Haemophilus B Conjugate Vaccine (Intramuscular)

Haemophilus B Conjugate Vaccine is an immunizing agent against deadly and transmissible Hib disease ' meant for children of a certain age group.


Haemophilus B Conjugate Vaccine protects patients against Haemophilus influenza type b bacterial infections (Hib).

As with other types of vaccines, small amounts are injected into patients to trigger the development of antibodies against the disease, subsequently boosting protection.

As a conjugate vaccine, it is engineered with the following strains:

Nevertheless, this vaccine does not provide adequate protection against the above strains of bacteria or viruses and should never be used as a substitute for the suggested immunization schedules for children or adults.

Top Reasons to Get Vaccinated with the Haemophilus B Conjugate Vaccine

Healthcare professionals recommend that children get immunized with the Haemophilus B Conjugate Vaccine due to the serious health complications that could arise from being exposed to Haemophilus influenza type b. Some examples include:

Children who acquire Meningococcal Meningitis due to Haemophilus influenza type b, are especially at an increased risk of suffering permanent damage, including:

  • Mental Retardation
  • Hearing Loss
  • Seizures
  • Vision Loss

In severe cases, this could moreover result in death. As a result, it is suggested that parents keep all immunization appointments on schedule to reduce the risks associated with Haemophilus influenza type b exposure.

The Haemophilus B Conjugate Vaccine is administered intramuscularly, and though it works the same way in most patients, the dosing schedule is different for each patient, in terms of age and weight.

In children, the vaccine is generally recommended for patients who are older than two months old and less than six years of age.

Children who have previously received this vaccine may additionally receive a supplementary dose of the Haemophilus B Conjugate Vaccine known as Hiberix®.

Hiberex is generally prescribed for children who are older than 15 months old and younger than 5 years of age.

This vaccine is not indicated for teens and adults, except in high-risk cases. Ask your healthcare provider for more details.

More About Hib Disease

Medical specialists can currently identify at least six different strains of the Haemophilus influenzae bacteria. Type B Haemophilus influenzae is found to be the notorious strain as it accounts for causing at least 95% of all cases of invasive Hib Disease.

When patients receive the Haemophilus B Conjugate Vaccine, they get targeted defense against this debilitating strain.

Readers should also note that this disease is very contagious. It can be acquired in one of two ways:

  • Airborne transfers' through droplets produced when infected patients cough or sneeze.
  • Touch ' Type B Haemophilus influenzae can also be acquired through touch or person to person contact

Not all cases of infection lead to severe reactions, however. In a number of cases, strains of the bacteria remain in the nose or throat until these die off. Sometimes, however, the bacteria enters the lungs or bloodstream and this is how a serious infection develops.

One of the main concerns associated with invasive Hib disease is the risk of developing meningitis. Some of the warning signs of this condition include:

  • A Stiff Neck
  • Loss Of Alertness
  • Fever

If you notice these symptoms in your child, seek medical help right away to decrease the risk of permanent neurological damage.

It is important for parents to note that the Haemophilus B Conjugate Vaccine does not cure invasive Hib disease. It is only intended to be a protective immunizing agent against type B strains of Haemophilus influenzae.

Conditions Treated?

  • Vaccine for Invasive Hib Disease

Type Of Medicine?

  • Vaccine, Immunizing Agent

Side Effects

The most common side effects of the Haemophilus B Conjugate Vaccine are:

  • Running Stools
  • Appetite Loss
  • Throwing Up
  • Feeling Nauseous
  • Pain and Swelling in the Ears
  • Feeling Dizzy or Lightheaded

Rare Side Effects the Haemophilus B Conjugate Vaccine are:

  • Pain in the Chest
  • Fluctuations in Body Temperature
  • Pale or Blue Looking Skin
  • Seizures
  • Muscle Weakness
  • Cold or flu like symptoms
  • Shortness of breath
  • Wheezing
  • An Abnormal Heartbeat
  • Hives and Rashes
  • Swelling in the Facial Area
  • Skin Irritations
  • Enlarged and Tender Lymph Nodes

When to Call a Doctor

Most of the common side effects associated with this vaccine generally subside with time. However, parents should consult a medical provider if the following symptoms occur or persist:

  • A Fever That Runs Higher Than 102 Degrees F (39 Degrees C)
  • Extreme Irritability
  • Less Energy Than Normal
  • Extreme Drowsiness
  • Persistent Piercing Crying for More Than 4 Hours
  • Hives or Difficulty Breathing


The Haemophilus B Conjugate Vaccine is only available with a written order from a medical provider. It is exclusively administered in pediatric groups and the dosing is generally provided by a trained nurse.

The vaccine is injected into the muscle. Medical providers generally gauge the dosing schedule based on the following criteria:

1. The age of the child at the first dosing of the Haemophilus B Conjugate Vaccine
2. The brand of Haemophilus B Conjugate Vaccine being used

The most common brands of the Haemophilus B Conjugate vaccine include:

  • ActHIB
  • Pedvaxhib
  • Hibtiter

On average, the following timetable is usually adhered to:

1st Series: Infants 2-6 months old
2nd Series: 2 Months Later
3rd Series: 2 Months Later

Booster Dose: 15-18 months old

Note: Parents should also note that other immunizations may be grouped together with the Haemophilus B Conjugate vaccine. If this is the case, then other shots are administered in other areas of the body.

Notes for Healthcare Providers

  • Preparation for Anaphylactoid Reaction ' Proper treatment provisions should be in effect in the event of an allergic reaction to the vaccine. This includes but isn't limited to keeping epinephrine handy.
  • Do Not Inject into Blood Vessels ' Read the instruction labels carefully before administering this medication. As a precaution, this vaccine should only be injected into a muscle.
  • Best Practices for Injections 'Use a new syringe and gloves each time and dispose of any used needles or gloves in a biohazard container, in order to reduce the risk of transferring transmissible diseases.

Missed Doses

If you miss a vaccination dose, contact your healthcare provider as soon as possible to catch up on the immunization schedule.


The following negative interactions have been found in patients receiving the Haemophilus B Conjugate Vaccine:

Contraindications with Pre-Existing Conditions

Contraindications with the Haemophilus B Conjugate Vaccine have been noted for patients with the following preexisting conditions:

  • Autoimmune Disorders ' Administering this vaccine may be counterproductive for patients with a weakened immune system.
  • Guillain-Barré syndrome ' Extra caution should be taken when prescribing this vaccine in patients with this underlying condition, as adverse interactions have been known to occur.


Find out the main precautions associated with the Haemophilus B Conjugate vaccine below:

Past Allergic Reactions

Tell your child's doctor if he or she has a history of allergies to medicines as well as dyes, foods, preservatives, or animal products. In particular, notify your child's physician of any sensitivities to latex. Both latex gloves and syringes containing dry natural latex are typically used when administering vaccinations. In the event of past allergies to latex, a substitute may be used.

New Adverse Reactions

If your child develops an adverse reaction after receiving a vaccination, consult your healthcare provider for advice on how to proceed. In many cases after receiving a vaccine, children may experience pain and swelling at the site of the injection, and this generally goes away after a few days. Your medical provider will instruct you on tips for care, including applying a cold compress to the site and what over-the-counter pain medicines are safe to use in infants and preschoolers.

Information for Parents

Additionally, a detailed medication guide is usually provided to parents to read through before and after children receive any type of vaccine, including Haemophilus B Conjugate. Read this in full before consenting with the treatment.

Upcoming Medical Tests

If your child has an upcoming medical test scheduled, be sure to tell your healthcare provider of any recent Haemophilus B Conjugate Vaccine received. This immunization could influence the results of medical tests, and subsequently provide false readings.

Children Younger than 2 Months Old

The Haemophilus B Conjugate Vaccine is not indicated for infants younger than 8 weeks of age due to the lower intolerance to bacterial exposure.

Children Older than 6 Years of Age

This vaccine is also not recommended for children older than 6 years of age. The line of reasoning is that this subset of patients are not at an imminent susceptibility to exposure to the Type B Haemophilus influenzae.

High Risk Groups

High risk patients receiving this vaccine should consult a doctor before entering areas where the risk of transfer is imminent. Certain brands of this medication will not provide immediate protection and it may take a few days for antibodies to develop.


The Haemophilus B Conjugate vaccine is supplied in vials.

Store in the original vials in a refrigerator at temperatures ranging from at 2-8 C (36-46 F). However, to preserve the integrity of the medicine, do not freeze.


The Haemophilus B Conjugate vaccine lowers the risk of invasive Hib disease in children younger than 6 years old. Studies confirm that this disease could lead to serious and possibly fatal conditions, including meningitis and pneumonia for example. In some cases, these conditions could result in death.

To put the risks associated with Hib disease into context, roughly 20-30% of all patients who survive meningitis generally walk away with permanent damage, including but not limited to hearing and vision loss, mental retardation, and other severe adverse effects. If is for these reasons healthcare specialists urge parents to keep all immunization schedules on time.

As with other types of immunizations, the Haemophilus B Conjugate vaccine could cause adverse reactions in patients receiving this treatment, including a severe allergic reaction, a fever, and more. However, healthcare specialists generally agree the benefits outweigh the risks. In addition, a number of assessments are completed before prescribing this vaccine to children. For example, your doctor will check for risk factors including past allergies to any medications, particularly vaccines or latex products; as well as the presence of Guillain-Barré syndrome or an autoimmune disorder. Negative interactions have been shown to occur in these cases.

The general goal for prescribing this vaccine is to improve protection against dangerous and potentially fatal diseases in infants over two months old and children up to 6 years of age. The vaccine is not indicated for teens or adults. Consult your healthcare provider for questions or concerns about getting protection against HIB disease and other transmissible bacteria or viruses.