Iodoquinol (Oral)

Iodoquinol is an element of a group of antiprotozoal medication which treats infections caused by protozoa.

Overview

Iodoquinol is part of a collection of medicines called antiprotozoals which treat infections caused by protozoa, tiny, microscopic one-celled animals. Only available by a physician's prescription, iodoquinol most often treats amebiasis, which is an intestinal infection caused by a parasite (Entamoeba histolytica); however, this medication may have uses for other types of infections if designated by your physician.

Treatment with iodoquinol, which contains iodine, may cause harmful effects should a patient take other medication that interacts with iodoquinol as the body tries to process the product. Patients with eye, liver, or kidney disease must inform their physician of their medical issues beforehand as their condition may worsen as a result of using this medication. In some cases, iodoquinol may cause an increased chance of side effects in patients with kidney, liver or thyroid disease or cause further deterioration of eye disease.

Iodoquinol is used for a 20-day period and works best when the amount of medication is kept at a consistent level, therefore, this drug must be taken at regularly spaced intervals. The full prescribed amount of medication must be finished regardless of whether the patient starts to feel better within a day or two. If the use of this medication stops early, consequently, there is a chance of the infection returning.

To prevent re-infection, the patient should wash their hands and scrub their fingernails often and have a shower or bath every day. It is crucial that all clothing, undergarments, towels and bed linens be washed in hot water and dried thoroughly in order to prevent anyone else from becoming infected.

One of the most important details concerning the usage of iodoquinol is to take caution when driving or working on complex or risky activities until the effects of the medication are recognized by the patient. Dizziness or visual abnormalities may be caused by iodoquinol and should be reported to your doctor as soon as possible.

Conditions Treated

Intestinal infections:

  • Amebiasis
  • Balantidiasis

Type Of Medicine

  • Amebicide, Intestinal
  • Halogenated Hydroxyquinoline

Side Effects

Contact your physician or healthcare professional at once if any of the following side effects transpire:

Less common:

  • Chills or fever
  • Itching, hives or rash
  • Neck swelling

High dosage with long-term use ' particularly in children:

  • Eye pain
  • Increase in weakness
  • Instability
  • Muscle pain
  • Numbness
  • Vision changes

Certain side effects may not need medical attention during this treatment as the body adjusts to this medication. Your physician may inform you of ways to decrease or avert some of these side effects, and, as a result, constant contact with your healthcare practitioner will help to answer any questions about them. If needed, the patient may contact the FDA at 1-888-FDA-1088 to report any side effects.

More common:

  • Bowel disorders
  • Stomach issues
  • Vomiting

Less common:

Dosage

Iodoquinol should be taken after meals to lessen stomach issues unless as otherwise prescribed by your healthcare practitioner. If the patient is unable to swallow the tablet whole, the medication may be crushed and mixed with a small amount of chocolate syrup or applesauce.

Ordinarily, the number of doses taken each day plus the time allowances between doses will depend on the medical problem of the patient. A healthcare practitioner will prescribe the dosage that best suits the patient's needs which may be based on an average or stronger dose of this medication.

For amebiasis:

  • Adults ' 630 or 650mg three times a day for 20 days except where severe or moderate cases of intestinal or extraintestinal amebiasis which may require additional medication
  • Children ' the dosage is based on body weight and would be determined by a physician. The average dose is 10 to 13.3mg per kilogram (4.5 '6mg per pound) of body weight three times a day for 20 days.

For balantidiasis:

  • 650mg three times daily for 20 days. Iodoquinol is used as an alternative if tetracycline is not available.

In order for the infection to clear up properly, this medication must be taken for the full treatment time. Should a dose of the medication be missed, it must be taken as soon as possible that day or as regularly scheduled.

A patient should never use a double dose of this product or continue to take the medication longer than necessary unless otherwise instructed by their physician. If there is suspicion of an overdose, the patient should contact their physician or poison control immediately.

Major Drug Interactions

Two major drugs, four brands and generic names interact with iodoquinol while 99 moderate drugs interact with this medication. As a recommendation, it is necessary to avoid combining any of the major drugs listed as the risk outweighs the benefits.

Major:

  • Cholera vaccine, live
  • Sabril (vigabatrin)
  • Vaxchora (cholera vaccine, live)
  • Vigabatrin

This is a partial list of moderate drug interactions that may interact with iodoquinol. Although it is best to avoid the mixtures of these medications with iodoquinol, under specific circumstances, these combinations may be used by adjusting the dosage or monitoring the patient during treatment.

Moderate:

  • Advicor (lovastatin / niacin)
  • Aspirin
  • Bortezomib
  • Bismuth subcitrate potassium / tetracycline
  • Caduet
  • Crestor
  • Dapsone
  • Didanosine
  • Enbrel (etanercept)
  • Epivir
  • Flagyl (metronidazole)
  • Gold sodium thiomalate
  • Humira
  • Hydroxychloroquine
  • Interferon
  • Jevtana (cabazitaxel)
  • Kyprolis (carfilzomib)
  • Lipitor (atorvastatin)
  • Lovastatin
  • Metronidazole
  • Niacin / simvastatin
  • Pacerone (amiodarone)
  • Red yeast rice
  • Secnidazole
  • Stavudine
  • Thalidomide
  • Tinidazole
  • Vinblastine
  • Vytorin (ezetimibe / simvastatin)
  • Xalkori (crizotinib)
  • Yervoy (ipilimumab)
  • Zafirlukast
  • Zalcitabine

Warnings

This medication may cause loss of vision or blurred vision; therefore, it is important for the patient to ensure that they know what type of reaction occurs from the use of this product. Accordingly, caution is advised when driving or using machines if the patient's vision is impaired.

Nevertheless, it is essential for the patient to inform their physician if they partake in regular testing of their thyroid before using this medication or should they have an allergy to iodine.

Although iodoquinol does not have an assigned category by the FDA, there are no specific studies with regard to pregnant women or women who breastfeed while taking this medication. Therefore, care should be taken if a patient is taking this medication while breastfeeding or during the pregnancy as the benefits must outweigh the risks in every situation.

Children are more likely to develop some side effects, especially if a high dose of this medication takes place over a long period of time.

There is an unknown factor as to whether this medication works the same way in younger adults as older adults. There is no particular information regarding iodoquinol in the elderly with respect to different age groups. Older adults with liver, kidney and thyroid conditions must inform their physician of these issues prior to using this product.

The patient should also inform their physician of any allergic reactions to any other medicine, preservatives, foods, animals or dyes.

Other medical problems

Certain medical conditions will affect the use of iodoquinol and it is necessary to notify your physician if you suffer from any of the following:

  • Eye disease
  • Liver disease
  • Kidney disease
  • Nerve problems
  • Thyroid disease

Storage

These tablets must be stored in a tight, closed container at room temperature'between 59-86 degrees F (15-30 degrees C) away from direct light, moisture and heat. Freezing iodoquinol tablets should never take place or have storage in any bathroom.

An important reminder for the patient is that this medication be kept out of the reach of children and pets and any outdated or unused medicine disposed of as directed by a physician or pharmacist. Do not flush medication down the toilet or drain unless instructed by a healthcare professional.

Summary

As a significant part of a patient's treatment with iodoquinol, the patient must continue using the medication during the 20-day time period even if they are feeling an improvement in their health. The patient should disclose any vitamins, herbal supplements, medications, or over-the-counter products they have been using as well as informing their healthcare practitioner of any allergy-related problems, including that of iodine.

Patients with thyroid, liver, eye or kidney disease should refrain from using this medication as it may worsen their condition. Iodoquinol can create unusual thyroid function test results for up to six months after discontinuing the medication, and, for that reason, the patient must disclose if they have used iodoquinol to all healthcare providers.

The patient should pay particular attention to any side effects or visual abnormalities that might occur while taking this product and inform their healthcare practitioner as soon as possible of any further discomfort while using this medication.

Discuss your diet with your physician as certain foods or beverages may also interact negatively with iodoquinol. As with any medication, the patient should communicate with their physician about the risks of taking iodoquinol and whether these risks outweigh the benefits for their individual case.