Levofloxacin (Ophthalmic)


Levofloxacin ophthalmic solution is an antibiotic eye drop that helps treat eye infections caused by bacteria, including conjunctivitis and corneal ulcers. Levofloxacin belongs to a class of medications known as fluoroquinolones or quinolone antibiotics.

Levofloxacin works by stopping a bacterial enzyme known as DNA gyrase, which is required by the bacteria to produce DNA, which is vital for the multiplication of the bacteria. Levofloxacin ophthalmic solution won't work against viruses.

Levofloxacin comes in these strengths:

  • Quixin'Levafloxacin 0.5 percent ophthalmic solution
  • Iquix'Levafloxacin 1.5 percent ophthalmic solution
  • The most common Levofloxacin side effects can include but aren't limited to:
  • Burning or pain
  • Taste changes
  • Temporary vision changes
  • Headaches
  • Feeling like there's something in the eye

Conditions Treated

  • Pink eye
  • Inflammation of eye cornea
  • Ulcer of eye cornea

Type Of Medicine

  • Quinolone antibiotic

Side Effects

As with any drug, Levofloxacin ophthalmic solution can bring about many side effects. Not everyone who uses this medication will have problems, though. In fact, the majority of people tolerate it fairly well. In most cases, the side effects that occur are mild and either don't require treatment or are easily treated by your doctor or you.

Some Levofloxacin side effects may be serious, and you should report them to your healthcare professional immediately. The following are some of the potentially serious effects of Levofloxacin ophthalmic solution:

  • Persistent or severe eye pain, irritation, or redness that doesn't disappear or that worsens with repeated application of this medication
  • Signs of an allergy, including:
  • Itching
  •  Hives
  • Unexplained rash
  •  Wheezing
  •  Difficulty with breathing or swallowing
  •  Unexplained swelling of throat/mouth

Common Levofloxacin side effects:

  • Fever
  • Temporary loss of eyesight
  • Headaches
  • Feeling like there's something in the eye
  • Sore throat
  • Temporary eye burning
  • Eye discomfort or pain
  • Sensitivity of eye to light
  • Headaches
  • Taste changes
  • Diarrhea
  • Blurred vision or decreased vision
  • Indigestion or heartburn
  • Infection
  • Eye discomfort or irritation
  • Throat irritation
  • Eye infection

Uncommon Levofloxacin side effects:

  • Allergic reactions
  • Dry eyes
  • Eyelid swelling
  • Eye itching

This section doesn't cover all of the potential side effects of Levofloxacin. Your healthcare professional can discuss with you a more comprehensive list of side effects.

Other Levofloxacin side effects not named above may occur in some people as well. If you develop any other effects, make sure to see your healthcare professional.


Apply Levofloxacin ophthalmic solution to your eye(s) as instructed by your healthcare professional. Wash your hands first before you apply the eye drops. To avoid contamination, don't let the tip of the dropper touch your eye(s) or other surface or don't touch the tip of the dropper.

While you're using Levofloxacin, don't wear contact lenses. Follow the manufacturer's instructions before you sterilize contact lenses, and consult your physician before you resume wearing them.

Look upward with your head tilted back, and pull the lower eyelid down to create a pouch. While holding the dropper just over your eye, put one eye drop into this pouch. Close your eyes gently while looking downward, and place one of your fingers at your eye's corner (near your nose). Put gentle pressure for one or two minutes and then open your eyes. This prevents the medicine from draining out. Do not rub your eye or blink.

Repeat the steps above if you're applying more than one eye drop. If instructed to use Levofloxacin ophthalmic solution in both eyes, please repeat the steps above for the other eye. Don't rinse the dropper. And replace the cap of the dropper after each use.

If you're applying any other type of eye medicine (such as ointments or drops), wait at least five minutes before applying the other medication. Apply eye drops before applying eye ointments to let the drops enter the eye.

To make the best use of Levofloxacin ophthalmic solution, use it regularly. Apply this medication at the same times daily so you can remember. Keep using Levofloxacin for the entire period prescribed, even if your symptoms clear after a short time. Discontinuing this medication too soon may let the bacteria continue growing, which can cause the infection to come back.

Levofloxacin ophthalmic solution may be toxic if swallowed. If somebody has had an overdose and has severe symptoms (such as difficulty with breathing or passing out), call 911 immediately. Otherwise, contact your local poison control agency immediately. If you're in the US, you can do so at 1-800-222-1222. If you're in Canada, you can call your provincial poison control agency.

Don't share Levofloxacin with anyone else.

This medicine has only been given for your current condition. Dispose of any unused medication after completing your treatment. Don't use it for another infection later unless your doctor instructs you to do that. In that case, you may require a different medication.

Notify your healthcare professional if your condition gets worse or persists.


When you're using Levofloxacin, it's really important to let your healthcare specialist know if you're using any of the drugs listed below.

Using Levofloxacin ophthalmic solution with any of these drugs is not advisable. Your healthcare specialist may opt to not treat you using Levofloxacin or adjust some of the drugs you take.

  • Amisulpride
  • Dronedarone
  • Piperaquine
  • Terfenadine
  • Cisapride
  • Sparfloxacin
  • Saquinavir
  • Amifampridine
  • Thioridazine
  • Pimozide
  • Bepridil
  • Ziprasidone
  • Mesoridazine

Using Levofloxacin ophthalmic solution with any of these drugs is normally not advisable, but may be necessary in some situations. If your physician prescribes both drugs together, he/she may adjust the dose or frequency of using one or both drugs.

  • Toremifene
  • Chlorpropamide
  • Clomipramine
  • Amitriptyline
  • Insulin Glulisine
  • Alogliptin
  • Donepezil
  • Aripiprazole Lauroxil
  • Paroxetine
  • Erythromycin
  • Delamanid
  • Venlafaxine
  • Procainamide
  • Ibutilide
  • Protriptyline
  • Foscarnet
  • Iloperidone
  • Bedaquiline
  • Gliclazide
  • Ketoconazole
  • Tetrabenazine
  • Apomorphine
  • Metformin
  • Sevoflurane
  • Amiodarone
  • Dasatinib
  • Trazodone
  • Exenatide
  • Olanzapine
  • Histrelin
  • Eribulin
  • Chlorpromazine
  • Insulin Degludec
  • Nateglinide
  • Prochlorperazine
  • Ondansetron
  • Asenapine
  • Repaglinide
  • Escitalopram
  • Pazopanib
  • Clarithromycin
  • Probucol
  • Galantamine
  • Ebastine
  • Pentamidine
  • Ivabradine
  • Famotidine
  • Telavancin
  • Aripiprazole
  • Pioglitazone
  • Sotalol
  • Perphenazine
  • Clozapine
  • Telaprevir
  • Citalopram
  • Dabrafenib
  • Insulin Bovine
  • Nelfinavir
  • Solifenacin
  • Pasireotide
  • Formoterol
  • Risperidone
  • Ribociclib
  • Efavirenz
  • Vemurafenib
  • Saxagliptin
  • Fingolimod
  • Posaconazole
  • Lumefantrine
  • Ofloxacin
  • Trimipramine
  • Theophylline
  • Mifepristone
  • Paliperidone
  • Domperidone
  • Chloroquine
  • Fluconazole
  • Tolazamide
  • Insulin Detemir
  • Pipamperone
  • Warfarin
  • Promethazine
  • Dofetilide
  • Pitolisant
  • Miglitol
  • Inotuzumab Ozogamicin
  • Gemifloxacin
  • Sulpiride
  • Desipramine
  • Deutetrabenazine
  • Triptorelin
  • Vilanterol
  • Cholera Vaccine, Live
  • Gatifloxacin
  • Crizotinib
  • Hydroxychloroquine
  • Liraglutide
  • Metronidazole
  • Lapatinib
  • Sunitinib
  • Mizolastine
  • Vardenafil
  • Glimepiride
  • Dapagliflozin
  • Azithromycin
  • Nilotinib
  • Fosphenytoin
  • Goserelin
  • Pramlintide
  • Sodium Phosphate, Dibasic
  • Degarelix
  • Tacrolimus
  • Dolasetron
  • Sitagliptin
  • Insulin Lispro, Recombinant
  • Leuprolide
  • Hydroquinidine
  • Moxifloxacin
  • Imipramine
  • Arsenic Trioxide
  • Doxepin
  • Linagliptin
  • Quinidine
  • Acetohexamide
  • Deslorelin
  • Cyclobenzaprine
  • Panobinostat
  • Nafarelin
  • Norfloxacin
  • Fluoxetine
  • Rilpivirine
  • Gliquidone
  • Moricizine
  • Telithromycin
  • Anagrelide
  • Glyburide
  • Insulin Glargine, Recombinant
  • Octreotide
  • Alfuzosin
  • Sertindole
  • Rasagiline
  • Mefloquine
  • Vorinostat
  • Disopyramide
  • Haloperidol
  • Quinine
  • Halofantrine
  • Granisetron
  • Canagliflozin
  • Rosiglitazone
  • Methadone
  • Zuclopenthixol
  • Insulin
  • Tizanidine
  • Ciprofloxacin
  • Tolterodine
  • Sodium Phosphate, Monobasic
  • Acenocoumarol
  • Sodium Phosphate
  • Glipizide
  • Acecainide
  • Tolbutamide
  • Felbamate
  • Buserelin
  • Tamoxifen
  • Propafenone
  • Acarbose
  • Vinflunine
  • Sorafenib
  • Benfluorex
  • Itraconazole
  • Atazanavir
  • Droperidol
  • Insulin Aspart, Recombinant
  • Gonadorelin
  • Pimavanserin
  • Voriconazole
  • Vildagliptin
  • Buprenorphine
  • Quetiapine
  • Ritonavir
  • Ranolazine
  • Vandetanib
  • Astemizole
  • Flecainide
  • Hydroxyzine

Using Levofloxacin with any of these drugs can raise your risk of some side effects, but taking both drugs at the same time could be your best bet for treatment. If your physician prescribes both medicines together, he or she may adjust the dose or frequency of using both or one of the medicines.

  • Lanthanum Carbonate
  • Aminolevulinic Acid


Before using Levofloxacin ophthalmic solution, let your doctor and pharmacist know if you have allergies to it or other quinolone antibiotics (including Ofloxacin, Norfloxacin, or Ciprofloxacin), or if you've got any other allergies. Levofloxacin may have inactive ingredients like Benzalkonium Chloride, a preservative that may cause allergies or other issues. For further details, please consult your pharmacist.

Before using Levofloxacin, let your doctor and pharmacist know about your medical past, especially of other conditions of the eye.

After applying Levofloxacin, your vision can get blurred temporarily. Don't use machinery, drive a car, or do anything that needs clear eyesight until you're certain you can safely carry out such activities.

Before having surgery, let your dentist or doctor know about all the medicines you take, including over-the-counter drugs, prescription drugs, herbal products, and vitamins.

In rare cases, severe allergic reactions may occur in people using Levofloxacin. Stop using Levofloxacin at once if you have any signs and symptoms of an allergy, including:

  • Itching
  • Hives
  • Unexplained rash
  • Throat tightness
  • Rapid heartbeat
  • Difficulty with breathing
  • Wheezing
  • Swelling of the face/lips/tongue

Levofloxacin doesn't kill all kinds of organisms that could cause infections of the eye. In rare cases, these non-susceptible organisms may overgrow after you use Levofloxacin ophthalmic solution for a long time. This may result in a second infection, for example a fungal infection.

If your eye problem seems to worsen, or if it hasn't improved within 7 days, consult your healthcare specialist. You may require a different medicine.

Bacterial infections of the eye, like conjunctivitis, can spread very fast. Thus, don't let the dropper tip touch your eye, to minimize the spread of the infection. In addition, make sure to wash your hands frequently while using Levofloxacin, especially after touching your eyes.

During pregnancy, Levofloxacin ophthalmic solution should only be applied when absolutely necessary. Discuss the pros and cons of applying this medication with your doctor.

It's not known whether Levofloxacin ophthalmic solution passes into human milk. The oral version of Levofloxacin gets into milk in little quantities but is not likely to affect a nursing baby. Before breastfeeding, consult your doctor.


Keep Levofloxacin in a sealed container, away from direct light, heat, and moisture. Keep the medication at room temperature and don't freeze it.

If the ophthalmic solution turns cloudy or brown or has particles, don't use it. Store all medicines away from pets and children.

Don't pour medicines into a drain or flush them down the toilet unless directed to do so. Discard Levofloxacin properly when it's no longer needed or it has expired. For more information, consult your local garbage disposal firm or pharmacist.


You shouldn't use Levofloxacin ophthalmic solution if you have allergies to it, or to a similar antibiotic like Ofloxacin (Floxin), Levofloxacin (Levaquin), Norfloxacin (Noroxin), Ciprofloxacin (Cipro), Lomefloxacin, etc.

Use Levofloxacin ophthalmic solution exactly as instructed by your healthcare professional. Don't use it in smaller or larger doses or beyond the duration prescribed. Follow the instructions on the prescription label.

Serious side effects have been reported with Levofloxacin use, including eye crusting or drainage, vision problems, severe eye irritation, increased light sensitivity, swelling or redness of the eye, feeling like there's something in the eye, or any new infection signs.

If your eye condition doesn't improve soon enough, or if it worsens, see your doctor.

This medication may increase your eye's sensitivity to light. To help minimize the discomfort, you can wear sunglasses and avoid exposing yourself to too much bright light.

Keep using Levofloxacin ophthalmic solution for the entire prescribed duration. Your symptoms may get better before the eye infection is cleared completely.

Don't use Levofloxacin with your contact lenses on. This medication may have a preservative that soft contact lenses may absorb. Before you put in your contact lenses, wait a minimum of 15 minutes after applying Levofloxacin ophthalmic solution.

You shouldn't wear contact lenses if you still have got the symptoms of the infection you're treating.

Last Reviewed:
March 26, 2018
Last Updated:
April 17, 2018
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