Lifitegrast (Ophthalmic)

Ophthalmic Lifitegrast (Xiidra) is a prescription eye drop medication used to treat signs and symptoms of Dry Eye Disease (DED).


Ophthalmic Lifitegrast works by reducing swelling in the eye's tissues. This medication blocks a certain protein found on the surface cells of the body. This protein can cause the eye to not produce tears or produce unhealthy tears. Lifitegrast binds to the LFA-1 which is a cell surface protein that is bound on leukocytes. Lifitegrast blocks interactions of LFA-1 with cognate ligand intercellular adhesion molecule-1 (ICAM-1).

This medication is available as a solution and with your doctor's prescription. This medication should only be taken as directed by your health care professional.

Conditions Treated

Dry Eye Disease (DED) symptoms

Type Of Medicine

Lymphocyte function-associated antigen-1 (LFA-1)

Side Effects

Along with Ophthalmic Lifitegrast's desired effects, this medication may also cause a variety of unwanted side effects. If you do experience any of these side effects you may need to seek immediate medical attention.

After administering Lifitegrast, consult your doctor immediately if you experience any of the following side effects:

  • Eye irritation
  • Eye discomfort
  • Changes in vision
  • Blurry vision
  • Redness in the eyes or around the eyes

There are some side effects that are less serious and do not require medical attention. The following side effects could disappear during the course of treatment with this drug as you continue to take the medication. Consult with your physician if any of the following side effects are bothersome or continue for a period of time:

  • Change in the ability to taste food
  • Loss of the ability to taste food
  • Cough
  • Headache
  • Itching in the eye
  • Eye drainage
  • Chest tightness
  • Throat irritation
  • Troubled breathing
  • Stuffy or runny nose
  • Fever
  • Watering in the eyes
  • Pain around the eyes and cheekbones

You could experience other side effects not listed here. If you notice any of these side effects or unusual side effects, contact your doctor immediately. Also, your healthcare professional may be able to inform you about ways to reduce or prevent some of these side effects.

Always contact your doctor for information on side effects before taking this medication.

Always seek medical attention if you experience any serious side effects from any medication.


Ophthalmic Lifitegrast comes as a liquid solution to be administered as drops in the eye. This medication comes in single-use containers (one dose per container).

Use this medication immediately after you open the container and discard any medicine you do not use. You should not save any of this medicine that is left over in the open container. If you do not use all of the medication in a single dose, discard the open container.

Dosage for treatment of Dry Eye Disease:

  • Adults instill one drop in each eye two times per day (12 hours apart)
  • Children should use the dose determined by the health care professional

Lifitegrast is instilled in each eye twice a day, every 12 hours or as directed by your doctor. This medication should be taken around the same time each day.

If you miss a dose, take the missed dose as soon as you remember. However, if it is almost time for your next dose, wait for that dose. Do not use double the amount for a missed dose.

Follow the directions given by your doctor and on your prescription label carefully and if you have any questions, ask your health care provider or pharmacist. Do not use more or less of this medication than prescribed.

To use this medication:

  • Wash your hands thoroughly with soap and water.
  • If you are wearing contact lenses, remove them. Wait at least 15 minutes after you take Lifitegrast before placing your contact lenses back in your eyes.
  • Remove one container from the container strip and hold the container upright and twist off the top.
  • Avoid touching your eye with the dropper tip; eye drops and the dropper must be clean.
  • Tilt your head back, pull down the lower lid of your eye and form a pocket.
  • Hold the tip down on the dropper with your other hand and get as close to your eye as possible without touching it; brace your remaining fingers against your face.
  • While looking up, squeeze the dropper so a single drop is administered into the pocket of your lower lid.
  • Close your eye for two to three minutes and tip your head down; do not blink your eyes while administering this medication.
  • Apply gentle pressure on your tear duct with your finger.
  • Wipe away any excess medicine with a tissue.
  • Repeat the above steps in your other eye.
  • Wash any excess medication off of your hands.

If your symptoms do not improve or become worse, consult with your health care professional.

Dosages listed here are generally recommended doses. Always follow the dosage listed on your medication package or the dosage given by your doctor.


Certain medications should not be used together; however, this medication has no known interactions.

Always tell your doctor about any prescription or non-prescription (over-the-counter) medications you are taking, including supplements and vitamins.


Your optometrist should examine your eyes on a regular basis to make sure this medicine is working properly and is not causing any serious side effects.

If you decide to use this medication, the risks of taking it should be weighed against the benefits to your condition. You should discuss the risks of taking this medication with your health care professional. When taking Lifitegrast, you should consider the following:

Allergies Inform your health care professional if you have any allergies to this or any other medication or any of the ingredients in this medication. Also tell your doctor if you have certain allergies to foods, preservatives, animals or dyes.

Pediatric Safety and efficacy has not been established for Ophthalmic Lifitegrast on pediatric patients.

Always inform your health care professional of all prescription and non-prescription medications, nutritional supplements, and vitamins you are currently taking or are planning to take. If you take any other eye drops or eye medication, be sure to mention these medications to your doctor.

Pregnancy: Inform your health care professional if you are pregnant, breastfeeding, or plan on becoming pregnant. If you do become pregnant while taking this medication, inform your doctor as soon as possible.

Contact Lenses: You should not administer Ophthalmic Lifitegrast eye drops while wearing contact lenses. If you are wearing contact lenses, remove them before instilling this medication and wait 15 minutes before putting your contacts back in your eyes.

Geriatric patients have not shown any adverse effects in the use of Ophthalmic Lifitegrast eye drops.

If you have any questions or concerns about these warnings or any other possible adverse effects while taking this medication, consult your health care professional.


Keep this and all medications out of the reach of children.

Keep this medication sealed and in the container it came in to protect it from the light and contamination. If any of the pouches are open, do not use and discard immediately. Keep the containers that hold this medication in the foil pouch until ready for use.

Store this medication at room temperature and away from excess heat or freezing temperatures.

Do not keep medication longer than needed. If this medication is expired, discard it appropriately. Do not throw away or flush this medication. To dispose of this medication properly, speak to your pharmacist or physician about the FDA's Safe Disposal of Medicines program for more information on how to discard this and other medications.


Ophthalmic Lifitegrast is used in the treatment of signs and symptoms of Dry Eye Disease (DED). This medication is administered by instilling the drops in each eye at 12-hour intervals, two times per day, or as directed by your doctor or pharmacist.

Ophthalmic Lifitegrast reduces swelling in the eye's tissues and works by blocking a cell surface protein which can cause the eye to produce unhealthy tears or not produce any tears at all.

While Ophthalmic Lifitegrast has no known interactions, you should review the warnings section to review any possible problems that could arise while using this medicine.

Side effects of this medication can include blurred vision, eye irritation or discomfort, changes in vision or redness in the whites of your eyes or eyelids. If you experience any of these side effects, contact your health care professional immediately.

If you are pregnant or plan on becoming pregnant or are breastfeeding, contact your health care professional.

Always tell your doctor about any medications you are taking, including prescription, non-prescription, and supplements.