Lisdexamfetamine Dimesylate (Oral)

Lisdexamfetamine Dimesylate capsules are prescribed for various disorders of the central nervous system such as binge eating and attention deficit hyperactivity.


A central nervous system condition known as ADHD, attention deficit hyperactivity disorder, causes symptoms such as difficulty being calm and still, controlling physical actions and trouble focusing in both adults and children. Thought to be a disorder involving the neurotransmitters of the brain firing hyperactively, ADHD can be debilitating, making it difficult to be in a classroom or office setting or to develop personal relationships. Lisdexamfetamine Dimesylate capsules, marketed and sold under the name Vyvanse, have been proven to increase the attention span while controlling restless symptoms in many age groups.

Lisdexamfetamine Dimesylate directly affects the storage of two neurotransmitters found in the brain, dopamine and norepinephrine, releasing them to increase focus and alertness in the patient. Lisdexamfetamine Dimesylate is a prodrug, meaning it has no activity until metabolized by the body, at which time it becomes dextroamphetamine. Making dopamine and norepinephrine neurotransmitters its main targets, dextroamphetamine provides more alertness and sustains thought processes and efforts to stay motivated in most patients.

Lisdexamfetamine Dimesylate is also prescribed for patients with a disorder to binge eat. Again, the action of blocking the uptake of dopamine and norepinephrine to create more focus directly affects the patient's compulsive actions to binge eat, making them better able to control their actions and keep themselves from binging on food.

Either condition, ADHD or BED, will require a complete therapy program that doesn't just include Lisdexamfetamine Dimesylate, but also includes educational, psychological and social therapies as well. Regular office visits will be scheduled for most patients to determine if they should continue on the drug route and what other treatments they require to lead full, healthy lives.

Amphetamine classification drugs include warnings to patients that Lisdexamfetamine Dimesylate use can be an addiction risk, forming a habit that the brain and the body come to depend on. Regular therapeutic dosage size will not cause undue addiction risk in most patients, but those who increase their dosage or abuse the drug may become dependent on it. Patients will find that, with long term use of Lisdexamfetamine Dimesylate, the more it takes to affect their symptoms as the tolerance to the drug rapidly develops in their body.

Conditions Treated

  • ADHD
  • BED

Type Of Medicine

  • Neurotransmitter uptake inhibitor
  • Dextroamphetamine
  • Dopamine uptake inhibitor
  • Central nervous system agent
  • Amphetamine

Side Effects

Affecting brain function and the central nervous system to provide focus and stability, Lisdexamfetamine Dimesylate may also cause unwanted symptoms that can be the sign of an underlying health issue that should be treated right away. Alert your physician if you have:

  • Out-of-control, repeated movements of the body, tics
  • Out-of-control vocalizations
  • Skin loosening, peeling or blistering
  • Uncomfortable, painful chest sensations
  • Chills
  • Coughing
  • Diarrhea
  • Difficulty breathing
  • Discouraged mood
  • Difficulty swallowing
  • Dizzy
  • Fainting spells
  • Irregular, rapid or pounding heart rhythm
  • Sad, empty or depressed feeling
  • Itching, welts or rash on skin
  • Irritable mood
  • Muscle or joint pain
  • Little to no appetite
  • Swollen patches on sex organs, hands, feet, legs, throat, eyelids, face, tongue or lips
  • No interest in pleasurable pursuits
  • Puffy, swollen eyes, lips, tongue or face
  • Lesions on skin are red in color with purple middles
  • Irritated, bloodshot eyes
  • Skin redness
  • Throat soreness
  • Ulcerated white sores on lips or mouth
  • Swollen lower legs or feet
  • Chest constriction
  • Difficulty concentrating
  • Insomnia
  • Repetitive movements such as twisting or twitching in the lips, tongue, arms, legs or face
  • Muscle weakness
  • Fatigue

Other side effects typically disappear over time and use of Lisdexamfetamine Dimesylate, as your system becomes accustomed to the medication. You should still let your doctor know of these symptoms in case there is a way to alleviate them:

  • Little to no appetite
  • Headache
  • Nauseated feeling
  • Pain in stomach or upper abdomen
  • Vomiting
  • Losing weight
  • Weeping or crying
  • Cutting oneself off from everything and everyone
  • Mouth dryness
  • Euphoric demeanor
  • Generally dissatisfied or dysphoric
  • Elevated body temperature
  • Paranoid demeanor
  • Emotional overreaction to everyday situations
  • Mood swings
  • Drowsy, sleepy demeanor

Seek emergency medical care if you or someone close to you notices symptoms of overdose, which include:

  • Cramps in abdomen or stomach
  • Blurry vision
  • Losing consciousness
  • Confused demeanor
  • Urine is dark in color
  • Faint, lightheaded or dizzy when rising
  • Rapid breathing
  • Spasms or cramps in muscles
  • Stiff, painful muscles
  • Nervous demeanor
  • Reflexes that overreact to normal stimulation
  • Panic disorder
  • Self harm incidents
  • Pounding noise in ears
  • Restless demeanor
  • Delusional
  • Seizures or spasms
  • Shaking hands, feet, arms or legs
  • Overactive sweat glands
  • Feet or hands shake or tremble
  • Violent tendencies

Any changes in your overall health or mental state should be reported to your physician in every case, to protect your wellbeing. You may experience symptoms other than those listed here; every patient is different. Symptoms that seem prolonged or severe or affect your daily life can be alleviated in most cases if you talk to your doctor.


When receiving your first prescription of Lisdexamfetamine Dimesylate, you will be provided with a printed informational leaflet that you should read and understand. Ask any questions of your physician or your pharmacist that are necessary to provide you with an entire picture on how this medication will work on your condition and any risks to your health it may cause.

Prior to being prescribed Lisdexamfetamine Dimesylate, you or your child will be screened for any cardiac diseases including questions about your family medical history. Be prepared to be subjected to physical testing as well as to provide medical information on any family members that have had fatal cardiac incidents.

Take your prescribed amount of Lisdexamfetamine Dimesylate exactly as written by your physician and do not increase the amount you take for any reason. Do not change the frequency in which you are instructed to take this drug and do not take it longer than you are supposed to. Taking too much Lisdexamfetamine Dimesylate can put you at risk for becoming addicted to the medication, creating a dangerous situation for your health. If you feel that your medication is no longer working effectively against your symptoms, get in touch with your doctor before altering your own dosage.

It is recommended that you take your dose of Lisdexamfetamine Dimesylate first thing in the morning, with or without eating a meal. Taking this drug later in the day could disrupt your sleep pattern by causing you to be more wakeful than normal.

Swallow the capsule whole without chewing, crushing or dividing it in any way. Children or patients who have difficulty swallowing may open the capsule, mix the contents with yogurt, juice or water, stir to dissolve and swallow immediately. After mixing, take the entire amount immediately without storing it for later.

ADHD patients who are at least six years old and through adulthood will most likely be prescribed 30 milligrams to be taken once daily. This dose may slowly be increased but will typically not exceed 70 milligrams in a 24 hour period. Children who are younger than six must have their dosage specifically written for them by their physician.

BED patients, typically adults, will also be prescribed 30 milligrams for a once daily dose as a general rule. This dosage may be increased but will not exceed 70 milligrams per day in amount. Children who are diagnosed with BED will have their prescriptions determined especially for them by their health care provider.

Missing a dose of Lisdexamfetamine Dimesylate should not prompt you to ever double your dose to make up the missing amount. Instead, skip the missing dose and resume your regular dosing schedule as soon as possible. It is not recommended that you miss a dose, as this medication works best by remaining in steady amounts in your system. Consult your physician if you have any questions about missing a dose.


Sensitive reactions to this medication or others like it that you've had in the past should be reported prior to being prescribed Lisdexamfetamine Dimesylate for treatment. Similarly, if you've poorly reacted to exposure to foods, animals, perfumes, dyes or preservatives in the past, you should also alert your physician to these situations as they could cause unwanted interactivity with this drug.

Pediatric patients who are at least six years old should have no difficulty or higher risks associated with taking Lisdexamfetamine Dimesylate to treat their ADHD symptoms. Children younger than six, however, may not be safe taking this drug and it may not work on their symptoms effectively. Use in very young patients is not recommended without caution as to the dosage size by the prescribing physician.

Elderly patients, due to common deficiencies in their heart function, may require an adjusted dosage to treat their ADHD or BED symptoms with Lisdexamfetamine Dimesylate. Other than cardiac concerns, there is no reason that geriatric patients cannot take this medication.

Active ingredients found in Lisdexamfetamine Dimesylate have been known to affect fetal health and cause low weight at birth, premature delivery situations and other adverse pregnancy results. Avoid taking this medication, if possible, while pregnant.

Women who breastfeed should avoid doing so if they are taking this medication. Discuss breastfeeding risks with your physician, as this medication will travel to your infant in your breast milk and possibly cause harm to your infant.

Some medications work together to provide a full treatment therapy to patients with multiple symptoms and Lisdexamfetamine Dimesylate may be prescribed with other medications for this reason. Other medicines, however, may interact poorly together and create dangerous health situations. Be sure to tell your physician if you are taking:

  • Furazolidone
  • Isocarboxazid
  • Iproniazid
  • Methylene Blue
  • Linezolid
  • Phenelzine
  • Moclobemide
  • Rasagiline
  • Procarbazine
  • Selegiline
  • Safinamide
  • Tranylcypromine
  • Sibutramine

Other medications, while not dangerous to take with Lisdexamfetamine Dimesylate, do not create the ideal situation for your overall health. Your physician may want to adjust your dosage if you currently take:

  • Donepezil

It is advised that patients who are taking Lisdexamfetamine Dimesylate avoid any other substances that affect the central nervous system during their treatment therapy. This includes any alcoholic beverages, seizure medication, sleep aids and tranquilizers. Discuss use of these substances with your physician.

You may be placed on a special diet or instructed to quit using tobacco products if you are taking Lisdexamfetamine Dimesylate. Listen carefully and follow all advice given to your by your doctor to maintain your health and wellbeing while being treated with this drug.

Medical issues such as the ones listed below may have an effect on how Lisdexamfetamine Dimesylate works on your condition. They may also increase the chances of unwanted symptoms occurring with use of the drug. Report these pre-existing conditions to your physician:

  • Alcoholism
  • Drug dependency
  • Sensitivity to amphetamines or products that contain them such as Desoxyn, Adderal, Dextrostat or Dexedrine
  • Heart disease, heart attacks, rhythm problems, failures or coronary artery conditions
  • Stroke
  • Manic depressive disorder
  • Bipolar symptoms
  • Problems with blood vessels
  • Depression
  • Hypertension
  • Mania
  • Muscle movement repetition or tics
  • Psychosis
  • Seizures
  • Tourette's syndrome
  • Severe kidney disease


Lisdexamfetamine Dimesylate has been known to cause dependence and abuse symptoms in some patients. Risk abuse assessment and evaluation will be performed on every patient prior to recommending a prescription of this medication. Patients will be monitored for any signs of dependency or abuse of this medication.

Expect to keep regular evaluation appointments with your physician to make sure the medication is working to combat your ADHD or BED symptoms without causing any adverse effects on your health. Your dosage may be adjusted or you may be removed from this medication depending on your response. You will typically be given blood tests as well as examinations of your heart and blood pressure to make certain you aren't suffering any ill effects on your health.

Avoid using this medication if you have recently used an MAO inhibitor type of medication including Marplan, Eldepryl, Parnate or Nardil. These medications can stay in your system for a few weeks, so let your doctor know even if you have taken it for some time.

Alert your physician to anything else you're taking when beginning your prescription of Lisdexamfetamine Dimesylate, including any over-the-counter medications or vitamins, herbs and holistic supplements to be safe from any interactions that can affect your health.

Medications that contain central nervous stimulators should be avoided during your treatment with this medication. This includes any diet supplements, asthma medications, cold and flu treatments, allergy treatments, tranquilizers and sleeping medications.

You may experience blurry vision and dizzy symptoms when you take this medication, so before you put yourself or others in danger by getting behind the wheel of a car or operating heavy equipment or tools, be certain of your ability and alertness in these situations.

This medication has been known to elevate the risk of some patients contracting blood vessel or heart problems including stroke and heart attack. Patients with a family medical history of these conditions are at an even higher risk. It is advised that you report symptoms such as difficulty breathing, chest pain or losing consciousness to your doctor right away.

Mood changes such as aggressive behavior, hostile demeanor, agitated, irritable mood swings or tendencies leaning toward suicide should be reported to your physician or to a person in authority immediately, especially if these are new conditions or worsening rapidly.

Lisdexamfetamine Dimesylate has been known to slow the growth of some children who use it long term to treat their ADHD symptoms. Your child's physician will regularly check the weight and height of your child to make sure they are not suffering from any growth inhibition with use of this medication.

Raynaud phenomenon has been reported in some patients using Lisdexamfetamine Dimesylate, which is a vascular disease that is typically noticeable in the fingers or toes as they change color from pale white to blue and feel cold to the touch. Report these symptoms to your doctor right away.

Alert any doctor providing you health care services that you are taking this medication; this includes dental professionals and any physicians performing medical tests, as their results may not be as expected.


Store this medication out of sight and reach of children and pets and in the original packaging for safety. Room temperature conditions, away from excessive heat, moisture or light are ideal for your capsules of Lisdexamfetamine Dimesylate as long as it is not allowed to freeze. Dispose of any unused or expired medication per the safety instructions provided to you by your pharmacist or physician. There may be a medicine recycling program in your local community that could benefit from your donation of unexpired, unused doses of this medication. Your physician will have all information necessary about this type of program.


Lisdexamfetamine Dimesylate is a longer lasting, less abused form of dextroamphetamine, a central nervous system inhibitor of the reuptake of two neurotransmitters that form the focus and concentration in the brain of health patients. By stopping the reuptake of dopamine and norepinephrine, these two neurotransmitters occur at a higher level in the patient's central nervous system, creating a more healthy level of alertness, focus and effort. This medication is used primarily in the treatment of ADHD and BED disorders, which include symptoms of binge eating, nervousness, restlessness and lack of focus.

Safe for patients who are at least six years old, Lisdexamfetamine Dimesylate has been named Vyvanse for market and sales purposes. It is prescribed in capsule format and is designed to be taken once per day, typically in the morning, either with or without a meal. Taking the medication later in the day may impair sleeping ability and cause insomnia in some patients. Patients are cautioned to take their dosage, typically 30 milligrams in size to begin with, on a regular basis to provide a steady level in their body. It is not advised that patients miss a dose, but if they do, they should skip it in favor of doubling their dosage amount.

Lisdexamfetamine Dimesylate has a risk of causing dependency and abuse in some patients, especially those with a history of drug or alcohol abuse. Caution and monitoring of these patients is mandatory and they are cautioned not to change their dosage unless advised to do so by their physician. Patients who have cardiac or blood vessel disorders, other mental disorders, and women who are pregnant or breastfeeding are all cautioned not to use this medication due to harmful effects it can have on health.

Patients should report unwanted symptoms such as mood swings, signs of muscle tics or vocal outbursts, adverse skin symptoms, flu-like symptoms or swelling and swollen patches on the body to their physician in case of severe, long-term effects on their health as the result of using this drug.