Iron Sucrose (Intravenous)

Overview

Iron sucrose treats anemia in people suffering with kidney disease. In most cases, individuals undergoing dialysis are subject to blood loss, causing the deficiency. Other cases where people are in need of iron sucrose treatments occur as a result of poor nutrition, where people's diets fail to produce sufficient amounts of iron for the body to produce new red blood cells. Sometimes, certain drugs can cause a similar effect, preventing the absorption of iron.

Iron is a necessary mineral and essential as a nutrient to help product red blood cells 'without it, we experience physical fatigue, slowing down our brain functions and the immune system's ability to fight infections. Women are more susceptible to disorder, but it does happen in men and children because of either poor diets or a health condition.

Concerns associated with iron deficiency:

  • Delayed development of motor functions and processing skills in newborns.
  • High risk during pregnancy for smaller or early term birth, leading to illness and sometimes fatal consequences.
  • Chronic fatigue may impair physical work abilities and mental functions for adults and adolescents.

The medicine is administered intravenously as directed by the doctor. The dosage and duration of treatment depends on the individual's health, age and response to treatment. Laboratory tests are done routinely to watch the patient's response and blood health.

Conditions Treated

Type Of Medicine

  • Anti-anemic iron supplement

Side Effects

All medicines have levels of side effects that vary from person to person. The levels of effects when taking this medicine depend on the individual's history and current health conditions. Side effects associated with this medicine range from mild to serious.

The following list details the most common, least common and rarest effects known to occur when taking this medicine. If you experience mild effects and the effects worsen or persist beyond a week, contact your doctor immediately. There are other effects not listed that may occur. If you discover other effects not on the list, tell your doctor.

Most common

Talk with your doctor about the effects. Not all situations need medical attention, but it is important to tell your doctor if you experience new side effects. In the meantime, do not stop taking any of your medicines without the doctor's approval.

Least common

  • Abdominal pain
  • Chills
  • Ear congestion
  • Fever
  • Increased thirst
  • Itching
  • Pain at the injection site
  • Runnynose
  • Sore

Allergic reactions are rare, but they can be triggered by introducing new medications. If you have known allergies before starting this treatment, tell your doctor. Individual medical decisions are based on your past and current health events. If you notice any other effects, tell your doctor.

Rare

  • Excessive tearing
  • High blood pressure
  • Itching eyes

Other side effects

Many patients don't realize the seriousness of the effects that prescription, non-prescription and self-imposed health treatments have on our overall health. Lifestyle choices about alcohol, tobacco, exercise routines and specific foods also affect your body's response to medications. Be sure your diet includes foods rich in vitamins and minerals to support your body's iron production.

You need to learn how to recognize the side effects and pay attention to the changes when adding a new medicine. It's the first step to managing good health.

Dosage

Based on your medical history and current health status, the doctor will decide the dose and duration of treatment. A trained medical professional administers this medication. Iron sucrose is mixed with a saline solution and intravenously administered slowly into your vein.

The following information includes only the average doses of this medicine. This medicine should be administered exactly as instructed by the doctor to ensure your body is able to accept the medicine to improve your health condition. If you have questions, ask the doctor or your pharmacist.

For iron deficiency anemia

Adult' Hemodialysis dependent chronic kidney disease

  • 5 milliliters (ml) equivalent to 100 milligrams (mg) undiluted' two to five minutes IV
  • 5 ml equivalent to 100 mg diluted '15 minutes IV
  • Maximum cumulative dose 1000 mg

Non-dialysis dependent chronic kidney disease

  • 10 ml equivalents to 200 mg undiluted two to five minutes IV
  • Consecutive treatments within a 14 day period
  • Maximum cumulative dose 1000 mg

Adult' Peritoneal dialysis dependent chronic kidney disease

  • 2 infusion of 15 ml equivalent to 300 mg' diluted in a maximum of 250 ml ' 90 minutes IV 14 day apart.
  • 3 infusion of 20 ml equivalent of 400 mg' diluted in a maximum of 250 m' 150 minutes IV over 14 days after second infusion
  • Maximum cumulative dose 1000 mg over a 28 day period

The doctor may recommend an alternative dose treatment using this medication.

Adult - Iron deficient anemic chronic kidney disease

  • 500 mg in 200 ml normal saline IV over three hours' two consecutive days

For children and adolescents aged 2 to 17 years, the doctor will decide. Dosages for iron replacement treatments in pediatric patients is not established.

Missed dose

The effectiveness of all medicines increase when the prescribed doses are taken as instructed. If you miss a dose, your doctor will have alternatives for treatment. Most importantly, continue taking the medicine as scheduled. Try not to miss an appointment.

Interactions

Medicines are intended to improve our health and, in most cases, they work well together. However, there are certain medication combinations that cause unwanted interactions. This medicine works effectively with other medicines for managing iron deficiency. The doctor will monitor your responses and adjust the doses or the rate of delivery when necessary to maintain your health during treatment.

Some health conditions require management by multiple medications. If you are taking any of these medicines listed or you believe you are taking medicines that may share similar ingredients, tell your doctor. There are medications not listed that interact with this condition. Your doctor will check the medications you are taking to verify any noted interactions.

  • Alfuzosin
  • Amifostine
  • Antipsychotic agents
  • Barbiturates
  • Benperidol
  • Blood pressure lowering agents
  • Brimonidine
  • Dimercaprol
  • Eltrombopag
  • Mycophenolic acid
  • Zinc

Over 50 drugs out of 800 brand name and generic medicines interact with iron sucrose:

  • Two caused major effects
  • 49 triggered moderate effects

Other interactions

It's not always the medicine that causes the interactions. In some cases, dietary items, health supplements, herbs and over the counter medicines can trigger a reaction. Your own lifestyle choices, such as alcohol or tobacco, can affect the interaction of a drug.

Taking this medicine with phytic acid (antioxidant) foods slow the absorption rate of iron. Talk with the doctor or ask to see a dietary nutritionist, since most plant foods contain phytic acid.

Other medical problems

Adverse reactions are caused by drug interactions. If you are taking over three medications daily, introducing a new medicine like iron sucrose can cause a reaction.

You doctor will decide if the reaction is serious and whether treatment should be adjusted or discontinued. Because most reactions are related to allergies, you may discover you have an allergy to this medicine. The symptoms will range from mild to serious.

Warnings

The US Food and Drug Administration (FDA) posts notices intended to protect public health and offer information for consumers and industry professionals when making health decisions involving drugs or medication.

Precautions

Abnormally low blood pressure (hypotension) has been reported in patients receiving iron sucrose treatments with no serious reactions. The reaction may be linked to the rate of delivery and the total dose administered. The doctor may ask for a lab test for a complete blood count.

It is important to talk with your doctor while you are receiving this medicine. Be sure to check and monitor your blood pressure at home. If you experience any deviations from a normal blood pressure stat, contact the doctor.

Pregnancy

There are no studies in pregnant women showing adverse effects, but precautions are still advised when taking medications or going through medical therapies. If you are pregnant or trying to conceive, talk with the doctor first.

  • Studies in women suggest that this medication poses a minimal risk to the infant when used during breastfeeding.
  • The safety and efficacy of this medication has not been established for infants.

Pediatrics

For children and adolescents aged 2 to 17 years, the doctor will decide dosage. Dosing for iron replenishment treatments in pediatric patients is not established.

Geriatrics

Clinical studies have not shown any differences in response to the medicine, between elderly adults and younger adults. Medical reviews have not reported geriatric-specific problems that would limit the use of this medicine for this age group. Precautions are necessary because elderly patients have a higher risk of developing organ disorders.

Storage

Keep this medicine and any medical supplies out of the reach of children or pets. The hospital staff manages the storage of this medicine between 68 to 77 Fahrenheit. If you need to store this medicine at home, talk with the doctor. Ask your doctor or the pharmacist for instructions on discarding the used materials.

  • Do not freeze this medication.
  • Do not flush medications or dispose of them in the household trash.
  • Do not keep outdated or medicines no longer needed.

Summary

This medicine has been successful in treating iron deficiency, but there are precautions to take if you have other, blood-related disorders. The best outcome happens with regular treatments prescribed by the doctor for replenishing iron stores in the body. Without iron, our bodies can't transport the oxygen needed to product healthy blood cells that are necessary to keep our body functioning. Good health depends on sufficient amounts of iron.

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