Gadodiamide (Intravenous)

Overview

Gadodiamide is a magnetic resonance imaging contrast agent (MRI). Contrast agents are used in helping to create a clear picture of the body during an MRI scan. MRI scans are a special kind of diagnostic procedure which use computers and magnets to help produce pictures or images of certain areas inside the body. They do not involve ionizing radiation (unlike x-rays).

This drug is given via injection before an MRI scan to assist in diagnosing issues with the spine, brain, stomach, chest, hip area, and various other areas of your body. This medication is only to be used via the guidance of a trained professional and is available in the dosage form of solution for injection.

Condition(s) treated?

  • MRI Scan

Type of medicine?

  • Solution

Side Effects

Along with the intended effects, gadodiamide can produce some other unwanted side effects. Not all of these side effects need to be present at the one time, but if they do occur, you may need to seek medical attention.

Let your doctor or healthcare professional know if you suffer from any of the following side effects whilst taking Gadodiamide:

Rare and less common side effects

  • Difficulty walking

Incidence not known

  • Muscle weakness

Many of the side effects that occur with this drug usually don't require any medical attention. You may find that these side effects begin to reduce or disappear completely as your body begins adjusting to the medication. You can contact your local pharmacist or doctor for advice on how to reduce or prevent these side effects if they are bothersome.

Less common or rare side effects

  • Change in taste

Not all possible side effects are listed above and you should seek medical attention if you notice anything unusual after receiving this medication. Remember that you can report all side effects to the FDA regardless of severity.

Dosage

The final dose of any medication will depend on a number of factors. This will include your age, weight and height, any current medications you are taking, your past medical conditions and your reaction to the specific dose.

Typical Adult Dose for CNS Magnetic Resonance Imaging:

0.2 mL/ kg which is administered via a bolus intravenous injection.

Typical Adult Dose for Vascular Magnetic Resonance Imaging

Kidney: 0.1 mL/kg administered via a bolus intravenous injection.

Intra-abdominal, intrathoracic, and pelvic cavities: 0.2 mL/kg administered via a bolus intravenous injection.

Interactions

Interactions between drugs can cause severe side effects and reduce the wanted effects of each drug you are taking. To reduce the risk of interactions, you should give your doctor or healthcare professional a full list of all the current medications you are taking, including your past medications. This should include all prescriptions and non-prescription drugs, herbal drugs and vitamins. You should also inform your doctor of any other medical conditions you suffer from including conditions that run in your family.

Let your physician know if you are taking any of the following medications.

  • Timolol

The presence of other medical conditions can affect the use of this medication. Ensure you inform your healthcare professional or doctor if you have any other medical conditions, especially:

  • Kidney problems, mild to moderate

Warnings

Certain medications may not be used around or at the time of eating food or some types of food as it could increase your risk of interactions. The use of alcohol or tobacco can also increase your risk of interactions. It's therefore important that you consult with your doctor about the use of this drug alongside various foods, tobacco or alcohol.

You should let your doctor or healthcare professional know if you have ever suffered from an allergic or unusual reaction to this medication. You should also make them aware of any other allergies you suffer from including to animals, dyes, preservatives and food. These allergies could increase your risk of interactions and severe side effects.

Pediatric population The appropriate studies conducted to date have not indicated a pediatric-specific problem that could limit the effectiveness of gadodiamide in children younger than two years old. However, efficacy and safety have not been established.

Geriatric population Appropriate studies conducted to date have not indicated a geriatric-specific problem that could limit the usefulness of this drug in the older population. However, older patients are more likely to have age-related kidney problems, which could require dose adjustments and caution in those who are receiving this drug.

Use in pregnancy and breastfeeding

This drug is under FDA pregnancy category C. It is unknown whether this medication will harm an unborn infant. Inform your doctor if you are pregnant or plan on falling pregnant. It is unknown whether this drug can pass into breast milk or affect a nursing infant. You should let your doctor or healthcare professional know if you are breastfeeding.

You should consult with your healthcare professional or doctor immediately if your child or you suffer from the following symptoms:

  • Dark or red patches on the skin

The following signs could be symptoms of an extremely serious disease known as nephrogenic systemic fibrosis (NSF).

This medication could cause a serious type of allergic reaction known as anaphylaxis. This can be a life-threatening condition and requires immediate medical attention. You should consult with your nurse or doctor immediately if you or your child suffer from any of the following signs:

  • A skin rash

Ensure your healthcare professional or doctor knows that you or your child have used this medication. This medication can affect the results of some medical tests (e.g. calcium or serum iron).

Storage

This drug will be kept in a medical setting, such as a hospital before use at room temperature.

Summary

When used correctly, this drug is successful in diagnosing certain disorders of the spine and brain, or the chest and stomach areas. A trained healthcare professional or doctor will give you this medication. This medication is given via a needle placed in one of your veins just before you receive an MRI scan.

Due to the number of side effects, it's important you let your doctor know if you have ever had an allergic reaction to this medication or similar medications. If your side effects don't begin to lessen in severity as time passes, you should contact your doctor or healthcare professional as soon as possible. It's unknown whether this drug will affect you during pregnancy and breastfeeding, you should therefore let your doctor know if you are currently pregnant or planning on becoming pregnant in the near future. If you require any further information about the use of this medication or have any questions, you should contact your local doctor for advice.