Hydrocodone and Chlorpheniramine (Oral)


Adults who suffer from incessant coughing, as well as nasal congestion, have found relief when taking the combination of hydrocodone and chlorpheniramine. This prescription-strength drug combines a narcotic antitussive/cough suppressant (hydrocodone) with an antihistamine (chlorpheniramine) to deal with both the coughing and the nasal congestion that often occurs with common colds and allergies.

Patients should be aware that this drug can be habit-forming especially when used for extended periods of time. The dependence can be both mental or physical in nature and physical dependency can cause serious withdrawal effects if the medication is stopped abruptly. If you have a past history of drug addiction, it may not be in your best interest to take this medication. Make sure that your doctor is aware of your past medical history in a thorough manner. If you feel like you are developing a dependence on this medication, be sure to notify your doctor right away. Always take this medicine as directed by your physician and do not stop taking it without first consulting with them.

It is possible to overdose on this drug combination and it is important that patients familiarize themselves with the signs and symptoms of overdose. If you should experience any overdose symptoms seek emergency medical care right away. Do not throw any unused or expired medication in the garbage or anywhere that children or pets could access it. Consult with your pharmacist on the appropriate methods for safe disposal of hydrocodone and chlorpheniramine.

This medication is not intended for long-term use due to the possibility of forming a dependence, and if your symptoms are not responding to the medication it is important that you notify your doctor to discuss alternative options for treatment. Do not take additional medication if you do not feel that it is working in an expected manner, speak to your doctor before making any changes to how you take hydrocodone and chlorpheniramine.

Your symptoms may begin to improve after a few doses of hydrocodone and chlorpheniramine but it is important that the entire course of treatment is taken in order to ensure that the symptoms do not return or worsen. If you do not take the entire course of treatment it is more likely that the symptoms may return and that they may not respond as well to hydrocodone and chlorpheniramine.

The combination of hydrocodone and chlorpheniramine comes in the following delivery methods:

  • Solution
  • Liquid

Conditions Treated

  • Coughing
  • Nasal congestions
  • Allergy symptoms

Type Of Medicine

  • Chlorpheniramine
  • Hydrocodone

Side Effects

The combination of hydrocodone and chlorpheniramine can cause some unwanted side effects, some of which will require additional medical attention and others that will likely dissipate on their own. Be sure to notify your doctor of all medications that you are currently taking and how you take them. There are certain medications and medical conditions that can exacerbate any side effects that you may experience. Notify your doctor if you have any reactions that linger for longer than a few days, become worse over time, or that cause you concern. Do not make any changes to how you are taking hydrocodone and chlorpheniramine without first discussing them with your doctor.

If you experience any of the following symptoms while you are taking hydrocodone and chlorpheniramine it is necessary to seek further medical attention as they may be a sign of a more serious problem:

Unknown likelihood:

  • Abdominal or stomach cramps
  • Difficulty breathing
  • Constipation
  • Spasm of the throat
  • Difficult urination
  • Chest tightness
  • Decrease in the frequency or amount of urination
  • Vomiting
  • Bloating
  • Pain in the stomach or abdominal area

Symptoms of overdose that require immediate emergency medical attention:

  • Blurred vision
  • Chest pain or discomfort
  • Cold and clammy skin
  • Confusion
  • Extreme sleepiness or unexplained drowsiness
  • Irregular, fast or slow, or shallow breathing
  • No muscle tone or movement
  • Pale or blue lips, fingernails, or skin
  • Slow or irregular heartbeat
  • Sweating
  • Unexplained tiredness or weakness

It is important that patients and their caregivers familiarize themselves with these overdose symptoms listed above because immediate medical care must be sought should they occur.

The combination of hydrocodone and chlorpheniramine can cause a number of unwanted side effects that occur while your system is adjusting to this drug. The following symptoms will typically go away on their own without any further attention. However, if they do linger for more than a few days or become worse, it is advisable to notify your doctor for further medical advice:

More likely:

  • Nausea
  • Dizziness
  • Headaches
  • Dry mouth
  • Irregular heartbeats
  • Drowsiness
  • Sleepiness or unusual drowsiness
  • Anxiety or irritability

Unknown likelihood:

  • Acid or sour stomach
  • Hives or welts
  • Fast heartbeat
  • Itching skin or rash
  • Chills or fever
  • Stomach discomfort or upset
  • Flushing or redness of the skin

There is also the chance that you may experience certain side effects that are not listed here. If they become worrisome it is always best practice to seek further medical advice from your doctor or pharmacist.


As the combination of hydrocodone and chlorpheniramine is a medication that can cause dependency as well as overdose, it is important to follow the prescription directions provided by your doctor. Be careful to take the drug as directed and not take more of it or take it for longer than it is prescribed. Hydrocodone and chlorpheniramine can also cause withdrawal symptoms so it is important to continue taking it until your doctor is consulted about stopping the medication. Do not take more of this medication than is prescribed, nor should you take it for a longer period of time than what is directed by your doctor. This drug can be habit-forming if taken for longer than 14 days and can also cause an overdose if taken above the prescribed amount.

This medicine is taken in liquid form and the dosage must be measured correctly with a proper measurement tool; do not use common household utensils to measure your medicine. An oral syringe, medicine cup or clearly marked measuring spoon are advised.

Inform the prescribing physician if you have any type of negative reaction when taking hydrocodone and chlorpheniramine as you may be allergic to it. Prior to beginning your course of treatment inform them of all allergies that you have, including allergic reactions to food, animals, substances such as cleaning materials, and other medications.

Children are advised to only use this medication under the close supervision of their doctor or pediatrician. The doses will vary on a case by case basis based on the size of the child and the severity of the condition.

If you are taking hydrocodone and chlorpheniramine for common allergy symptoms such as coughing, nasal congestion, a runny nose, or sneezing, take five milliliters every four-six hours as necessary. Do not exceed four doses in a 24-hour period.

It is important that patients do not take a double dose in the event that they miss a scheduled dose. If you have missed a dose and it is close to your next scheduled dose it is advised that the missed dose be skipped entirely. If you miss a dose and are unsure what to do, contact your pharmacist for further advice.

If you don't feel that the medication is working as expected, contact your doctor to discuss your concerns prior to making any changes to how you are taking the medication.

Major Drug Interactions

There are certain drugs that should not be taken by patients who are taking hydrocodone and chlorpheniramine. If you are taking safinamide or naltrexone your doctor will likely prescribe an alternative medication to you. There are other drugs that have been known to increase the likelihood of unwanted side effects when taken with hydrocodone and chlorpheniramine. Patients who are currently taking one of those medications may have their doctor adjust the dosage and frequency with which they take one or both of the medications. If you have any questions regarding the contraindications of any medications that you are currently taking, be sure to discuss these concerns and questions thoroughly with your doctor prior to starting your course of treatment with hydrocodone and chlorpheniramine.

If you are taking one of these two drugs your doctor may opt to prescribe an alternative to hydrocodone and chlorpheniramine. Be sure to notify your doctor if you are taking one of these drugs prior to starting your course of treatment:

  • Safinamide
  • Naltrexone

If you are taking one of the following medications your doctor may alter the way that you take one or both of them. Notify your doctor if you are taking hydrocodone and chlorpheniramine concurrently with any of the following and begin to experience any significant side effects:

  • Acetophenazine
  • Zopiclone
  • Almotriptan
  • Ziprasidone
  • Amitriptyline
  • Vortioxetine
  • Amoxapine
  • Vilazodone
  • Aprepitant
  • Trimeprazine
  • Asenapine
  • Trifluperidol
  • Baclofen
  • Triazolam
  • Bosentan
  • Tranylcypromine
  • Bromopride
  • Topiramate
  • Tizanidine
  • Bupropion
  • Tilidine
  • Butabarbital
  • Thioridazine
  • Butorphanol
  • Thiopropazate
  • Carbinoxamine
  • Thiethylperazine
  • Carisoprodol
  • Telithromycin
  • Chloral Hydrate
  • Tapentadol
  • Chlorpromazine
  • Sulpiride
  • Clarithromycin
  • St John's Wort
  • Clonazepam
  • Sertindole
  • Clozapine
  • Secobarbital
  • Conivaptan
  • Ritonavir
  • Dantrolene
  • Rifampin
  • Desvenlafaxine
  • Remifentanil
  • Dezocine
  • Ramelteon
  • Diazepam
  • Quazepam
  • Difenoxin
  • Propiomazine
  • Diltiazem
  • Promazine
  • Diphenoxylate
  • Procarbazine
  • Dolasetron
  • Prazepam
  • Doxylamine
  • Piritramide
  • Droperidol
  • Pimozide
  • Phenytoin
  • Erythromycin
  • Phenelzine
  • Eszopiclone
  • Periciazine
  • Ethopropazine
  • Perampanel
  • Fentanyl
  • Pentazocine
  • Fluconazole
  • Paregoric
  • Fluoxetine
  • Palonosetron
  • Flurazepam
  • Oxymorphone
  • Fosaprepitant
  • Oxazepam
  • Fospropofol
  • Opium Alkaloids
  • Granisetron
  • Ombitasvir
  • Haloperidol
  • Nitrazepam
  • Hexobarbital
  • Nelfinavir
  • Hydroxytryptophan
  • Nalbuphine
  • Idelalisib
  • Melperone
  • Morphine
  • Imatinib
  • Molindone
  • Medazepam
  • Iproniazid
  • Moclobemide
  • Isoflurane
  • Midazolam
  • Ketamine
  • Methylene Blue
  • Ketobemidone
  • Methohexital
  • Levomilnacipran
  • Methdilazine
  • Linezolid
  • Metaxalone
  • Lorazepam
  • Meperidine
  • Meptazinol
  • Lormetazepam
  • Mephobarbital
  • Lurasidone
  • Mephenesin
  • Meclizine
  • Meprobamate
  • Loxapine
  • Mesoridazine
  • Lorcaserin
  • Methadone
  • Lopinavir
  • Methocarbamol
  • Levorphanol
  • Methotrimeprazine
  • Ketoconazole
  • Metopimazine
  • Ketazolam
  • Mirtazapine
  • Itraconazole
  • Modafinil
  • Isocarboxazid
  • Moricizine
  • Indinavir
  • Morphine Sulfate Liposome
  • Iloperidone
  • Nefazodone
  • Hydroxyzine
  • Nicomorphine
  • Hydromorphone
  • Olanzapine
  • Halothane
  • Opium
  • Halazepam
  • Orphenadrine
  • Furazolidone
  • Oxycodone
  • Fosphenytoin
  • Paliperidone
  • Fluspirilene
  • Papaveretum
  • Fluphenazine
  • Paritaprevir
  • Flunitrazepam
  • Pentobarbital
  • Flibanserin
  • Perazine
  • Ethylmorphine
  • Perphenazine
  • Ethchlorvynol
  • Phenobarbital
  • Estazolam
  • Pimavanserin
  • Enflurane
  • Pipotiazine
  • Efavirenz
  • Posaconazole
  • Dronedarone
  • Primidone
  • Donepezil
  • Prochlorperazine
  • Dixyrazine
  • Promethazine
  • Diphenhydramine
  • Propofol
  • Dihydrocodeine
  • Quetiapine
  • Dichloralphenazone
  • Rasagiline
  • Diacetylmorphine
  • Remoxipride
  • Dexmedetomidine
  • Risperidone
  • Dasabuvir
  • Saquinavir
  • Cyclobenzaprine
  • Selegiline
  • Codeine
  • Sodium Oxybate
  • Clorazepate
  • Sufentanil
  • Clobazam
  • Suvorexant
  • Chlorzoxazone
  • Telaprevir
  • Chlordiazepoxide
  • Temazepam
  • Ceritinib
  • Thiopental
  • Cariprazine
  • Thioproperazine
  • Carbamazepine
  • Thiothixene
  • Butalbital
  • Tiotropium
  • Buspirone
  • Tolonium Chloride
  • Buprenorphine
  • Tramadol
  • Brotizolam
  • Trazodone
  • Bromazepam
  • Trifluoperazine
  • Boceprevir
  • Triflupromazine
  • Atazanavir
  • Verapamil
  • Aripiprazole
  • Voriconazole
  • Anileridine
  • Zaleplon
  • Amobarbital
  • Zolpidem
  • Alprazolam
  • Zotepine
  • Alfentanil

If you are currently taking the following medications you may be more susceptible to unwanted side effects from taking them concurrently with hydrocodone and chlorpheniramine. Your doctor may make alterations to how you take one or both of the medicines.

  • Escitalopram

Be sure to notify your healthcare team of all medications that you are taking prior to beginning your hydrocodone and chlorpheniramine course of treatment. Be sure to include both prescription and non-prescription medications as well as herbal remedies, and vitamin and mineral supplements.

Avoid the following substances while you are taking hydrocodone and chlorpheniramine as they may cause significant side effects:

  • Grapefruit Juice
  • Ethanol

Patients who are suffering from any of the following conditions may experience complications when taking hydrocodone and chlorpheniramine. Notify your doctor if your condition worsens or you have any serious side effects while taking the medication:


Patients who have taken an MAO inhibitor, also known as an MAOI, within 14 days should not take hydrocodone and chlorpheniramine. Consult with your doctor for alternative solutions if you are taking or have recently taken:

  • Parnate
  • Nardil
  • Marplan
  • Eldepryl

Due to the possibility of hydrocodone and chlorpheniramine becoming habit forming it is important that you take it exactly as directed by your physician. If you are taking the medication and do not think that it is working, do not take more, contact your doctor for further medical advice.

Hydrocodone and chlorpheniramine can cause you to feel drowsy or even lightheaded. It is important to understand how this medication will affect you prior to driving, operating machinery, or partaking in any activity that requires full alertness.

It is important to avoid any Central Nervous System (CNS) depressants such as alcohol and cold medications as the use of hydrocodone and chlorpheniramine can exacerbate the effects. This also includes:

  • Muscle relaxants
  • Seizure medication
  • Pain medications containing narcotics
  • Sleeping aid medications

It may be necessary to use laxatives or take other measures while taking hydrocodone and chlorpheniramine as this medication can cause serious constipation. If you do experience this condition it is advised that you increase the level of fluids that you take each day and add more fiber to your diet. If these steps do not help to relieve the problem, your doctor may recommend the use of laxatives.

It is important to review your complete medical history as well as all of the drugs and medications that you are taking with your doctor prior to beginning your hydrocodone and chlorpheniramine course of treatment.


It is always recommended that patients keep all medications in their original packaging. Hydrocodone and chlorpheniramine should be kept away from moisture, extreme heat and cold, and should not be allowed to freeze.

Because of the potential for an overdose of this medication, it is important that it be kept out of the reach of both children and pets and that it is disposed of properly.

If you have unused, excess, or expired medication at the time that you complete your course of treatment, consult with your pharmacist about the appropriate method of disposal.


Patients who suffer from coughing and nasal congestion that does not respond to other medications may find relief by taking hydrocodone and chlorpheniramine a combination that relieves both coughs and nasal congestion caused by the common cold or upper respiratory allergies. This drug can become habit-forming if taken for a prolonged period of time, and withdrawal symptoms are possible when it is no longer taken. Patients are advised to take this medication as directed and do not stop taking it without first consulting with their doctor.

It is possible to overdose on hydrocodone and chlorpheniramine and patients should familiarize themselves with the signs and symptoms of overdose and seek immediate emergency medical care should they occur. Advise your doctor of the medications that you are currently taking prior to beginning your hydrocodone and chlorpheniramine course of treatment.