Liothyronine (Intravenous)

Liothyronine will improve symptoms like slow speech, lack of energy, lack of alertness, hair loss, weight gain, feeling cold, and dry skin.


Liothyronine helps treat precoma or myxedema coma, an extremely serious hypothyroidism complication. Hypothyroidism is a problem where your thyroid gland doesn't produce sufficient thyroid hormone.

Liothyronine also helps treat an inflamed thyroid gland known as goiter.

It works by supplying your body with the thyroid hormone.

Liothyronine injection may be an alternative to the oral medication when the oral method of intake is not allowed or when a fast effect is needed.

This medication is only available with a doctor's prescription and is sold under the brand name Triostat.

Liothyronine comes in the following forms of dosage:

  • Injectable
  • Solution

Common Liothyronine side effects include irregular, slow, or fast heartbeat, dizziness, or fainting.

Conditions Treated

  • Myxedema
  • Myxedema Coma

Type Of Medicine

  • Thyroid hormone

Side Effects

Aside from its useful effects, Liothyronine may bring on some adverse effects. While not all of the effects below can happen, if they do happen they may require medical care.

Check with your nurse or doctor right away if you suffer any of these effects:

More common:

  • Fainting
  • Dizziness
  • Irregular, slow, or fast heartbeat

Less common:

  • Blurred vision
  • Bluish color
  • Confusion
  • Chest heaviness or tightness
  • Chest discomfort or pain
  • Skin color changes
  • Lack of breathing
  • Absence of blood pressure or pulse
  • Nervousness
  • Nausea
  • Irregular breathing
  • Heart stops
  • Headache
  • Fever
  • Extreme fatigue
  • Dilated neck veins
  • Decreased urine output
  • Lightheadedness, faintness, or dizziness when rising from a sitting/lying position
  • Wheezing
  • Weight gain
  • Vomiting
  • Unusual tiredness/weakness
  • Unconsciousness
  • Troubled breathing
  • Swelling of lower legs, feet, fingers, or face
  • Sweating
  • Pounding in ears
  • Shortness of breath

Symptoms of overdose:

  • Irritability
  • Weak pulse
  • Cold, clammy skin
  • Menstrual changes
  • Lightheadedness
  • Increased bowel movements
  • Shaking or trembling of feet or hands
  • Shakiness in feet, legs, hands, or arms

Some Liothyronine side effects may happen that don't normally require medical care. These effects may disappear during treatment as you adjust to Liothyronine injection. In addition, your healthcare provider may suggest methods to reduce or prevent some of the effects below. See your healthcare provider if you've got any questions about these effects, if they continue, or if they're troublesome.

Less common:

  • Twitching

Although it might be rare, some patients may develop very serious and sometimes life-threatening side effects when using a medication. Get medical assistance or tell your doctor promptly if you develop any of these signs/symptoms that may indicate a very serious side effect:

  • Signs of an allergy, including hives; rash; swollen, red, peeling, or blistered skin with/without fever; tightness in throat or chest; wheezing; unusual hoarseness; troubled speech or breathing; or swelling of face/mouth/lips/throat/tongue.
  • Signs of excess blood sugar, such as more thirst, more hunger, feeling sleepy, urinating more often, confusion, fast breathing, flushing, or fruity-smell.
  • Signs of a fragile adrenal gland, such as very serious vomiting or upset stomach, very serious passing out or dizziness, feeling of extreme tiredness, muscle weakness, mood changes, weight loss, or not feeling hungry.
  • Abnormal heartbeat
  • Chest pressure or pain or fast heartbeat
  • Feeling excitable and nervous
  • Headache
  • Feeling irritable
  • Sweating a lot
  • Being bothered by heat
  • Menstrual (period) changes
  • Huge weight gain, shortness of breath, or swelling in legs or arms

Other Liothyronine side effects not mentioned above may also develop in some people. If you have any other effects, see your healthcare professional at once.


This medication comes in an injectable variety that is given intravenously (straight into a vein) by a qualified healthcare professional.

The Liothyronine dose your healthcare professional recommends will be determined by the following:

  • The medical disorder being treated
  • The other medical disorder you have
  • Other drugs you're taking
  • How you react to Liothyronine

Depending on the disorder being treated, the normal initial dose is 10-50 micrograms.

For treating precoma or myxedema coma, adults should be injected with 25-50 micrograms into their vein. Doses are usually administered at least 4-12 hours apart. Patients with severe conditions caused by insufficient thyroid hormone may require higher doses. Patients with suspected or known cardiovascular disease may receive lower doses of 10-20 micrograms.

As for children, their dose and use must be decided by your doctor. Contact your child's doctor about the use of Liothyronine in children. Although this medication can be prescribed for kids with selected medical conditions, precautions will apply.

Never use Liothyronine if it has particles, it's discolored or cloudy, or if the container is damaged.

If you've missed a dose of Liothyronine, get in touch with your doctor promptly.

If Liothyronine is given in a medical environment by a healthcare professional, an overdose is unlikely to occur. However, if you suspect you've used too much Liothyronine, call up your local poison control agency or healthcare professional, or get emergency medical care right away.


Tell your healthcare professional about all the drugs you take, such as over-the-counter and non-prescription drugs, herbal supplements, and vitamins. Especially tell your healthcare professional if you use:

  • Warfarin
  • Theophylline
  • Soy isoflavones
  • Rifampin
  • Rifabutin
  • Phenytoin
  • Prednisone/other corticosteroids
  • Phenobarbital/other barbiturate medicines
  • Herbal medicines or medicines for decreasing weight or appetite
  • Female hormones, including birth control pills or contraceptives
  • Medications for mental depression
  • Medicines for breathing difficulties and colds
  • Medicines for diabetes
  • Ketamine
  • Digoxin
  • Amiodarone
  • Carbamazepine
  • The list above may not contain all the possible interactions. Please give your healthcare professional a list of the medicines, dietary supplements, or herbs you use. Also let them know if you take alcohol, smoke cigarettes, or take illegal drugs. Some of these things may interact with Liothyronine.


It's vitally important to have your progress regularly checked by your doctor. This will enable them to determine if Liothyronine is working well and to determine if you should keep taking it. You may need urine and blood tests to check for adverse effects.

Tell your physician if you're allergic to Liothyronine or some of its ingredients. Also tell him or her if you're allergic to any medications similar to Liothyronine, any other drugs, food, or other things. Describe the allergy and its signs, such as itching; hives; rash; wheezing; cough; shortness of breath; swelling of throat/tongue/lips/face; or any other symptoms.

Tell your healthcare professional if you have a weak adrenal gland or overactive thyroid gland.

You must consult your doctor to ensure that it's safe to take Liothyronine with all your health conditions and medicines. Please don't stop, start, or alter the dose of a medicine without first consulting your doctor.

The presence of certain medical disorders may affect your use of Liothyronine. Be sure to inform your physician if you've got any other medical disorders, especially:


Clotting disorder

Untreated adrenal deficiency

History of heart problem

Untreated thyrotoxicosis; overactive thyroid'you shouldn't use Liothyronine if you've got any of these medical conditions

Other adrenal gland disorders

Myxedema (tissue or skin condition caused by hypothyroidism)

Underactive pituitary gland'take Liothyronine carefully. You may need dosage adjustment.

You should not receive a Liothyronine injection if you're also taking artificial rewarmers.

Liothyronine shouldn't be used to treat obesity or for weight loss. This medication is not effective for weight loss and when used in larger quantities, it may lead to more serious medical problems. Be sure to talk to your healthcare professional about the possible risks related to this medication.

Liothyronine has been reported to cause some serious side effects, including the following:

Liothyronine may interfere with your blood sugar'you should have your blood sugar checked more often, especially when you start or stop using Liothyronine, or when your amount of medication is adjusted as Liothyronine can affect your levels of blood sugar.

Liothyronine may make heart problems worse'if you suffer any of the symptoms below, give your doctor a call right away:

Hypothyroidism may sometimes lead to infertility in both men and women. You shouldn't use Liothyronine to treat infertility unless it's due to hypothyroidism.

If you're at least 65 years old, exercise caution when taking a Liothyronine injection. You could develop more side effects.

This medication is not recommended for use by children. Consult your doctor about this.

This medication is for you only. Please don't share it with anybody else, even if their symptoms look like yours.

Tell your healthcare professional if you plan on becoming pregnant or are pregnant. You'll need to discuss the risks and benefits of taking Liothyronine while you're pregnant.

Inform your healthcare provider if you're nursing an infant. You'll need to discuss with your doctor any risks of Liothyronine to your baby.


Liothyronine is administered in a clinic or hospital and won't be kept at home. However, if you need to keep this medication at home, consult your healthcare professional about how to do so.


You'll need regular examinations and blood tests occasionally to check your response to Liothyronine. If you take this medication for your underactive thyroid, it could be weeks before you see an improvement. Consult your healthcare provider if your symptoms don't improve.

If you suffer from diabetes (high blood sugar), you'll need to closely check your blood sugar while you're using Liothyronine.

Liothyronine may affect the level of other medications in your body. Talk to your healthcare professional if you're using other drugs alongside Liothyronine. You blood work may need to be closely monitored while you're taking Liothyronine with other medications.

If you've got any queries about Liothyronine, please consult your healthcare providers, including your nurse, doctor, or pharmacist.

If you suspect there's been a Liothyronine overdose, get medical care or call up your poison control agency immediately. Be prepared to show or tell when it happened, what was taken, and how much was taken.

If you're at least 65 years old, exercise caution when using Liothyronine. You could develop more side effects.

Make sure you don't forget to take your dose. If this happens, see your healthcare provider right away.

Create a list of the drugs you take, including prescription drugs, nonprescription drugs, vitamins, natural products, or dietary supplements. Give your doctor this list.

Before you start using any new mediation, be sure to talk to your physician. Also, don't stop using any medicine without your physician's approval.