Mangafodipir (Intravenous)

Mangafodipir is a contrast imaging agent used in radiology procedures to provide a diagnosis of the liver during an MRI (Magnetic Resonance Imaging) scan.

Overview

The medicine is given by injection into a vein of the patient by a nurse or healthcare professional. This is usually done at a hospital, clinic or diagnostic center. A doctor usually supervises the procedure.

The drug is slowly infused into a vein over a period of time before the procedure is performed.

The MRI scan helps the doctor to detect the presence of lesions caused by hepatocellular carcinomas or metastatic disease.

Mangafodipir is the generic name for this medicine which is sold in the US as Teslascan. It may be used for other procedures, such as an MRI of the pancreas, not discussed in this guide.

Condition treated

Diagnosis of the liver

Type Of Medicine

  • Paramagnetic contrast agent

Side Effects

Mangafodipir may cause unwanted side effects that may require immediate medical care. Other side effects may occur and go away on their own. The reported side effects are known to be transient (lasting for a short time) or mild in intensity.

Although they rarely occur, if you experience any the following side effects tell your doctor as soon as you can:

Rarely occur

  • Irregular heartbeat
  • Rash or hives on the skin
  • Shortness of breath
  • Pain in the chest
  • Swelling of the face
  • Itching

There may be some side effects that occur in patients but generally do not require medical attention. They can be managed by the patient and typically go away on their own as the body gets used to the medicine.

The following are examples of such side effects. If any of them occurs but becomes bothersome, gets worse or does not go away, tell your doctor.

More commonly occur

  • Vomiting
  • Nausea
  • Warm sensation at the area the medicine was injected
  • Redness at the area the medicine was injected

Less commonly occur

  • Headache
  • Dizziness
  • Pain in the stomach or abdomen
  • Cold sensation at the area where the medicine was injected
  • Sensation of pressure at the area where the medicine was injected
  • Pain felt at the area where the medicine was injected

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. You may ask your doctor or healthcare professional about ways you can prevent, reduce or treat side effects.

You may report side effects by calling the US FDA at 1-800-FDA-1088.

Dosage

The medicine is supplied as a solution for intravenous injection. The recommended dosage for adults is 0.5-ml per kilogram (kg) of your body weight.

For liver imaging, it will be administered as a single dose before the MRI procedure begins by a nurse or healthcare professional. This is usually done under direct supervision of your doctor. It should be infused into your vein at a rate of 2-3 ml per minute.

Your dose will be different from other patients. It depends on the condition you are being treated for, your body weight, and whether you have any other medical problem that could interact with the drug.

When taking your dose, carefully follow all directions given to you by your doctor, nurse or healthcare professional.

Missed dose

This medicine is not usually prescribed for patients to take by themselves at home. It is administered as a single dose at a hospital or clinic.

Overdose

This medicine is injected at a hospital or clinic by a nurse or healthcare professional under direct supervision of a doctor. There is no known data of overdose.

Interactions

Food, alcohol, and tobacco

Food, alcohol, and tobacco or other medicines or medical problems may affect the way this MRI imaging agent works.

Your doctor, nurse or healthcare professional may tell you to avoid alcohol, tobacco or certain foods before the MRI procedure.

It is important that you also let your doctor know if you use or plan to use other medicines or have other medical problems. This will help your doctor determine if it is safe to treat with Mangafodipir.

Other medicines

Adequate studies have not been done to determine if this drug interacts with other medicines used by the patient. There is currently no known adverse drug interaction.

This does not mean that there are no medicines that could cause adverse interaction. You may talk with your doctor for more information.

Other medical problems

Tell your doctor about all medical problems you have or have a history of. They may affect how the medicine is supposed to work or may cause other medical problems.

Patients who have the following medical conditions may be at a higher risk of developing an allergic reaction to the intravenous injection.

  • Immune system problems (or history of)
  • Allergies (or history of)

This medicine is known to cause side effects, especially vomiting and nausea. Use the medicine with caution in patients with the following conditions as it may cause additional related problems:

  • Vomiting
  • Nausea
  • Acid reflux (acid backing up from the stomach) or other similar stomach problems

Warnings

  • Use Mangafodipir only if your doctor prescribed it as a treatment for you to use prior to an MRI diagnostic test of your liver.

Your doctor should talk to you about your medical history and the potential benefits and risks involved in taking Mangafodipir before deciding whether to treat you with this drug.

  • Do not use Mangafodipir if you are allergic to it or any of its inactive ingredients.
  • Tell your doctor if you have allergies to other medicines, foods, dyes, preservatives or animals.
  • Although there is no known information about adverse interaction of the drug with other medicines, let your doctor know about all prescription or non-prescription vitamins or medicines, and any herbal products you take or plan to take.
  • Do not use the medication in children under 12 years of age unless use and dose are determined by a doctor. Because there is no specific information relating to its safety and efficacy for use in pediatrics, it should not be used.
  • If you are pregnant, may be pregnant or breastfeeding tell your doctor. There may be a risk of harm to an unborn baby or breastfeeding infant if you take the medicine.
  • This medicine should be used with caution in elderly patients to prevent side effects that may develop due to their age.
  • Ensure you tell your doctor about all medical problems you have or have a history of. You should use this medicine with caution if you have or have a history of allergy, poor immunity, vomiting, stomach problems, or nausea.
  • Patients who have or have a history of problems with their immune system or allergies may be more at risk for developing an allergic reaction to the medicine.
  • Let your doctor know if you have any medical condition that becomes worse whenever you lie on your back. Tell your doctor, especially if you have problems with digestion such as gastroesophageal reflux disease (GERD) or reflux esophagitis.
  • Also, make sure your doctor knows if you have difficulty rolling over onto your side.
  • The use of Mangafodipir may affect certain medical test results. Tell your doctor or lab technician you have used the medicine before any test is carried out.
  • Before doing any medical or dental procedure or surgery, tell your doctor or dentist that you used Mangafodipir.
  • Do not use this medicine repetitively. It is intended for single intravenous use only. The safety and efficacy of repeated doses have not been studied or established.

Storage

Patients are not required to store this medicine since it is usually stored at the hospital or clinic where it will be administered to the patient.

Summary

Mangafodipir has been effectively used in radiology for diagnosis relating to problems of the liver. The medicine works to provide clear, detailed images of this organ.

This contrast imaging agent is intravenously infused into patients undergoing an MRI (Magnetic Resonance Imaging) scan of the liver. The MRI scan helps the doctor detect the presence of lesions caused by hepatocellular carcinomas or metastatic disease.

The medicine is administered by a healthcare professional at a hospital, clinic or diagnostic center, under the direct supervision of a doctor.

There is no known adverse interaction of this drug with food, alcohol, tobacco or other drugs.

Patients who have or have a history of problems with their immune system or allergies may be more at risk for developing an allergic reaction to the medicine.

The usual side effects range from being transient to mild. The most common effects are nausea and vomiting. Side effects generally do not usually require emergency medical attention.

However, patients who have stomach problems, problems with digestion such as gastroesophageal reflux disease (GERD), or reflux esophagitis may have an increased risk of adverse reaction.

Mangafodipir is intended for single intravenous use only. The safety and efficacy of repeated doses have not been established.