Haemophilus B Conjugate and Hepatitis B Vaccine (Intramuscular)


Haemophilus B Conjugate and Hepatitis B Vaccine is a vaccine that exposes your body to the Haemophilus influenza type b (Hib) bacteria and hepatitis B virus. In turn, your body creates its own protection against the diseases in the form of antibodies. It is, therefore, a combination immunizing agent used to prevent future infections.

If you were to get an infection with Haemophilus influenza type b (Hib) bacteria, then this could potentially cause a range of life-threatening illnesses. This includes illnesses such as pneumonia (a lung disease), epiglottitis (a throat disease that causes suffocation), meningitis (a brain disease), septic arthritis (a bone and joint disease), and pericarditis (a heart disease).

If a child were to contract Hib meningitis, then they may either die or be left with serious life-altering damage. This includes problems like partial blindness, deafness, mental retardation, or epilepsy. The HBV infection is one of the major causes of many serious liver diseases. This includes cirrhosis and hepatitis, and a liver cancer known as primary hepatocellular carcinoma.

If a pregnant woman was to carry the hepatitis B virus or have hepatitis B infections, then they can transfer this disease on to their child when they are born. As a result, the newborn child will suffer serious long-term illnesses.

It is recommended that all newborn babies, young children, and infants receive immunization against the hepatitis B disease. Be aware that this vaccine is administered by a trained nurse or doctor in a medical setting. You cannot access it on your own.

Condition(s) treated

  • Haemophilus influenza type b (Hib) bacteria

Type of medicine

  • Suspension

Side Effects

As well as providing protection against diseases, it is possible that the Haemophilus B Conjugate and Hepatitis B Vaccine could cause a number of unwanted side effects. In some cases, these side effects need little cause for concern, but in other cases, they might. Directly below is a list of the more serious side effects that can occur after receiving the Haemophilus B Conjugate and Hepatitis B Vaccine. Inform your nurse or doctor immediately if you or your child experience any of the following.

More common

  • A fever that is more than 103 degrees Fahrenheit

Less common

  • Ear congestion

Incidence not known

  • Convulsions

As well as these more serious side effects, it is entirely possible you or your child will experience less serious ones that require less cause for concern. In fact, you may find that they pass as time passes and your body becomes used to the medicine. Directly below is a list of such side effects. However, if you find that the side effects are lingering or causing necessary distress, then you can still talk to a doctor. They may be able to advise on ways to reduce them.

More common

  • Irritability

Less common

  • Weight loss


  • White patches with diaper rash

Incidence not known

  • Redness of the skin

It is possible that you or your child will experience other side effects that are not listed here. If that is the case, then you can still contact your doctor. They can answer any questions you have and possibly advise on ways to reduce them.


Your child will receive the Haemophilus B Conjugate and Hepatitis B Vaccine from a trained nurse or doctor. It comes via a shot in the top of one of your child's muscles, in most cases the thigh.

It is most commonly given in 3 doses.These occur when they are 2,4, and then 12 to 15 months old. If the schedule will be different, then your child's doctor will advise you on this.

It is important that you meet all scheduled appointments and allow your child to get all doses of this vaccine. If you miss a point for any reason, then you should make another vaccine as soon as possible.


It is possible that the Haemophilus B Conjugate and Hepatitis B Vaccine will interact with other drugs you child might currently have. In many cases, these interactions should be avoided, but in other cases, they may be necessary. If the interaction is necessary, then your doctor may alter the doses of the other medicine so as to limit the interaction as much as possible. You should inform your child's doctor of any and all drugs your child is currently receiving. Here is a list of drugs which are known to interact with the Haemophilus B Conjugate and Hepatitis B Vaccine moderately.

  • Doxorubicin

Here is a list of drugs which are known to cause minor interactions when used alongside the Haemophilus B Conjugate and Hepatitis B Vaccine.

  • Live, trivalent, influenza virus vaccine

As well as interacting with drugs, it is possible that this vaccine will interact with certain parts of your dietary intake. Your doctor may advise you or your child make certain changes to what you eat, drink, or smoke.

Finally, this vaccine could interact with existing medical problems you or your child has. In particular the following:

  • A weak immune system from a medicine or disease (such as those who have HIV infection, are receiving a steroid, or who have chemotherapy for cancer). This vaccine may not work as well in patients with this condition


Before giving your child this vaccine, the doctor or nurse will want to ensure your child is indeed safe to receive it. As a part of this process, they will need to know about any allergies they have. This could be animals, preservatives, foods, or dyes.

As of writing, there have not been appropriate studies conducted on the use of the Comvax® vaccine on children older than 15 months old and younger than 6 weeks. Safety and efficacy have not yet been established for this age range.

The Comvax® vaccine is not recommended for use on geriatric or adult patients.

As of writing, it is unclear as to whether there are suitable studies on the effects this vaccine has on pregnant or breastfeeding women.

It is important that you meet all scheduled appointments for your child's dosages. At these appointments, you can inform the doctor of any unwanted effects your child has experienced following each injection.

If, after receiving this injection your child gets hives, a skin rash, or experiences an allergic reaction, you should inform your doctor immediately.

If your child is allergic to latex rubber, you should inform the doctor. An allergic reaction may occur as the vaccine vials can possibly contain a natural dry latex rubber.

Before having any other medical tests, inform the doctor that your child is currently receiving this vaccine. It may affect the results of some medical tests.

Be aware that this vaccine does not necessarily protect your child from diseases which are caused by hepatitis B or haemophilus influenza type b infection if they are already infected at the time of receiving the injections.


You will not need to worry about the storage of this medicine.


The Haemophilus B Conjugate and Hepatitis B Vaccine is a very important vaccine for your child to receive in order to protect against the dangers of hepatitis B and haemophilus influenza type b infection. Do be aware that your child will need multiple shots given at certain periods of time subsequent to the first one. It is important that you attend all necessary appointments so that your child is fully covered.

It is possible that your child will experience certain side effects after receiving each shot. If this is the case, you can discuss these side effects with your doctor to see if there is a way to reduce them. If they are serious, then you should seek medical assistance immediately. If you have any other questions regarding the Haemophilus B Conjugate and Hepatitis B Vaccine, then you should address these to your child's doctor.