Hydrocortisone and Iodoquinol (Topical)


Vytone comes as a two-drug regimen. Iodoquinol is the component of the medication that serves as an antibiotic and whose treatment objective is to block bacterial or fungal growth. On the other hand, hydrocortisone is a corticosteroid that relieves symptoms of skin infection such as redness, itching, and other discomforts of the infected area.

The hydrocortisone and iodoquinol regimen is for topical use (external application on the skin), and only a doctor can prescribe it. The product is available in cream form.

Some of the skin conditions hydrocortisone and iodoquinol can treat include eczema, athlete's foot, and anal itching. Likewise, a doctor may recommend the medication to people with ringworm affecting various parts of the skin, dermatitis, and genital itching.

Conditions Treated

Type Of Medicine

  • Antibiotic/anti-inflammatory

Side Effects

Some patients report various side effects while using hydrocortisone and iodoquinol. Doctors usually assess the benefits of using such medication against any potential unwanted outcomes before prescribing it to a patient. Your physician will also advise you regarding undesired treatment outcomes that require immediate medical attention, for example, the softening of the skin.

Inform your doctor right away if, while using hydrocortisone and iodoquinol, the affected skin area develops blisters, a burning sensation, or flaking. It is not yet clear how likely it is for the medication to cause swelling, crusting, or severe redness of the affected surfaces, but you need to keep an eye out for such incidences and report them to your physician without delay.

It is also possible for the mouth area to develop redness or flaky skin while using hydrocortisone and iodoquinol. In other cases, the skin becomes thinner and more vulnerable to bruising. Similarly, hairy body areas may develop discomforts such as itching and burning, or even root hair pus. Also, pay attention to your face, legs, groin, and other parts if you are using Vytone, and see your doctor once you notice symptoms like red/purple lines around those areas.

Hydrocortisone may cause a severe rash, indicating a serious skin infection that requires prompt treatment. Minors who use the topical drug may also face a higher risk of retarded growth and slowed weight gain.

Some hydrocortisone and iodoquinol side effects do not always require urgent medical attention. Such symptoms may improve as you continue taking your medication, failure to which, professional intervention may be necessary. For example, any acne or pimples that develop on your skin due to the drug are not typically a cause for concern, unless they fail to go away within reasonable time.

The medication may also cause skin color changes, such as the lightening of dark areas under treatment, which is not usually indicative of a severe side effect. Likewise, no immediate medical intervention is necessary if body parts like the forehead, limbs, or back begin to grow more hair than usual.


The right amount and strength of hydrocortisone and iodoquinol for treating various skin conditions differ from patient to patient. As such, your doctor will assess your situation and formulate appropriate dosing. The product also has instructions on the label, which you should follow strictly unless your healthcare professional gives a different set of directives.

Your doctor will formulate a prescription of hydrocortisone and iodoquinol that stipulates the number of applications per day, the time spacing between each use, the amount of cream for each dose, and the period for which you should continue applying the medication. Do not deviate from the correct dosage or stop using the drugs prematurely.

Adults and minors aged 12 and above using hydrocortisone and iodoquinol to treat infections due to fungal or bacterial attacks should apply the topical medication to the affected skin area thrice or four times daily. If your child is under 12 years, see a doctor for more appropriate dosage.

Always strive to apply the cream the exact number of times your healthcare practitioner prescribed for each day, but if you miss a treatment, administer the medication at your earliest convenience. However, be sure there is a reasonable time interval between any two doses especially when you are trying to compensate for a missed application.

Prepare to administer the medication by first washing your hands with water and a sanitizer. Next, apply a thin film of the cream on the infected skin area and rub it in a uniform, soft manner.

Major Drug Interactions

The use of hydrocortisone and iodoquinol along with other medication or substances may cause undesirable outcomes if there are interactions. So, your doctor will seek to know about any other medicines that you are taking before they can approve your use of the skin infection cream. Several precautions are possible to avoid potentially severe drug interactions. For example, you may have to apply Vytone less often or in smaller doses if you are using another drug that may cause any severe medicinal interference or health ramifications.

The doctor may choose not to prescribe hydrocortisone and iodoquinol to a patient who is already taking Desmopressin or rotavirus vaccination. Alternatively, the dosage of some or all of the other drugs the patient is using may need to change to allow for the safe and efficient application of Vytone.

Cyclosporine and any other medication capable of weakening the immune system may interact with hydrocortisone and iodoquinol and cause undesirable outcomes. The same is true of prednisone and any treatments or substances that contain corticosteroids.

In certain circumstances, hydrocortisone and iodoquinol affect the validity of lab tests. For example, patients getting tested for thyroid function or phenylketonuria should be wary of possibly skewed lab results if they are using Vytone.

Your doctor will assess the possibility of treating your skin infection without hydrocortisone and iodoquinol if you are already taking other medications such as Aceclofenac, Bemiparin, Celecoxib, Clonixin, Droxicam, or Etofenamate. The healthcare practitioner will formulate a special dose of the anti-infective/anti-inflammation regimen if you have to use it with these other drugs. A similar precaution is necessary for patients on flufenamic acid, Ibuprofen, Ketoprofen, Lumiracoxib, Phenylbutazone, or Rofecoxib.

There is the possibility of a patient on hydrocortisone and iodoquinol facing a higher risk of side effects if they are applying the cream while using drugs such as:

  • Alcuronium
  • Colestipol
  • Licorice
  • Primidone

There are many more drugs that are capable of interfering with the way Vytone works in the human body. The patient does well to make a list of all non-prescription and prescription medication they are using and to share that information with the doctor before beginning any skin infection treatment.

While no special diet is necessary for a patient applying hydrocortisone and iodoquinol, it is always imperative to consult the doctor over any potential interactions between the medicine and food, beverages, or substances such as tobacco and alcohol. If you are considering using the topical medication, ask your physician about any necessary changes to your mealtime.


  • Hydrocortisone and iodoquinol have potentially severe health ramifications that require an in-depth analysis by a healthcare practitioner, so do not use these without your doctor's prescription.
  • If the site of application or the area around it has an infection, notify your doctor about it.
  • Avoid applying Vytone to an infected skin area with a severe injury, large open wounds, cuts, burns, or other forms of damage.
  • Diabetic patients should notify their doctor about their condition before beginning their Vytone skin therapy. People with Cushing's syndrome (or a history of) should also share that information with their physician.
  • Let your physician know if you think you have another skin infection before you can start using hydrocortisone and iodoquinol.
  • If you have had any allergies to hydrocortisone, other drugs, or substances/chemicals that hydrocortisone contains, let your doctor know beforehand. You may ask the healthcare practitioner or pharmacist to provide you with a list of the ingredients in the antibiotic/ anti-inflammatory cream. Discuss the appropriate dosing or treatment option with the practitioner in case the medication contains elements that are also in specific animals, foods, dyes, etc. that have caused you health problems in the past.
  • Do not ingest hydrocortisone and iodoquinol or let it get into your mouth, eyes, nose, or vagina. The medication is for external use only. Use clean water to wash the cream off any accidentally exposed skin areas or body openings.
  • Always leave the skin area under treatment uncovered. Only your doctor may recommend bandaging or wrapping the area after applying the medication. Occlusive dressing may be necessary for patients with psoriasis who are using Vytone to treat a skin infection.
  • If a child's diaper area is the subject of treatment with hydrocortisone and iodoquinol, use loose-fitting diapers on them. Do not cover such regions with plastic pants either, because doing so may accelerate the rate at which the skin absorbs the drugs, exposing the child to more treatment harm.
  • Improve your chances of full recovery by applying the medication for the entire duration of treatment your doctor prescribed.
  • Minimize unwanted side-effects by not using the cream more often, in larger quantities per dose, or for a longer period than your doctor ordered.
  • A healthcare practitioner can only offer the best medical help if you or your child sees them regularly for the assessment of treatment progress. During any such evaluation, the doctor may identify unwanted hydrocortisone and iodoquinol side effects and intervene before it is too late.
  • The skin condition should improve within the first few weeks (typically 14 days) of treatment with hydrocortisone and iodoquinol in both adults and minors, failure to which the patient should seek immediate medical attention.
  • You may not be comfortable with the change of skin or hair color that Vytone can cause.
  • Let your doctor or lab personnel know that you are applying hydrocortisone and iodoquinol ahead of any medical screening. The drugs may skew your tests results, rendering them unreliable.
  • Avoid exposing the skin areas under treatment to skincare products, including cosmetics.
  • It is not yet clear how hydrocortisone and iodoquinol may affect children under the age of 12, so you want to consult your doctor about the right dosing for your child if they are in this age bracket.
  • If you are breastfeeding, pregnant, or planning a pregnancy, notify your doctor ahead of using hydrocortisone and iodoquinol.


  • Keep hydrocortisone and iodoquinol in a tightly-sealed prescription box, ensuring minors cannot access or open it.
  • Ascertain storage at room temperature, and do not expose the cream to extreme heat. Keep it away from water or moisture.
  • Do not put hydrocortisone and iodoquinol in the freezer or refrigerator.
  • Let go of any expired or no-longer-in-use medication. Your local healthcare giver or pharmacist may provide proper drug disposal directives.


Hydrocortisone and iodoquinol are available in cream form and are used to treat various skin conditions. Based on a thorough assessment of your complication, a doctor may prescribe the medication to prevent the growth of bacteria or fungus in the case of eczema, athlete's foot, or dermatitis among numerous other conditions. The regimen helps relieve symptoms such as inflammation, redness, and itching of the skin.

You may start enjoying the benefits of hydrocortisone and iodoquinol within the first few weeks of use without any severe side effects. Feel free to contact your doctor if you do not see any symptom improvements within a reasonable time or in case of any critical unpleasant outcomes while you are applying the cream.

Available for purchase as Vytone, the medication is for external application on infected skin only. Do not use hydrocortisone and iodoquinol on cuts, burns, or damaged skin. You should not use without a prescription, or deviate from the dosage your doctor specified. Following the user directives that the healthcare giver provides enhances the effectiveness of the regimen while reducing the risk of unwanted effects.