Histamine (Intradermal)


Histamine is used for a test to determine the quantity of acid that your stomach is producing. In turn, Histamine is able to help diagnose any problems or diseases that are in your stomach.

The basic procedure of carrying out this test is as follows. Before the medicine is injected, the contents of your stomach are first emptied via a tube. The appropriate amount of Histamine is then injected under your skin. After 5 minutes have passed, your stomach contents will then be emptied again, and the acidity levels of the contents are tested. This process may need to be repeated several times. In order to prevent against unwanted side effects, you may find that you are injected with an antihistamine prior to the histamine injection.

Be aware that you can only obtain this drug following a prescription and it is administered by a trained doctor in a hospital setting. The whole process can be very effective but is only suitable for certain patients. It is possible that Histamine could interact with other drugs or other pre-existing medical conditions.

Condition(s) treated

  • Diagnosis of disease or problems in the stomach

Type of medicine

  • Injectable

Side Effects

As well as having the intended effects, it is possible that Histamine will cause a range of other side effects to occur. These side effects can range in their severity, and many patients may simply experience no side effects at all. Directly below is a list of the more severe side effects that can occur after you are injected with Histamine. If you experience any of them at all, you should contact your doctor immediately.

More common

Less common or rare

  • Difficulty breathing

As well as these more serious side effects, you could potentially experience any of the less worrying ones listed below. These side effects are less of a cause for immediate concern. In fact, you may find that they pass over time as your body gradually adjusts to the medicine. However, if you do experience any of the following after being injected with Histamine, and find them lingering or bothersome, then you can still contact your doctor. They may be able to advise you on certain ways to reduce the effects and can answer any other questions or concerns you have.

More common

Aside from the side effects listed here, it is possible that you can experience others. If this is the case and Histamine has caused you to experience some other unwanted side effects, you can discuss them with your doctor. They may be able to offer you guidance on how to proceed.


You will not need to worry about the dosages of this medicine. It will be calculated by a trained doctor and then administered in a hospital setting prior to the testing procedure taking place.

It is given via a needle which is placed under your skin. If you have any questions about the dosage or would like to discuss the procedure further, you can do so best with your doctor.


It is possible that Histamine will interact with other drugs you are currently taking. In many cases these interactions are unwanted and your doctor will do their best to avoid them, such as by altering one or both of the medicines. In other cases, an interaction may be necessary as taking both drugs is the best course of treatment for you. If this is the case then your doctor may need to alter the doses you receive of one or both of the medicines. Either way, it is for your doctor to decide the most appropriate course of action. You should, therefore, advise them of any drugs you are currently taking, this includes both prescription and non-prescription drugs. Directly below are some of the drugs which are known to interact moderately with Histamine.

  • Trimipramine

As well as interacting with drugs, it is possible that Histamine will interact with certain parts of your dietary intake. This includes what you eat, drink, and smoke. In order to limit any unwanted interactions after your test has taken place, your doctor may advise you to make certain alterations to what you consume on a daily basis. For example, they may require you to smoke less tobacco or drink less alcohol.

Finally, it is possible that Histamine will interact with other medical problems that you are currently suffering from. You should inform your doctor of your complete medical history so that they can ensure minimal risk of an interaction occurring in this form. Below is a list of medical problems which are known to interact more severely with Histamine.

  • Lung disease (particularly asthma). Histamine may make this condition worse


Before deciding to go forward with this test and use Histamine, your doctor will need to ensure you are a suitable patient for receiving it. They will thoroughly examine all areas of your medical condition. As a part of this, they will need to be made aware of any allergies you have to dyes, preservatives, animals, or food.

As of writing, there is no information available regarding the use of Histamine across different age groups. Therefore, it is not apparent as to whether it has a notably different effect on pediatric patients compared to adults. Instead, your doctor will be able to advise whether this is a suitable and safe drug for your child to receive.

Similarly, there is no such evidence for examining the use of this drug in geriatric patients compared to young adults. Your doctor is best placed to advise on any increased risks or the chance of experiencing unwanted side effects. It is worth noting however that many medicines have not yet been fully tested across all age ranges.

As of writing, there appear to be no adequate studies into how the use of Histamine effects women who are breastfeeding. Your doctor is best placed to inform you of any potential risks. Together, you can then weigh any risks up with the benefits of using the drug.

During your test, it is important that you do not swallow any saliva. Doing so may affect the final results of the test.

Your doctor will explain to you the full process of carrying out the test. If you have any concerns or apprehension, then you should address these to your doctor before beginning the test.


You will not need to worry about the storage of this drug. It is administered in a medical setting by a trained doctor or nurse. It is their responsibility to deal with its safe storage and transportation.


If you are currently suffering from a stomach problem or disease, then Histamine may be a necessary drug used as a part of the test in determining the acidity levels of your stomach. You can find details regarding the process of this test above. It may sound like a worrying procedure, but is rather straightforward and you can discuss any concerns you have with your doctor. Due to the nature of the test itself, you can only access the intradermal form of Histamine following a doctor's prescription. You will not need to worry about the storage or dosage of his medicine, as it is all handled by the doctor.

However, you should be honest and forthright when answering any questions your doctor may have. It is possible that this medicine will interact with other drugs you are taking, and possibly with other medical conditions you may have. By being honest with your answers, your doctor can decide whether this is indeed the best course of treatment for your condition. If you experience any worrying side effects following the test, you should address these to the doctor present. Finally, if you have any other questions about the use of this drug or the test itself, you should address these to your medical professional.