Gadobenate is known in the US under the brand name Multihance. The drug is used in a clinic or hospital environment as a diagnostic aid during certain MRI procedures.
The drug comes in solution form for intravenous administration. It is only ever administered by an appropriately trained medical professional prior to an MRI scan being taken.
MRI (magnetic resonance imaging) uses magnets and computer software technology to create pictures of particular parts of the patient's body. Gadobenate is generally used when MRI scans are being taken of the spine, brain and certain other areas of the body.
It should be noted that gadobenate cannot cure the condition that you are undergoing testing for. It is purely a diagnostic tool that is used to make the images produced during your MRI scans clearer.
In addition to providing the effects it is designed to produce, gadobenate sometimes causes a few unwanted side effects in some patients. Many patients do not suffer any unexpected effects at all when being treated with this drug. However, if you do notice anything odd, you may need to check with your doctor, in case the effect needs further medical treatment.
Some patients have reported the following side effects, following treatment with gadobenate. However, these effects are experienced only rarely. If you do notice any of these, you must tell your nurse or treating physician right away:
Gadobenate can cause some side effects that do not generally require further medical assistance. These effects usually disappear during treatment, once your body has adjusted to the drug. Your nurse or doctor may be able to give you some advice on how to prevent or manage some of the side effects.
If any of the effects that are mentioned below prove to be especially persistent or disabling, you should ask your nurse or doctor for advice.
In rare instances, patients who have received gadobenate have reported some of the following side effects:
It should be noted that the side effects mentioned in this guide may not be the only ones that are experienced by patients who have received gadobenate. If you notice any other effects, you should tell your nurse or treating physician as soon as possible.
You will only ever be given gadobenate if you are in a hospital or clinic for diagnostic MRI tests.
The medication is administered intravenously via a needle placed into one of your veins, immediately prior to your MRI scan by an appropriately trained medical professional.
Some medications must never be used at the same time as doing so can cause an undesirable interaction. In other cases, it may be appropriate to use both drugs together at a slightly adjusted dose or frequency rate, even though interactions could still take place. Be sure to tell your nurse or treating physician if you are using any prescription or over the counter drugs, before you receive your gadobenate infusion.
Some medicines should not be used at mealtimes or when eating particular food groups, as this could cause an interaction to take place. In addition, using tobacco or alcohol with some drugs can trigger interactions. Be sure to discuss this aspect of your treatment with your doctor.
Some historical or existing medical conditions can cause interactions to occur while using this medication. For this reason it is very important that you discuss your medical history fully with your treating physician before receiving treatment with gadobenate.
Gadobenate should be used with caution in patients who have a history of any of the following conditions. These conditions can cause the side effects of the drug to become worse:
This drug must be used with extreme care in patients who have a history of any of the following conditions, as to do so could trigger more serious side effects:
Although gadobenate can be used in patients with the hereditary disorder Dubin-Johnson syndrome, care should be taken as the slower removal of the drug from the body that would result could increase the effects.
Before you decide to accept treatment with a particular medication, you should consider the benefits and risks of doing so. You can make this decision based on discussions with your medical team.
Be sure to tell your treating physician if you have ever suffered an allergic reaction to gadobenate or to any other medication. You should also mention if you have ever had a bad reaction to food colors, preservatives, particular food groups, or animal by-products.
Although there have been no studies carried out to date that would indicate potential problems in using gadobenate in children over two years of age, no such research has been undertaken in children under the age of two years.
No studies have been performed into the use of gadobenate MultipackTM in children. It is therefore not known whether the use of this drug is safe or effective in these cases.
Although there has been no research to suggest that using gadobenate in elderly patients is inappropriate, caution should be taken. Geriatrics are more likely to suffer from age-related kidney problems, so the dose of the drug may require adjustment to take this into account.
There is nothing to suggest that using gadobenate in pregnant women could present a risk to the fetus. However, you should inform your treating physician if you are pregnant and weigh the benefits against the potential risks of receiving this medication.
Similarly, there have been no studies that show that this drug passes into breast milk. However, you may wish to consider using an alternative form of feeding solution for your infant if you are breastfeeding. Once your diagnostic tests are over and the drug has passed out of your body, you may then resume breastfeeding.
You must attend your doctor on a regular basis throughout your treatment with gadobenate to make sure that the drug has not caused any side effects and is working effectively. These appointments will also be used to discuss the results of your MRI tests and to map out future treatments and tests.
Some patients may develop a serious disease called nephrogenic systemic fibrosis (NSF), following treatment with gadobenate. If you or your child have any of the following symptoms, check with your GP right away:
Anaphylaxis has been noted in some patients who have received gadobenate. This is a potentially life-threatening allergic reaction that always requires prompt medical assistance. Tell your nurse right away if you notice any of the following symptoms immediately after receiving this drug:
Check with your nurse or doctor immediately if you notice any mild burning feelings, reddening or swelling, or sensations of cold or warmth around the injection site.
Some patients can experiences incidences of arrhythmia, including QT prolongation when having treatment with gadobenate. This condition causes alterations to your heartbeat and sometimes causes fainting. If you notice any signs of heart rhythm issues, including pounding, rapid, or irregular heartbeats, tell your doctor right away.
Before undertaking any form of medical tests, you must tell the presiding physician or nurse that you have received treatment with gadobenate. Some test results can be affected by this medication.
You must not use any other form of medication while you are receiving gadobenate, including over the counter drugs, herbal remedies, vitamin supplements, and diet pills, unless their use has first been discussed with your treating physician.
This medication is not prescribed for home use. It will be stored in an appropriate setting in the hospital or clinic where you will be receiving your treatment.
Gadobenate is only used in hospitals and medical clinics prior to MRI diagnostic scans. The drug is a contrasting agent. It is administered via intravenous injection by a trained medical professional, immediately prior to your scan. This medication cannot cure your condition; it is used purely as a diagnostic tool.
This medicine can cause a number of potentially serious side effects in some patients who have a history of certain medical conditions. You should therefore attend your doctor for check-ups following your treatment to make sure that the drug has not caused any persistent problems.