Liotrix (Oral)

Liotrix is used to increase the level of thyroid hormones in the body in the treatment of hypothyroidism and other conditions of the thyroid.


Liotrix is provided in the forms of Euthroid and Tyrolar tablets for the treatment of certain conditions of the thyroid. The medication increases the amount of the thyroid hormone in the body to treat hypothyroidism, enlargement of the thyroid gland and thyroid cancer. Liotrix can also be used as a diagnostic aid in the diagnosis of problems affecting the thyroid gland.

Liotrix is only available for use when prescribed by a doctor and may also be prescribed for the treatment of other conditions. Liotrix should not, however, be used in the treatment of obesity or for weight loss. Life threatening results can occur from such use and from use in conjunction with weight loss medications.

Condition treated

  • Thyroid cancer
  • Enlargement of the thyroid
  • Hypothyroidism
  • Diagnosis, of problems with the thyroid

Type Of Medicine

  • Diagnostic aid
  • Hormonal treatment

    Side Effects

In addition to the desired effects that Liotrix can have on conditions of the thyroid, other unwanted side effects can also occur. While they may not all occur in any patient, where they do occur medical attention may be required.

You must contact your doctor immediately if you experience any of the following side effects from the use of Liotrix:

  • Wheezing
  • Weight gain
  • Unusual tiredness or weakness
  • Unable to sleep
  • Troubled breathing or swallowing
  • Trouble sleeping
  • Trouble concentrating
  • Trembling or shaking of hands or feet
  • Tiredness
  • Tightness in chest
  • Swollen joints
  • Swelling of eyelids, face, lips, hands, or feet
  • Sluggishness
  • Slowed heartbeat
  • Sleeplessness
  • Skin rash
  • Shortness of breath
  • Shakiness in legs, arms, hands, feet
  • Redness of skin
  • Nausea
  • Muscle pain or stiffness
  • Muscle aching or cramping
  • Loss of interest or pleasure
  • Lack or loss of strength
  • Lack of appetite
  • Joint pain, stiffness or swelling
  • Itching skin
  • Irritation
  • Irritability
  • Increased weight
  • Increased sweating
  • Increase in blood pressure
  • Hoarseness or husky voice
  • Hives or welts
  • Headache
  • Fever
  • Feeling sad or empty
  • Feeling cold
  • Fear, nervousness
  • Fast, irregular, pounding, or racing heartbeat or pulse
  • Dryness of the eye
  • Dry skin and hair
  • Discouragement
  • Difficulty in moving
  • Depressed mood
  • Constipation
  • Chest pain

Liotrix can also cause thinning of the hair or hair loss to occur. This may be distressing but does not normally necessitate that you contact your doctor. This side effect may become bothersome and you should consult your doctor for advice on how to alleviate it if it does.

Other side effects can also occur from the use of Liotrix that may not have been listed here. If you experience any other side effects from the use of Liotrix then you should inform your doctor. If you believe that your immediate health is at risk, however, then you should contact the emergency services.


Liotrix will usually need to be taken regularly for the rest of your life when treatment has begun. You should not ever cease use nor make changes to your dose without first checking with your doctor. Doing so may cause severe symptoms of hypothyroidism to return.

You may not notice any effect from the use of this treatment for several weeks. You should continue taking it and an improvement in symptoms will occur.

The dose of this medication that you receive will depend largely on the condition that you are being treated for. Other dosing changes may be made because of your wider medical condition, age and other personal factors. You should only ever take this medication as directed to by your doctor and should not ever take a higher dose or take it more frequently than prescribed. The following information is to serve as a guideline only and should not be used to adjust your dose:

When treating hypothyroidism:

  • Adults should be treated with 6.25mcg of liothyronine and 25mcg of levothyroxine once per day. This dose may be further increased but your treatment with Liotrix should not ever be in excess of 37.5mcg of liothyronine and 150mcg of levothyroxine.
  • Children being treated for hypothyroidism should be treated as for congenital hypothyroidism (as below).

When treating congenital hypothyroidism:

  • Children aged from 0-6 months should be treated with 3.1mcg of liothyronie and 12.5mcg of levothyroxine. This can be increased up to a maximum of 6.25 mcg of lipthyronine and 25mcg of levothyroxine once per day.
  • Children aged 6' 12 months should be treated with 6.25 mcg of liothyronie and 25mcg of levothyroxine each day. This may be increased to a maximum of 9.35 mcg of liothyronie and 37.5mcg of levothyroxine.
  • Children aged from 1-5 should be treated with 9.35 mcg of liothyronie and 37.5mcg of levothyroxine once per day. This can be increased up to 12.5 mcg of liothyronie and 50mcg of levothyroxine.
  • Children aged 6-12 should be treated with 12.5 mcg of liothyronie and 50mcg of levothyroxine per day at first. This may be increased up to a maximum of 18.75mcg of liothyronie and 75mcg of levothyroxine.
  • Children over the age of 12 should be treated with 18.75mcg of liothyronie and 75mcg of levothyroxine. The dose may be increased as required.

If a dose of this medication is missed then you should take it as soon as you are able to. If you are close to your next dose being due, however, then you should skip the dose you have missed and return to the normal schedule. Do not ever take double doses of this medication.


Liotrix can interact with other drugs in the body and this must be avoided. Some drug interactions can be life-threatening and others may prevent one another from working properly. To avoid drug interactions occurring during your treatment it is essential that you inform your doctor of all other medications that you are taking. This includes all other prescribed medications, over the counter treatments or herbal remedies. Where drug interactions occur medications may not be prescribed together at all or changes may be made to the dose or dosing schedule. It is especially important that you inform your doctor if you are taking any of the following medications:

The use of Liotrix in conjunction with any of the following is not normally recommended. In some cases both treatments may be required, however, and your doctor may adjust the dose of medication or the frequency of use:

  • Trimipramine
  • Tianeptine
  • Protriptyline
  • Opipramol
  • Nortriptyline
  • Mirtazapine
  • Melitracen
  • Maprotiline
  • Lofepramine
  • Ketamine
  • Imipramine
  • Doxepin
  • Dibenzepin
  • Desipramine
  • Clomipramine
  • Amoxapine
  • Amitriptylinoxide
  • Amitriptyline
  • Amineptine

Using Liotrix in conjunction with the following medications may increase the risk of certain side effects occurring. Use of both drugs may still be the best treatment for you and in this case the dose and dosing schedule may be adjusted so that you can take both treatments:

  • Warfarin
  • Simvastatin
  • Sevelamer
  • Ritonavir
  • Rifapentine
  • Rifampin
  • Rabeprazole
  • Phenytoin
  • Phenprocoumon
  • Phenindione
  • Patiromer
  • Pantoprazole
  • Omeprazole
  • Magnesium Trisilicate
  • Magnesium Oxide
  • Magnesium Hydroxide
  • Magnesium Carbonate
  • Magaldrate
  • Lopinavir
  • Lanthanum Carbonate
  • Lansoprazole
  • Kelp
  • Iron
  • Imatinib
  • Fosphenytoin
  • Estropipate
  • Estrone
  • Estriol
  • Estradiol
  • Esterified Estrogens
  • Esomeprazole
  • Eltrombopag
  • Dihydroxyaluminum Sodium Carbonate
  • Dihydroxyaluminum Aminoacetate
  • Dicumarol
  • Dexlansoprazole
  • Conjugated Estrogens
  • Colesevelam
  • Ciprofloxacin
  • Chromium
  • Cholestyramine
  • Calcium Citrate
  • Calcium Carbonate
  • Calcium Acetate
  • Anisindione
  • Aluminum Phosphate
  • Aluminum Hydroxide
  • Aluminum Carbonate, Basic
  • Acenocoumarol

Other medications not listed here can also interact with Liotrix. To prevent drug interactions from putting you at risk you should inform your doctor of all substances you take.

Interactions can also occur with food and drinks. You should discuss your use of tobacco, alcohol, and food and drinks with your doctor before use. When taking Liotrix it is especially important that you do not consume the following during use:

  • Enteral Nutrition
  • Soybean

Other medical problems from which you suffer can also affect the use of Liotrix. This is because some conditions may be worsened by medication for the treatment of other conditions. In other cases certain medical conditions may prevent the medication from working properly. Before taking Liotrix it is especially important that you inform your doctor if you suffer from any of the following conditions.

This medication should not be used in patients with the following conditions:

  • Adrenal insufficiency
  • Thyrotoxicosis

Dosage adjustments may be required in patients suffering from the following conditions:

  • Clotting disorder
  • Diabetes
  • Heart disease
  • History of heart disease
  • Other adrenal gland problems

Inform your doctor of all medical problems from which you suffer. Other problems not listed herein may also affect the use of this treatment.


Before you begin use of Liotrix it is important that you consider the risks of use in relation to the benefits of use. This medication is usually required for a lifetime so it is important to consider the side effects and all other factors. Make the decision to use this medication with your doctor having taken all of the following into account:

Allergies 'It is very important that you inform your doctor if you have ever had an allergic reaction or unusual reaction to any medication in the past. You must also inform your doctor of any other allergies from which you suffer including allergies to foods, dyes, preservatives, animals and other substances.

Pediatric' Studies performed to date have not identified any limitations to the use of Liotrix in children.

Geriatric ' There are no known limitations to the use of Liotrix in elderly patients. Caution should be used, however, as elderly patients are more likely to have conditions of the heart, liver or kidney that may affect the use of this treatment.

Pregnancy' There is only a minimal risk to the use of this medication in pregnant women. Previous studies have not shown signs of fetal abnormalities from use.

Breastfeeding'Studies have shown a minimal risk to infants from the presence of levothyroxine in breastmilk. The risks from the presence of liothyronine are unknown. Patients should consider the risks in relation to the benefits of continuing to breastfeed.

Your doctor will need to make regular checkups with you when you are being treated with this medication. This will allow them to make dosage adjustments where required, check that the treatment is still needed and look for any unwanted side effects that could be occurring. To allow for these checks to be made blood and urine tests may be taken at each visit for analysis.

Liotrix should not ever be used for the treatment of obesity or for the purpose of weight loss. This medication is ineffective for this purpose and when taken in large quantities can cause potentially life-threatening and fatal consequences.

Infertility can sometimes occur in both men and women from the use of Liotrix. The medication should not ever be used to cause this, however, and is ineffective as a contraception. Patients should discuss this with their doctor if they are concerned about infertility or are planning to have children in the future. They may be advised to freeze sperm or eggs in case infertility occurs.

You should call your doctor immediately if you start to suffer any kind of chest pain, irregularity of heart rate or nervousness. These may be signs of problems developing from use of the medication and may need to be treated straight away.

Patients who suffer from diabetes must regularly assess and record sugar levels in their blood or urine when taking this treatment as it may impact the levels. You should do so as instructed by your doctor and should be alert to changes, especially around times when doses of the medication are changed.

This medication can cause the occurrence of temporary loss of hair. This will happen in the initial period of 1-2 months of treatment, but the body should then adjust to the treatment and the side effect usually abates with normal hair growth returning. This may not always be the case. If you have any concerns about this then you should consult your doctor for advice.


This medication should be stored in a refrigerator but should not be frozen at any time.

Always keep the medication out of the reach of children.

Dispose of any unwanted or outdated medication safely.


Liotrix is an oral medication that increases the level of the thyroid hormone in the body. It is used in the diagnosis or thyroid conditions and in the treatment of a range of conditions of the thyroid. Conditions treated include enlargement of the thyroid, hypothyroidism and thyroid cancer.

Use of Liotrix is usually required for life once treatment has started.

This medication should not ever be used in the treatment of obesity or for weight loss. To do so can put the patient at serious risk of fatal medical complications and the treatment is also ineffective for this purpose.

Liotrix can cause a temporary thinning of the hair and hair loss to occur. This will usually only last for the first few months and then normal hair growth will usually resume. If you have any concerns about this then consult your doctor before use.