Lidocaine (Intradermal)


Lidocaine (pronounced LYE-doe-kane) is used as a local anesthetic to create numbness or loss of feeling before patients undergo some medical procedures. Lidocaine acts to block pain signals at the nerve endings located within the skin. This is not an anesthetic that produces unconsciousness in a patient such as a general anesthetic will during the course of surgery. Only a physician can prescribe the use of this medication.

Conditions Treated

  • Pain

Type Of Medicine

  • Anesthetic, Local (Amino Amide)

Side Effects

This medication is prescribed to those patients where the benefits of the medications are greater than the risks of the occurrence of side effects. The patient must make the prescribing physician aware of any conditions that could cause side effects to occur. The occurrence of severe side effects is unusual when using this medication, and most patients will not suffer undue adverse reactions.

Some side effects that can occur include the following:

Most common

  • Itching skin
  • Redness or flushing of the skin
  • Small purple or red spots appearing on the skin
  • Unusually warm skin temperature

Less common

  • Pain, swelling, burning, bruising or bleeding at the site of application of medication
  • Nausea or vomiting

Intended for both children and adults, this medication may have side effects that require medical attention. Inform your physician of your condition and always read the directions on the label and/or follow your physician's exact instructions when using this medication.

There are a variety of side effects ranging from mild to more serious in nature, and from common to the rare or unknown occurrence. Become aware of the potential side effects and consult your physicians thoroughly before using any medication. If you experience side effects, contact your physician immediately or call 911.

Remember to report any side effects to your physician promptly and follow their directions. Ask your doctor how to reduce or prevent side effects before you begin treatment. You may report side effects to the FDA at 1-800-FDA-1088 or at their website [].


The dosage of this medication will vary for different patients and the needs of those patients. Be sure to follow the exact directions of your physician when using this medication. These instructions are only an average dosage example, be sure to do only as your physician instructs you when taking this medication.

Trained medical personnel or nursing staff will administer this medication when needed, as prescribed by a physician at the time of use. This medication is administered by the use of a small round container that is placed on the skin, a needle is not used to inject this medication into the skin. You will hear an audible popping noise when the medication is administered.

This medication is for use on the skin area only. This medication is not used on skin areas that have cuts, scrapes, bruises or other injuries. Use with extreme caution, taking care not to get this medication into the eyes, mouth, or nose areas. If this medication gets into these areas, flush affected areas with water until completely free of the effects of this medication.


It is important for your physician to be aware of all the medications you take because interactions can occur for the combination of two or more different medications. When a medication needs to be taken with other medications and there are known interactions between them, the physician prescribing them may decide to adjust dosages and timing of medications to allow them to be used together.

When using this medication, the physician should be aware if you take the following medication:

  • Dihydroergotamine
  • Dronedarone
  • Saquinavir
  • Vernakalant
  • Amiodarone
  • Amprenavir
  • Arbutamine
  • Atazanavir
  • Bupropion
  • Cobicistat
  • Dasabuvir
  • Delavirdine
  • Disopyramide
  • Donepezil
  • Encainide
  • Etravirine
  • Flecainide
  • Fosamprenavir
  • Fosphenytoin
  • Fospropofol
  • Hyaluronidase
  • Lopinavir
  • Metoprolol
  • Mexiletine
  • Moricizine
  • Ombitasvir
  • Paritaprevir
  • Phenytoin
  • Procainamide
  • Propafenone
  • Propofol
  • Quinidine
  • Sotalol
  • St John's Wort
  • Succinylcholine
  • Telaprevir
  • Tocainide

Increased risks of adverse reactions may occur with the use of either of the following medications, however using these medications in conjunction with lidocaine may be the optimal medication combination for some patients. If these medications are used together, your physician may adjust the dosage and times of dosing. Do not use these medications without supervision by a physician and only used as directed by your physician.

  • Cimetidine
  • Penbutolol

Those who drink alcohol or use tobacco may be at increased risk of developing adverse reactions from this medication. Also, it is known that the use of food, alcohol or tobacco can cause adverse reactions in those taking this medication and should be avoided at the times this medication is being used. Food consumption should also be limited, and when using on the mouth or throat, food should not be consumed within one hour of use of this medication.


All patients using this medication will need to consult with a physician through all stages of use. Your physician will monitor your use of this medication closely, and any known allergies or conditions that would interfere with use must be reported before using. Any conditions or side effects as a result of the use of this medication need to be reported as soon as possible to your physician or healthcare provider.


Inform your physician if you have ever had an allergic reaction to using this or any other medications. You must also inform your physician of any other allergies you may have, including allergies to preservatives, dyes, foods, or to animals.


Safety and efficacy have not been established in a pediatric patient under 3 years of age, and it is not known if there are potentially severe adverse reactions in this group of patients. Anytime this or any medication is used, always follow the instructions of your physician, and never use this medication for non-prescribed conditions or for any other purpose than as prescribed.

Children should be kept away from this medication, and extreme care should be taken to avoid getting this medication in the mouth of children, where harm is known to have been caused.


There have been no studies performed as to the use of lidocaine injections in the geriatric population, and there is no known data to support information as to the safety and efficacy of this medication. Always follow the advice of a physician when using this medication.


Studies in animals have provided no evidence of harm to an unborn fetus in the womb. Studies have indicated there is no risk to an unborn fetus in the womb of women, as known, or any other adverse effects in pregnant women.


Women who are nursing have reported a minimal risk when using this medication.


Keep this medicine out of the reach of children. Store below freezing in a closed container, preferably at room temperature away from direct light, moisture and heat sources. Do not keep medicine any longer needed or that is outdated.

Ask your physician or healthcare provider how medicine should be disposed of after use is completed.


Lidocaine as a local anesthetic is an effective treatment for preventing pain and preparing a patient for certain surgical procedures or testing. Lidocaine is in a family of medicines that are known as local anesthetics and is used to numb the skin of the patient to prevent pain. It acts to block the nerve endings which produce pain in the skin of the patient prior to medical procedures and is highly effective as a pain management tool.

This medication is generally safe, although if not used properly serious side effects have been known to occur. Side effects range from mild to moderate, and from common to rare or unknown. No lasting adverse ongoing health issues have been reported after use has been discontinued. Do not use alcohol or tobacco before or immediately after using this medication, and do not eat food for a period of time determined by your physician prior to or after the use of this medication.

Before using this medication, a physician should be consulted and all allergies to this medication or any other medications and animals, foods, dyes, or preservatives should be reported before use. A needle is not used to administer this medication, instead, a small round container that emits an audible popping sound when depressed is used.

The patient should communicate with a physician while using this medication. Food consumption should also be limited, and when using for the mouth or throat, food should not be consumed within one hour of use of this medication. This medication should be stored away from heat and direct light at a controlled room temperature of (15'30°C, 59'86°F).

Only trained health professionals or nursing staff should oversee the use of this medication. Side effects should be immediately reported to hospital staff or to your physician. This medication is administered by hospital staff or nursing staff when needed only. Only a physician can prescribe this medication.