Hydrocortisone Butyrate (Topical)

Hydrocortisone Butyrate is a corticosteroid medication used to treat symptoms of several skin conditions available by a doctor's prescription only.

Topical Hydrocortisone Butyrate can provide relief for certain skin conditions, such as seborrheic dermatitis and atopic dermatitis.

General Overview

Hydrocortisone Butyrate, administered by a topical application route, is an intermediate therapeutic corticosteroid (a cortisone-like medicine/steroid) used to provide relief for certain skin conditions and conditions such as seborrheic dermatitis and atopic dermatitis. Symptoms of itching, redness, swelling, and irritation experienced in those who respond to treatment (adults and pediatric patients ranging in age from 18 months to three years) are alleviated by application of a topical ointment cream or solution to the skin.

Side effects are usually mild-to-moderate, though sometimes severe. In the case of severe side effects, a physician's care and treatment may become medically necessary. Dosage schedules usually occur by dosing several times over the course of a day, without skipping doses to achieve the full benefit of using the medication. Storage of this medication requires no special accommodations or facilities, although care should be used to prevent those not being treated from coming in contact with the medication.

The use of alcohol and tobacco, as well as a number of over-the-counter and other medications can interact with this medication and care should be taken to understand the prescribing physician's instructions as to use.

Conditions Treated

Type Of Medicine

  • Topical corticosteroid

Common Side Effects

This medication may cause a range of undesired side effects. In patients who experience any of these side effects, contacting the prescribing physician immediately is strongly advised, as this medication may need to be discontinued permanently.

Discontinue use temporarily and contact the physician if you experience any of the following common side effects:

  • Skin irritation
  • Scaly rash
  • Burning sensation of the skin
  • Unusually warm skin
  • Scaling, crusty, or red skin
  • Rose coloration or flushing of the skin
  • Itching skin

There may also occur in some circumstances other side effects, although not completely known, such as:

  • Redness or scaling of the mouth area
  • Soreness or swelling of the skin
  • Weakness, thinning or wasting away of skin
  • Blistering or dryness of skin
  • Thinning of the skin combined with easy bruising in areas such as fingers or face

Other serious side effects that require immediate consultation with a physician and treatment include hair bumps (folliculitis), stretch marks, acne, or extreme or unwanted growth of hair. Many of these side effects will not be severe enough to require medical attention or treatment, though there may be discomfort, and consultation with a physician about experienced side effects should never be avoided.

In some cases, side effects can be reduced or counteracted without having to discontinue use. In infants, due to higher body-to-mass ratios, pediatric use may trigger systemic toxicity and side effects may occur. Many of these side effects will disappear as the body becomes conditioned to the use of this medicine, and use may not have to be discontinued.

A health care professional can provide instruction on how to prevent or reduce side effects without the need to discontinue use. These side effects and additional side effects not listed that are known or unknown may develop in some cases and your healthcare professional can assist you in identifying issues and provide steps to take in the event they do occur.

Since side effects may become severe enough to require medical attention, great care should be taken to keep your physicians consistently informed as to the patient's progress and all incidents of side effects, or potential side effects, should be noted and reported on a regular schedule set by caregiver/patient and healthcare professionals.

Recommended Dosage

Dosage of this medication varies and will not be the same for the different types of patient or for the specific condition it is prescribed for. Your physician's orders should be followed at all times. Read label directions carefully and never use this medication against your physician's advice. The information here describes the common average dosing instructions. If different from your physician's directions, always follow your physicians specific, exact directions.

The strength of your medicine will determine the dosage of the medicine you will take. The condition you are treating determines how you will take the medicine, such as the length of time you will take medicine before discontinuing, time between individual doses, as well as the number of times in a day you will take the doses.

When treating skin conditions involving redness, swelling, or itching symptoms: use a cream or ointment

  • Pediatric patients ' apply to the affected skin two-three times per day
  • Adult patients' apply to the affected skin two-three times per day

When treating seborrheic dermatitis: use a solution

  • Pediatric patients 'apply to the affected skin two-three times per day
  • Adult patients' apply to the affected skin two-three times per day

When treating atopic dermatitis: use cream or lotion

  • Pediatric patients aged 3 months to 18 months ' apply to affected skin two times per day
  • Pediatric patients less than 3 months of age'Dosage and use must be directed by physician

If you miss a dose, apply a dose as soon as possible, and resume dosing according to your schedule. In no case should dosing exceed the physician's recommendations and directions.


Serious interactions may occur from using this medication and as such health care professionals may decide to switch medication to a lower strength medication, reduce the frequency of application, or to discontinue use altogether.

Alcohol and tobacco will interact with this medication. Avoiding use of these substances is recommended for the entire duration of medication use.

Many over-the-counter medication cause interactions, as well as other cortisol-based medications. You should always consult at length with your physician about the medications you use or come in contact with and your alcohol and tobacco consumption, if any. The physician will assist in preparing you to prevent any drug interactions from occurring, and the orders and advice of your physician must be followed at all times.


This medication must be monitored carefully, and pediatric patients must be regularly seen by their physician or healthcare personnel to prevent and treat and situations of the occurrence of side effects. This is extremely important for the safety of pediatric patients (children). Any side effects must be promptly reported, and the advice of the physician or other healthcare professionals must be followed.

The overuse of this medication or using it for longer than prescribed can result in serious problems with the functioning of the adrenal glands, and should always be avoided as major risks to health can occur under these conditions.

Immediately contact your physician and have the child seen by healthcare professionals if symptoms such as fainting or dizziness, irregular or fast, pounding heartbeat, tiredness, weakness or excessive urination or thirst develop. Never use any cosmetic products or additional skin or body care products on skin areas being treated by this medication.

This medicine is not to be taken orally and it is intended for topical use on skin areas only. Take care, especially with pediatric patients, to prevent using on body areas such as mouth, nose, eyes, or vaginal areas. If any of these areas do make contact with this medicine, immediately flush with water until all medicine is fully removed from the affected areas.

Other steps to take when using this medicine:

  • Do not wrap or bandage skin areas being treated unless a physician gives you permission.
  • Airtight or occlusive dressings should not be used for wounds unless a physician gives permission.
  • Apply a thin layer to the surface of skin only.
  • Always wash hands thoroughly after applying this medicine and do not make contact with people, pets or food until hands are properly cleaned.
  • If medicine is applied to pediatric patients wearing a diaper, do not use tight-fitting diapers and/or plants made of plastic unless a physician gives you permission.
  • Do not wrap or bandage skin areas being treated unless a physician gives you permission.
  • Airtight or occlusive dressings should not be used for wounds unless a physician gives permission.

Those who suffer from the following conditions should consult thoroughly with their physician before using this medication, as medication use can cause severe reactions:

If the patient experiences any of these conditions or develops them during use of this medication, this should be reported to the physician immediately to prevent adverse reactions and dangerous side effects. The physician will be able to recommend treatment options should the discontinuation of this medication become necessary. Always be honest with your physicians and healthcare professionals about your health and the use of this medication in order to prevent adverse reactions or side effects from becoming a serious health issue.

Some may experience an allergy to this medication, and testing must be done before use of medication to determine is any existing allergies are present. Allergies can cause severe symptoms, some requiring medical attention.

Do not use this medication for other skin conditions other than prescribed, or use for burns. Always use as directed and immediately report any adverse reactions or side effects to the appropriate professionals responsible for patients care, without hesitation.

Proper Storage

This medication should be stored at room temperature, avoiding direct sunlight at all times. Keep this medication away from heat and moisture. This medication should be kept in an area that is not reachable by children or others. Never stockpile or keep this medication after your treatment plan is completed, or store or use for any other purpose than prescribed.

If unclear as to how to handle unused, outdated, or medication leftover after treatment is completed, ask your healthcare professionals for instructions on how to properly dispose of or give unused medication to your physician or healthcare professional.


Hydrocortisone Butyrate is a commonly prescribed medication and fairly tolerated by most patients without severe side effects, and is effective at treating the skin conditions for which it is prescribed. It is very important to know the side effects of this medication and be aware of any potential reactions or interactions which may occur to guard against severe or life-threatening issues to develop, such as adrenal gland damage.

In order to prevent side effects from occurring in pediatric patients, following the prescribing physician's directions at all times is extremely important. One should never use more of this medication than directed or for purposes other than prescribed. Staying in contact with health care professionals who carefully monitor the use of this medication is absolutely essential for the safety of the patient, and for the success of the treatment itself.

Usually, patients do not have severe side effects and this medication is deemed safe for use by the majority of all patients. Properly storing and disposing of medication is necessary for the safety of others, and it should be kept away from unsupervised children. One must always use care when handling this medication, washing hands when applying and avoiding contact with others, self and food as allergic reactions may occur in those who are allergic to it.

Medication is for topical use and should never be swallowed or ingested or come into contact with exposed skin or burn tissue. If swallowed, contact a poison control center immediately and inform your physician or health care professionals for additional instructions and/or to get replacement medication as needed.

Proper use of this medication will result in the lessening of the severity of the symptoms medication is intended to treat in most cases.

Improper use of medication to treat conditions other than prescribed can result in adverse reactions. Never use this medication for someone other than it is prescribed to, such as other children with similar symptoms, as only a physician can prescribe this medication and treat these conditions safely by monitoring the use of medication and condition of the patient.