Hyaluronidase (Injection, Subcutaneous)

Hyaluronidase is used when other medications cannot be injected into the veins of the patient. It is used with other medications for subcutaneous injection to help the spread of the medication into the body.


Hyaluronidase is a spreading agent that is used to increase the uptake of medication into the body. It is used where the other medication cannot be injected into the veins of the patient for some reason. Both medications are then injected under the skin and the Hyaluronidase helps the medication to be absorbed into the body. This type of delivery is only used when the required drug cannot be delivered into the body through the vein.

Hyaluronidase is also used to help in the absorption of fluids and radioactive materials that have been subcutaneously injected. This may be required during subcutaneous urography, for example.

Hyaluronidase is a naturally occurring substance in the body that is also found in pigs and cows. The substance is harvested from these animals for treatment before being cleaned of any animal residue. Hyaluronidase can also be grown in a laboratory from human cells.

Hyaluronidase should only ever be administered under the direct supervision of a doctor. It is prescribed as a powder for solution or as a solution. Both are injected subcutaneously and are available in the following brands:

  • Vitrase
  • Hylenex
  • Hydase
  • Amphadase

Condition treated

  • None

Type Of Medicine

  • Spreading substance

Side Effects

In addition to helping with the spread of medication through the body, Hyaluronidase can also cause the occurrence of unwanted side effects. Other side effects may also occur from the use of the medication that is being aided by this treatment. These side effects will not be listed herein. Of the side effects from Hyaluronidase not all will occur, but in certain cases they will require that the patient seek immediate medical attention.

You should consult your doctor immediately if you experience any of the following side effects from the use of Hyaluronidase:

  • Coughing
  • Difficulty with swallowing
  • Dizziness
  • Hives
  • Increased heartbeat
  • Itching
  • Puffy or swollen around the eyes, lips, face or tongue
  • Reddening of the skin
  • Skin rash
  • Swelling with a hive-like appearance that occurs on the:
  • Tongue
  •  Throat
  •  Sex organs
  •  Lips
  •  Legs
  •  Hands
  •  Feet
  •  Face
  •  Eyelids
  • Tightness across the chest
  • Unusual tiredness
  • Unusual weakness
  • Welts

It is also possible to suffer an overdose from the use of Hyaluronidase and use of this treatment can cause an overdose of other treatments to occur. If you believe that you or anyone else is suffering from an overdose then you should seek emergency medical help straight away. The symptoms of an overdose include the following:

  • Blurring of vision
  • Chills when warm
  • Confusion or disorientation
  • Dizziness or faintness
  • Fast or pounding heartbeat
  • Irregularity of heartbeat or pulse
  • Lightheadedness when rising from sitting or lying
  • Nausea
  • Reddening of the skin
  • Sweating when cool
  • Swelling
  • Unusual tiredness
  • Unusual warmth of skin
  • Unusual weakness
  • Vomiting

Hyaluronidase can also cause some side effects to occur that are mild and not indicative of other medical problems developing. These side effects will usually abate over time but if they develop and become bothersome or are continuing then you should inform your healthcare professional and seek advice on alleviating them. These side effects can occur at the site of injection and include:

  • Warmth
  • Ulceration
  • Tingling
  • Tenderness
  • Swelling
  • Stinging
  • Soreness
  • Scarring
  • Redness
  • Rash
  • Pain
  • Numbness
  • Lumpiness
  • Itching
  • Inflammation
  • Infection
  • Hives
  • Feeling of pressure being applied
  • Discoloration or change in skin color
  • Coldness
  • Burning
  • Blistering
  • Bleeding

Other side effects from the use of Hyaluronidase could also occur that have not been listed herein. If you experience any other side effects then you should contact your doctor for advice on how to react in each case. If you believe that your immediate health is at risk, however, then you should contact the emergency services.


This medication will be administered by a nurse or doctor and should be given in a hospital or clinic only. You will be injected with a shot under the skin in the same location as you are injected with other medications.

You will need to undertake a skin test before you are given this treatment. This will ensure that you do not have an allergy to the substance before it is injected under your skin.

The dose of this medication that is used will differ for each patient and will depend on the other medications being given, your medical condition and other personal factors. The dose will be determined by the prescribing doctor in each case and no specific dosing information can be given herein.


Certain medications should never be used in conjunction with one another. In some cases, they may interact with each other in the body with serious consequences. In other cases, they may prevent one another from working or may increase the side effects that may be experienced through use. While Hyaluronidase is intended for use with other medications, it should not be used with certain treatment. Before you receive treatment with Hyaluronidase it is vital that your doctor is aware of all other medications that you are taking. This includes prescribed medications, over the counter treatments, herbal remedies and any dietary supplements that you take.

The use of Hyaluronidase is not usually recommended for use with the following treatments. Both may be administered but your doctor may need to adjust the dose of medications or change the timings or frequency of use:

  • Tetracaine
  • Ropivacaine
  • Propoxycaine
  • Proparacaine
  • Procaine
  • Prilocaine
  • Mepivacaine
  • Lidocaine
  • Etidocaine
  • Dibucaine
  • Cocaine
  • Chloroprocaine
  • Butacaine
  • Bupivacaine Liposome
  • Bupivacaine
  • Benzocaine

Hyaluronidase may interact with other medications that have not be listed. Ensure that your doctor is aware of all substances that you are taking.

Other medical problems can also impact the use of Hyaluronidase. This is because certain medications may other medical conditions worse or the side effects from use may be increased. You must inform your doctor of all other medical conditions from which you suffer. This is especially important in the following cases

  • Infection at the site of injection

O When used with this condition the chance of side effects occurring will be greatly increased.

Other medical conditions that have not been listed can also cause problems for the use of Hyaluronidase. Ensure your doctor is aware of all conditions from which you suffer.


Before beginning use of any medication you must weigh the benefits of use against the potential risks. You should do so with your doctor and for Hyaluronidase use you should ensure that the following has been considered:

Allergies ' You must inform your doctor of all allergies from which you suffer. This includes any allergies to foods, dyes, animals, preservative and other substances. You should be especially clear if you have ever reacted badly to any animal derived medications in the past. You may be required to do a skin test before use.

Pediatric ' The safe and effective use of this treatment in children has not been established. You should discuss this with your doctor.

Geriatric' There are no known limitations to the use of Hyaluronidase in elderly patients. Caustion should always be used where other medical conditions are present in the patient however. Such age-related conditions as conditions of the kidney and liver may prohibit use with certain other medications.

Pregnancy' You must inform your doctor if you are pregnant before you receive treatment. There is a category C risk for use in pregnant women, meaning that it should only be used where the benefit of doing so clearly outweighs the risks. There may also be risks that occur from the other medication that is being administered. Discuss pregnancy with your doctor.

Breastfeeding ' The risks of breastfeeding during use are unknown. There may also be risks to breastfeeding with the other medication administered. You should discuss breastfeeding with your doctor.

You will be monitored during and after treatment with Hyaluronidase. This allows the doctor to see that it is working properly and to determine whether you should continue using the medication.

This medication may be made from animals or from donated human blood. There is a possibility that human blood may carry viruses and in the past, these have been transmitted to people who have received the samples. The risk is very low and the blood is tested for viruses, but there is a minor risk of infections being transmitted through treatment. You should discuss this with your doctor if you are concerned about this risk.

Some patients may be seriously allergic to this treatment. You should inform your doctor if you notice any symptoms of allergy at all following treatment. This is particularly important if you begin to have trouble with breathing.

You should not take any other medications in conjunction with this treatment unless they have been previously approved by the doctor. Doing so can expose you to serious risks of side effects that could occur.


Hyaluronidase must be stored in the refrigerator but should not ever be frozen.

Always keep this medication out of the reach of children.

Dispose of outdated medication properly and safely.


Hyaluronidase is a spreading substance that does not directly treat any condition. It is used to promote the absorption of other medications into the body when they are injected under the skin. This medication is used when medications cannot be put directly into the veins and should not be used as a preference for delivery.

Hyaluronidase is derived from human blood samples or from cows or pigs. The medication is a naturally occurring substance and it is injected beneath the skin in the same location as the medication that is being used for the treatment of a condition.

Certain side effects that could occur from use may require that you seek medical attention immediately. Patients should be alert to the symptoms of overdose with use too as an overdose of Hyaluronidase or overdose of the medication being used in conjunction could possibly occur.

Patients should not use any other medications in conjunction with Hyaluronidase unless they have been directed to by their doctor. Doing so could put the patient at serious risk.