Ioversol (Injection)


In order to confirm whether patients are suffering from particular conditions, various tests must be carried out. If doctors suspect a patient has a heart condition, for example, an angiography enables them to examine the heart in minute detail and confirm whether a problem exists and, if so, what part of the heart is failing to function normally. Similarly, CT scans can be used to examine any part of the body and to diagnose numerous medical conditions.

If diagnostic tests are to be successful, however, it's essential that doctors can obtain accurate data from them. In the case of imaging tests, such as scans and x-rays, physicians must be able to see the results clearly in order for them to be able to make an accurate diagnosis.

To ensure that clear images are available following a diagnostic test, a contrast agent may be used. As a diagnostic contrast medium, Ioversol can be administered prior to medical tests or during the procedure itself.

Administered via intravenous injection, Ioversol highlights the relevant blood vessels or structures and enables physicians to determine where blockages occur. Alternatively, if the contrasting agent leaks into another, physicians may be able to confirm that a bodily structure in unstable and in need of repair.

Regardless of what type of condition the patient may have, an accurate diagnosis is the first step to obtaining the right treatment. By using a contrasting agent, such as Ioversol, physicians can carry out more accurate diagnostic tests and prevent patients from having more invasive tests. As diagnostic contrast mediums allow for greater accuracy, a diagnosis can be made more quickly and, if required, treatment can then commence.

Conditions Treated

  • Used as a diagnostic contrast medium

Type Of Medicine

  • Radiopaque contrast agent

Side Effects

Once Ioversol has been administered, patients may experience some side-effects. If the following side-effects are fairly mild, they may not require additional medical treatment:

  • Bad taste
  • Vomiting
  • Dry mouth
  • Collection of blood under the skin
  • Pale skin, redness or pain at the site of the injection
  • Deep, dark purple bruise

Whilst the above side-effects may be fairly mild, patients should obtain medical advice if they experience severe adverse effects or if their side-effects are prolonged.

Patients will also need to obtain immediate medical help if they develop the following side-effects after being given Ioversol solution as a contrast agent:

  • Jaw, back or arm pain
  • Hoarseness
  • Blood in the urine or stools
  • Hives
  • Blue fingernails and lips
  • Welts
  • Blurred vision
  • Itching
  • Crawling, burning, numbness, itching, tingling, prickling or "pins and needles" feelings
  • Rash on the skin
  • Bruising
  • Lightheadedness, faintness or dizziness when getting up suddenly from a sitting or lying position
  • Changes in skin color
  • Fainting
  • Chest discomfort or pain
  • Headache
  • Chest heaviness or tightness
  • Feeling of constant movement of surroundings or self
  • Confusion
  • Increased sweating
  • Coughing
  • Vomiting or coughing up blood
  • Pale skin
  • Coughing that sometimes produces a frothy pink sputum
  • Tenderness, swelling or pain in the leg or the foot
  • Decrease in the frequency of urination
  • Pains in the groin, chest or leg, particularly in the calves of the leg
  • Decrease in urine volume
  • Fast, noisy, difficult breathing, sometimes with wheezing
  • Painful urination
  • Difficulty in passing urine (dribbling)
  • Nervousness
  • Severe headache with a sudden onset
  • Difficulty with swallowing
  • Nausea
  • Sensation of spinning
  • Lightheadedness or dizziness
  • Seizures
  • Persistent oozing or bleeding from mouth, nose or puncture sites
  • Agitation
  • Pounding in the ears
  • Unusual weakness or tiredness, may be severe
  • Rapid weight gain
  • Loosening, peeling or blistering of the skin
  • Redness of the skin
  • Chills
  • Severe numbness, particularly on one side of the body or face
  • Irregular, fast or slow heartbeat
  • Coma
  • Irregular or slow breathing
  • Confusion
  • Stupor
  • Depression
  • Sudden loss of coordination
  • Diarrhea
  • Sudden onset of shortness of breath for no apparent reason
  • Extremely high body temperature or fever
  • Sudden onset of slurred speech
  • Fast, shallow breathing
  • Sudden vision changes
  • Fast, weak heartbeat
  • Sweating
  • Fever
  • Swelling around the eyes
  • Hostility
  • Swelling in the ankles and legs
  • Irritability
  • Sore throat
  • Large, hive-like swelling on the eyelids, tongue, hands, feet, legs, face, lips, throat, hands or sex organs
  • No sensation in the legs
  • Lethargy
  • Inability to move the legs
  • Muscle cramps
  • Thirst
  • Muscle twitching
  • Clammy, pale skin
  • Not able to pass urine
  • Irritated, red eyes
  • White spots, ulcers or sores on the lips or in the mouth
  • Tenderness, warmth, pain, skin discoloration, swelling and prominent superficial veins over the affected area

If patients experience any side-effects which are not listed above, they should also obtain medical advice.


As patients are given Ioversol prior to or during a diagnostic test, the contrast agent will be administered in a clinical setting, such as a treatment center or a hospital. Ioversol will be delivered into the patient's vein via a needle and will be administered by a healthcare professional.

Ioversol can be used to facilitate numerous different types of medical tests and the patient's dose will depend on the type of test they are due to undergo. In addition to this, the strength of Ioversol solution used will affect how much of the contrast agent the patient is given.

If patients are due to undergo an aortography, for example, they may be given 10-80 milliliters of Ioversol, although the average dose for this procedure is 45 milliliters. This may be increased if necessary but patients are not normally given more than 250 milliliters of Ioversol during this procedure. When Ioversol is delivered in this volume for the purposes of an aortography, a solution of 320mg/mL is normally used.

Alternatively, if patients are undergoing a head imaging scan, they may be given 50-150 milliliters of Ioversol at a strength of either 300mg/mL or 320mg/mL. Instead of this dose, patients may be given 100-250 milliliters of Ioversol solution at a strength of 240mg/mL.

As Ioversol takes effect very quickly, patients will usually be given the contrasting agent immediately before the procedure is carried out. If necessary, additional Ioversol may be administered during the procedure.

Patients will be monitored whilst receiving Ioversol and will not have to calculate or administer the contrast agent themselves.

Potential Drug Interactions

Although some medicines can be used in conjunction with one another, this is not applicable to all medications. If used together, some medicines can have a potentially harmful effect if an interaction occurs between the two substances. Due to this, the use of Ioversol is not normally recommended if patients are taking the following medicine:

  • Metformin

As well as interacting with other prescription medicines, Ioversol could interact with over-the-counter medication, supplements and/or vitamins. Patients should tell their physician if they have used any of these substances before is administered and should obtain medical advice if they plan to take or use any medicines, vitamins or supplements after being given Ioversol.


If patients have existing medical conditions or a history of certain conditions, it may affect the use of Ioversol. Due to this, patients should discuss their existing health and their medical history with their physician before Ioversol is prescribed. The following conditions are particularly relevant if the patient is due to be given Ioversol:

Although Ioversol may be administered to pediatric during diagnostic procedures, only Ioversol at a strength of 320mg/mL and 350mg/mL for use in angiographies and 320mg/mL for use in CT scans has been tested in this population. Due to this, pediatric patients may not be given Ioversol for other types of tests and may not be prescribed Ioversol at different strengths.

Ioversol can increase the risk of patients suffering heart attacks, blood clotting problems and/or strokes when it is used during angiographic procedures. Patients must inform their physician immediately if they experience any of the following symptoms:

  • Trouble breathing
  • Unusual sweating
  • Nausea
  • Cheat pain which may spread to the jaw, arms, back or neck
  • Severe or sudden headache
  • Faintness
  • Coughing up blood
  • Weakness or numbness in one leg or arm or along one side of the body
  • Problems with walking, speech or vision

After Ioversol has been administered, patients could experience severe kidney problems, particularly if too much Ioversol solution has been used. If patients notice any of the following symptoms, they should notify their physician immediately:

  • Decreased urine output
  • Confusion
  • Agitation
  • Dizziness
  • Muscle twitching
  • Headache
  • Swelling of the ankles, face or hands
  • Rapid weight gain

If patients suffer from any of the following symptoms, they should inform their doctor straight away:

  • Feeling or warmth of coldness at the injection site
  • Mild burning pain or redness at the injection site
  • Swelling or peeling of the skin at the injection site

When patients are undergoing diagnostic tests using Ioversol, they may be exposed to radiation. If patients are concerned about the risks that radiation poses, they should discuss this with their physician before the test is carried out.

Ioversol can affect the results of some medical tests. Patients should inform any healthcare professional who examines them that they have been treated with Ioversol solution. Patients will need to inform their dentist that they have been given Ioversol, if they are due to undergo any dental work.

It is not known whether Ioversol poses a risk to the unborn fetus if it is administered to pregnant patients. However, it's believed that Ioversol does cross the placenta and reaches fetal tissue. Due to this, the risk of Ioversol causing harm to an unborn fetus cannot be ruled out. If patients are pregnant, they should notify their physician before Ioversol is administered. Unless necessarily, Ioversol should not be administered to pregnant patients and should only be used if the benefits clearly outweigh the risks.

Currently, it is not known whether Ioversol passes to infants via breastmilk. However, other contrasting agents are known to be transferred in this way. Due to this, patients may be advised to suspend breastfeed once Ioversol has been administered. Patients should consult with their physician in order to determine when they can resume breastfeeding.

Before being given Ioversol, patients should tell their physician if they have any allergies or if they have ever experienced an allergic reaction when given a contrasting agent and/or iodine. In some cases, Ioversol can cause a serious allergic reaction involving anaphylaxis. If patients exhibit the following symptoms, they will need emergency medical treatment:

  • Rash on the skin
  • Itching
  • Shortness of breath
  • Wheezing
  • Sweating
  • Tightness in the chest
  • Swelling of the tongue, throat or face
  • Difficulty swallowing
  • Hoarseness
  • Hives
  • Difficulty breathing


Ioversol solution should be stored in accordance with the manufacturer's instructions and/or the medication guidelines. Generally, Ioversol should be stored at approximately 25?C (77?F), although it may be stored at temperatures between 15?-30?C (59?-86?F). Ioversol may be stored at a warmer temperature for one month if a contrast media warmer is used. However, Ioversol should be protected from direct light and/or sunlight.

As Ioversol is administered in a clinical setting by a healthcare professional, patients will not have to store this substance themselves.


In order for patients to access successful treatments, it's vital that they have an accurate diagnosis. When Ioversol is used as a contrasting agent, the accuracy of diagnostic tests can be increased. As a result, the use of Ioversol can ensure that patients are able to obtain an accurate diagnosis as quickly as possible and that they can base their treatment decisions on reliable diagnostic data.

As well as being used during diagnostic procedures on adult patients, Ioversol may be prescribed to pediatric patients for some types of diagnostic tests. In addition to this, Ioversol solution can be used during numerous types of diagnostic tests. Due to this, Ioversol is a much-used contrasting agent and is one of the most commonly-used contrast mediums.