Hydrocodone and Pseudoephedrine (Oral)


Adults who suffer from temporary symptoms associated with the common cold often find relief by taking the combination of hydrocodone and pseudoephedrine which is available via prescription. These two medications treat both coughing as well as nasal congestion in order to provide total relief. Because hydrocodone is a narcotic it can become habit-forming when used for an extended length of time.

Hydrocodone directly affects the cough-center of the brain in order to successfully suppress coughing, thereby providing much-needed relief to the patient. Pseudoephedrine acts as a decongestant and reduces blood flow into the nasal passages by constricting the blood vessels in that area of the body.

Patients that need to use this drug combination for a lengthy period of time may develop a dependence on the narcotics contained in the hydrocodone. The dependence can be both physical and mental in nature, and if the patient stops taking this drug abruptly they may experience symptoms of withdrawal. These symptoms can be avoided by slowly weaning yourself off of the drug under your doctor's supervision. Do not stop taking this medication or change the way that you take it without first consulting with your doctor.

Because this drug has been reported to cause overdoses in some cases, it is important that patients and their caregivers familiarize themselves with the signs and symptoms of overdose and call 911 or go to the nearest emergency room should they occur. This medication is not considered appropriate for use in children, nor is it recommended for use by pregnant women.

The delivery methods in which this drug combination are available are:

  • Syrup
  • Tablet
  • Liquid
  • Solution

Conditions Treated

  • Asal congestion
  • Oughing

Type Of Medicine

  • Hydrocodone
  • Pseudoephedrine

Side Effects

Like many medications, the use of hydrocodone and pseudoephedrine can cause unwanted side effects. If you are taking this medication it is advised that you familiarize yourself with the different types of possible side effects as the occurrence of a number of them does require further medical attention. In some cases, the patient will experience symptoms as the medication enters their system and the body adjusts to its presence. If you experience any symptoms that become worse or do not go away after a few days medical advice should be sought.

If any of the following side effects and symptoms occur it is advisable that you check with your doctor right away as further medical attention may be necessary as these may be a sign of a more serious problem:

More likely:

  • Blurred vision
  • Confusion
  • Dizziness
  • Dizziness, faintness, or lightheadedness
  • Fainting
  • Fast, slow, or irregular heartbeat
  • Sweating
  • Unexplained tiredness or weakness

Unknown likelihood of occurrence:

  • Frequent urge to urinate
  • Trouble with sleeping
  • Bulging soft spot on the head of an infant
  • Sleeplessness
  • Convulsions
  • Shakiness in the legs, arms, hands, or feet
  • Decrease in urine volume
  • Pale or blue lips, fingernails, or skin
  • Difficult or painful urination
  • Loss of appetite
  • Difficulty having a bowel movement
  • Headaches
  • Drowsiness
  • Abdominal or stomach cramps or pain
  • Irregular, fast or slow, or shallow breathing
  • Difficulty in passing urine
  • Nervousness
  • Difficult or troubled breathing
  • Pounding in the ears
  • Diarrhea
  • Shortness of breath
  • Decrease in the frequency of urination
  • Trembling or shaking of the hands or feet
  • Change in the ability to see colors, especially blue or yellow
  • Unable to sleep
  • Bloating
  • Vomiting

While your body is adjusting to the presence of hydrocodone and pseudoephedrine you may experience some of the side effects listed below. These symptoms do not typically require further medical attention but if they do not go away on their own or if they worsen, contact your physician for further medical advice. Your doctor may also be able to give you recommendations that could potentially lessen the impact of these symptoms:

More likely:

  • Relaxed and calm
  • Fear
  • Sleepiness
  • Mood changes
  • Nausea
  • Unexplained drowsiness, dullness, tiredness, weakness, or sluggishness

Unknown likelihood of occurrence:

You may experience certain side effects that are not listed here. Any symptom that becomes bothersome or concerning, should be reported to your prescribing physician. Likewise, if you have a reaction or side effect that does not dissipate in a few days or becomes worse it is advised that you seek medical attention.


Due to the habit-forming nature of hydrocodone and pseudoephedrine, it is important for patients to take this medication as directed by their prescribing physician.

If you are taking the liquid form of hydrocodone and pseudoephedrine be sure to use a proper measuring device such as a medicine cup, oral syringe, or properly marked measurement spoon. Common household utensils do not provide the level of accuracy and consistency that is necessary when taking this medication.

This medication is not recommended for use by children or anyone under the age of 18.

The dosage guidelines provided below represent that amounts typically taken by patients using hydrocodone and pseudoephedrine. Always follow the prescription instructions provided by your doctor, even if they differ from those outlined below.

Do not make any changes to how you take hydrocodone and pseudoephedrine without first consulting with your doctor. Do not stop taking this medication without first receiving advice from your physician as the abrupt stoppage of this medication can cause withdrawal symptoms.

If you are utilizing an oral solution as your method of delivery of hydrocodone and pseudoephedrine in the treatment of nasal congestion and relief from coughing:

The daily dosage of hydrocodone and pseudoephedrine: 5 milliliters every four-six hours as necessary. Do not exceed four doses or 20 millimeters in one 24-hour period.

If you inadvertently miss a dosage of this medication, take the skipped dose as soon as you realize that it was missed. If it is close in time to your next scheduled dosage, then skip the missed dosage altogether. If you have missed a dose and are unsure what to do, consult with your pharmacist for further guidance.

Major Drug Interactions

Certain drugs are contraindicated for use with hydrocodone and pseudoephedrine and taking both drugs at the same time should be avoided. Your doctor may need to change a drug that you are taking for a different condition while you are taking hydrocodone and pseudoephedrine in order to avoid harm. If you are taking a drug that does not react well when taken with hydrocodone and pseudoephedrine your doctor may change the dosage and/or frequency with which you take one or more of the medications.

The use of these following drugs concurrently with hydrocodone and pseudoephedrine is contraindicated and can be dangerous. If you are currently taking one of the following medications your doctor may change them to another medicine in order to prevent unnecessary risk while taking hydrocodone and pseudoephedrine.

  • Dihydroergotamine
  • Furazolidone
  • Iproniazid
  • Isocarboxazid
  • Linezolid
  • Methylene Blue
  • Moclobemide
  • Naltrexone
  • Nialamide
  • Phenelzine
  • Procarbazine
  • Rasagiline
  • Safinamide
  • Selegiline
  • Tranylcypromine

The use of the medications listed below concurrently with hydrocodone and pseudoephedrine is not recommended. If your doctor believes that the use of these drugs together is the best course of treatment for your situation, they may alter the dosage or the frequency with which you take one or both of them.

  • Zolpidem
  • Alprazolam
  • Zaleplon
  • Anileridine
  • Verapamil
  • Aripiprazole
  • Triflupromazine
  • Atazanavir
  • Trifluoperazine
  • Boceprevir
  • Tranylcypromine
  • Bromazepam
  • Topiramate
  • Brotizolam
  • Tizanidine
  • Buspirone
  • Thiothixene
  • Butalbital
  • Thioproperazine
  • Carbamazepine
  • Thiopental
  • Cariprazine
  • Temazepam
  • Ceritinib
  • Telaprevir
  • Chlordiazepoxide
  • Suvorexant
  • Chlorzoxazone
  • Sufentanil
  • Clobazam
  • Sodium Oxybate
  • Clorazepate
  • Selegiline
  • Codeine
  • Saquinavir
  • Cyclobenzaprine
  • Risperidone
  • Dasabuvir
  • Remoxipride
  • Dezocine
  • Rasagiline
  • Diazepam
  • Quetiapine
  • Difenoxin
  • Propofol
  • Diltiazem
  • Promethazine
  • Diphenoxylate
  • Prochlorperazine
  • Donepezil
  • Primidone
  • Dronedarone
  • Posaconazole
  • Efavirenz
  • Pipotiazine
  • Erythromycin
  • Pimavanserin
  • Eszopiclone
  • Phenobarbital
  • Ethopropazine
  • Perphenazine
  • Fentanyl
  • Perazine
  • Flibanserin
  • Pentobarbital
  • Flunitrazepam
  • Paritaprevir
  • Flurazepam
  • Papaveretum
  • Fosaprepitant
  • Oxymorphone
  • Fospropofol
  • Oxazepam
  • Guanethidine
  • Opium Alkaloids
  • Haloperidol
  • Ombitasvir
  • Hexobarbital
  • Nitrazepam
  • Hydroxyzine
  • Nelfinavir
  • Iloperidone
  • Nalbuphine
  • Indinavir
  • Morphine
  • Iproniazid
  • Molindone
  • Isoflurane
  • Moclobemide
  • Ketamine
  • Midazolam
  • Ketobemidone
  • Methylene Blue
  • Levorphanol
  • Methotrimeprazine
  • Lopinavir
  • Methocarbamol
  • Lormetazepam
  • Methadone
  • Lurasidone
  • Mesoridazine
  • Medazepam
  • Meprobamate
  • Meperidine
  • Acetophenazine
  • Mephobarbital
  • Mephenesin
  • Meptazinol
  • Melperone
  • Metaxalone
  • Meclizine
  • Methdilazine
  • Loxapine
  • Methohexital
  • Lorazepam
  • Methyldopa
  • Linezolid
  • Metopimazine
  • Ketoconazole
  • Midodrine
  • Ketazolam
  • Modafinil
  • Itraconazole
  • Moricizine
  • Isocarboxazid
  • Morphine Sulfate Liposome
  • Iobenguane
  • Nefazodone
  • Imatinib
  • Nicomorphine
  • Idelalisib
  • Olanzapine
  • Hydromorphone
  • Opium
  • Halothane
  • Orphenadrine
  • Halazepam
  • Oxycodone
  • Furazolidone
  • Paliperidone
  • Fosphenytoin
  • Paregoric
  • Fluspirilene
  • Pentazocine
  • Fluphenazine
  • Perampanel
  • Fluconazole
  • Periciazine
  • Fentanyl Citrate
  • Phenelzine
  • Ethylmorphine
  • Phenytoin
  • Ethchlorvynol
  • Pimozide
  • Estazolam
  • Piritramide
  • Enflurane
  • Prazepam
  • Droperidol
  • Procarbazine
  • Doxylamine
  • Promazine
  • Dixyrazine
  • Propiomazine
  • Diphenhydramine
  • Quazepam
  • Dihydrocodeine
  • Ramelteon
  • Dichloralphenazone
  • Remifentanil
  • Diacetylmorphine
  • Rifampin
  • Dexmedetomidine
  • Ritonavir
  • Dantrolene
  • Secobarbital
  • Conivaptan
  • Sertindole
  • Clozapine
  • St John's Wort
  • Clonazepam
  • Sulpiride
  • Clarithromycin
  • Tapentadol
  • Chlorpromazine
  • Telithromycin
  • Chloral Hydrate
  • Thiethylperazine
  • Carisoprodol
  • Thiopropazate
  • Carbinoxamine
  • Thioridazine
  • Butorphanol
  • Tilidine
  • Butabarbital
  • Tolonium Chloride
  • Buprenorphine
  • Tramadol
  • Bromopride
  • Triazolam
  • Bosentan
  • Trifluperidol
  • Baclofen
  • Trimeprazine
  • Asenapine
  • Voriconazole
  • Aprepitant
  • Ziprasidone
  • Amobarbital
  • Zopiclone
  • Alfentanil
  • Zotepine

The use of Escitalopram while taking hydrocodone and pseudoephedrine may cause a higher risk of side effects or other unwanted reactions; if you are taking this drug your doctor may alter your dosage or how often you take the medication prior to beginning your course of treatment with hydrocodone and pseudoephedrine.

If you use tobacco products or drink alcohol on a regular basis it is advisable that you inform your doctor of these habits as they may impact how your body reacts to taking hydrocodone and pseudoephedrine. Inform your doctor, or another health professional such as a nurse that is working with you, of any overall changes to your general health and wellness.

It is best to avoid exposure to the following substances while you are taking hydrocodone and pseudoephedrine:

  • Ethanol
  • Grapefruit Juice

If you suffer from another medical condition, especially those listed below, the use of hydrocodone and pseudoephedrine may have a negative effect on the condition or the condition may affect the way that your body reacts to hydrocodone and pseudoephedrine. Be sure to inform your doctor if you suffer from or have a medical history of any of the following:


Most patients that use hydrocodone and pseudoephedrine do so on a temporary basis for the treatment of symptoms related to the common cold. If you are using this medication for an extended period of time your doctor may order diagnostic testing such as urine and blood tests, to monitor and manage the effectiveness of the medication and to also check for unwanted side effects. It is important that patients keep all appointments for testing and follow-up with their doctor while taking hydrocodone and pseudoephedrine.

If you have used any of the following drugs, or another MAO inhibitor, it is important that you notify your doctor and not use hydrocodone and pseudoephedrine until it is safe to do so.

  • Eldepryl
  • Marplan
  • Nardil
  • Parnate

It is possible to overdose on this medication and patients should familiarize themselves with following symptoms. If they occur it is important that emergency medical care is sought immediately. Call 911 or go to the nearest emergency room if you experience any of the following while you are taking hydrocodone and pseudoephedrine:

  • Seizures
  • Extreme dizziness or weakness
  • Cold, clammy skin
  • Shortness of breath
  • Slow heartbeat or breathing

Due to the potential of this medication to become habit-forming it is important that it is taken as prescribed. If you feel that the drug is not effective do not take more than the prescribed dosage. In fact, no alterations to the prescribed instructions should be made without first discussing with your doctor.

In some instances, patients have reported feeling extreme drowsiness or dizziness after taking hydrocodone and pseudoephedrine. Be sure to understand how your body reacts to this medication before you engage in any activities that require full alertness such as driving a car or operating heavy machinery.

This medication affects the Central Nervous System (CNS) and causes other medications that alter the CNS to have a more intense impact on the system. If you are taking hydrocodone and pseudoephedrine be sure to avoid the use of alcohol or any other CNS-affecting drug. If you are taking any of the following be sure to discuss your use with your physician prior to starting your hydrocodone and pseudoephedrine course of treatment:

  • Medicine for seizures or barbiturates
  • Tranquilizers
  • Allergies or colds
  • Other prescription pain medicine or narcotics
  • Anesthetics, including some dental anesthetics
  • Sleeping medicine
  • Muscle relaxants
  • Sedatives

Because the combination of hydrocodone and pseudoephedrine contains narcotics, the prolonged use of this medication can cause the patient to suffer from severe constipation. If not successfully alleviated, constipation can cause further harm. While taking hydrocodone and pseudoephedrine it is important to increase the amount of water and other liquids that you drink and to add more fiber to your diet. If these changes do not help, your doctor may recommend the use of a laxative to remedy the problem.

If you use hydrocodone and pseudoephedrine while you are pregnant your newborn may suffer from neonatal symptoms and withdrawal syndrome. Alert your doctor right away if the baby shows signs of any of the following symptoms:

  • An abnormal sleep pattern
  • Vomiting
  • Fever
  • Failure to gain weight
  • Irritability
  • Shakiness or tremor
  • High-pitched cry
  • Weight loss
  • Diarrhea

Be sure to inform your doctor of all medications that you are currently taking, both prescription and non-prescription as well as any herbal remedies or vitamin and mineral supplements. Review your past medical history with your doctor in a comprehensive manner prior to starting your hydrocodone and pseudoephedrine course of treatment.


It is always best practice to keep all medications in their original packaging. Store hydrocodone and pseudoephedrine combination in a moisture-free area that does not experience extreme heat or cold. Do not allow the medication to freeze.

Keep this and all medications out of the reach of children and pets.

If at the conclusion of your course of therapy you have excess, unused, or expired medication be sure to dispose of it in the proper manner. If you are unsure of how to properly and safely dispose of the unused hydrocodone and pseudoephedrine consult with your pharmacist for further direction.


Adults who suffer from severe instances of nasal congestion and coughing associated with the common cold often find relief from the drugs hydrocodone and pseudoephedrine taken in combination. These drugs help to relieve both symptoms on a temporary basis although this medication is not recommended for long-term use. Due to hydrocodone and pseudoephedrine containing narcotics, this medication can become habit-forming both mentally and physically.

Because of the potential for patients that are taking hydrocodone and pseudoephedrine to develop a dependence on the medication it is important that it is taken exactly as prescribed. If you do not feel that the medication is effective, speak with your doctor prior to making any changes to how you take the drug.

It is possible to overdose on this drug and patients and their caregivers should familiarize themselves with the signs and symptoms that require immediate emergency medical attention.

When taking hydrocodone and pseudoephedrine for an extended period of time be sure to discuss stopping the medication with your doctor prior to doing so in order to avoid any withdrawal symptoms.

This medication is not recommended for use in pregnant women due to the effects that it can have on the developing fetus, nor is it appropriate for use in children.