Lisinopril (Oral)

Overview

The prescription drug called lisinopril, alone or paired with other drugs, is an effective treatment for the symptoms related to hypertension. This ACE inhibitor helps to lower the patient's blood pressure and prevent the occurrence of serious medical conditions such as heart attacks and strokes that can be caused by prolonged high blood pressure.

This ACE inhibitor is effective in preventing the following medical conditions from occurring:

  • Stroke
  • Heart attack
  • Kidney issues
  • Severe damage to the blood vessels

Lisinopril is effective in increasing the flow of blood throughout the body and also in increasing the amount of oxygen that is delivered to the heart.

This medication is also administered in the event of heart failure or of a heart attack. When the lisinopril course of treatment is started within the first 24-hour period following an event, it can help to forestall some of the damage to the heart muscle that typically occurs with such instances.

The use of lisinopril has been reported to cause anaphylaxis in some cases. Patients and their caregivers are encouraged to know the signs and symptoms of this reaction and know what steps to take should they occur.

Intestinal angioedema can occur while taking this medication. Notify your doctor immediately if you experience any severe pain in the stomach or abdomen area; this may occur either with or without vomiting and nausea.

African American patients have a higher likelihood of developing angioedema and this medication may be less effective for such patients. Discuss these concerns with your doctor prior to starting the course of treatment.

Do not take any potassium supplements while taking this medication. Do not use any products such as salt substitutes that may contain potassium as it is possible for patients on lisinopril to develop a condition known as hyperkalemia which is caused by excess amounts of potassium in the bloodstream.

Any women of childbearing age who are taking lisinopril should employ effective contraceptive methods while taking this drug as it can cause harm to the developing fetus.

Lisinopril comes in the following two methods of dosage delivery:

  • Solution
  • Tablet

Conditions Treated

  • High blood pressure

Type Of Medicine

  • Angiotensin-converting enzyme (ACE) inhibitor

Side Effects

Lisinopril, like many prescription medications, can cause unwanted side effects in addition to the desired outcomes of the drug. Patients and their caregivers are encouraged to recognize the differences between the symptoms that may be a sign of a more serious issue, and those that will likely go away on their own.

If any of the following side effects and symptoms should occur it is important to contact your doctor for further medical advice:

More likely:

  • Blurred vision
  • Unexplained tiredness
  • Sweating
  • Confusion
  • Dizziness, faintness, or lightheadedness
  • Weakness
  • A decrease in urine output or decrease in urine
  • Cloudy urine

Less likely:

  • Abdominal or stomach pain
  • Sneezing
  • Chest pain
  • Nausea
  • Symptoms of the common cold
  • Loss of one's voice
  • Diarrhea
  • Fever
  • Ear congestion
  • Vomiting
  • Headaches
  • Difficulty breathing
  • Nasal congestion
  • Coughing
  • A runny nose
  • Chills
  • Sore throats
  • Body aches or pain

A rare likelihood of occurrence:

  • Arm, back, or jaw pain
  • Chest discomfort, tightness, or heaviness
  • Fast or irregular heartbeat
  • A general feeling of discomfort or illness
  • Joint pain
  • Loss of appetite
  • Muscle aches and pains
  • Shivering
  • Trouble sleeping

As your system adjusts to the introduction of lisinopril you will likely experience some symptoms that will dissipate on their own. Should any of these symptoms last longer than a few days or become worse, contact your doctor for further medical advice:

Less likely:

  • Loss of sexual ability, desire, drive, or performance
  • Inability to have or keep an erection
  • Decreased interest in sexual intercourse
  • Rash
  • Lack or loss of strength

A rare likelihood of occurrence:

  • Acid or sour stomach
  • The sensation of spinning
  • Swelling
  • Indigestion
  • Heartburn
  • Burning, crawling, itching, numbness, or feelings
  • Muscle cramps
  • The feeling of constant movement of self or surroundings
  • Stomach discomfort or upset
  • Belching

The above list of side effects is comprehensive in nature, yet it is possible that you may experience some symptoms that are not listed here. In the event that the patient experiences any side effects that last longer than a few days or become worse, contact your prescribing physician for further medical advice.

Dosage

The successful treatment of hypertension involves more than simply taking a pill. Your doctor will review potential changes that you can make to your diet and activity level that can help you to successfully manage this incurable condition. Review all changes that you plan to make with your physician prior to enacting them and keep them apprised of your progress. Most importantly, you will be encouraged to adopt a low-sodium diet that can help to make managing your hypertension more effective.

High blood pressure can often occur without the appearance of any significant symptoms or signs that you have the condition. Many people feel completely well until they are diagnosed with hypertension. Because of this, it can be tempting to be lulled into a false sense of security and begin to act in a complacent manner.

As this medical condition does not currently have a cure, it is important to continue taking the medication in order to effectively manage your hypertension. Patients must also keep all follow-up appointments with their doctors as scheduled.

Even moderate hypertension can cause further complications such as heart attacks, heart failure, stroke, kidney disease, and blood vessel issues if the condition is not managed in a proactive manner.

The oral liquid should be measured with the enclosed spoon as common household utensils do not provide the level of accuracy that is necessary to ensure a proper dosage. The marked spoon that is provided should be used to measure each dose and thoroughly rinsed afterward.

The dosage guidelines that are outlined below represent the typically prescribed amounts; however, your doctor may prescribe a different dosage amount. It is important to always follow the instructions that are provided with your prescription and not make any alterations to the way that you take this medication without first discussing such changes with your doctor.

For the treatment of hypertension:

Adults: Initially, 10 milligrams taken one time each day. Once the effectiveness of the medication has been determined, your doctor may alter the amount of your dosage with a maximum daily dosage of 40 milligrams in one day.

Children 6 years of age and older:

The amount of this medication that children are typically prescribed is based on their weight; initially, .07 milligrams will be prescribed for each kilogram of the child's weight. Once the patient's system has had time to adjust to the medication, the prescribing physician may increase it or make other changes. The typical maximum dosage amount of this medication is 40 milligrams per day.

This medication is not intended for use in children who are younger than 6 years old.

For the treatment of heart failure:

Adults: Initially, 5 milligrams taken one time each day. Once the effectiveness of the medication has been determined, your doctor may alter the amount of your dosage with a maximum daily dosage of 40 milligrams in one day.

Children: any use of this medication for the treatment of heart failure will be determined by the child's physician on a case by case basis.

For immediate treatment after a heart attack:

Adults: Initially, 5 milligrams in the first 24-hour period, and then another 5 milligrams. After a 48-hour period, the patient will take 10 milligrams. From that point forward the typical dose is 10 milligrams taken one time per day.

Patients who inadvertently miss a scheduled dose should take it as soon as possible. Do not take a double dose in order to make up for one that is skipped. If you have any questions about what to do after missing a scheduled dose of this medication, contact your pharmacist for further instruction.

Major Drug Interactions:

Like most other prescription drugs, lisinopril is contraindicated for use with certain other medications. There are certain medications that your doctor may change if lisinopril is deemed to be the best treatment for your condition. If you are taking other drugs that are known to have complications when taken with lisinopril the way in which you take one or both of the drugs may be altered. There are other medications that when taken with lisinopril may have a higher risk of the patient experiencing side effects. Your doctor may alter the way in which you take one or both of the medications and may be able to share strategies with you to minimize the chance of experiencing unwanted side effects.

It is not recommended that lisinopril is taken with these two medications. Your doctor may change your medication to an alternative option in order to avoid taking these medicines concurrently with lisinopril:

  • Sacubitril
  • Aliskiren

Taking lisinopril concurrently with the drugs listed below is not recommended and your doctor may alter the way in which you take one or both of the medications:

  • Triamterene
  • Azathioprine
  • Spironolactone
  • Azilsartan Medoxomil
  • Potassium
  • Canrenoate
  • Mercaptopurine
  • Eprosartan
  • Lithium
  • Irbesartan
  • Valsartan
  • Losartan
  • Everolimus
  • Olmesartan Medoxomil
  • Eplerenone
  • Sirolimus
  • Candesartan Cilexetil
  • Telmisartan
  • Azilsartan
  • Trimethoprim
  • Amiloride
  • Alteplase, Recombinant

It is not recommended to take lisinopril at the same time as the drugs listed below as the risk of side effects may be increased. Your doctor may change the way in which one or both of the drugs are taken:

  • Aceclofenac
  • Tolmetin
  • Amtolmetin Guacil
  • Tizanidine
  • Azosemide
  • Tenoxicam
  • Bufexamac
  • Sodium Salicylate
  • Bupivacaine
  • Salicylic Acid
  • Capsaicin
  • Proquazone
  • Choline Salicylate
  • Propionic Acid
  • Dexibuprofen
  • Piroxicam
  • Flufenamic Acid
  • Piketoprofen
  • Dipyrone
  • Parecoxib
  • Ethacrynic Acid
  • Oxaprozin
  • Etofenamate
  • Nimesulide
  • Felbinac
  • Nesiritide
  • Fepradinol
  • Lornoxicam
  • Naproxen
  • Floctafenine
  • Morniflumate
  • Flurbiprofen
  • Mefenamic Acid
  • Gold Sodium Thiomalate
  • Lumiracoxib
  • Indomethacin
  • Nepafenac
  • Ketorolac
  • Diclofenac
  • Loxoprofen
  • Ketoprofen
  • Meclofenamate
  • Ibuprofen
  • Meloxicam
  • Furosemide
  • Nabumetone
  • Salsalate
  • Niflumic Acid
  • Fenoprofen
  • Nimesulide Beta-Cyclodextrin
  • Etoricoxib
  • Oxyphenbutazone
  • Etodolac
  • Phenylbutazone
  • Droxicam
  • Piretanide
  • Diflunisal
  • Proglumetacin
  • Dexketoprofen
  • Propyphenazone
  • Clonixin
  • Rofecoxib
  • Celecoxib
  • Feprazone
  • Bupivacaine Liposome
  • Sulindac
  • Bumetanide
  • Tiaprofenic Acid
  • Bromfenac
  • Tolfenamic Acid
  • Aspirin
  • Torsemide
  • Acemetacin
  • Valdecoxib

Inform your doctor of any lifestyle habits that you have that may interfere with the way in which your body reacts to lisinopril, such as the use of alcohol or tobacco products. This medication is typically taken with a low-sodium diet and your doctor may have other recommendations on certain lifestyle changes that can be beneficial in the treatment of hypertension.

The use of this medication can have an effect on the way that certain medical conditions react, with some worsening or causing other complications. If you suffer from any of these conditions that are listed below be sure to discuss your concerns with your doctor prior to starting your lisinopril course of treatment:

  • Angioedema treated with other ACE inhibitors
  • Fluid imbalances
  • Diabetes
  • Patients who have kidney problems and are also taking aliskiren
  • Liver disease
  • Electrolyte imbalance
  • Kidney problems
  • Diabetes patients who are also taking aliskiren
  • Heart or blood vessel problems
  • Collagen vascular disease together with kidney disease
  • Hereditary or idiopathic angioedema

Warnings

The treatment of hypertension is an ongoing endeavor and as such your doctor will likely order regular diagnostic testing such as blood tests and urine screenings. Because this is an incurable condition that can cause serious medical issues if not effectively treated, it is important to keep all follow-up appointments and undergo all testing as scheduled.

This medication should not be used during pregnancy as it can cause damage to the developing fetus. Maintain effective contraceptive methods while taking this medication. Patients who become pregnant while taking this medication should inform their doctor immediately.

The use of lisinopril has been reported to cause anaphylaxis in some cases. Patients and their caregivers are encouraged to know the signs and symptoms of this reaction and know what steps to take should they occur.

If you experience any of the following signs and symptoms of this harmful and potentially fatal reaction call 911 or seek emergency medical care right away:

  • Rash
  • Difficulty breathing
  • Swelling of your hands, face, mouth, or throat
  • Itching
  • Difficulty swallowing
  • Hoarseness

Intestinal angioedema can occur while taking this medication. Notify your doctor immediately if you experience any severe pain in the stomach or abdomen area; this may occur either with or without vomiting and nausea.

African American patients have a higher likelihood of developing angioedema and this medication may be less effective for such patients. Discuss these concerns with your doctor prior to starting the course of treatment.

This medication can cause lightheadedness or even fainting in some instances. Take care when rising from a lying or sitting position especially if you are also taking water pills. Do not drive, operate heavy machinery, or undertake any other activity that requires full alertness without first understanding how your body reacts to lisinopril. If you do feel lightheaded, lie down until the dizziness passes.

Any illness that occurs while taking this medication should be reported to your doctor. If you experience any prolonged diarrhea or vomiting you can develop dehydration or lose too much salt which can cause you to develop low blood pressure. Be sure to stay thoroughly hydrated while taking this medication.

If you have a low white blood cell count you can be more susceptible to infections and should avoid anyone who is currently suffering from an infection. If you develop any of the signs of infection be sure to confer with your doctor before it develops into something more serious. Patients who are taking this medication and experience a sore throat, chills and a fever should notify their prescribing physician.

Patients who are taking lisinopril may develop a condition known as hyperkalemia which is caused by an excess of potassium in the bloodstream. Notify your doctor immediately if you experience:

  • Abdominal or stomach pain
  • Numbness or tingling in the hands, feet, or lips
  • Difficulty with breathing
  • Weakness or heaviness of the legs
  • Nervousness
  • Irregular heartbeat
  • Shortness of breath
  • Confusion
  • Nausea or vomiting

It is important that patients who are taking lisinopril avoid taking any potassium supplements or products such as salt substitutes that contain potassium. If you are unsure about the safety of any product, discuss them with your prescribing physician prior to use.

Serious liver problems can occur in patients who are using lisinopril; notify your doctor as soon as possible if you experience:

  • Pale stools
  • Nausea
  • Upper stomach pain
  • Dark urine
  • Unexplained tiredness or weakness
  • Loss of appetite
  • Yellow eyes or skin

Lisinopril can affect your blood sugar. Your doctor will likely require regular diagnostic tests to ensure that you do not develop this condition.

Inform all doctors that you may see that you are taking this medication especially if you are discussing having surgery. This includes any dental surgeries or procedures as well. It is likely that you will be required to stop taking this medication prior to undergoing any surgical procedure.

Do not start taking any new medications while you are taking this medication. Avoid over the counter remedies for sinus infections, colds and the like as they can interfere with how your body reacts to this medication. Do not take weight loss medicines while you are taking this drug. Discuss any changes to the medications that you take with your doctor prior to making any alterations.

Storage

Patients are always advised to store all medications in their original packaging in a low-moisture environment and away from direct light. Keep the medication at room temperature, do not expose this medication to extreme heat or cold; do not allow it to freeze.

Store this and all medications out of the reach of small children and pets.

Make sure to dispose of all unused, excess, and expired medication in a safe and appropriate manner. Speak with your pharmacist for further guidance on proper disposal methods.

Medication that has been mixed (liquid) may be stored for a period no longer than four weeks at room temperature or cooler temperature.

Summary

The prescription drug called lisinopril, alone or paired with other drugs, is an effective treatment for the symptoms related to hypertension. This ACE inhibitor helps to lower the patient's blood pressure and prevent the occurrence of serious medical conditions such as heart attacks and strokes that can be caused by prolonged high blood pressure.

This ACE inhibitor is effective in preventing the following medical conditions from occurring:

  • Stroke
  • Heart attack
  • Kidney issues
  • Severe damage to the blood vessels

Lisinopril is effective in increasing the flow of blood throughout the body and also in increasing the amount of oxygen that is delivered to the heart.

This medication is also administered in the event of heart failure or of a heart attack. When the lisinopril course of treatment is started within the first 24-hour period following an event, it can help to forestall some of the damage to the heart muscle that typically occurs with such instances.

The use of lisinopril has been reported to cause anaphylaxis in some cases. Patients and their caregivers are encouraged to know the signs and symptoms of this reaction and know what steps to take should they occur.