When babies are born prematurely, they may develop various health problems. If the fetus has not spent long enough in the mother's womb, its organs, blood vessels and arteries may not have formed correctly or may not be working optimally. Neonatal intensive care units are routinely used to treat premature babies and reverse any conditions that have occurred due to their early delivery.
Prior to birth, a baby's pulmonary artery and aorta are connected by the ductus arteriosus blood vessel. Although this blood vessel is an essential part of fetal circulation systems, it should close soon after the baby has been born.
In some cases, however, the ductus arteriosus remains open and, as a result, oxygen-poor blood from the pulmonary artery can mix with oxygen-rich blood from the aorta. When this happens, extra strain is put on the baby's heart and blood pressure within the lung arteries increases.
Although the cause of ductus arteriosus is still unknown, it is more common in babies who have been born prematurely. When premature babies are affected by patent ductus arteriosus, Ibuprofen Lysine can be used to close the blood vessel and reduce pressure on the heart and lung arteries.
Appropriate for use in premature babies weighing between 1.1-3.3 pounds, Ibuprofen Lysine is believed to close the blood vessel by inhibiting prostaglandin synthesis. As prostaglandin E2 is the strongest vasodilator of the ductus arteriosus, inhibiting its effects cause the blood vessel to close.
Whilst any surgical procedure performed on premature infants carries risks, Ibuprofen Lysine can be used to successfully treat patent ductus arteriosus and is the procedure is often performed when the baby is just a few hours old. By acting quickly, physicians can reduce respiratory distress and lower the risk of damage occurring to the patient's heart and/or lungs.
As with any type of medication, Ibuprofen Lysine may sometimes cause patients to suffer side-effects. As Ibuprofen Lysine is used to treat infants, they are unable to voice their distress or vocalize any side-effects they are experiencing. Patients should, therefore, be carefully monitored and medical intervention should take place if any of the following side-effects are exhibited:
If any other side-effects are noticed after treatment with Ibuprofen Lysine, medical assistance should be sought.
Parents, guardians, caregivers and healthcare practitioners should also be aware of the symptoms of an Ibuprofen Lysine overdose. If too much of this medication is given, patients will need emergency medical treatment. The symptoms of an Ibuprofen Lysine overdose can include, but are not limited to:
When babies are treated with Ibuprofen Lysine, they are typically given three doses of the medication, administered intravenously. Generally, the initial dose is 10mg of Ibuprofen Lysine per kilogram of bodyweight, whilst the second and third doses are 5mg of medication per kilogram of body weight. The second and third doses are usually administered 24 and 48 hours after the initial dose of Ibuprofen Lysine.
Although the above dosing information represents the standard treatment for patent ductus arteriosus, every patient will be assessed individually. Doctors may, therefore, alter the patient's dose, depending on their clinical presentation.
If the ductus arteriosus blood vessel does not close following the treatment outlined above or if the blood vessel re-opens, further treatment with Ibuprofen Lysine may be administered.
As Ibuprofen Lysine is given intravenously in a clinical setting, parents, guardians and caregivers will not be required to calculate the patient's dose or administer the medication.
As some medications can interact with others, doctors may not treat a premature baby with Ibuprofen Lysine if they are already being treated with:
In addition to this, the use of Ibuprofen Lysine is not normally recommended if the patient is also being treated with any of the following:
Although the use of Ibuprofen Lysine is not usually recommended alongside the above medicines, doctors may decide that it is in the patient's best interests to proceed with treating using more than one of these medications.
Parents, guardians and caregivers should also be aware that the patient may experience more side-effects if Ibuprofen Lysine is used in conjunction with any of the following medications:
If the patient has been diagnosed with any other medical conditions, it may affect their treatment with Ibuprofen Lysine. The following conditions can be particularly relevant if treatment with this medication is being considered:
Ibuprofen Lysine can change how a patient reacts to an infection. If parents, guardians or caregivers notice the baby exhibiting the following symptoms, they should notify their physician immediately:
Ibuprofen Lysine may affect the action of platelets in the blood and, therefore, the blood's ability to clot. If parents, guardians or caregivers notice the baby is experiencing any of the following symptoms, they should obtain medical help straight away:
Typically, Ibuprofen Lysine is stored in single-use vials. These vials should remain sealed until they are ready for use and the medicine should be administered within thirty minutes of being prepared. In most cases, Ibuprofen Lysine can be stored at room temperature but should be protected from light.
However, Ibuprofen Lysine does not generally contain preservatives. Due to this, solution should not be kept once the vial has been opened.
As this medicine is administered by a qualified healthcare practitioner in a clinical setting, parents, guardians or caregivers should not be required to store Ibuprofen Lysine at home.
Whilst it's not uncommon for premature babies to be born with health issues, advancements in medical science mean that many premature babies can be treated successfully. If an infant is born with patent ductus arteriosus, Ibuprofen Lysine can be administered intravenously in order to close the blood vessel.
As the medicine can be given over a fifteen minute period, the procedure can be carried out fairly quickly and is often successful after the first course of treatment. Once Ibuprofen Lysine has been used to successfully close the blood vessel, the pressure on the patient's heart and lungs is reduced and they are, therefore, less likely to suffer from additional complications.