Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate (Oral)

Overview

When patients develop urinary tract infections, they may require a number of medications in order to treat them effectively. As well as taking medication to relieve the pain caused by the infection, for example, patients will also require medication to rid their body of the infection itself.

Rather than prescribing numerous medications when treating urinary tract infections, physicians tend to prescribe Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate as a combination medication. By doing so, patients get the benefits of numerous medicines, but are only required to take a minimal number of tablets or capsules.

Although this combination medicines appears to contain numerous active ingredients, each one plays a significant role in treating the patient. As an antispasmodic medicine, Hyoscyamine helps to prevent bladder spasms and muscle cramps, whilst Phenyl Salicylate helps to reduce the pain caused by the infection. In addition to this, Methylene Blue and Methenamine work as antiseptic drugs to clear the infection from the patient's body and Sodium Phosphate increases the efficacy of Methenamine by making the patient's urine more acidic.

As this treatment contains various medicines, physicians must ensure that the patient is able to tolerate each active ingredient before prescribing it. If so, Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate can be used to provide pain relief and curative treatment for patients who have been diagnosed with urinary tract infections.

In addition to this, Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate may be given to patients who have undergone diagnostic testing or surgical procedures. When tests are carried out on the urinary tract, patients may experience some side effects afterwards. They may have a frequent urge to urinate, for example, or have some pain as a result of the procedure itself.

By prescribing patients with Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate, physicians can ensure that the patient doesn't experience pain following the procedure and that symptoms, such as bladder spasms or increased urination, are adequately controlled.

As patients may be more at risk of developing a urinary tract infection following a procedure or test, Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate can also mitigate this risk and help prevent the patient from developing a subsequent infection.

Conditions Treated

  • Urinary tract infections and associated symptoms

Type Of Medicine

  • Antispasmodic (Hyoscyamine)
  • Antiseptic (Methenamine and Methylene Blue)
  • Pain reliever (Phenyl Salicylate)
  • Phosphorus (Sodium Phosphate)

Side Effects

Taking any medication can cause the patient to experience some adverse effects, but specific side effects are often associated with certain medications. When patients take Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate, for example, they may experience the following side effects:

  • Rapid pulse
  • Blurred vision
  • Dizziness

If patients do experience the above side effects when using this medication, they should consult their doctor immediately.

Patients should also be aware that taking Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate can cause their urine to become a blue color. Although this is normally a temporary side effect, patients should obtain medical advice if they are concerned about this change or if this side effects continues for a significant period of time.

Dosage

When patients are prescribed Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate, their doctor will provide specific dosage instructions. Generally, patients are advised to take one capsule or one tablet, four times per day.

However, there are various strengths of medication available. Patients may be given a combination with contains 0.06mg or 0.12mg of Hyoscyamine, for example. Similarly, the strength of Methenamine may vary from 81.6mg up to 118mg, depending on the exact preparation that is prescribed.

When doctors are prescribing Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate, they will determine what dose is appropriate for the patient, based on their current presentation, medical history, age and weight.

If pediatric patients are prescribed Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate, for example, they are usually advised to take one tablet or capsule four times per day, but these tablets and capsules tend to be the lowest strength available.

When taking Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate, patients should attempt to drink more fluid than usual, as this will help them to pass more urine. By increasing the frequency of urination, patients can help their body to expel the infection more quickly. However, drinking excessive amounts of fluids can be harmful in some cases, so patients should consult their doctor regarding the appropriate amount of fluid to consume.

Unless patients are advised to stop taking Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate, they should continue taking the medicine until the course of treatment has finished. Even if the patient's symptoms subside, they should continue taking the medication as their doctor instructs them to do. If patients stop taking Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate too quickly, their symptoms may return and may be harder to treat in the future.

If patients forget to take a dose of Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate, they should take their medication as soon as they remember to do so. However, if their next dose of medicine is almost due, patients should skip the missed dose and continue with their normal dosing schedule. Patients should not attempt to take a double dose of Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate, even if an earlier dose has been missed.

If patients are unsure how to take this medicine, they should seek advice from their physician or pharmacist.

Potential Drug Interactions:

Whilst some medicines can be taken at the same time, others cannot be. When some drugs are taken alongside one another, there is a risk of them interacting and this could be harmful to the patient. Due to this, Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate should not be prescribed if the patient is already taking any of the following medicines:

  • Acetazolamide
  • Sulfadiazine
  • Amifampridine
  • Sulfabenzamide
  • Amisulpride
  • Sulfacytine
  • Amitriptyline
  • Sulfamethazine
  • Amoxapine
  • Sulfamethoxazole
  • Amphetamine
  • Sulfacetamide
  • Bepridil
  • Sulfapyridine
  • Bupropion
  • Sulfanilamide
  • Carbamazepine
  • Fluvoxamine
  • Carbidopa
  • Fluoxetine
  • Carbinoxamine
  • Hydroxytryptophan
  • Cisapride
  • Escitalopram
  • Citalopram
  • Sulfamerazine
  • Clomipramine
  • Entacapone
  • Cyclobenzaprine
  • Linezolid
  • Desipramine
  • Levomilnacipran
  • Desvenlafaxine
  • Levodopa
  • Dextroamphetamine
  • Imipramine
  • Doxepin
  • Isocarboxazid
  • Doxylamine
  • Mafenide
  • Dronedarone
  • Mirtazapine
  • Duloxetine
  • Milnacipran
  • Lisdexamfetamine
  • Terfenadine
  • Nortriptyline
  • Tryptophan
  • Phentermine
  • Opicapone
  • Maprotiline
  • Paroxetine
  • Mesoridazine
  • Phenelzine
  • Tranylcypromine
  • Pimozide
  • Trazodone
  • Piperaquine
  • Thioridazine
  • Rizatriptan
  • Trimipramine
  • Safinamide
  • Zonisamide
  • Saquinavir
  • Venlafaxine
  • Selegiline
  • Protriptyline
  • Sertraline
  • Pseudoephedrine
  • Silver Sulfadiazine
  • Potassium
  • Sparfloxacin
  • Vortioxetine
  • Sulfasalazine
  • Vilazodone
  • Sulfathiazole
  • Ziprasidone
  • Sulfisoxazole
  • Zolmitriptan
  • Sumatriptan

Similarly, taking any of the following medicines at the same time as Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate is not usually recommended:

  • Aceclofenac
  • Tacrolimus
  • Acemetacin
  • Alfuzosin
  • Sunitinib
  • Almotriptan
  • Telithromycin
  • Amineptine
  • Tapentadol
  • Amiodarone
  • Sulpiride
  • Amitriptyline
  • Tenoxicam
  • Amitriptylinoxide
  • Telavancin
  • Amoxapine
  • Sufentanil
  • Celecoxib
  • Solifenacin
  • Chloroquine
  • Sotalol
  • Chlorpheniramine
  • Sorafenib
  • Chlorpromazine
  • St John's Wort
  • Ciprofloxacin
  • Sulindac
  • Citalopram
  • Sibutramine
  • Clarithromycin
  • Procainamide
  • Degarelix
  • Pimavanserin
  • Delamanid
  • Protriptyline
  • Desipramine
  • Prochlorperazine
  • Deslorelin
  • Propyphenazone
  • Dexibuprofen
  • Posaconazole
  • Dexketoprofen
  • Proquazone
  • Dextromethorphan
  • Promethazine
  • Dibenzepin
  • Quetiapine
  • Diclofenac
  • Piroxicam
  • Difenoxin
  • Piketoprofen
  • Dihydrocodeine
  • Proglumetacin
  • Diphenoxylate
  • Propafenone
  • Dipyrone
  • Procarbazine
  • Disopyramide
  • Pitolisant
  • Dofetilide
  • Gemifloxacin
  • Dolasetron
  • Flecainide
  • Domperidone
  • Floctafenine
  • Donepezil
  • Droperidol
  • Fenoprofen
  • Droxicam
  • Gatifloxacin
  • Efavirenz
  • Fluconazole
  • Eletriptan
  • Granisetron
  • Erythromycin
  • Gonadorelin
  • Escitalopram
  • Etodolac
  • Goserelin
  • Etofenamate
  • Halofantrine
  • Etoricoxib
  • Histrelin
  • Felbinac
  • Hydrocodone
  • Fentanyl
  • Haloperidol
  • Fepradinol
  • Hydroxychloroquine
  • Feprazone
  • Hydroxyzine
  • Fingolimod
  • Ibutilide
  • Fluoxetine
  • Iloperidone
  • Flibanserin
  • Imipramine
  • Flufenamic Acid
  • Ibuprofen
  • Flurbiprofen
  • Indomethacin
  • Frovatriptan
  • Meclofenamate
  • Furazolidone
  • Mifepristone
  • Iobenguane I 123
  • Methadone
  • Iproniazid
  • Meperidine
  • Ivabradine
  • Meloxicam
  • Ketoconazole
  • Metronidazole
  • Ketoprofen
  • Niflumic Acid
  • Lapatinib
  • Nimesulide
  • Leuprolide
  • Nepafenac
  • Levofloxacin
  • Naratriptan
  • Lithium
  • Nefazodone
  • Lofepramine
  • Naproxen
  • Lopinavir
  • Nafarelin
  • Lorcaserin
  • Nilotinib
  • Lornoxicam
  • Nimesulide Beta Cyclodextrin
  • Loxoprofen
  • Nabumetone
  • Lumefantrine
  • Nialamide
  • Lumiracoxib
  • Oxycodone
  • Mefenamic Acid
  • Opipramol
  • Mefloquine
  • Oxaprozin
  • Melitracen
  • Oxymetazoline
  • Moclobemide
  • Octreotide
  • Morniflumate
  • Ofloxacin
  • Morphine
  • Ondansetron
  • Morphine Sulfate Liposome
  • Oxymorphone
  • Pentazocine
  • Moxifloxacin
  • Phenylbutazone
  • Norfloxacin
  • Parecoxib
  • Nortriptyline
  • Perflutren Lipid Microsphere
  • Oxyphenbutazone
  • Quinidine
  • Dasatinib
  • Quinine
  • Dabrafenib
  • Ranolazine
  • Paliperidone
  • Crizotinib
  • Rasagiline
  • Clomipramine
  • Remifentanil
  • Cocaine
  • Pasireotide
  • Rofecoxib
  • Panobinostat
  • Clozapine
  • Salmeterol
  • Periciazine
  • Clonixin
  • Pazopanib
  • Sevoflurane
  • Palonosetron
  • Codeine
  • Tetrabenazine
  • Bupropion
  • Tianeptine
  • Buserelin
  • Tiaprofenic Acid
  • Brompheniramine
  • Tiotropium
  • Buspirone
  • Tizanidine
  • Buprenorphine
  • Tolfenamic Acid
  • Bufexamac
  • Tolmetin
  • Bromfenac
  • Tramadol
  • Butorphanol
  • Trazodone
  • Asenapine
  • Trimipramine
  • Aripiprazole
  • Triptorelin
  • Arsenic Trioxide
  • Valdecoxib
  • Astemizole
  • Vandetanib
  • Atropine
  • Vardenafil
  • Bedaquiline
  • Vemurafenib
  • Bromazepam
  • Vinflunine
  • Azithromycin
  • Voriconazole
  • Apomorphine
  • Ziprasidone
  • Anagrelide
  • Zuclopenthixol
  • Amtolmetin Guacil

Although this medication should not usually be taken in conjunction with the above medicines, doctors may feel it's appropriate in some cases. If so, the patient's dose of Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate may be modified in order to reduce the risk of interactions occurring.

If patients take Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate at the same time as the following medicines, their risk of experiencing side effects may be increased:

  • Acarbose
  • Magnesium Carbonate
  • Aluminum Carbonate, Basic
  • Glimepiride
  • Aluminum Hydroxide
  • Dihydroxyaluminum Sodium Carbonate
  • Aluminum Phosphate
  • Chlorpropamide
  • Magaldrate
  • Dihydroxyaluminum Aminoacetate
  • Glipizide
  • Calcium Acetate
  • Glyburide
  • Magnesium Hydroxide
  • Calcium Carbonate
  • Insulin
  • Tolbutamide
  • Calcium Citrate
  • Insulin Aspart, Recombinant
  • Calcium Acetate
  • Tolazamide
  • Insulin Bovine
  • Nateglinide
  • Insulin Degludec
  • Repaglinide
  • Insulin Detemir
  • Metformin
  • Insulin Glargine, Recombinant
  • Magnesium Trisilicate
  • Insulin Glulisine
  • Magnesium Oxide
  • Insulin Lispro, Recombinant

Patients should also be aware that interactions can occur between prescription medicines, over the counter medications, vitamins and supplements. Patients should, therefore, notify their doctor if they are taking any of these substances before Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate is prescribed.

Similarly, patients should obtain medical advice before using any new medicines, supplements or vitamins once they have started taking this medication.

Warnings

If patients have any existing health problems, it may affect the use of Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate. The following conditions are particularly relevant if treatment with this medicine is being considered:

  • Intolerance or allergy to salicylates or belladonna
  • Congestive heart failure
  • Glaucoma
  • Coronary heart disease
  • Heart rhythm problems
  • Heart disease
  • Urinary problems
  • Stomach ulcers
  • Intestinal or stomach blockage
  • Severe muscle weakness (Myasthenia gravis)

Although Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate may be prescribed to pediatric patients, it should not normally be used to treat patients who are under the age of six years.

If the patient's symptoms do not improve with treatment or worsen, they should contact their physician for further advice.

If patients experience the following side effects, they should stop taking this medication immediately and contact their physician:

  • Dizziness
  • Rapid pulse
  • Blurred vision

Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate will only alleviate symptoms if taken as instructed. It should not be used in isolation to treat serious urinary tract infections.

If pregnant patients take Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate, it may cause harm to their unborn baby. As a result, this medication should not be prescribed to pregnant patients unless the benefits vastly outweigh the risks.

It is not known whether Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate can be transferred to an infant via breastfeeding or whether it poses a risk to infants if transferred in this way. Due to this, patients are generally advised not to breastfeed when taking this medication and should seek medical advice before doing so. As the medicine may remain in the patient's system, they should obtain medical advice before resuming breastfeeding after taking their last dose of this medication.

Before using Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate, patients should tell their doctor whether they have any allergies. If the patient experiences an allergic reaction when taking this medicine, they will require emergency medical help. An allergic reaction may include the following symptoms:

  • Difficulty swallowing
  • Rash on the skin
  • Itching
  • Hives
  • Difficulty breathing
  • Wheezing
  • Hoarseness
  • Swelling of the hands, face, lips, throat, mouth or tongue

Storage

Generally, Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate can be kept at room temperature but should be kept away from direct light, heat and moisture. When keeping this medicine at home, patients should ensure that children and pets cannot gain access to it.

If patients are advised to stop taking this medicine or if the medicine reaches its use-by date, patients should contact their physician's office or pharmacist and use a designated medicine disposal service.

Summary

As Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate contains numerous active ingredients, it can be extremely effective in treating urinary tract infections or minimizing symptoms following a diagnostic procedure.

As well as treating the infection itself, Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate and Sodium Phosphate can reduce the pain experienced by the patients and help to prevent muscle spasms and painful urination.