Kanamycin (Injection)

Kanamycin, known in the marketplace as Kantrex, is injected into patients who have bacterial infections in order to kill the bacteria and stop the growth of new infections.

Overview

Kanamycin is considered to be an aminoglycoside antibiotic type of medication. It kills bacteria and fights infections as well as preventing new growth. Kanamycin is typically used for a short period of time, an average of seven days but no more than 10 days total. Kanamycin does not treat viral infections, but is an effective treatment for severe infections such as tuberculosis. It is also effective on E.coli infections, as well as different species of bacteria.

Kanamycin works by forming a bond with a portion of the bacteria that is in control of using proteins to further the growth of the organism. By binding with this part of the bacteria, Kanamycin stops it from synthesizing these proteins and cutting off a major supply useful to its growth. By cutting off the growth of the bacteria, it soon dies without producing more and the infection is healed by the body.

Conditions Treated

  • Bacterial infections
  • Tuberculosis

Type Of Medicine

  • Aminoglycoside antibiotic

Side Effects

Kanamycin treatment of bacterial infections may also affect the operation of other vital organs, causing unwanted health effects. Should you experience the following symptoms, alert your physician right away:

  • Agitated mood
  • Stools with blood or tar-like appearance
  • Urine that is cloudy or bloody
  • Skin or lips with bluish tinge
  • Vision changes or blurriness
  • Needles and pins, tingling, itching or burning sensations
  • Pains in chest
  • Chills
  • Coma
  • Confused demeanor
  • Unexplained noises like buzzing or ringing in ears
  • Coughing
  • Depressed mood
  • Urine frequency or amount decreases
  • Depressed mood
  • Difficulty moving
  • Difficulty breathing
  • Lightheaded, dizziness or fainting when rising
  • Drowsy, lethargic
  • Dry mouth
  • Vertigo or spinning sensation
  • Ears feel blocked
  • Elevated body temperature
  • Headache
  • Irritated mood
  • No sense of balance
  • Hearing changes or loss
  • Stiff, painful muscles
  • Twitching, spastic muscles
  • Nausea
  • Breathing stops
  • Pain in side or lower back
  • Joint pain
  • Difficulty or pain when urinating
  • Skin paleness
  • Rapid gaining of weight
  • Seizures
  • Spinning sensation
  • Shaking legs, feet, hands or arms
  • Gasping for breath
  • Throat soreness
  • White, ulcerated spots on mouth or lips
  • Stupefaction
  • Sweats
  • Swollen ankles, hands or face
  • Glands are swollen
  • Thirsty
  • Shaking or trembling in feet or hands
  • Difficulty hearing
  • When exerting energy, breathing is difficulty
  • Spastic movements of the eye
  • Bruising or bleeding that is unexpected
  • Fatigue
  • Muscle weakness

Other patients have reported the following side effects, which typically disappear over time with continued use of Kanamycin. Report the following symptoms to your physician in case there are ways to lessen their severity:

  • Excess gas
  • Diarrhea
  • Stools are light, fatty or frothy
  • Rash on skin
  • Weight loss that is sudden
  • Vomiting

Any changes to your overall health or demeanor should be communicated to your doctor or nurse in case of underlying health issues that may prove severe or prolonged. There may be painful irritation or redness caused by the injection itself, so notify your physician if you have any symptoms involving that area.

Dosage

Kanamycin may be injected into a vein or into a muscle of the shoulder or thigh. Tests to determine with certainty that the infection you have is bacterial in nature should be performed prior to treatment, if possible. This keeps the continuing effectiveness of antibiotics such as Kanamycin effective because they are not over-used or used inappropriately.

Dosage will be calculated by your physician and based on your body mass. The recommended injected dosage for children and adults is 15 micrograms per kilogram of body weight every day until the infection is gone and no more than 10 days of treatment. The dosage may be increased if the physician believes high blood concentrations of the drug are the most effective form of treatment for the infection.

Patients will not be given more than 1.5 grams of the medication in a 24 hour period for their own safety. Patients with low kidney function will need to be tested for creatinine levels and their dose of Kanamycin adjusted accordingly to provide safe treatment.

Improvement of symptoms should occur within 24 to 48 hours after initially giving Kanamycin. Treatment with Kanamycin should not go on longer than 5 days if symptoms do not improve.

Interactions

Previous sensitivity to a dose of Kanamycin or any other medication should be information that is passed on to your physician. Also let them know if you have any reactions to foods, animals, perfumes, dyes or preservatives at this time.

With the exception of premature and newborn infants, pediatric patients should be able to be treated with Kanamycin with the same success and risks as adult patients. Adjust the dosage of this medication and use cautiously in newborn or premature patients.

Geriatric patients who have kidney problems should avoid treatment with Kanamycin, if possible. If treatment is absolutely necessary, the dosage must be adjusted to accommodate this low function of the kidneys. Otherwise, geriatric patients should have no problem being treated with Kanamycin.

Women who are pregnant should not be treated with Kanamycin, as there has been proven harm to the fetus with use of this medication. If you think you may be pregnant or if you have become pregnant while being treated with Kanamycin, notify your doctor immediately.

In regard to using Kanamycin in women who are breastfeeding, it has been proven that the medication does enter the breast milk, though the amount is small. As it can be harmful to newborn babies, however, it is advised that breastfeeding stop during treatment with Kanamycin for the protection of the infant.

The use of some medications together provides an overall therapeutic regimen that can be beneficial in treating diseases of many kinds. Other combinations of drugs are dangerous and should be avoided if possible. It is advised that you avoid any other medications while you are being treated with Kanamycin for this reason and this includes any over-the-counter medication as well as herbal and vitamin therapies and holistic remedies as well. If you cannot avoid other medications, make sure your doctor knows about everything you are taking.

The following medication has been known to adversely react with Kanamycin and should be avoided:

  • Ataluren

These medications, while not dangerous when combined with Kanamycin, may render it ineffective or at a greater risk for unwanted health effects. Alert your physician if you are taking:

  • Atracurium
  • Alcuronium
  • Cidofovir
  • Cholera live vaccination
  • Colistimethate Sodium
  • Cisatracurium
  • Doxacurium
  • Decamethonium
  • Fazadinium
  • Ethacrynic Acid
  • Furosemide
  • Foscarnet
  • Hexafluorenium
  • Gallamine
  • Metocurine
  • Lysine
  • Pancuronium
  • Mivacurium
  • Rapacuronium
  • Pipecuronium
  • Succinylcholine
  • Rocuronium
  • Vecuronium
  • Tubocurarine

Certain unwanted health effects may increase if you take the following medication while you are being treated with Kanamycin:

  • Bumetanide

Discuss the use of tobacco products and the consumption of some foods and alcoholic beverages with your doctor prior to your treatment with Kanamycin in case any of these substances may cause adverse health effects.

Patients who suffer from the following conditions should alert their physicians of the fact as they could become worse after treatment with Kanamycin. They could also alter the effectiveness or the instance of certain adverse effects of the drug. Let your doctor know if you have:

  • Asthma
  • Sensitivity to sulfites
  • Disease of the kidneys
  • Muscle problems
  • Myasthenia gravis
  • Nerve diseases
  • Parkinson disease

Warnings

Expect to be scheduled for follow-up appointments to monitor the progress of the Kanamycin against your bacterial infection and to repeat your dosage if necessary. Keep all appointments if possible, rescheduling only in case of emergency and keeping the new appointment as close to your old one as possible. You may need to have tests on your hearing function as well as your nerve function in addition to urine and blood sample testing to make sure you are safe to continue this treatment.

If you do not experience improvement in your symptoms within 24 to 48 hours, report this to your physician in case you are infected by a strain of bacteria that is resistant to Kanamycin.

It is imperative that you inform your physician if you are pregnant prior to being treated with this drug, as it is proven to cause harm to developing babies. Use effective birth control while you are being treated with Kanamycin and inform your doctor right away if you think you may have become pregnant during your treatment.

Anaphylaxis, a life-threatening hypersensitivity to this medication is possible during your treatment. If you have itching skin with hives, a hoarse voice, difficulty breathing or swallowing or any swelling in your face, mouth or hands after your treatment, get in touch with your doctor right away.

There are increased risks to your hearing and sense of balance when you are being treated with Kanamycin. Report symptoms that are signs of damage to your balance or hearing to your doctor at once; these include spinning or constant moving sensations, dizziness, lightheaded feeling, buzzing or ringing in the ears or loss of hearing.

If you experience severe weakness in your muscles or fatigue in your muscle function or if you have difficulty breathing when you are being treated with Kanamycin, these symptoms should be reported to your physician immediately for your own health.

Kanamycin has been linked to severe kidney problems with use in some patients. Report signs of kidney damage to your physician right away, including drowsiness, being thirsty all the time or loss of appetite. Patients who have kidney damage may also experience a change in the amount or frequency they urinate, show blood in their urine, become very drowsy for no reason or have vomiting, nausea and swollen feet or lower legs and muscle weakness.

Avoid taking other medicines unless your physician has specifically approved their use with your Kanamycin treatment. This includes anything you can purchase without a prescription or herbal and vitamin supplements and holistic therapies as well.

Storage

Hospitals, pharmacies and clinics are typically where Kanamycin is found, but if you must store this medicine in your home, you will be advised on how to do so safely by your physician or pharmacist. The manufacturer recommends a room temperature environment without exposure to moisture, light or heat sources.

Dispose of any unused or expired Kanamycin safely according to the manufacturer's directions or those received from your healthcare provider or pharmacist.

Summary

Kanamycin, an aminoglycoside antibiotic type of medication, is injected by doctors into patients who have been diagnosed with bacterial infections such as tuberculosis. This medication effectively binds to a cellular structure in the bacteria, preventing it from growing and eventually causing it to die. When the bacterium is eradicated from the body, it can begin to heal from the damage it has caused.

Patients typically experience an improvement in their symptoms within 24 to 48 hours and should seek alternate treatment if they do not see any signs of improvement after 3 to 5 days. Patients are injected into a vein or muscle and will receive a dosage amount calculated on their body mass.

Kanamycin is safe for children and adults, but is not recommended for newborn or premature infants. It is also not recommended for women who are pregnant or those who are breastfeeding. Avoid becoming pregnant while being treated with Kanamycin.

This medication has been known to cause damage to the kidney and liver function. Geriatric patients with low kidney function and those on dialysis should be dosed with caution and their creatinine levels monitored regularly for safety.

Report signs of anaphylaxis as well as any symptoms that indicate you have experienced a loss in your hearing or balance. Problems with your kidneys may also occur while you are being treated with Kanamycin, so report any unusual symptoms involving your kidney function or if you are passing urine with signs of blood, passing less urine than normal or less frequently urinating than normal.

Avoid using other medications, tobacco products, certain foods and alcoholic beverages during your treatment with Kanamycin unless approved by your physician. Let your doctor know if you have previous kidney disease or any sensitivity to this or other drugs.