Hydroxyzine (Intramuscular)


Hydroxyzine injections are administered by a doctor or other medical professional; cases of self-administration are very rare. In most cases, this medication is used to relax the patient prior to surgery or another medical procedure and encourages sleep. It is often used in dental settings as well. The drug can also be administered following an operation to help aid the recovery process. This medication is also an effective treatment of allergic reactions that are associated with chronic urticaria and asthma.

Patients will typically receive this medication while in the hospital or another clinic-like setting and any significant symptoms that are experienced by the patient should be immediately reported to the medical team. It is strongly advised that the patient remains at the hospital until all effects of the drug have dissipated as hydroxyzine has been reported to cause extreme dizziness and drowsiness. Do not drive after receiving this injection as it may make it unsafe for you to operate an automobile.

This medication is an antihistamine that blocks the production of histamine thereby relieving many symptoms caused by common allergies. Other uses include controlling the anxiety experienced by patients with certain types of heart disease, lessening withdrawal symptoms that occur during alcohol detox, and counteracting vomiting and nausea. If you have received this medication it is important that all other CNS depressing medications are avoided. If you are currently taking other antihistamines, cold remedies, or sleep aids be sure to discuss this usage with your doctor prior to the administration of the hydroxyzine injection.

Patients should be aware of the possibilities of heart issues when taking this medication. Be sure to inform your medical team of your full medical history and that of your immediate family. Notify the medical staff at once if you experience any changes to your heart rhythm including a rapid or irregular heartbeat or strong pounding. These symptoms may be a sign of a more serious problem.

Hydroxyzine (intramuscular delivery) utilizes the following dosage delivery method: Solution.

Conditions Treated

  • Anxiety and nervousness
  • Chronic urticaria
  • Asthma
  • Vomiting and nausea

Type Of Medicine

  • Respiratory Agent

Side Effects

Hydroxyzine can cause certain unwanted side effects in addition to its stated medical purpose. Some of these may be a sign of a more serious problem and should receive further medical attention while others will likely dissipate on their own after a period of a few days. If you experience any significant reactions or ones that worsen or linger longer than a few days it is advisable to notify your doctor for further medical advice.

If you experience any of the following symptoms, be sure to notify your medical team at once as they may be a sign of a more serious problem:

Unknown likelihood of occurrence:

  • Warmth at the injection site
  • Pain
  • Burning
  • Blue-green to black skin discoloration
  • Discoloration of the skin
  • Ulceration
  • Hives
  • Tenderness
  • Inflammation
  • Stinging
  • Lumps
  • Scarring
  • Rash
  • Numbness
  • Pain, redness, or sloughing of skin at the injection site
  • Itching
  • Bleeding
  • Infection
  • Redness
  • The feeling of pressure
  • Soreness
  • Coldness
  • Swelling
  • Blistering
  • Tingling

Other symptoms may occur as your body adjusts to the introduction of hydroxyzine into your system. The following list of side effects are typically not ones that will require further medical attention, however, notify your medical team right away if they become worse or last longer than a few days:

Rare likelihood:

  • Trembling or shaking feet or hands
  • Shakiness in your extremities, feet, or hands

Unknown likelihood of occurrence:

  • Dry mouth
  • Drowsiness

In addition to the side effects that are listed above, some patients may experience others that are not included; it is always best practice to inform your medical team of any symptoms that are of concern, worsen, or last longer than a few days.


Hydroxyzine is injected into a muscle of the patient while they are in the hospital or another clinic-like setting. The dosage amount will be determined by the prescribing doctor, often prior to surgery or another medical procedure, and administered by a nurse or another member of the medical team. This drug is typically administered by a healthcare professional and is not usually self-administered.

Major Drug Interactions

There are a number of medications that should not be taken concurrently with hydroxyzine and your doctor will likely prescribe an alternative or change the other medications that you are currently taking. Another group of medications may heighten the likelihood of side effects when taken together, and your doctor may change the dosage or how you take one or both of the medications. It is important to inform your medical team of all of the medications that you are currently taking as well as those that you have stopped taking recently.

When relaying the information concerning your medications, be sure to include both prescription and non-prescription drugs as well as any herbal remedies, or vitamin and mineral supplements.

Patients that are currently taking any of the following medications may have their doctor prescribe an alternative to hydroxyzine or change one of the other medications as hydroxyzine is contraindicated for use with the following medications:

  • Amifampridine
  • Terfenadine
  • Bepridil
  • Sodium Oxybate
  • Dronedarone
  • Piperaquine
  • Pimozide
  • Ziprasidone
  • Saquinavir
  • Mesoridazine
  • Sparfloxacin
  • Cisapride
  • Thioridazine
  • Amisulpride

The use of hydroxyzine with the drugs contained in this list may heighten the likelihood of side effects and your doctor may alter the dosage or how you take one or both of the medications:

  • Vorinostat
  • Amitriptyline
  • Vinflunine
  • Apomorphine
  • Venlafaxine
  • Arsenic Trioxide
  • Vardenafil
  • Astemizole
  • Triptorelin
  • Azithromycin
  • Trazodone
  • Bromazepam
  • Toremifene
  • Buprenorphine
  • Tizanidine
  • Buserelin
  • Tetrabenazine
  • Carbinoxamine
  • Telavancin
  • Chlorpromazine
  • Tapentadol
  • Citalopram
  • Tacrolimus
  • Clomipramine
  • Sulpiride
  • Codeine
  • Sotalol
  • Cyclobenzaprine
  • Solifenacin
  • Dasatinib
  • Sodium Phosphate, Dibasic
  • Delamanid
  • Sevoflurane
  • Deslorelin
  • Ritonavir
  • Disopyramide
  • Remifentanil
  • Dolasetron
  • Quinine
  • Doxepin
  • Quetiapine
  • Droperidol
  • Propafenone
  • Efavirenz
  • Prochlorperazine
  • Erythromycin
  • Probucol
  • Famotidine
  • Pitolisant
  • Fentanyl
  • Pimavanserin
  • Flecainide
  • Periciazine
  • Fluconazole
  • Pentazocine
  • Formoterol
  • Pazopanib
  • Fosphenytoin
  • Paroxetine
  • Gatifloxacin
  • Panobinostat
  • Gonadorelin
  • Oxymorphone
  • Granisetron
  • Ondansetron
  • Haloperidol
  • Ofloxacin
  • Hydrocodone
  • Norfloxacin
  • Hydroquinidine
  • Nelfinavir
  • Ibutilide
  • Moxifloxacin
  • Imipramine
  • Morphine
  • Ivabradine
  • Mizolastine
  • Lapatinib
  • Metronidazole
  • Levofloxacin
  • Mefloquine
  • Meclizine
  • Alfuzosin
  • Meperidine
  • Lumefantrine
  • Mifepristone
  • Leuprolide
  • Moricizine
  • Ketoconazole
  • Morphine Sulfate Liposome
  • Itraconazole
  • Nafarelin
  • Iloperidone
  • Nilotinib
  • Hydroxychloroquine
  • Octreotide
  • Hydromorphone
  • Olanzapine
  • Histrelin
  • Oxycodone
  • Halofantrine
  • Paliperidone
  • Goserelin
  • Papaverine
  • Gemifloxacin
  • Pasireotide
  • Galantamine
  • Pentamidine
  • Foscarnet
  • Perflutren Lipid Microsphere
  • Fluoxetine
  • Perphenazine
  • Flibanserin
  • Pipamperone
  • Fingolimod
  • Posaconazole
  • Felbamate
  • Procainamide
  • Escitalopram
  • Promethazine
  • Eribulin
  • Protriptyline
  • Ebastine
  • Quinidine
  • Doxylamine
  • Ranolazine
  • Domperidone
  • Risperidone
  • Dofetilide
  • Sertindole
  • Dihydrocodeine
  • Sodium Phosphate
  • Desipramine
  • Sodium Phosphate, Monobasic
  • Degarelix
  • Sorafenib
  • Dabrafenib
  • Sufentanil
  • Crizotinib
  • Sunitinib
  • Clozapine
  • Tamoxifen
  • Clarithromycin
  • Telaprevir
  • Ciprofloxacin
  • Telithromycin
  • Chloroquine
  • Tiotropium
  • Butorphanol
  • Tolterodine
  • Bupropion
  • Tramadol
  • Bromopride
  • Trimipramine
  • Bedaquiline
  • Vandetanib
  • Atazanavir
  • Vemurafenib
  • Asenapine
  • Vilanterol
  • Aripiprazole
  • Voriconazole
  • Anagrelide
  • Zolpidem
  • Amiodarone
  • Zuclopenthixol

Alert your medical team to any lifestyle habits that may impact how you react to your medications, such as regular alcohol intake or the use of tobacco products. Your doctor should also be informed of any changes to your overall health and wellness.

If you currently suffer from the following medical conditions your doctor may change the way that you are administered hydroxyzine as these conditions can have an effect on how the medicine affects you, and it can also have a negative impact on these conditions:

  • Heart rhythm problems
  • Electrolyte imbalance
  • Heart failure
  • Heart disease
  • Heart attack


This medication is typically administered in the hospital or another clinic-like setting and there will be healthcare staff nearby in case you experience any significant negative reactions.

Hydroxyzine should not be used in the early trimesters of pregnancy, and your doctor should be informed if you are pregnant. Do not use this medication while pregnant as it can be harmful to the developing fetus.

Patients may develop a permanent condition known as necrosis beneath the skin where the injection is administered, this depression is preceded by the following symptoms:

  • Depressed or indented skin
  • Blue-green to black skin discoloration
  • Pain, redness, or peeling off of the skin

Alert your medical-care team right away if you experience any of those symptoms.

As an antihistamine, hydroxyzine will affect how your system reacts to other CNS depressants including alcohol. Do not take any of the following types of medications while you are being treated with hydroxyzine without checking with your doctor first:

  • Allergy medications
  • Other antihistamines
  • Seizure medications including barbituates
  • Muscle relaxants
  • Any anesthesia (included those used by a dentist)
  • Cold medicines
  • Any sleeping aids or tranquilizers

It has been reported that hydroxyzine has caused dizziness and extreme drowsiness in some cases. Be sure that the effects of this medication have worn off before you leave the hospital. Do not drive yourself home from your surgery or medical procedure if you are still feeling dizzy or drowsy.

This medication may cause alterations to the way that your heart acts, including changes to the rhythm. If you experience any of the following symptoms notify your doctor or medical team immediately, if you or anyone in your family has experienced a condition such as QT prolongation you may be more susceptible to these reactions:

  • Dizziness
  • Fainting
  • Uneven heartbeat
  • Accelerated heartbeat
  • Excessive pounding


Due to the fact that this injection is administered in a hospital setting, there are no storage guidelines necessary as it will not typically be self-administered at home.


Patients that are in the hospital or other clinic-like settings for surgery or another medical procedure are often given an injection of hydroxyzine in order to alleviate the symptoms of stress and nervousness that many people experience in such situations. This drug may also be injected following surgery to help aid the recovery process.

The drug is also effective as an antihistamine in extreme cases of asthma or chronic urticaria. Patients that experience serious vomiting and nausea may also be given an injection of hydroxyzine to treat those symptoms. This medication is also used in cases of alcohol withdrawal to help alleviate the stress and anxiety that is associated with that process.

There are several medications that are contraindicated with this drug, and hydroxyzine should not be used in combination with them. Additional drugs have been known to cause significant side effects and your doctor may alter the way in which you take one or both of the medications if they are taken together. Be sure to notify your entire medical team of all of the medications that you are currently taking including both prescription and non-prescription as well as any herbal remedies and both vitamin and mineral supplements.

Hydroxyzine (intramuscular route) is injected into the muscle by a doctor, nurse, or another member of your medical team. It is highly unlikely that this medication would be self-administered in this format, nor would it be prescribed outside of a hospital or clinic setting.