Gonadorelin (Injection intravenous)

Gonadorelin is a hormone treatment that is used to promote responses of the pituitary gland and hypothalamus.


Gonadorelin is a treatment that uses the same hormones as the naturally produced gonadotropin-releasing hormone (GnRH). This naturally produced hormone is usually released by the hypothalamus gland. Use of this treatment triggers responses of the pituitary gland and the release of other hormones in the body. These hormones include luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

This treatment is normally used to test the function of the hypothalamus and pituitary glands in children. LH and FSH are hormones that help to control normal development in children so the use of Gonadorelin allows the doctor to test that these hormones are being correctly released.

In adults LH and FSH are key elements in the control of fertility. Gonadorelin can be used as a fertility treatment in adults as it promotes ovulation so that an egg may be fertilized. It is used in patients not regularly ovulating or menstruating because of a dysfunctional hypothalamus gland. In this case, the use of Gonadorelin replaces the GnRH that is not being released correctly.

This medication is available by prescription-only and is administered as either a powder for a solution or as a kit. It is injected as the drug Factrel.

Condition treated

  • Hypothalamus function, test
  • Pituitary gland, test
  • Infertility

Type Of Medicine

  • Hormone treatment

Side Effects

In addition to the required effects from the use of Gonadorelin, patients may also experience other unwanted side effects from use. While not all side effects may occur, when they do patients may need to seek medical attention.

You should contact your doctor immediately if you experience any of the following side effects:

  • Continued flushing of the skin
  • Difficulty with breathing
  • Increased heartbeat

You must check with your doctor as soon as possible if the following side effects occur:

  • Changed skin at site of injection
  • Hives
  • Itching
  • Pain
  • Rash
  • Redness
  • Swelling at injection site

Other side effects could also occur that do not normally require you to seek medical attention. The following side effects are usually mild and will abate over time. If they do become bothersome or are suffered for a long period of time, however, you can seek advice from your doctor on how to relieve these side effects:

  • Abdominal pains or discomfort
  • Flushing that abates after a short period of time
  • Headaches
  • Lightheadedness
  • Nausea or sickness
  • Stomach pains or discomfort

Other side effects can also occur that have not been listed herein. If you experience any other side effects then you should contact your doctor for advice.


When you are receiving Gonadorelin for the purposes of tests you will need to give samples of blood so that the body's response may be measured. Gonadorelin is injected into a vein or under the skin and blood samples will need to be taken at regular intervals before and after injections. This will allow the doctor to determine whether LH and FSH are being properly released by the body.

When this treatment is being used for fertility treatment then the patient may sometimes be given a kit to self-administer the dose at home. In this case, the patient will be instructed how to administer the dose. Make sure you understand this fully and clearly before agreeing to take the medication in this manner and make sure you follow your doctor's instructions closely.

The dose of this medication will differ depending on a range of factors. The condition being treated, the dose of the medication and the age of the patient will affect the dose and use of this treatment. You should only ever take it as it has been prescribed to you and should not make any changes to the dose unless instructed to by the doctor. The following information is a guideline only and should not be used to adjust your dose:

When injecting Gonadorelin using a Lutrepulse pump in the treatment of amenorrhea or infertility as a result of hypothalamus or pituitary problems:

  • Adults should be treated with 5mcg every 90 minutes for 21 consecutive days. This is injected either into a vein or under the skin over a period of one minute. The dose may be adjusted between 1mcg and 20mcg as required and as determined by the doctor.
  • This medication should only be used in those over the age of 18.

When injecting Gonadorelin for the purposes of testing the response of the hypothalamus and pituitary glands:

  • Adults should be injected with a single dose of 0.1mg.
  • Children aged 12+ should be treated with 2mcg/kg of body weight. This should not exceed a single injection of 100mcg.
  • Below the age of 12, the use and dose of Gonadorelin must be determined by the doctor.


Use of Gonadorelin can be prohibited if you are using other medications. This is because some medications may interact with each other in the body and in doing so may cause severe side effects. In other cases, treatments may prevent one another from working or may increase the risk of the occurrence of certain side effects.

Before you begin use of Gonadorelin you must inform your doctor of all medications that you are taking. This includes all over the counter treatments, prescribed medications, and supplements or herbal remedies too. This is especially important if you are taking any of the following treatments:

The use of this medication is not recommended if you are also receiving the following treatments. In these cases your doctor may decide not to use this medication at all:

  • Ziprasidone
  • Thioridazine
  • Terfenadine
  • Sparfloxacin
  • Saquinavir
  • Piperaquine
  • Pimozide
  • Mesoridazine
  • Dronedarone
  • Cisapride
  • Bepridil
  • Amisulpride
  • Amifampridine

The use of Gonadorelin in conjunction with the following medications would not normally be recommended, but in some cases you doctor may prescribe both medications together. When this happens the use or dose of one or both treatments may be adjusted:

  • Zuclopenthixol
  • Vorinostat
  • Voriconazole
  • Vinflunine
  • Vilanterol
  • Venlafaxine
  • Vemurafenib
  • Vardenafil
  • Vandetanib
  • Trimipramine
  • Trazodone
  • Toremifene
  • Tolterodine
  • Tizanidine
  • Tetrabenazine
  • Telithromycin
  • Telavancin
  • Telaprevir
  • Tamoxifen
  • Tacrolimus
  • Sunitinib
  • Sulpiride
  • Sotalol
  • Sorafenib
  • Solifenacin
  • Sodium Phosphate, Monobasic
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate
  • Sevoflurane
  • Sertindole
  • Ritonavir
  • Risperidone
  • Rilpivirine
  • Ranolazine
  • Quinine
  • Quinidine
  • Quetiapine
  • Protriptyline
  • Propafenone
  • Promethazine
  • Prochlorperazine
  • Procainamide
  • Probucol
  • Posaconazole
  • Pitolisant
  • Pipamperone
  • Pimavanserin
  • Perphenazine
  • Perflutren Lipid Microsphere
  • Pentamidine
  • Pazopanib
  • Pasireotide
  • Paroxetine
  • Panobinostat
  • Paliperidone
  • Ondansetron
  • Olanzapine
  • Ofloxacin
  • Octreotide
  • Norfloxacin
  • Nilotinib
  • Nelfinavir
  • Moxifloxacin
  • Mizolastine
  • Mifepristone
  • Metronidazole
  • Methadone
  • Mefloquine
  • Lumefantrine
  • Levofloxacin
  • Lapatinib
  • Ketoconazole
  • Ivabradine
  • Itraconazole
  • Imipramine
  • Iloperidone
  • Ibutilide
  • Hydroxyzine
  • Hydroxychloroquine
  • Hydroquinidine
  • Haloperidol
  • Halofantrine
  • Granisetron
  • Gemifloxacin
  • Gatifloxacin
  • Galantamine
  • Fosphenytoin
  • Foscarnet
  • Formoterol
  • Fluoxetine
  • Fluconazole
  • Flecainide
  • Fingolimod
  • Felbamate
  • Famotidine
  • Escitalopram
  • Erythromycin
  • Eribulin
  • Efavirenz
  • Ebastine
  • Droperidol
  • Doxepin
  • Donepezil
  • Domperidone
  • Dolasetron
  • Dofetilide
  • Disopyramide
  • Desipramine
  • Delamanid
  • Dasatinib
  • Dabrafenib
  • Cyclobenzaprine
  • Crizotinib
  • Clozapine
  • Clomipramine
  • Clarithromycin
  • Citalopram
  • Ciprofloxacin
  • Chlorpromazine
  • Chloroquine
  • Bedaquiline
  • Azithromycin
  • Atazanavir
  • Astemizole
  • Asenapine
  • Arsenic Trioxide
  • Aripiprazole
  • Apomorphine
  • Anagrelide
  • Amitriptyline
  • Amiodarone
  • Alfuzosin

Other interactions that have not been listed herein can also occur. You must inform your doctor of all medications that you are taking to ensure that no drug interactions take place during use.

Other existing medical problems can also impact on the use of this treatment. You should inform your doctor of all medical conditions from which you suffer. This is particularly important in the following cases:

  • Gonadotropin-releasing hormone adenoma

O Use with this condition can worsen problems with the pituitary gland and can in some cases cause sudden blindness to occur.

  • Hormone dependent tumors or other hormone dependent conditions

O The increased release of hormones could cause some of these conditions to worsen and develop.


Before beginning use of this medication, you should consider the risks of use in relation to the benefits of use with your doctor. For this treatment you must ensure that you have considered all of the following factors:

Allergies 'You should inform your doctor of any allergies that you have suffered from in the past. This is particularly important if you have ever reacted badly or unusually to any other medications.

Pediatric ' Gonadorelin has been studied for safe use in children aged 12+. Limitations to use in children over this age has not been demonstrated but the administered dose should be lower. Children below the age of 12 may be more sensitive to the effects of the treatment, however, and infants may be extremely sensitive to it. The use in infants is not recommended.

Pregnancy and breastfeeding 'If you are already pregnant or are breastfeeding then you should discuss use with your doctor before beginning treatment.

When being treated using a Lutrepulse pump you will need to make regular checks with the doctor. The doctor will need to ensure that the pump is working properly and assess the response to the treatment. Changes to dose may be made slowly and check-ups will need to be made after each change.

When using this treatment in order to become pregnant you should follow other advice given to you by your doctor. Your doctor will give you advice on when it is best to have sexual intercourse in order that you may be able to become pregnant. You should also follow advice on when not to have sex to avoid conception of twins or triplets.

You should inform your doctor immediately if you believe that you have become pregnant during use of this treatment.


Gonadorelin will commonly be given in a hospital and will not be stored by the patient. If you are storing this medication at home then you should follow the specific instructions as given by your doctor.

Always keep medications in a secure place out of the reach of both children and pets.

You should consult your doctor or pharmacist for advice on how to safely dispose of this medication.


Gonadorelin is a hormone treatment that is used both in tests and in treatment for infertility.

Gonadorelin is an artificial version of the naturally produced gonadotropin-releasing hormone (GnRH). This hormone stimulates the hypothalamus and the pituitary gland. In doing so the body is normally caused to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

Gonadorelin can be used to test the function of the pituitary gland and hypothalamus in children aged 12 or older. For this test, a single dose is given and blood samples are taken before and after use at regular intervals to test function. The hormones released are used in the development of the body and this function test is used to determine any problems with this developmental system.

In adults, Gonadorelin is used over a longer period of time for the treatment of certain forms of infertility. The medication is administered every 90 minutes for this treatment through the use of a Lutrepulse pump. Patients will need to regularly check in with the doctor to ensure this is working and to have their dose checked. Patients will also be given advice on when to have sexual intercourse. This advice will help you to determine the best time to conceive and when not to have intercourse so that you may avoid conception of twins or triplets.

Gonadorelin can interact with a wide range of medication in the body so it is very important that you make your doctor aware of all other medications that you are taking. You should not use any other medication in conjunction with this treatment unless it has been approved by the doctor.

Gonadorelin should not be used to treat infertility in patients below the age of 18.