Gadofosveset (Injection)


Patients that undergo the diagnostic test known as magnetic resonance angiography (MRA) are typically given an injection of Gadofosveset to help the medical team see their blood vessels more clearly. MRAs are a diagnostic tool used to detect and manage blockage in the arteries. This injection is classed as a gadolinium-based contrast agent (GBCA).

If you suffer from a blockage in the aorta or another blood vessel your doctor may use an MRA in the diagnosis and management of your condition. The Gadofosveset solution will be injected into your vein prior to the administration of the scan. This diagnostic procedure is conducted at a hospital or other clinic-like setting, and due to this, you will not need to self-administer the dosage. Patients will not be given this solution except as part of an MRA scan and therefore will not need to store the location in their homes.

There are a number of possible side effects that can occur with the use of Gadofosveset and patients with allergies may be more susceptible to having a negative reaction. It is important that your doctor is aware of all allergies that you may have prior to conducting this procedure. If you are concerned about allergies or other reactions that you may experience, your doctor or another member of your medical team can address them prior to the MRA.

Patients who suffer from kidney conditions may have difficulties with the administration of Gadofosveset. If you suffer from this condition your doctor will review the signs and symptoms of complications that you should look for. After the procedure is completed, you may wish to stay at the facility until you are certain that you are feeling well and any side effects that occurred with the use of Gadofosveset have passed.

The use of this solution has been known to cause anaphylaxis shock in some cases. It is important that patients familiarize themselves with this reaction and know to immediately signal for help should they experience it. Be sure to ask any questions or voice any concerns when your doctor or nurse review the potential side effects and reactions that may occur from the use of Gadofosveset prior to your MRA scan.

Conditions Treated

  • Used as a contrast agent in magnetic resonance angiography

Type Of Medicine

  • Diagnostic agent, radiological contrast media

Side Effects

Because this solution is administered as part of an MRA procedure you will have an entire medical team close by to deal with any serious side effects that you may experience. Many patients report of discomfort, such as itching, at the site of the injection. Any such reaction should dissipate after a few moments, but should any effect that you experience worsen or last longer than several minutes, it is advisable to notify one of the medical team that is administering the scan.

More likely:

  • Coughing
  • Itching
  • Unexplained tiredness or weakness
  • Skin rash
  • Fast heartbeat
  • Shortness of breath
  • Hives
  • Tightness in the chest
  • Dizziness
  • Trouble swallowing
  • Wheezing

Less likely:

  • Blurred vision
  • Headaches
  • Pounding in the ears
  • Sensation of warmth or heat
  • Nervousness
  • Redness of the skin, in face and neck areas
  • Slow or fast heartbeat
  • Faintness, dizzy, or lightheaded
  • Sweating

Discomfort at the site of your injection will likely dissipate after a few moments, but if it does not, advise one of the medical staff that is conducting the scan. Any symptoms that you experience that continue or appear after you leave the medical facility should be reported to your doctor.

Less likely:

There is a chance of the following at the site of your injection:

  • Tingling
  • Burning
  • Swelling
  • Discoloration of the skin
  • Soreness
  • Hives
  • Redness
  • Inflammation
  • Pain
  • Lumps
  • Numbness
  • Bleeding
  • Rash
  • Itching
  • Scarring
  • Infection
  • Stinging
  • The feeling of pressure
  • Tenderness
  • Coldness
  • Ulceration
  • Blistering
  • Warmth

Any of the following symptoms listed below may signal a more serious problem and should be reported to a nurse or doctor right away:

  • Loss of taste
  • Change in taste
  • Nausea
  • Feeling cold

The above lists of side effects may not contain all of the symptoms that you might experience with your MRA. If you have a symptom that becomes worse or causes you concern, it is always best practice to notify your doctor or another member of your medical team.


This contrast agent solution is administered as part of an MRA scan. Because these procedures are conducted in a hospital or other clinic-like setting your doctor will determine the amount of your dosage. Gadofosveset is never self-administered as patients will receive the injection from a nurse or another member of their medical care team.

Major drug interactions:

Prior to conducting an MRA your doctor or another member of your healthcare team will thoroughly review your medical history. It is important that you inform them of all allergies from which you suffer, this includes allergic reactions to medications, different types of food, substances such as animal dander as well as any other allergy of which you are aware.

A member of your healthcare team will also review all of your current medications as well as any that you have stopped taking in the recent past. When you are disclosing this information it is important that you provide thorough and accurate details to the staff member. Include all medications that you take and how often and at what dosage you take them. Be sure to inform them of any over the counter medicines as well as vitamin and mineral supplements and herbal remedies that you use.

You will be informed of any changes that you may be required to make such as not eating or drinking for a certain period of time prior to the procedure. Present all questions and concerns that you may have to your doctor before your scan and be sure that you feel that they are addressed in a complete manner before proceeding.

Patients who suffer from respiratory diseases such as bronchial asthma, or any other condition affecting that part of the body, may have a higher likelihood of having an allergic reaction to the use of Gadofosveset. Prior to your MRA, your healthcare provider will need to be informed of all medical conditions from which you suffer.

If you have any of these ailments your doctor may choose a different solution than Gadofosveset:

  • Diabetes
  • Heart disease
  • Asthma
  • Kidney problems
  • Heart rhythm problems
  • Hypertension (high blood pressure)
  • Allergies
  • Kidney conditions


The use of Gadofosveset can cause a serious issue known as nephrogenic systemic fibrosis (NSF), if you experience any of the following side effects notify your doctor immediately prior to leaving the hospital:

  • Itching or burning
  • Pain in the ribs and hips that is felt deep in the bones
  • Stiffness in the joints
  • Limited range of motion in the extremities
  • Muscle weakness
  • Dark or red patches on the extremities
  • Swelling of your skin in the weeks and days after the procedure

The following symptoms may be signs of anaphylaxis shock and patients that experience any of them should notify their doctor or nurse right away:

  • Chest pain
  • Itching
  • Swelling of the face, tongue, and throat, or respiratory issues
  • Confusion
  • Skin rashes
  • Lightheadedness
  • Sweating
  • Cold, clammy skin
  • Dizziness
  • A warm feeling at the site of the injection
  • A cold feeling at the site of the injection
  • Swelling or redness at the site of the injection

Use of this medication has been reported to cause QT prolongation in some cases. This condition is identified by the changes in the patient's heart rhythm. If you experience fainting, any changes to the rhythm of your heartbeat, or an irregular or increased heartbeat it is important that you notify the medical team immediately.


This solution is never self-administered, therefore, storage concerns are not applicable.


Gadofosveset is a contrast agent that is used during magnetic resonance angiography (MRA) scans, a common diagnostic tool used to detect blockage of the aorta or other blood vessels. Patients that suffer from kidney disease or have certain allergies may have an increased risk of allergic or other negative reactions to this solution and their doctors may instead use a different contrast dye.

Patients are advised to remain at the hospital following their procedure until they are feeling completely well and any side effects that they may have experienced have dissipated.

Report any significant reactions that you have to the medical team and do not leave the facility until they have passed. This solution can cause serious side effects and reactions and it is best practice to remain under medical supervision until you are certain that you have not had a reaction.

It is important that your physician is aware of all medications that you are taking and that you have informed them of all medical conditions.