Gadobutrol (Intravenous)

Overview

Patients who undergo diagnostic testing that utilizes contrast agents, such as MRAs and MRIs, will likely be injected with gadobutrol. These diagnostic scans are commonly used to diagnose or manage issues with the breasts, brain and spine, as well as other areas of the body. The gadolinium-based contrast agent (GBCA) is used in magnetic resonance imaging that does not require radiation.

Patients will have this contrast agent injected into their system as part of the MRI procedure. Because it is administered in a hospital or other medical care facility, a healthcare professional will handle the storage and injection of the gadobutrol solution. Patients who have allergies or are concerned about the use of gadobutrol as part of their MRA or MRI are advised to discuss such concerns with their physician, prior to the procedure.

This solution can cause a number of different conditions to worsen, and patients with a prior history of severe or long-lasting kidney issues may be directed to use a different contrast agent. If you suffer from kidney problems or disorders, it is important to discuss your concerns with your doctor prior to your MRA or MRI.

As the injection occurs in a hospital or other clinic setting, it is important that you remain at the facility if you feel unwell in any way. You may experience discomfort in the area of the injection site that should dissipate on its own, but if the unpleasant feelings do not go away, notify the medical team that is conducting the procedure.

It has been reported that the use of gadobutrol has been known to cause a reaction known as anaphylaxis. This allergic reaction can be harmful and even life-threatening, and requires immediate emergency medical attention and care. Patients who will be administered a gadobutrol injection in conjunction with their MRA or MRI procedure should familiarize themselves with the signs and symptoms associated with the reaction and, if they experience any such symptoms, should report them to a member of their medical team immediately.

Most symptoms or feelings of discomfort that occur with the use of gadobutrol will likely dissipate on their own in a short amount of time. Any side effects that linger or appear after days or weeks following your procedure should be reported to your doctor as soon as possible.

Conditions Treated

Used as a contrast agent in:

  • Magnetic resonance imaging (MRI) scans of the spine, breasts, brain and other areas of the body
  • Magnetic resonance angiography (MRA) scans to monitor or diagnose renal artery disease or supra-aortic issues

Type Of Medicine

  • Diagnostic agent
  • Radiological contrast media

Side Effects

Most medications and solutions can cause unwanted side effects in addition to their stated purpose. Because gadobutrol is administered in a hospital or clinic setting, the attending medical staff should be notified immediately of any complications that you experience. While you are receiving the MRI, you may experience some uncomfortable or unpleasant symptoms at the site of the injection.

There is a rare likelihood of any of the following at the site of your injection:

  • Tingling
  • Burning
  • Swelling
  • Discoloration of the skin
  • Soreness
  • Hives
  • Redness
  • Inflammation
  • Pain
  • Lumps
  • Numbness
  • Bleeding
  • Rash
  • Itching
  • Scarring
  • Infection
  • Stinging
  • The feeling of pressure
  • Tenderness
  • Coldness
  • Ulceration
  • Blistering
  • Warmth

Notify the medical team if you experience any of the following signs and symptoms as they may signal a more serious problem:

Rare occurrence:

  • Sweating
  • Convulsions
  • Redness of the face, neck, arms, or chest
  • Fast, pounding, or irregular heartbeat or pulse
  • Loss of consciousness
  • General feeling of discomfort or illness
  • Hives or welts, itching, or skin rash
  • Blurred vision
  • Paleness of the skin
  • Feeling of warmth
  • Redness of the skin
  • Difficult or labored breathing
  • Tightness in the chest
  • Confusion
  • Unusual tiredness or weakness

Unknown likelihood of incidence:

  • Stopping of the heart
  • Burning, dry, or itching eyes
  • Sneezing
  • Coughing
  • No breathing
  • Difficulty with swallowing
  • Muscle stiffness or weakness
  • Hoarseness
  • Increased sweating
  • Bluish color of the skin or lips
  • No blood pressure or pulse
  • Discharge from the eyes or excessive tearing
  • Noisy breathing
  • Slow or irregular breathing
  • Deep bone pain
  • Stiff joints or trouble moving
  • Chest pain
  • Swelling of the mouth or throat
  • Burning sensation
  • Unconsciousness

Patients have reported certain symptoms occurred when they received gadobutrol in conjunction with an MRI. If you experience any of the signs or symptoms listed below, they will likely dissipate on their own. If your side effects worsen or linger for longer than a day or two, notify your doctor in order to receive further medical advice.

Less likely:

Rare occurrence:

  • Change in sense of smell
  • Unexplained warm skin
  • Dizziness
  • Feeling hot or cold
  • Loss of taste
  • Dry mouth
  • Vomiting
  • Change in taste

While this list aims to be comprehensive in nature, you may experience certain symptoms or side effects that are not listed here. If you are concerned by any reaction that you experience following an MRA or MRI that utilized gadobutrol, it is always best practice to confer with a medical professional.

Dosage

Gadobutrol is administered as part of the overall MRA or MRI procedure by a doctor, nurse or another healthcare professional in a hospital or clinic setting. The solution is injected into the patient's vein with the dosage amount determined on a case by case basis.

Major Drug Interactions:

Your doctor or another healthcare professional will review your complete medical health history prior to administering gadobutrol as part of an MRA or MRI diagnostic procedure. It is important that you disclose all allergies during this conversation, including those to foods, medicines, animals and other substances.

It is important that you also disclose all of the medications that you are currently taking, along with the dosage and frequency with which they are taken. This includes both prescription and non-prescription strength medications, including those available over the counter, as well as any herbal remedies or vitamin and mineral supplements.

Discuss with your doctor any modifications that should be made prior to your MRA or MRI procedure, such as limitations on what you may eat or drink within a certain timeframe surrounding the scan.

If you suffer from any respiratory conditions, allergies or bronchial asthma, you may be at higher risk of experiencing an allergic reaction to the gadobutrol. Be sure to inform your doctor or the healthcare professional who administers the gadobutrol of any such conditions.

Patients with a history of ongoing or recent kidney issues should avoid this injection unless absolutely necessary. Your doctor will provide further guidance in the event that this is applicable to your situation.

Warnings

There will be medical staff on-hand before, during and after the administration of the gadobutrol injection. If you do not feel well when at the conclusion of the MRA or MRI, inform the healthcare professional assisting you and they can provide further medical guidance. There are certain symptoms that may be a sign of a more serious problem, such as a disease called nephrogenic systemic fibrosis (NSF), and should be reported immediately:

  • Itching or burning
  • Pain in the ribs and hips that is felt deep in the bones
  • Stiffness in the joints
  • Limited range of motion in the extremities
  • Muscle weakness
  • Dark or red patches on the extremities
  • Swelling of your skin in the weeks and days after the procedure

The use of gadobutrol as part of an MRA or MRI scan has been reported to increase the risk of developing a condition called acute kidney injury, which is sometimes referred to as AKI. If you have any kidney issues that are severe, your chances of developing AKI may be elevated, especially in cases where high dosage amounts are administered.

Anaphylactic shock has been reported in some patients that have received gadobutrol. This reaction can be dangerous, and even life-threatening, in some cases. If you experience any of the following signs and symptoms, it is important that you seek immediate emergency medical attention:

  • Chest pain
  • Itching
  • Swelling of the face, tongue and throat
  • Respiratory issues
  • Confusion
  • Skin rashes
  • Lightheadedness
  • Sweating
  • Cold, clammy skin
  • Dizziness
  • A warm feeling at the site of the injection
  • A cold feeling at the site of the injection
  • Swelling or redness at the site of the injection

Storage

Because this solution is administered as part of the MRI procedure that is conducted at a hospital or other medical care facility, patients will not need to worry about the proper storage of gadobutrol.

Summary

Patients who undergo diagnostic testing that utilizes contrast agents, such as MRAs and MRIs, will likely be injected with gadobutrol. These diagnostic scans are commonly used to diagnose or manage issues with the breasts, brain and spine, as well as other areas of the body. This gadolinium-based contrast agent (GBCA) is used in magnetic resonance imaging that does not require radiation.

Patients will have this contrast agent injected into their system as part of the MRI procedure. Because it is administered in a hospital or other medical care facility, a healthcare professional will handle the storage and injection of the gadobutrol solution.

Prior to their MRA or MRI procedure, patients should familiarize themselves with the signs and symptoms of anaphylactic shock, as this is a possible reaction to the use of this solution. There are other signs that can be evidence of a more serious problem, and patients should remain at the treatment facility for as long as necessary following their scan. If you have a prior history of kidney issues, your doctor may opt to not use this contrast agent due to the increased likelihood of complications.

Notify your medical team of all medicines that you are currently taking, as well as any allergies from which you suffer. Do not neglect to include all over the counter drugs and non-prescription medications, as well as herbal remedies and all vitamin and mineral supplements that you take.