Icatibant (Subcutaneous)

Overview

Icatibant treats and manages sudden incidents caused by hereditary angioedema (HAE). It also lessens the severity of symptoms. However, the medication is not a cure for this immune system disorder passed through hereditary DNA. The events can happen at any time; stress, injury or an illness can prompt an episode.

Individuals treated for this condition need to recognize the symptoms, since they can occur without warning. Left unattended, serious consequences include disfigurement, disability and death.

Icatibant is approved for self-administration or administration by a health care professional. Its safety and effectiveness has not been established for patients younger than 18 years of age.

The medication is injected into the abdominal area. Be sure to follow your doctor's instructions when self-administering. If your symptoms persist, contact the doctor immediately. Do not use more than three doses within 24 hours.

Conditions Treated

  • Hereditary angioedema (HAE)

Type Of Medicine

  • Anti-inflammatory

Side Effects

Some side effects appear at the start of treatment and fade away as your body adjusts to the medication. The level of effect due to family genetics is manageable with proper care and following your doctor's instructions for using this medicine.

It's important to share all of your health, medical and family history with your doctor. The information will help in predicting how you may react to this medicine. Your doctor will have solutions for prevention or relief of side effects.

All medicines have some level of side effects that vary from person to person. The level of effect from taking this medicine depends on the individual's history of health conditions. If you have a sudden attack affecting the throat or the upper airways, be sure to administer the prescribed injection and seek medical assistance. An attack in these areas will cause breathing problems. The side effects associated with this medicine range from mild to serious, if they don't receive proper medical attention. If you are taking medicines for allergies related to breathing difficulties, let your doctor know.

Here's a list of the most common, least common, allergic and injection site side effects that have occurred. If you experience mild effects that get worse or persist for longer than a week, contact your doctor.

There are other effects not listed that may occur. If you experience other effects that are not listed, contact your doctor. The effects may be related to your current lifestyle routines.

Most common

  • Chills
  • Discoloration of the skin
  • Fever
  • Hives
  • Inflammation
  • Swelling

Talk with your doctor about the effects. Not all effects are visible. The doctor needs to know how your body is responding to the medicine. Not all situations need medical attention, but it's important for your doctor to know how you are feeling. Do not stop taking the medicine or change the dose without your doctor's approval.

Least common

If any of these effects occur and cause you stress, seek medical attention for your own comfort. Allergic reactions are rare, but they can be triggered by introducing new medications. Sometimes, an adjustment to existing medicines will help prevent a side effect.

If you have known allergies before starting this treatment, tell your doctor. Individual medical decisions are based on your past and current health events. If you notice any other effects, tell your doctor.

Less than 10% of treated individuals experienced adverse effects with this medicine. Less than 2% experience dizziness. 10% of treated individuals experienced injection site reactions.

Serious allergic reactions

  • Dizziness
  • Itching
  • Rash
  • Swelling in the face, tongue or throat
  • Trouble breathing

Injection site reactions

  • Bruising
  • Burning sensation
  • Pain
  • Redness
  • Swelling

Dosage

Some individual prescriptions are self-administered at home, while other patients may receive treatment at the hospital. Depending on the dose and the severity of your condition, it's important to follow your doctor's instructions and read the product label about precautions.

If this is a new medicine for you, your pharmacist can explain how to administer it and get them to answer any questions you have.

The information below includes only guideline dosages of this medicine. The volume of medicine you take depends on the strength of the medicine. Your doctor will prescribe the number of doses you should take each day and the time allowed between doses. Take the medicine exactly as you are instructed to by the doctor. If you have questions, ask your doctor or pharmacist before administering the medicine.

Your doctor will monitor your condition. If you recognize unusual changes in your body as a result of or reactions to the medication, tell your doctor. Before self-administering, be sure to wash your hands with soap and water.

  • Check the prefilled syringe and make sure the fluid is clear and colorless.
  • If the liquid is cloudy, do not administer 'use another syringe.
  • Administer the dose into the injection site as directed by your doctor.
  • Discard the supplies as instructed¬†' do not reuse the supplies or share this medicine.

For Hereditary Angioedema

Adults

  • 30 milligrams (mg) or 3 milliliter (ml) injected under the skin.
  • Additional doses may be prescribed every six hours for recurring or persistent symptoms.
  • Maximum is three doses over each 24 hour period.

Children

  • Your doctor will determine the dose.

Missed dose

If you miss a dose, take it as soon as possible. The only exception is if it is almost time to take the next dose; in this case, skip the missed dose and continue with your normal schedule. Contact your doctor about the missed dose. Do not double the dose as you could trigger a serious side effect.

Overdose

In any situation when an accidental or unintended overdose occurs, contact emergency assistance immediately. If a child is involved in this overdose, contact the pediatric poison information center in your area for instructions.

Interactions

Medicines are intended to improve our health. In most cases, they work well together, but there are certain medication combinations that cause unwanted interactions. Icatibant has shown to work effectively with other medicines for managing HAE. The doctor will monitor your responses and adjust the doses of the drugs when necessary to maintain your health during treatment.

Prescription medicines, as well as health supplements, herbal remedies and over the counter treatments, can cause side effects. Your lifestyle choices regarding alcohol and tobacco intake, exercise and specific foods also affect your body's response to medications.

There are health conditions requiring the use of multiple medications and doctors monitor the interactions for any change in effects or increased health risks. Because all medicines go through a development process and in many instances, they share the same chemical compounds. If you are taking multiple prescriptions, they may change the outcome of treatment due to the chemical quantities.

If you have been taking certain medications daily for a long time, let your doctor know. It could change how you respond to this medication. If you recognize changes in your health or the condition being treated talk with the doctor. The changes could be an interaction between the two medicines.

If you are taking the medicines listed or medicines that share similar ingredients, tell your doctor. There are medications not listed that interact with this condition. Your doctor will check your medications you are taking to verify if there are noted interactions.

  • Benazepril
  • Captopril
  • Enalapril
  • Fosinopril
  • Moexipril
  • Ocrelizumab
  • Perindopril
  • Quinapril
  • Ramipril
  • Trandolapril

Adverse reactions

There are over 500 medicines undergoing investigation or experimentation related to escalating levels of interactions when combined with icatibant. If you experience any adverse reactions, talk with your doctor. Adverse reactions are caused by drug interactions. If you are taking more than three medications daily, introducing a new medicine like icatibant can cause a reaction.

Your doctor will decide the seriousness of the reaction and whether it is caused by an unknown element in your own health history. Because most reactions are related to allergies, you may have an allergy to this medicine. The symptoms will range from mild to serious.

Existing health conditions

If you suffer from other disorders and take prescription medicines for treatment, let your doctor know. Learning to recognize the side effects of or changes in these conditions can prevent serious consequences to your health. It's important to always maintain good health. Taking all of your medications as scheduled is critical to recovery for any illness. When taking two different medicines together, the doctor will make sure both conditions are treated with workable doses to avoid serious side effects.

Warnings

There are no warnings posted on icatibant and health care reports show this medicine successful in the prevention of angioedema. There are two precautions noted when taking this medication.

  • Airway obstruction can occur during an HAE attack¬†' treatment recommendations include administering the prescribed injection and contacting medical assistance immediately.
  • Dizziness happens for some individuals' if you are experiencing this side effect, do not drive or operate machinery.

Pregnancy

During clinical tests with animals, no adverse effects were reported. If you are pregnant or planning to conceive, you should talk with your doctor before starting any treatment with icatibant.

Breastfeeding

Data determining the risk passed to the infant when using this medication is insufficient. If you are breastfeeding, talk with your doctor to discuss the potential risks to you and the health of your baby.

Pediatrics

The medication's safety and effectiveness in this age group has not been established.

Geriatric

Health studies show no specific problems related to this age group when taking this medicine. Systemic exposure is a precaution for this population and doctors are recommending regular monitoring associated with any changes to health.

Storage

Keep this medicine out of the reach of pets and children. You can store this medicine in the refrigerator or at room temperature, but do not freeze it. Refrigeration temperatures should range between 36 to 77 Fahrenheit. Keep it stored in the original package until you are ready to use it.

Be sure to discard the used prefilled syringes and all the medical supplies in a sealed container to prevent unintended handling or injuries. Ask your doctor or the pharmacist for instructions on discarding the used materials.

Summary

Overall, this medicine has been effective in controlling HAE symptoms, but not curing the disorder. Individuals taking this medicine need to follow the doctor's instruction for drug therapy and lifestyle choices. Some individuals may need to take this medicine for the rest of their life with dose adjustments. It's in your best interest to meet with your doctor and understand the benefits of this medicine compared to the health risk of not receiving treatment.