Lesinurad is a prescription medication that is effective in the treatment of hyperuricemia because it is combined with a xanthine oxidase inhibitor (febuxostat or allopurinol) for the treatment of gout. This medication reduces uric acid levels within the blood.
Only patients with less than optimal uric acid levels that have been obtained with a xanthine oxidase inhibitor alone are approved to get this medication.
This medication can only be obtained with a valid prescription from your doctor. It is available in tablet form, and is currently manufactured under the US brand name of zurampic.
Patients who have juvenile gout (Lesch'Nyhan syndrome) or tumour lysis syndrome should not take this medication. Also, individuals have severely impaired kidney function should avoid lesinurad, including hemodialysis and kidney transplant patients.
In addition to the many beneficial aspects of medications, certain drugs can trigger undesired side effects for some patients. While it is not typical for each of the following side effects to take place while on lesinurad, if any of them to take place, they could require emergency medical care.
Consult with your medical care professional right away if you experience one or more of the side effects below:
Certain side effects of lesinurad can take place that do not typically require medical care. These particular side effects will likely diminish on their own, throughout the course of treatment, as you become more adjusted to the medication. Your doctor should be able to inform you of methods to reduce or prevent certain site effects of lesinurad. Consult with your medical professional if the side effects below become troublesome after taking lesinurad, if they become prolonged, or if any questions come up regarding them.
Additional side affects that were not included here could also take place for certain individuals taking lesinurad. If other side effects are observed, be sure to consult with your doctor.
Contact your physician if you are seeking medical advice regarding side effects. Side effects may also be reported to the Food and Drug Administration by calling 1-800-FDA-1088.
Always take lesinurad as instructed by your physician. Never take an amount of lesinurad that is greater than your doctor prescribed. Do not take this medication more frequently than directed. Finally, do not take lesinurad for a duration that is longer then your physician instructed.
An overview summary should be distributed with this medication. Follow and read all of these directions in their entirety. Consult with your physician with any questions you may have.
Take lesinurad with a xanthine oxidase inhibitor (such as febuxostat or allopurinol), and with water and food right away after waking up.
Be sure to drink enough fluids to satisfy your body's unique requirements. Be sure to drink a minimum of 68 ounces (2 liters) in order to produce an adequate amount of urine; doing so can aid in the prevention of severe kidney issues.
Different patients will be given a dose of lesinurad that is suitable for their unique medical condition. Please ensure that you are always following the instructions given by your doctor or your medication label instructions. The dosage information included here summarizes only general doses of lesinurad. Patients must not adjust their own dose without being instructed to by their physician.
The medication strength will determine how much lesinurad you will be prescribed. In addition, the total amount of doses taken daily, the allotted time from one dose to the next, and the total duration for which lesinurad is taken depends directly on the medical issue for which this medication is prescribed.
Patients who have accidentally skipped a dose of lesinurad should allow the missed dose to remain skipped, and they should return to the original dosage schedule. Do not take a double dose of lesinurad under any circumstances.
While typically medications should not ever be combined, in special circumstances two drugs can be used at the same time even if there is a likelihood that an interaction may take place. Under these circumstances, your physician may be inclined to adjust your dose of lesinurad, or they may choose to pursue additional types of precautions to protect you as a patient. While taking lesinurad, it is imperative that to your doctor is aware of any of the following medications you may already be taking. The medications listed below have a potentially significant interaction potential with this drug, however the list is not all-inclusive.
Taking lesinurad with the medications below is not usually suggested, however special cases may require the combination. If your doctor decides to prescribe both medications, they will likely reduce they dose or frequency for either or just one medication.
Some medications should not be taken with food or near mealtime due to the likelihood of interactions taking place. The use of tobacco, alcohol, or some medications could also trigger serious interactions to take place. Discuss with your physician how the use of tobacco, alcohol, and even food impacts the use of lesinurad.
Patients with additional medical concerns could experience impacts in the usefulness of lesinurad. Be sure to inform your physician of other medical concerns you may have, specifically:
It is essential that your progress be monitored regularly to ensure lesinurad is working as it should. Urine and blood tests could be required to monitor for undesired side effects of the medication.
Kidney issues could be caused by this medication. Inform your physician immediately if you experience unusual weakness or tiredness; swelling of the hands, ankles, or face; seizures; sudden weight gain; nausea; twitching of the muscles; lethargy; headaches; dizziness; depression; or reduced output of urine after taking lesinurad.
Blood vessel or heart issues could take place from the use of this medication. Inform your physician if you experience inability of movement of the facial, legs, or arm muscles; slow speech or speaking difficulty; sweating; discomfort or pain in the neck, back, jaw, or arms; vomiting or nausea; confusion; discomfort; or chest pain.
Women should have an alternate method of birth control in place in addition to their primary method to ensure they do not become pregnant while on this medication. Lesinurad can cause birth control injections, patches, and pills to be more ineffective than normal. Consult with your physician with any concerns or questions.
Other medications should not be taken at the same time as lesinurad unless previously approved by your medical care professional. This refers to nonprescription as well as prescription medications, and even vitamin supplements and herbal remedies.
When a patient is deciding whether or not lesinurad is right for them, they must compare the potential dangers of the medication against the benefits it may provide. It would be a good idea to make this decision carefully with your doctor. Consider the aspects below when deciding whether or not lesinurad is a beneficial choice for you.
Always let your doctor know if you currently have allergies or if you have ever had an allergic reaction to any medication, especially lesinurad. Also inform your doctor of other kinds of have allergies you may have, including to animals, preservatives, dyes, or types of food. For products that are nonprescription, carefully read the ingredients summary or package label carefully.
It has not yet been determined whether or not lesinurad is both effective and safe for the pediatric population. Current research has not yet been conducted on how age impacts the side effects and benefits of lesinurad.
Current research conducted has not examined if there are issues that are specific only to the elderly population that could potentially inhibit the effectiveness of lesinurad for geriatric patients.
Adequate research has not yet been conducted for women who breastfeed while taking lesinurad. It is not apparent whether or not there is a risk to the incident if the mother takes this medication while she breastfeeds. Women should compare the possible benefits against the risks that could occur prior to taking lesinurad while breastfeeding.
Be sure to keep lesinurad in a sealed container in a location that is far from moisture, direct light, heat, and freezing temperatures. These elements could potentially alter the chemical composition of this medication.
Do not keep lesinurad in an area that is easily accessible to children. Medication that is no longer necessary or that is expired should be disposed of. Your physician can inform you of how to properly dispose of unused medication.
Lesinurad is an effective treatment for hyperuricemia due to the fact that it is combined with a xanthine oxidase inhibitor (febuxostat or allopurinol) for gout treatment. This medication can reduce the level of uric acid within the blood.
Patients with very low uric acid levels are currently the only individuals approved to get a lesinurad prescription. A prescription of this medication must be obtained through your physician, who will perform a physical exam.
Individuals who have juvenile gout (Lesch-Nyhan syndrome) or tumour lysis syndrome should not take this medication. In addition, some patients who have seriously impaired kidney function should avoid lesinurad (including hemodialysis and kidney transplant patients).