Isoxsuprine (Oral, Injection)


Isoxuprine is often used in conjunction with other treatments to combat the symptoms of various blood vessel diseases. It functions by helping the blood vessels to widen. This increases blood flow and improves circulation to different parts of the body, including the extremities (hands, feet and digits). This helps to decrease symptoms such as cold feet or hands. It can also be effective in improving memory and judgment by encouraging greater blood flow to the brain.

This medication can also be useful as a labor suppressant or anti-contraction medication. It is typically prescribed to prevent premature birth and is often used in conjunction with betamethasone, a medication which increases the maturity of lungs in the fetus. However, this medication can take one or two days to start working, making Isoxsuprine a useful medication for creating more time for the administration of betamethasone and various other medicines, such as steroids, which can boost the development of the fetus and increase the chances of its healthy arrival in the event of a premature birth.

Type Of Medicine

  • Vasodilator

Conditions Treated

Side Effects

Like all medications, Isoxsuprine can cause some unwanted side effects along with its desired effects. The most common side effects reported by patients undergoing treatment with this medication include the following:

As the patient continues to take this medication as prescribed by a qualified doctor, many (if not all) of these side effects should begin to lessen. If side effects persist over time or appear to get worse, the patient is advised to consult their doctor as soon as possible. In some cases, a doctor or pharmacist may be able to recommend over the counter remedies or other prescription drugs to alleviate certain symptoms.

The majority of patients will only experience very minimal side effects while using Isoxsuprine' if they observe any at all. The drug is designed to alleviate blood vessel problems which can become serious if left untreated, and most doctors agree that the benefits of treating these conditions far outweigh the risks of experiencing minor side effects.

Some side effects may be increased when the drug is administered via injection, as it is distributed throughout the body in much greater concentrations in comparison to when it is ingested orally.

Other side effects may also occur, albeit very rarely. Some of the rarest side effects reported by patients using Isoxsuprine include:

  • Nausea
  • Vomiting
  • Slow heartbeat

Because this medication can cause dizziness, patients are advised to refrain from driving or operating heavy machinery in the workplace until it has been observed that this medicine does not have a detrimental effect on them.

Not all side effects may have been reported. Patients who experience side effects which are not listed in the literature supplied with this medication are advised to inform their doctor and to report their symptoms to the FDA.


Like all medications, it is incredibly important for the patient to take Isoxsuprine only as directed by a physician. The means that patients should avoid taking any more of this drug than advised, both in terms of frequency and dose size. In addition to this, the patient should also be prepared to stop taking the medication if advised to do so by a doctor, even if they still have a supply of it remaining.

Isoxuprine is available in the following dose sizes:

  • 10mg oral tablet
  • 20mg oral tablet
  • Compounding powder for injection

When taken orally, Isoxsuprine can be consumed with or without food. However, it should be taken with a glass of water. The dosage of this medication will vary according to the individual needs of the patient ' making it important for them to listen carefully to the instructions at the time this medicine is prescribed. The patient may also follow the instructions printed on the side of the packaging of this drug.

Isoxsuprine is typically taken three to four times per day. The optimal dosage will be decided by the patient's physician who will take several different factors into account, including the height, weight, age and condition of the patient.

Patients are warned against taking double doses of Isoxsuprine. In the event of missing a dose, the patient should simply take the missed dose as soon as possible, unless it is nearer the time to take the next dose. In this case, the patient should simply omit the missed dose and continue with the dosing schedule as standard from the next dose onwards.

If the patient experiences signs of an overdose (chest pain, fast heartbeat, difficulty breathing, seizures, unconsciousness) they may require immediate medical attention. In this instance, the patient or their caregiver should contact their local poison control center on 1800-222-1222 or emergency services on 911.


All drugs have the potential to interact with other medicines or chemicals within the body. These interactions can cause one or more medicines to become ineffective. In some instances, interactions can even give rise to potentially dangerous or even fatal side effects. Because of these risks, patients are advised to keep a detailed list of all medications they are currently taking. This includes complementary medicines, vitamins, herbal supplements and over the counter remedies.

The following is a partial list of medications known to interact negatively with Isoxsuprine. Patients who are currently undergoing treatment with one or more of these drugs should inform their doctor or healthcare provider prior to starting therapy with Isoxsuprine:

  • Ziprasidone
  • Verteporfin
  • Vardenafil
  • Trimeprazine
  • Triflupromazine
  • Trifluoperazine
  • Treprostinil
  • Tranylcypromine
  • Tizanidine
  • Thiothixene
  • Thioridazine
  • Thiethylperazine
  • Tadalafil
  • Sodium Nitrite/Sodium Thiosulfate
  • Sodium Nitrite
  • Sildenafil
  • Selexipag
  • Selegiline
  • Safinamide
  • Risperidone
  • Riociguat
  • Rasagiline
  • Quetiapine
  • Propiomazine
  • Promethazine
  • Promazine
  • Prochlorperazine
  • Procarbazine
  • Phenylephrine/Promethazine
  • Phenelzine
  • Perphenazine
  • Pentoxifylline
  • Paliperidone
  • Olanzapine
  • Nesiritide
  • Nefazodone
  • Molindone
  • Minoxidil Topical
  • Methotrimeprazine
  • Methdilazine
  • Mesoridazine
  • Meperidine/Promethazine
  • Maraviroc
  • Lurasidone
  • Loxapine
  • Linezolid
  • Licorice
  • Isocarboxazid
  • Iloprost
  • Iloperidone
  • Haloperidol
  • Garlic
  • Furazolidone
  • Fluphenazine
  • Fluoxetine/Olanzapine
  • Epoprostenol
  • Empagliflozin/Metformin
  • Empagliflozin/Linagliptin
  • Empagliflozin
  • Dextromethorphan/Promethazine
  • Dapagliflozin/Saxagliptin
  • Dapagliflozin/Metformin
  • Dapagliflozin
  • Codeine/Promethazine
  • Codeine/Phenylephrine/Promethazine
  • Clozapine
  • Chlorpromazine
  • Cariprazine
  • Canagliflozin/Metformin
  • Canagliflozin
  • Brimonidine Topical
  • Brimonidine Ophthalmic
  • Brimonidine/Timolol Ophthalmic
  • Brimonidine/Brinzolamide Ophthalmic
  • Brexpiprazole
  • Avanafil
  • Asenapine
  • Aripiprazole
  • Apraclonidine Ophthalmic
  • Apomorphine
  • Amyl Nitrite/Sodium Nitrite/Sodium Thiosulfate
  • Amitriptyline/Perphenazine
  • Amifostine


Most patients will require regular medical evaluations and/or blood tests during treatment with this medication to monitor progress and to ensure side effects are not causing further complications. Patients should stick to their appointments and re-arrange missed appointments as soon as is feasible.

Medications designed to treat hypertension (high blood pressure) and other heart conditions can increase the effects of Isoxsuprine. Special monitoring may be required in these instances.

Patients who develop a rash should stop taking Isoxsuprine immediately. This is because it may be a sign of a hypersensitive reaction to this medication which can potentially be dangerous.

Although Isoxsuprine is useful for preventing premature labor, it is not suitable for postpartum use (immediately after delivering a baby). It may not be suitable for patients who suffer from one or more types of bleeding disorder, either.

Isoxsuprine is a pregnancy category C medication. It is therefore unknown whether Isoxsuprine is excreted into breast milk. Official FDA guidelines suggest that this medicine should not be taken while breastfeeding. Nursing mothers are advised to discuss the benefits and risks of breastfeeding while taking pregnancy category C medications with their doctor or healthcare provider.


Isoxsuprine should be stored in the packaging it was shipped in, at room temperature. It should be kept away from sources of heat, light and moisture, therefore making it unsuitable for storage in a bathroom cabinet. Instead, the patient should keep it in a locked, dedicated medicine cabinet if possible, out of the reach of children and/or pets.

Patients who need to dispose of unwanted, unused or expired Isoxsuprine should do so in a hygienic, safe manner, and in accordance with state law and FDA guidelines. This medicine should not be flushed down a toilet or drain. Many pharmacies offer medication'œtake back  programs where medicines are recycled or disposed of free of charge ' patients are advised to avail of such programs.


While Isoxsuprine is an incredibly beneficial drug, it can also pose something of a risk to patients 'particularly when they fail to communicate properly with their healthcare providers. As a treatment designed to increase blood flow, Isoxsuprine helps to stop the extremities from feeling cold and can even help improve cognitive ability. In pregnant women who are about to give birth prematurely, it can help to prevent the early arrival of the baby, giving it a greater chance of survival.

However, this medication can produce feelings of dizziness, impairing the day-to-day function of the patient. It may also interact with other medicines, potentially worsening certain conditions. To avoid this, the patient should be honest and forthcoming about their current medication regimen.

When taken correctly, Isoxsuprine can help to provide relief to conditions which affect the blood vessels. To achieve this, patient and doctor must work together to ascertain the optimum dose and frequency of use.