Furosemide (Injection)

Overview

Furosemide is a medication from the group loop diuretics, more commonly known as water pills. Furosemide works by increasing the flow of urine from the body, making the patient excrete more liquid.

Furosemide is given as an injection to treat patients who are suffering from edema or fluid retention when caused by certain conditions of the heart, liver or kidneys. The conditions that cause edema may include liver disease or cirrhosis, heart failure or kidney disease.

This medication should only be administered under the direct supervision of a doctor.

Condition treated

  • Edema

Type Of Medicine

  • Loop diuretic

Side Effects

In addition to the required effects of using Furosemide, other unwanted side effects can also occur as a result of use. Not all of the side effects listed herein may occur in each patient, but in cases where they do, medical attention may need to be sought.

If you begin to experience any of the following after being injected with Furosemide then you should inform your doctor immediately.

The following side effects occur only rarely:

  • Chest pains
  • Chills when warm
  • Coughing
  • Feverishness
  • General feeling of tiredness
  • General feeling of weakness
  • Headaches
  • Hoarseness
  • Lower back pain
  • Painful or difficult urination
  • Shortness of breath
  • Side pain
  • Soreness of the throat
  • Sores or ulcers appearing on the mouth
  • Swelling or pain of the glands
  • Tightness across the chest
  • Unusual bleeding
  • Unusual bruising
  • Unusual tiredness
  • Unusual weakness
  • Wheezing
  • White spots appearing on the lips or mouth

The frequency of these side effects occurring is unknown:

  • Back pain
  • Black stools with a tar-like appearance
  • Bladder spasming
  • Bleeding of the gums
  • Blistering or peeling of the skin
  • Bloody urine
  • Blurring of vision
  • Breath odor with fruity scent
  • Burning, crawling or prickling sensation
  • Cloudy urine
  • Cold sweats
  • Confusion or disorientation
  • Constipation
  • Continued ringing or buzzing that is not experienced by others
  • Coughing up of blood
  • Diarrhea
  • Dizziness, faintness, or lightheadedness when rising from sitting or lying
  • Dry and/or flushed skin
  • Dryness of the mouth
  • Feverishness with or without chills
  • Increased heartbeat
  • Increased hunger
  • Increased or decreased need to urinate
  • Increased thirst
  • Indigestion
  • Irritated eyes
  • Itching
  • Joint stiffness
  • Joint swelling
  • Leg pain
  • Loosening of the skin
  • Loss of appetite
  • Loss of hearing
  • Nausea
  • Nosebleeds
  • Pain felt at the site of injection
  • Pains of stomach, side, abdomen or back
  • Paleness of the skin
  • Pins and needles or tingling feelings on the skin
  • Puffy or swollen around the eyes, face, lips or tongue
  • Red spots appearing on the skin
  • Scaling of the skin
  • Skin rash
  • Stools with a clay-like coloration
  • Sweating
  • Swelling of the feet or the lower legs
  • Troubled breathing when exerting oneself
  • Unpleasant breath odor
  • Unusual weight loss
  • Vomiting
  • Yellowing of the eyes
  • Yellowing of the skin

Side effects that are not usually a cause for medical attention to be sought can also occur. These side effects may be mild and do not normally indicate that a wider medical problem is developing. If these side effects are bothersome or continue for a long period, then seek advice from a doctor.

  • Feeling that self or surroundings are constantly moving
  • Hives
  • Increased sensitivity of the skin to sunlight
  • Muscle spasms
  • Redness or discoloration of the skin
  • Restlessness
  • Sensation of spinning
  • Severe sunburn
  • Weakness
  • Welts

Other side effects that have not been listed herein can also occur in patients. If other side effects occur, then you should check with your doctor what to do.

Dosage

This medication will be injected by a nurse or doctor and is usually administered in a hospital. The treatment can be injected intravenously into a vein or subcutaneously into a muscle.

Your doctor or nurse may give you several shots of this medication until your condition has improved. Once you are more stable, you will be given an oral treatment to take instead. This works in the same way and you will be given a dosing schedule to effectively control your condition.

The following dosing information is for the injected medication only and is to be used as a guideline only. Your doctor will determine and administer the correct dose for you:

  • Adults should initially be treated with 20 to 40mg of medication. This dose is then increased by 20mg every two hours until the necessary clinical response is achieved.
  • Infants and children may be given 1 to 2mg/kg of body weight every six hours.

Interactions

Furosemide injections can cause unwanted reactions when used in conjunction with other medications. You should inform your doctor of all medications that you are taking before you begin use of this treatment. In some cases, violent reactions may occur, causing serious medical conditions; in other cases, certain medications can prevent others from working.

The use of Furosemide injection is not recommended in patients also receiving the following medications. Your doctor may decide against use of this medication in these cases:

  • Vasopressin
  • Valdecoxib
  • Tolmetin
  • Tolfenamic Acid
  • Tobramycin
  • Tiaprofenic Acid
  • Tenoxicam
  • Sulindac
  • Streptomycin
  • Sotalol
  • Sodium Salicylate
  • Salsalate
  • Salicylic Acid
  • Rofecoxib
  • Proquazone
  • Propyphenazone
  • Proglumetacin
  • Piroxicam
  • Piketoprofen
  • Phenylbutazone
  • Parecoxib
  • Oxyphenbutazone
  • Oxaprozin
  • Nimesulide Beta Cyclodextrin
  • Nimesulide
  • Niflumic Acid
  • Netilmicin
  • Nepafenac
  • Neomycin
  • Naproxen
  • Nabumetone
  • Morniflumate
  • Metolazone
  • Meloxicam
  • Mefenamic Acid
  • Meclofenamate
  • Lumiracoxib
  • Loxoprofen
  • Lornoxicam
  • Lithium
  • Levomethadyl
  • Ketorolac
  • Ketoprofen
  • Ketanserin
  • Kanamycin
  • Ibuprofen
  • Gentamicin
  • Foscarnet
  • Flurbiprofen
  • Flufenamic Acid
  • Floctafenine
  • Feprazone
  • Fepradinol
  • Fenoprofen
  • Felbinac
  • Etoricoxib
  • Etofenamate
  • Etodolac
  • Ethacrynic Acid
  • Droxicam
  • Droperidol
  • Dofetilide
  • Dipyrone
  • Digitoxin
  • Diflunisal
  • Diclofenac
  • Dexketoprofen
  • Dexibuprofen
  • Dasabuvir
  • Clonixin
  • Cisplatin
  • Choline Salicylate
  • Chloral Hydrate
  • Celecoxib
  • Bufexamac
  • Bromfenac
  • Bepridil
  • Aspirin
  • Arsenic Trioxide
  • Amtolmetin Guacil
  • Amikacin
  • Acemetacin
  • Aceclofenac

Using the following medications can also prohibit the use of this treatment because they will increase the likelihood of certain side effects occurring. Your doctor may still prescribe both, but may make the decision to adjust the dose or frequency of use of one of the treatments:

  • Zofenopril
  • Vecuronium
  • Tubocurarine
  • Trandolapril
  • Temocapril
  • Spirapril
  • Ramipril
  • Quinapril
  • Perindopril
  • Pentopril
  • Pancuronium
  • Moexipril
  • Lisinopril
  • Licorice
  • Imidapril
  • Gossypol
  • Ginseng
  • Germanium
  • Fosinopril
  • Fludrocortisone
  • Enalaprilat
  • Enalapril
  • Dibekacin
  • Delapril
  • Cyclosporine
  • Clofibrate
  • Cilazapril
  • Cephaloridine
  • Carbamazepine
  • Captopril
  • Benazepril
  • Aliskiren
  • Alacepril

Interactions can also occur with other medications that have not been listed here. To ensure no interactions will occur, you should inform your doctor of all medications you are taking, whether they were prescribed, purchased over the counter or are herbal remedies.

Other medical problems from which you suffer can also have an impact on the use of the Furosemide injection. You should inform your doctor of all medical conditions from which you suffer before beginning use. This is especially important if you suffer from any of the following conditions.

Use of Furosemide with the following medical conditions may make them worse:

  • Allergy to sulfa medications
  • Bladder problems
  • Blood or bone marrow problems
  • Dehydration
  • Electrolyte imbalance
  • Enlargement of the prostate
  • Gout
  • Hearing problems
  • Hyperuricemia
  • Hypovolema
  • Severe liver disease
  • Systemic lupus erythematosus
  • Tinnitus
  • Trouble with urination

Patients with the following condition should not be treated with Furosemide:

  • Anuria

Other medications may need to be adjusted in patients with the following conditions:

Caution should be used in patients with the following condition:

  • Kidney disease

The following conditions could cause a worsening of side effects in the patient:

Other medical conditions that have not been listed here could also impact on the use of the Furosemide injection. You should inform your doctor of your full medical history before use.

Warnings

Before using the Furosemide injection you should consider the risks of doing so and weigh them in relation to the benefits of use. This is a decision that you should make with your doctor, having ensured that the following has been taken into account:

Allergies

You should inform your doctor if you have ever reacted unusually to any medications in the past. This is particularly important if you have an allergy to sulfa medications, which may prohibit the use of this medication. You should also inform your doctor of any other allergies from which you suffer.

Pediatric

There are no known limitations to the use of this medication in children. Premature babies, however, have been shown to have in increased tendency towards suffering from certain side effects, including kidney stones and hearing problems. Caution should be used in childhood use.

Geriatric

There are no known limitations on the use of this medication in elderly patients. However, elderly patients are more likely to have conditions of the liver, heart or kidney that may limit the safe and effective use of the Furosemide injection. Elderly patients are also more likely to have bladder or urinary conditions that could cause greater side effects to occur from use.

Pregnancy

You must inform your doctor if you are pregnant. There is a risks present when this treatment is undertaken during pregnant and it should only be used where the benefits of use clearly outweigh the risks of use. Use during pregnancy may cause your unborn baby to become bigger than normal. You must inform your doctor if you believe that you have become pregnant during use.

Breastfeeding

There are no studies to determine the risk of the use of this medication in breastfeeding mothers. You should weigh the benefits against the potential risks of use with your doctor before beginning treatment.

Your doctor will need to monitor you while you are using this treatment. Blood and urine tests may be taken during treatment. When you switch to the oral medication, you will also need to be checked regularly by a doctor to ensure that the medication is working properly.

This medication can cause potassium to be lost from the body. This will occur more commonly in patients who have liver disease or in patients who are using adreocorticotropic hormones or steroids. It is also more likely if you eat a lot of licorice or have been taking laxatives for a long period of time. The symptoms of potassium loss should be reported to a doctor immediately and include the following:

  • Dryness of the mouth
  • Increased thirst
  • Muscle cramping
  • Vomiting
  • Nausea

You should stop use of this medication immediately if you suffer a decrease in hearing or have sensations of movement. Inform your doctor immediately and cease treatment at once.

This medication can change the level of sugar in the blood, which can cause problems in diabetic patients. You should inform your doctor if you notice changes to levels from test results.

You may become more sensitive to sunlight when using this medication, so you should take precautions to avoid becoming burned. A common side effect of use is severe sunburn. To avoid this, you should cover up in the sun, wear suncream and avoid being in direct light, particularly between 10am and 3pm, when the sun is strongest.

You must inform any medical professional you are dealing with that you are taking this medication. This medication can have an impact on the results of certain tests that they may need to carry out and may prohibit them from carrying out certain procedures.

You should not take any other medications when you are using this treatment unless your doctor has approved the use. This includes treatments for control of appetite, asthma medications and treatments for coughs, hay fever, colds or sinus problems.

Storage

This medication should be kept at room temperature below 25°C.

Do not refrigerate or freeze this medication.

Summary

Furosemide is an injected medication that is used to combat fluid retention in the body. This medication is used to stabilize the patient before they switch to the oral version of this medication for ongoing treatment.

Furosemide is used in patients who have fluid retention, also known as edema, that has been caused by liver disease or cirrhosis, heart failure or kidney disease.

This medication is suitable for use in patients of all ages, but particular care needs to be taken when it is used in premature babies, as there can be an increase in the occurrence of kidney stones and hearing problems in these cases.

Pregnant women should avoid use of Furosemide, as it can cause an increase in the size of the unborn baby. You must inform your doctor before use if you are pregnant and must inform your doctor immediately if you become pregnant while using the ongoing oral treatment of Furosemide.

Furosemide can cause a range of unwanted side effects to occur in the patient, some of which will require them to seek further medical attention. Patients should be aware of the side effects and risks of use before being treated with Furosemide. Ensure that you have considered these factors with your doctor before you begin use.

Furosemide can be injected into the vein or into the muscle of the patient and should only be administered under the supervision of a doctor in a hospital environment. You will need to be monitored by a doctor while receiving this treatment.