Ixekizumab (Subcutaneous)

Ixekizumab is used in the treatment of patients who are suffering from a form of plaque psoriasis that will benefit from the treatment with phototherapy.


Ixekizumab is used in the treatment of certain forms of moderate or severe plaque psoriasis. The medication is an immunosuppressant that is used to reduce the effects of a chemical in the body. In doing so it reduces inflammation and can reduce the symptoms of plaque psoriasis including the flaking of the skin.

Ixekizumab is injected under the skin of the patient in the form of Taltz. The medication is available only with a doctor's prescription and can also be used in the treatment of psoriatic arthritis.

Condition treated

  • Plaque Psoriasis

Type Of Medicine

  • Immunosuppressant

Side Effects

In addition to the required effects from the use of Ixekizumab, other unwanted side effects can also occur. While not all side effects listed herein may occur, in some cases the patient may need to seek medical attention for treatment of the side effect.

You should consult your doctor immediately if any of the following side effects occur from the use of Ixekizumab:

Occurring more commonly:

  • Body aches
  • Body pain
  • Burning of the eyes
  • Chills experienced when warm
  • Coughing
  • Difficulty in breathing
  • Discharge from eyes
  • Dryness of the eyes
  • Ear congestion
  • Excessive tearing
  • Feverishness
  • Headaches
  • Hoarseness
  • Itching of skin
  • Itching of the eyes
  • Itching of the genitals
  • Loss of voice
  • Lower back pains
  • Nasal congestion
  • Pain or difficulty experienced during urination
  • Runny nose
  • Side pains
  • Sneezing
  • Soreness of the mouth or tongue
  • Soreness of the throat
  • Swelling, reddening or pain experienced in the eye, eyelid or inner eyelid
  • Unusual tiredness
  • Unusual weakness
  • White patches appearing on the mouth or tongue

Occurring only rarely:

  • Hives
  • Itching
  • Rectal bleeding
  • Reddening of the skin
  • Severe diarrhea
  • Severe pain of the stomach
  • Skin rash
  • Swellings with the appearance of hives on the:
  •  Eyelids
  •  Face
  •  Feet
  •  Hands
  •  Legs
  •  Lips
  •  Sex organs
  •  Throat
  •  Tongue
  • Welts

Ixekizumab may also cause other side effects that do not normally require that you seek medical attention. These side effects are usually milder and will often abate over time as the body becomes used to the treatment being received. If the following side effects do become bothersome or are ongoing, however, then you can seek advice from your doctor about how to alleviate them:

  • Nausea

At the site of injection:

  • Warmth of the skin
  • Ulceration
  • Tingling
  • Tenderness
  • Tenderness
  • Swelling
  • Stinging
  • Soreness
  • Scarring
  • Redness
  • Rashing
  • Pressure on the skin
  • Pain
  • Numbness
  • Lumps
  • Itching
  • Inflammation
  • Infection
  • Hives
  • Discoloration of the skin
  • Coldness
  • Burning
  • Blistering
  • Bleeding

Ixekizumab may also cause other side effects that have not been listed herein to occur. If you experience any other side effects then you should contact your doctor for advice. If you believe your health to be at immediate risk, however, then you should always seek emergency medical attention.


This medication is to be injected under the skin of the patient by a trained medical professional. The site of injection will usually be in the upper arm, abdomen or thigh.

The medication will be provided with a medication guide that should be thoroughly read and understood by the patient. If you do not understand any of the medication guide or have any questions after reading it then you should consult your doctor before receiving the treatment.

Ixekizumab may be self-administered at home in some cases. When the patient does not need to be kept in hospital for treatment the medication can be used at home. If this is the case then you will be taught how to use the medication by a nurse or doctor and you must follow these steps exactly. If you have any doubt about how to administer this treatment then you should not do so. You will be shown where the injection can be given.

Ixekizumab can be administered using an autoinjector that is prefilled with the correct dose. Alternatively it may be administered from a prefilled syringe.

The area of injection should be changed with each use to prevent further irritation of the skin from occurring. You should keep record of the injection sites you use and rotate them so that you are never injecting into the same location too frequently.

The full dose from an injector or prefilled syringe may not be used, but you should not keep any extra dose. Dispose of the injectors after use safely as directed to by the nurse or doctor. These injectors are single use only and should not be kept once opened.

If the medication changes color or appears to have particulates in it then you should not use the treatment and should contact your doctor.

The dose of this medication that is given will vary dramatically from patient to patient. The dose will depend on the severity of the condition and on a range of other factors including the health of the patient too. You should only ever take this medication as you have been directed to by your doctor. The information below is to be used as a guideline only and should not be used to adjust your dose:

  • In treating adults ' 160mg for the initial dose in week 0. This is followed by one 80mg dose taken in weeks 2, 4, 6, 8, 10 and 12. Following this 80mg is used every 4 weeks by the patient.
  • In treating adults' The use and dose of this medication must be determined by the prescribing doctor.

You must take this medication on a fixed schedule as directed by your doctor. If you miss a dose then you should contact your doctor for advice.


Certain medications should never be used together. This is because they can interact in the body with severe consequences. Some medications can cause serious complications when used together and the results may be life-threatening in some cases. Others may prevent each other from working and may increase the risk or severity of side effects that may occur.

To prevent medication interactions from occurring with your use of Ixekizumab, it is essential that you inform your doctor of all medicines that you are taking before you begin treatment. This includes all other prescribed treatments, any over the counter medications and any other substances that you are taking.

Other medical problems from which you are suffering can also affect the use of this medication. You should inform your doctor of all other health conditions that you have. This is particularly important in the following cases

  • Inflammatory bowel disease is a condition that may be worsened by the use of Ixekizumab.
  • History of infection' Use of Ixekizumab may prevent the infections from healing.
  • Inactive tuberculosis infection ' This must be treated before use of Ixekizumab.

Other interactions that have not been listed herein could also occur from the use of Ixekizumab. You should inform your doctor of your full medical history before beginning treatment to prevent interactions from occurring.


Before deciding to use Ixekizumab, it is important that you consider the risks of use and weigh them against the benefits of use of the treatment. You should choose to take this medication with your doctor only after having taken all of the following into account:

Allergies'You must inform your doctor of any unusual reactions you have had to medications in the past. Allergies to medication can prohibit the use of this treatment. You should also inform your doctor of any other allergies from which you suffer.

Pediatric' The safety and efficiency of this medication has not been established in children. You should discuss this with your doctor and other more appropriate treatments may be found.

Geriatric' There are no known limitations to the use of this medication in elderly patients. Caution should be used because of the increased likelihood of other age-related conditions being present in the patient, however.

Breastfeeding' The risks of using this medication while breastfeeding are unknown. You should discuss use with your doctor and determine the best action to take.

Pregnancy ' This medication is categorized as a category C risk during pregnancy. You must inform your doctor before beginning treatment if you are pregnant. You must also inform your doctor if you become pregnant during use and should use contraception to prevent this from occurring.

It is important that you check in with your doctor regularly during treatment with this medicine. You may need to give blood samples to check for the presence of unwanted side effects.

If you develop any symptoms of infection including coughs and colds then these must be reported to your doctor immediately. You may find it harder to fight infection during use and may need additional treatment for infections.

You will need to be tested for tuberculosis before beginning treatment. If you have ever had a positive result to such a test in the past then you must inform your doctor.

Serious allergic reactions can occur to this medication. After treatment you must inform your doctor if you experience any of the following symptoms:

  • Rash
  • Itching
  • Hive-like swellings

You should to receive any vaccinations or immunizations during treatment with Ixekizumab. To do so will expose you to risk of catching the infection you are attempting to protect yourself from. As your immune system will be lowered your body may be unable to fight the infection and the live culture may infect you. Members of your household should also avoid receiving certain vaccinations and immunizations while you are being treated as there will be a risk of you developing the infection.

You may develop a condition known as inflammatory bowel disease from the use of this medication. You must inform your doctor immediately if you experience any of the following symptoms of this:

  • Bleeding from the rectum
  • Severe pain in the abdomen or stomach
  • Severe diarrhea

You should not take any other medications in conjunction with this treatment. This includes all prescribed medication and over the counter treatments. Discuss all other medications that you are taking with your doctor before you begin use.


This medication should be stored well out of the reach of children.

You should not keep unwanted, used or outdated medications for any longer than necessary. Dispose of them safely as directed to by your medical professional. Ensure that they are kept out of the reach of children and pets during disposal and put them in a hard container that cannot be pierced by the needle before disposal.

  • Never reuse a needle or syringe.
  • Store this medication in the refrigerator but do not allow it to freeze. Store in the original container.
  • Allow the medication to warm to room temperature for 30 minutes before injection.


Ixekizumab is an injection used in the treatment of plaque psoriasis. It is used in the treatment of patients who will benefit from phototherapy and is injected beneath the skin.

The medication can be administered by a nurse or in some cases may be given to the patient to administer at home. In these cases the patient will be taught how to administer the treatment and must follow the directions given precisely. A full syringe may not be used in treatment but any leftover medication should be disposed of along with the needle.

This medication can cause a range of serious side effects to occur and it is important that the patient understands the risks as well as the benefits before use. This medication comes with a medication guide that you should ensure you have read and understood before you begin treatment.

You should not take any other medications in conjunction with this treatment unless you have discussed this beforehand with your doctor. The use of other medications may cause interactions to occur.