that is caused by arthritis.

This product is available in the following two delivery methods:

  • Tablet
  • Capsule, Extended Release

Conditions Treated

Type of Medicine

  • Nonsteroidal Anti-Inflammatory (NSAID)

Side Effects

Many medications can cause unwanted side effects, some of which may be an indicator of a more serious issue. If you are taking flurbiprofen and experience any of the following symptoms it is important that you notify your doctor as further medical attention may be necessary:

Less Likely:

  • Abdominal or stomach pain
  • Swelling
  • Constipation
  • Serious pain or discomfort in the stomach
  • Frequent urge to urinate
  • Bloody or cloudy urine
  • Lower back or side pain
  • Bladder pain
  • Difficult, burning, or painful urination
  • Rash

Rare Likelihood:

  • Back or leg pains
  • Weight gain
  • Blistering, peeling, or loosening of the skin
  • Upper right abdominal or stomach pain
  • Bloody nose
  • Burning feeling in the chest or stomach
  • Unpleasant breath odor
  • Chills
  • Tightness in the chest
  • Coughing
  • Swollen or painful glands
  • Dark urine
  • Swelling of the face, fingers, feet, or lower legs
  • Difficulty breathing
  • Stomach upset
  • Dilated neck veins
  • Sores, ulcers, or white spots on the lips or in the mouth
  • Extreme fatigue
  • Slow or fast heartbeat
  • Feeling faint, dizzy, or lightheaded
  • Yellow eyes or skin
  • Fever with or without chills
  • Severe or continuing stomach pain
  • General feeling of tiredness or weakness
  • Redness, swelling, or soreness of the tongue
  • Headaches
  • Red, swollen skin
  • Hives or itching
  • Red skin lesions, often with a purple center
  • Increased blood pressure
  • Pounding in the ears
  • Increased thirst
  • Large, flat, blue, or purplish patches on the skin
  • Irregular breathing
  • Noisy breathing
  • Joint pain, stiffness, or swelling
  • Nausea
  • Light-colored stools
  • Indigestion
  • Loss of heat from the body
  • Muscle pain
  • Loss of appetite
  • Nervousness
  • Shakiness and unsteady walk
  • Nosebleeds
  • Irregular heartbeat
  • Pinpoint red or purple spots on the skin
  • Pale skin
  • Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • Increased sensitivity of the skin to sunlight
  • Red, irritated eyes
  • Hoarseness
  • Redness or other discoloration of the skin
  • High fever
  • Scaly skin
  • Greatly decreased frequency of urination
  • Severe sunburn
  • Flushing or redness of the skin, especially on the face and neck
  • Skin rash, encrusted, scaly and oozing
  • Feeling of warmth or heat
  • Sore throat
  • Fast heartbeat
  • Stomach bloating or cramping
  • Dizziness
  • Sweating
  • Difficulty swallowing
  • Swelling or inflammation of the mouth
  • Decreased urine output
  • Tenderness in the stomach area
  • Cracks in the skin
  • Troubled breathing
  • Clay-colored stools
  • Unsteadiness, trembling, or other problems with muscle control or coordination
  • Chest pain
  • Unusual tiredness or weakness
  • Blurred vision
  • Vomiting
  • Bloody diarrhea
  • Weight loss
  • Bleeding gums

Patients who are taking flurbiprofen need to familiarize themselves with the following signs of overdose and be ready to seek immediate emergency care. Discuss any concerns about overdose that you may have with your doctor prior to beginning your flurbiprofen course of treatment.

Symptoms of Flurbiprofen Overdose

  • Change in consciousness
  • Pale or blue lips, fingernails, or skin
  • Heartburn
  • Loss of consciousness
  • Unusual drowsiness, dullness, or feeling of sluggishness
  • Fast or slow, or shallow breathing
  • Pain or discomfort in the chest, upper stomach, or throat

As your body adjusts to the flurbiprofen in your system, you may experience some temporary symptoms that will likely go away on their own. Typically, these side effects dissipate on their own and require no further medical care. If, however, you experience any of these symptoms and they worsen or linger for more than a few days, notify your doctor for further guidance.

Less Likely:

  • Acid or sour stomach
  • Tremor
  • Changes in vision
  • Stomach discomfort
  • Diarrhea
  • Sleepiness
  • Excess air or gas in the stomach or intestines
  • A runny nose
  • Feeling of constant movement of self or surroundings
  • Passing gas
  • Full feeling
  • Loss of interest or pleasure
  • Hearing loss
  • Lack or loss of strength
  • Lack of appetite
  • Trouble sleeping
  • Lightheadedness
  • Irritability
  • Loss of memory
  • General feeling of discomfort or illness
  • Problems with memory
  • Feeling sad or empty
  • Sensation of spinning
  • Fear
  • Sneezing
  • Discouragement
  • Stuffy nose
  • Continuing ringing or buzzing or other unexplained noise in the ear
  • Trouble concentrating
  • Belching

Rare Likelihood:

  • Redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
  • Discharge or excessive tearing
  • Burning, dry, or itching eyes
  • Transient, mild, pleasant aromatic odor
  • Confusion
  • Twitching

This list aims to be a comprehensive guide to the unwanted side effects that you may experience while taking flurbiprofen, however, it is possible that you may have a reaction that is not included above. If you are concerned with any symptoms that you have while taking flurbiprofen it is always best to confer with prescribing physician to receive further direction.


The following dosage information represents the typical amounts and frequencies commonly prescribed for flurbiprofen. If your doctor has prescribed a different amount or has instructed you to take in a different manner, it is important that you follow those directions.

Do not take more than the prescribed amount as there is a possibility of overdose associated with the use of this drug. It is always best practice to thoroughly discuss any concerns or questions that you may have about taking flurbiprofen with your doctor before making any changes.

Patients are advised to take these tablets in their original form and to swallow them whole. Do not attempt to chew the tablet; do not break it or cut it either.

In order to be effective, flurbiprofen must maintain a certain level of presence in your system. Due to this, it must be taken regularly and in the amount advised by your physician. You may need to wait two weeks, or possibly even longer, in order to feel the total effects of relief that are provided by flurbiprofen. If you have any concerns when beginning your course of treatment, be sure you discuss them with your doctor before making any changes to how you take this medication.

This drug is taken orally, and the same typical doses and frequencies are shared by both rheumatoid arthritis patients and those that are taking it as part of their treatment for osteoarthritis. It is not advised that children take flurbiprofen without the direction of their doctor or pediatrician who will adjust the dosage information on a case by case basis.

Patients will typically take between 200 and 300 milligrams of flurbiprofen each day; this dosage will be divided into either 2, 3, or 4 equal doses as directed by the doctor. Your prescribing physician will also advise you on the amount of time that should elapse between doses.

If you miss one of your flurbiprofen doses, it is important that you take it right away upon realizing that it was skipped. However, if it is close in time to your next scheduled dose, it is best to skip it completely. If you have missed a dose and are unsure of what to do, the best course of action is to contact your pharmacist for guidance. When taking flurbiprofen it is important that you never take a double dose as this can be harmful to your overall health and wellness.

Major Drug Interactions

Flurbiprofen is contraindicated with certain medications and oftentimes your doctor may opt to change one of the prescriptions to avoid any unwanted complications.

Patients that are currently taking Ketorolac are strongly advised to avoid concurrent treatment with flurbiprofen. However, your doctor may believe that the use of these two medications is the best course of action to treat your medical needs.

If you are taking any of the drugs below and your doctor prescribes flurbiprofen for treatment of your arthritis symptoms, they may adjust the dosage and frequency of one or both of the medications. If you are taking flurbiprofen and one of the medicines listed below, it is important that you notify your doctor of any negative reactions that you experience.

  • Abciximab
  • Vortioxetine
  • Acemetacin
  • Vilazodone
  • Amiloride
  • Valdecoxib
  • Amitriptyline
  • Trimipramine
  • Amoxapine
  • Triamterene
  • Anagrelide
  • Torsemide
  • Ardeparin
  • Tolfenamic Acid
  • Aspirin
  • Tinzaparin
  • Bemiparin
  • Ticagrelor
  • Benzthiazide
  • Tianeptine
  • Betamethasone
  • Tacrolimus
  • Bivalirudin
  • Sulfasalazine
  • Budesonide
  • Sodium Salicylate
  • Bumetanide
  • Sertraline
  • Celecoxib
  • Salicylic Acid
  • Chlorothiazide
  • Rofecoxib
  • Choline Magnesium Trisalicylate
  • Reviparin
  • Cilostazol
  • Protriptyline
  • Clomipramine
  • Proquazone
  • Clopamide
  • Proglumetacin
  • Cortisone
  • Prednisolone
  • Cyclosporine
  • Pralatrexate
  • Dalteparin
  • Piroxicam
  • Deflazacort
  • Phenyl Salicylate
  • Desirudin
  • Phenprocoumon
  • Dexamethasone
  • Pentoxifylline
  • Dexketoprofen
  • Pemetrexed
  • Dibenzepin
  • Parnaparin
  • Diflunisal
  • Paramethasone
  • Dipyridamole
  • Oxaprozin
  • Dothiepin
  • Olsalazine
  • Droxicam
  • Nimesulide Beta Cyclodextrin
  • Edoxaban
  • Niflumic Acid
  • Eplerenone
  • Nefazodone
  • Eptifibatide
  • Nadroparin
  • Ethacrynic Acid
  • Morniflumate
  • Etofenamate
  • Metolazone
  • Felbinac
  • Methyclothiazide
  • Fepradinol
  • Mesalamine
  • Feverfew
  • Floctafenine
  • Melitracen
  • Fluocortolone
  • Meclofenamate
  • Flurbiprofen
  • Mefenamic Acid
  • Fondaparinux
  • Loxoprofen
  • Ginkgo
  • Lofepramine
  • Heparin
  • Levomilnacipran
  • Hydrocortisone
  • Ketoprofen
  • Ibuprofen
  • Indapamide
  • Imipramine
  • Meloxicam
  • I-Magnesium Salicylatendomethacin
  • Iloprost
  • Lepirudin
  • Hydroflumethiazide
  • Lithium
  • Hydrochlorothiazide
  • Lornoxicam
  • Gossypol
  • Lumiracoxib
  • Furosemide
  • Meadowsweet
  • Fluvoxamine
  • Aceclofenac
  • Fluoxetine
  • Xipamide
  • Flufenamic Acid
  • Methotrexate
  • Feprazone
  • Methylprednisolone
  • Fenoprofen
  • Milnacipran
  • Etoricoxib
  • Nabumetone
  • Etodolac
  • Naproxen
  • Escitalopram
  • Nepafenac
  • Epoprostenol
  • Nimesulide
  • Enoxaparin
  • Nortriptyline
  • Duloxetine
  • Opipramol
  • Doxepin
  • Oxyphenbutazone
  • Dipyrone
  • Parecoxib
  • Digoxin
  • Paroxetine
  • Diclofenac
  • Pentosan Polysulfate Sodium
  • Diazoxide
  • Phenindione
  • Dexibuprofen
  • Phenylbutazone
  • Desvenlafaxine
  • Piketoprofen
  • Desipramine
  • Polythiazide
  • Danaparoid
  • Prasugrel
  • Dabigatran Etexilate
  • Prednisone
  • Cyclopenthiazide
  • Propyphenazone
  • Clopidogrel
  • Protein C
  • Clonixin
  • Reboxetine
  • Citalopram
  • Rivaroxaban
  • Choline Salicylate
  • Salicylamide
  • Chlorthalidone
  • Salsalate
  • Certoparin
  • Sibutramine
  • Cangrelor
  • Spironolactone
  • Bufexamac
  • Sulindac
  • Bromfenac
  • Tenoxicam
  • Bismuth Subsalicylate
  • Tiaprofenic Acid
  • Beta Glucan
  • Ticlopidine
  • Bendroflumethiazide
  • Tirofiban
  • Balsalazide
  • Tolmetin
  • Argatroban
  • Treprostinil
  • Apixaban
  • Trichlormethiazide
  • Amtolmetin Guacil
  • Trolamine Salicylate
  • Amitriptylinoxide
  • Venlafaxine
  • Amineptine
  • Vorapaxar
  • Acenocoumarol
  • Warfarin

Patients who are taking flurbiprofen, as well as any of the drugs in the list below, may have an increased chance of experiencing unwanted side effects. If you encounter any difficulties while taking flurbiprofen and one of these, discuss the situation with your doctor as they may be able to alter the way that you take one or both of the medications in order to lessen the unwanted symptoms.

  • Acebutolol
  • Valsartan
  • Alacepril
  • Timolol
  • Azilsartan
  • Telmisartan
  • Benazepril
  • Sotalol
  • Bisoprolol
  • Quinapril
  • Captopril
  • Practolol
  • Carvedilol
  • Perindopril
  • Cilazapril
  • Penbutolol
  • Dicumarol
  • Olmesartan
  • Enalaprilat
  • Nadolol
  • Esmolol
  • Metoprolol
  • Imidapril
  • Losartan
  • Labetalol
  • Delapril
  • Lisinopril
  • Levobunolol
  • Metipranolol
  • Irbesartan
  • Moexipril
  • Fosinopril
  • Nebivolol
  • Eprosartan
  • Oxprenolol
  • Enalapril
  • Pentopril
  • Pindolol
  • Celiprolol
  • Propranolol
  • Carteolol
  • Ramipril
  • Candesartan
  • Spirapril
  • Betaxolol
  • Temocapril
  • Azilsartan Medoxomil
  • Trandolapril
  • Atenolol
  • Zofenopril

If you use alcohol or tobacco be sure to inform your doctor of such habits. It may be required that you make alterations to your daily routine, such as the times that you eat your meals, in order to accommodate the dosage schedule of your medication. If you have any concerns while taking flurbiprofen, the best practice is to address them directly with the prescribing physician. Your doctor should also be notified of any changes that occur in the way that you take your medications or in your overall health and wellness.

Flurbiprofen may have a negative effect on the overall health of patients who suffer from the following conditions and ailments. If you are being treated for multiple medical issues, it is important that your physician is informed of any changes to your overall health as well as all of the medications that you are taking.


While you are taking flurbiprofen your doctor may order blood, urine, or other diagnostic tests in order to monitor your progress. As flurbiprofen does not cure arthritis it is likely that you will take this medication for a long period of time in order to manage the symptoms. Follow all direction that is provided by your doctor, and adhere to all scheduled appointments and tests.

You may experience an increased level of risk for stroke or heart attack while taking this medication. If you have already experienced heart issues you may be even more susceptible to further complications. As you take this for longer and longer periods, your risk for more serious health ailments may also increase. Notify your doctor right away if you ever feel chest pain that is localized or that spreads to your neck, jaw, back or arms. Likewise, if you have slurred speech, unexplained nausea, difficulty breathing, or feel faint.

Flurbiprofen has been reported to cause internal bleeding in some patients, especially in the intestines and stomach. If you have a medical history of stomach ulcers, are 60 years or older, smoke on a regular basis, are a regular drinker, or are in generally poor health you may be at higher risk for this condition. Patients that are using blood thinners, steroids, or certain other medications may also be at a higher risk for bleeding in the stomach and intestines.

Liver problems have also been reported in patients that are taking flurbiprofen. If you notice any symptoms such as pale stools, unexplained nausea, and vomiting, loss of appetite, upper abdomen or stomach pain, and a yellowish tint to your eyes or skin, notify your doctor as soon as possible.

Serious kidney problems are possible in patients who are taking flurbiprofen. If you experience any of the following signs or symptoms, call your doctor immediately:

  • Loss of appetite
  • Change in the frequency with which you urinate
  • Change in the amount of urine that you dispel
  • Drowsiness
  • Swollen feet
  • Swelling in your lower legs
  • Problems with breathing
  • Blood in your urine
  • Increased thirst
  • Nausea or vomiting

Side Effects that May be a Sign of a More Serious Medical Issue:

If you notice any of the below signs or symptoms occurring, contact your doctor immediately for further advice and direction:

  • Decreased frequency of urination
  • Unexplained weight gain
  • Swelling of the extremities
  • Skin rash
  • A yellow tint to the skin or eyes
  • Serious stomach pain

It is possible that you may experience serious heart issues while taking flurbiprofen. If you experience any of the signs and symptoms listed below, seek emergency medical attention right away.

  • Tightness in the chest
  • Slurred speech
  • Irregular or accelerated heart rate
  • Chest pain
  • Unexplained flushing
  • Warm skin
  • General feeling of weakness

There is the possibility of experiencing an allergic reaction known as anaphylaxis while taking flurbiprofen. This reaction is rare but it is also dangerous and can be life-threatening in certain situations. If you experience any of these symptoms it is imperative that you seek emergency medical treatment right away. If you are allergic to aspirin or any other NSAIDs you may be at higher risk of having an anaphylaxis reaction. Seek help immediately if you experience:

  • Irregular pulse or heartbeat that is accelerated
  • Gasping for air/breath
  • Fainting or losing consciousness
  • Unexplained changes to the color of your face
  • Swelling that resembles hives
  • Any puffiness or swelling in the eye area

Patients may experience serious skin disruptions when taking flurbiprofen. If you experience any peeling or loose skin, ulcers or other sores on the skin, red lesions, acne, skin rash, or chills and fever when taking flurbiprofen notify your doctor as soon as possible.

Do not use this medication while pregnant. Flurbiprofen has been known to cause serious fetal damage, especially when taking in the later trimesters of pregnancy. If you are of childbearing age and are taking flurbiprofen be sure to use an effective contraceptive. If you become pregnant while taking this medication, it is important that you tell your doctor immediately.

While taking this medication it is important to maintain regular eye care, especially annual eye exams. If you experience any changes to your vision while on flurbiprofen be sure to notify your ophthalmologist as soon as possible.

Your doctor needs to be aware of all medications that you are taking concurrently with flurbiprofen. This includes both prescription and non-prescription medications, any herbal remedies, over the counter medications, and vitamin and mineral supplements. Be sure to inform them of any changes to the medications that you are taking, the frequency with which you take them, and any changes in your overall health and wellness.


It is always best practice to store medication in its original packaging. Do not expose the medicine to direct light, moisture, or extreme heat or cold; do not allow the medication to freeze.

This and all medications should be kept out of the reach of children and pets.

Do not keep excess, expired, or unused medicines. If you are unsure of how to properly dispose of this medicine, consult with your doctor or pharmacist to learn the most appropriate method of disposal.

Because of the possibility of overdose that is associated with flurbiprofen, it is important that these instructions are followed.


The prescription drug flurbiprofen is used in the treatment of pain and discomfort caused by osteoarthritis and rheumatoid arthritis. This medication does not cure arthritis and must be taken on a continuous basis in order to be effective. Classed as a nonsteroidal anti-inflammatory medication, commonly referred to as NSAIDs, this medicine can help to relieve joint pain, stiffness. inflammation and swelling that is caused by arthritis.

Patients that are taking flurbiprofen should familiarize themselves with the signs of possible overdose, as well as the numerous signs and symptoms that may occur when there are more significant health issues.

Some patients have been reported to experience anaphylactic shock while taking this medication, an allergic reaction that can be harmful or even life-threatening. Understand the signs and symptoms of this reaction and seek immediate emergency medical help if they occur.

Women who are pregnant should not take this drug as it may cause harm to the fetus, especially in the later trimesters of pregnancy. If you are of childbearing age and are taking flurbiprofen be sure that you are also taking an effective contraceptive. Notify your doctor immediately if you become pregnant while taking this medication.