Immune Globulin Bovine (Oral)

Immune globulin bovine is used for clinical dietary management of enteropathy as well as to manage chronically loose  or frequent stools related to IBS and HIV-associated enteropathy.

It works by binding the toxic materials that bacteria produces in the intestinal tract so they cannot cause problems.


Immune globulin bovine is used as a medical food and given to patients with enteropathy whose digestive systems have a difficulty with ingesting, digesting, absorbing or metabolizing food and some nutrients. It can also be prescribed to help those with certain forms of IBS manage stools that are happening too frequently or chronically loose. This medicine may also be helpful in the restoration of a stable gut environment and proper absorption of nutrients.

This medical food works by binding toxic materials released by bacteria in the intestinal tract. Once the materials are bound together, they are less likely to penetrate through the intestinal lining and cause problems.

Conditions Treated

  • Enteropathy

Type Of Medication

  • Digestant

Brand Names and Other Names:

  • EnteraGam

Side Effects

Besides its necessary and intended effects, immune globulin bovine sometimes causes undesirable side effects. Side effects are not common, but there is the possibility of experiencing one or more. In some cases, you may need to seek out medical attention if they appear.

You should talk to your doctor right away if you experience shortness of breath as a result of taking this medication.

There are some side effects that may occur with use of this medicine which generally do not require immediate medical attention. They should fade as your body adjusts to having the medicine in your system. A list of these side effects includes:

  • Difficulty in having a bowel movement

If you find that these effects continue for an extended period of time or are severe in nature, talk to your doctor about how to prevent or reduce their impact. You should also talk to your doctor if you have any questions about these side effects. If you experience a reaction you believe is being caused by this medication that has not been mentioned already, discuss it with your doctor or pharmacist.

The situation happens rarely, but it is possible for a severe allergic reaction to occur while taking this medicine. If you find yourself experiencing signs of this kind of reaction, seek medical attention immediately. Symptoms of a severe allergic reaction include:

If you have any questions or concerns about possible adverse reactions to this medication, talk to your doctor about them at your next appointment.


Always follow the directions given by your doctor when taking immune globulin bovine. You should not take any more or less of it than the directions state. You should also not take it any more often than directed, and you should not use it for a longer amount of time than your doctor has directed you to take it. Doing these things increases your chances of experiencing side effects.

Adults using this medical food for clinical dietary management of their enteropathy should use one single packet every day, either as one dose or divided into morning and evening doses.

Children older than the age of two should be given one-half of a packet, either as one dose or divided into morning and evening doses.

If it is needed for a child under the age of two, follow the instructions given by your doctor when it comes to use of and exact amount per dose.

Immune globulin bovine can be taken with or without food.

Should you miss a dose, take it as soon as you are able after realizing you missed the dose. If it is nearly time for you to take the next dose, though, skip the dose you missed and take the next dose at the time you regularly take it. Do not take two doses at the same time.

Instructions for using immune globulin bovine:

  • Empty the packet into a cup or glass.

The information stated above is the manufacturer's recommendation for using this medicine. When in doubt, follow the directions your doctor has given you. Your doctor uses them as a starting point when determining the right instructions and dosage amounts for you specifically.

Types of Interactions

Although the usage of immune globulin bovine is intended to help manage conditions such as enteropathy or IBS, it can interact within your body in a negative fashion under certain conditions. It may be a medication you are taking, something you are eating, or another medical condition you have. Discuss the risk of negative interactions with your doctor.

Drug Interactions:

There are no reports of drugs (prescription or over-the-counter), vitamins, or nutritional supplements that have negative interactions with this medicine. Even so, it is still a good idea to make sure your doctor is aware of anything you are taking, whether it is for treatment of another medical condition or for your overall health.

Food and Drink Interactions:

There are no specific foods or drinks known to interact with this medication. However, you should inform your doctor of the foods you eat on a regular basis. It is possible for there to be interactions that are not widely reported.

Disease Interactions:

There is one medical condition known to have a negative interaction with immune globulin bovine, which is an allergy to beef.

While there may not seem to be many interactions listed, it is always possible for this medication to have a negative interaction with something you are already taking, something you are eating or drinking, or some other medical condition you have. While you are discussing your diet, lifestyle choices, and current medical condition with your doctor, you should also give your doctor a list containing the names of all of the medications you are taking.


As much as possible, keep any appointments you make with your doctor. They will need to check on your progress as well as the continuing effects of immune globulin bovine on a regular basis.

If you experience shortness of breath or trouble breathing, call your doctor immediately.

Do not take this medication if you are allergic to beef or immune globulin bovine.

Tell your doctor if you are pregnant or breastfeeding. There may be risks associated with using immune globulin bovine during this period of time. You and your doctor will need to discuss the risks and benefits associated with it.

Storage Instructions

Store immune globulin bovine in a closed container in a place that stays at room temperature. Keep the medicine away from sources of heat, such as an oven or stove in the kitchen. Also keep it away from sources of moisture, such as a sink or the shower in your bathroom. Do not leave the packets sitting in a part of your home where they can be exposed to direct sunlight, such as a windowsill or counter space situated underneath a window.

Make sure this medication is stored somewhere that is safely out of reach of children and pets.

Be sure to dispose of any packets of the medicine that have expired or that you are not using once your doctor tells you to stop.

Disposal Instructions:
When you have finished treatment with immune globulin bovine or when the medication is past its expiration date, you should make plans to properly dispose of it.

Do not hold onto extra doses once you are done taking it. While it may seem like a good idea, it is not necessary to do so.

Unless you have been instructed to, do not dispose of this medication by flushing it down the toilet, or by pouring it down the sink.

Make sure to discuss appropriate disposal methods for this medicine with your doctor or pharmacist.


Immune globulin bovine can be helpful in restoring stability to the gut environment for patients with enteropathy, IBS, and other conditions that affect the intestinal tract. However, there are problems that can occur while taking it that only a doctor can determine. A doctor can only do this if their patient is willing to have open and honest conversations with them about their medical history and current condition. Patients need to open up about everything from their daily habits to the medications they take on a regular basis, no matter how embarrassing or difficult it may feel to do so.

It is always in a patient's best interest to talk about these things with their doctor. Once a doctor has this information, they can help patients create the best possible treatment plan.

At their best, conditions like enteropathy and IBS are an inconvenience for patients who have them. At their worst, they can be debilitating. With the right treatment plan in place, medications like immune globulin bovine allow these patients to go about their daily lives and enjoy a better quality of life.


  • Immune Globulin Bovine:
  • Diarrhea-predominant irritable bowel syndrome (IBS-D)
  • Immune Serum
  • Headache
  • Increase in how often/how much you need to urinate
  • Nausea or stomach cramps
  • Swelling in the face or hands
  • Swelling or tingling in the mouth or throat
  • Tightness in the chest area
  • Difficulty breathing
  • Always add at least 4 ounces of water (or another liquid you would prefer to drink, with the except of hot liquids).
  • Stir the liquid and powder until they are completed mixed together, then drink. Do not shake the mixture.
  • If you need to, you can mix the powder in with pudding, yogurt, or other similar foods.
  • EnteraGam FAQs:
  • Mayo Clinic Immune Globulin Bovine:
  • U.S. National Library of Medicine Immune Globulin Bovine (By Mouth):
Last Reviewed:
March 26, 2018
Last Updated:
April 23, 2018