Meclizine, Buclizine, and Cyclizine (Oral, Parenteral)

Used to relieve dizziness, vomiting and nausea, Meclizine, Buclizine, and Cyclizine can be prescribed to treat vertigo, motion sickness and sickness caused by other conditions.

Overview

Known for their antiemetic properties, Meclizine, Buclizine, and Cyclizine can all be used to relieve the symptoms of nausea and vomiting. In certain instances, Meclizine, Buclizine, and Cyclizine may also be used to prevent these symptoms from occurring. If patients regularly suffer from motion sickness, for example, they may use Meclizine, Buclizine, and Cyclizine before travelling to prevent them from becoming unwell.

Although Meclizine, Buclizine, and Cyclizine can each be used to treat vertigo-induced dizziness, nausea and vomiting, they are different medications. All act as antihistamines and affect the histamine receptors in the medulla area of the brain. As this region controls vomiting, inhibiting the histamine receptors can prevent the patient from vomiting and/or feeling nauseous.

Meclizine, Buclizine, and Cyclizine also suppress vestibular stimulation and labyrinth excitability. In doing so, they can relieve the symptoms of dizziness, often associated with vertigo. Buclizine and Cyclizine, in particular, can have a local anesthetic effect in some instances, and all three medications can act as a light sedative.

Available in various forms, patients can take Meclizine, Buclizine, and Cyclizine as a tablet, syrup, capsule, elixir or as a solution. This is particularly useful for patients who are already experiencing nausea or vomiting and may struggle to swallow tablets or capsules when they are feeling unwell.

Whilst some strengths of Meclizine, Buclizine, and Cyclizine are only available with a doctor's prescription, some forms of Meclizine, Buclizine, and Cyclizine can be purchased from a pharmacy, without the need for a prescription. However, patients are always advised to access medical advice before using Meclizine, Buclizine, and Cyclizine, particularly if the cause of their symptoms is unknown.

Conditions Treated

Type Of Medicine

  • Antiemetic
  • Antihistamine

Side Effects

As Meclizine, Buclizine, and Cyclizine work in similar ways, the side effects associated with one of these medications tend to apply to the other two as well. Although serious side effects are not commonly caused by Meclizine, Buclizine, and Cyclizine, patients may experience the following adverse effects when using these medications:

  • Double or blurred vision
  • Rash on the skin
  • Drowsiness
  • Constipation
  • Upset stomach
  • Diarrhea
  • Painful or difficult urination
  • Trouble sleeping, restlessness or nervousness
  • Dizziness
  • Headache
  • Dryness of throat, nose or mouth
  • Loss of appetite
  • Fast heartbeat

If the above side-effects are fairly short-lived and are not bothersome to the patient, further medical treatment may not be needed. However, if side-effects persist or are severe, patients should obtain medical advice.

Furthermore, patients should access medical help if they experience any other side-effects when using Meclizine, Buclizine, and Cyclizine.

Dosage

When patients use Meclizine, Buclizine, and Cyclizine, they should follow the medication guide and manufacturer's instructions, as well as their doctor's advice. The appropriate dose of medication will depend on the specific drug used by the patient, the cause of their symptoms and the format of the medication they're using.

If Buclizine is used to prevent motion sickness, for example, it may be taken in the form of a chewable tablet. If so, adult or teenage patients are usually advised to take 50mg approximately thirty minutes before travel. If necessary, this dose can be repeated four to six hours later. However, patients should not take more than 150mg of Buclizine in one day. If the medication is used to treat children or infants, their caregivers must ensure that it is safe for pediatric patients and that a lower dose is provided.

Alternatively, motion sickness can be prevented or treated with Cyclizine. When prescribed Cyclizine for this reason, adults and teenagers are usually advised to take a 50mg tablet, approximately thirty minutes before they start travelling. If required, another dose can be taken but at least four to six hours should be left between doses and patients should not take more than 200mg of Cyclizine per day. If patients between the ages of six and twelve years are using Meclizine, Buclizine, and Cyclizine tablets, they should take an initial dose of 25mg, thirty minutes before they travel. Additional doses can be given, but they should be at least six to eight hours apart and patients should not be given more than 75mg per day.

If necessary, Cyclizine can also be administered via an injection. However, if Cyclizine is delivered in this way, a healthcare practitioner may need to administer it so it is not often used outside of a clinical setting. When Cyclizine is used via intramuscular injection, it may be for the reduction of postoperative nausea and/or vomiting.

When patients take Meclizine, they can take the medication as a standard tablet or as a chewable tablet. If adults or children over the age of twelve years are taking Meclizine for the treatment of motion sickness, they are usually instructed to take 25-50mg, approximately one hour before they travel. If required, another dose can be administered but at least twenty four hours should be allowed to pass in between doses of Meclizine.

If patients are taking Meclizine to treat vertigo-related dizziness, the standard dose for adults and children over the age of twelve years is 25-100mg per day. However, this daily dose should be divided into smaller, equal doses and taken throughout the day.

Although these are standard dosing instructions for treatment with Meclizine, Buclizine, and Cyclizine, patients should obtain medical advice before using any medication. Whilst some forms of Meclizine, Buclizine, and Cyclizine can be prescribed to pediatric patients, they may only be available with a doctor's prescription.

If patients require an oral solution, syrup or elixir, they should consult their physician or follow the manufacturer's instructions when using this type of medication.

In some instances, patients may be unable to take medication orally. If so, Meclizine, Buclizine, and Cyclizine can be administered via a parenteral feeding tube. If Meclizine, Buclizine, and Cyclizine is to be delivered in this way, patients or their caregivers will be given specific instructions so that the medication can be administered safely and in the appropriate dose.

If patients forget to take a dose of Meclizine, Buclizine, and Cyclizine, they should take their medication as soon as they remember to. However, if the next dose of medicine is due relatively soon, patients should simply skip the missed dose and continue with their usual treatment schedule. It is not appropriate to take an extra or double dose of Meclizine, Buclizine, and Cyclizine, even if a previous dose has been missed.

If patients are unsure how or when to take Meclizine, Buclizine, and Cyclizine, they should contact their physician or pharmacist for advice.

Potential Drug Interactions

Before using Meclizine, Buclizine, and Cyclizine, patients must consult a healthcare practitioner if they are taking any other medicines. As some drugs can interact with one another, it may not be safe to take Meclizine, Buclizine, and Cyclizine in combination with some other medicines.

For example, Meclizine, Buclizine, and Cyclizine should not be used alongside any of the following:

  • Amifampridine
  • Desipramine
  • Amisulpride
  • Dronedarone
  • Amitriptyline
  • Doxepin
  • Amoxapine
  • Dofetilide
  • Amprenavir
  • Darunavir
  • Arsenic Trioxide
  • Droperidol
  • Atazanavir
  • Nortriptyline
  • Bepridil
  • Nelfinavir
  • Bromopride
  • Phenelzine
  • Carbamazepine
  • Pargyline
  • Cisapride
  • Nefazodone
  • Clarithromycin
  • Rifampin
  • Clomipramine
  • Rifabutin
  • Cobicistat
  • Rasagiline
  • Colchicine
  • Procarbazine
  • Fosamprenavir
  • Piperaquine
  • Fosphenytoin
  • Posaconazole
  • Furazolidone
  • Pimozide
  • Idelalisib
  • Phenytoin
  • Imipramine
  • Sparfloxacin
  • Indinavir
  • Selegiline
  • Iproniazid
  • Sodium Oxybate
  • Isocarboxazid
  • Saquinavir
  • Itraconazole
  • Safinamide
  • Ketoconazole
  • St John's Wort
  • Ritonavir
  • Levomethadyl
  • Linezolid
  • Terfenadine
  • Lopinavir
  • Rifapentine
  • Mesoridazine
  • Tranylcypromine
  • Methylene Blue
  • Trimipramine
  • Metoclopramide
  • Thioridazine
  • Moclobemide
  • Venlafaxine
  • Phenobarbital
  • Ziprasidone
  • Protriptyline

Similarly, taking Meclizine, Buclizine, and Cyclizine in conjunction with any of the following medicines is not usually advisable:

  • Abciximab
  • Mefloquine
  • Abiraterone
  • Meperidine
  • Acecainide
  • Methotrimeprazine
  • Aceclofenac
  • Meloxicam
  • Acemetacin
  • Meprobamate
  • Acenocoumarol
  • Metrizamide
  • Afatinib
  • Melitracen
  • Ajmaline
  • Metronidazole
  • Alfentanil
  • Methadone
  • Alfuzosin
  • Nabumetone
  • Almotriptan
  • Nalbuphine
  • Alprazolam
  • Nefazodone
  • Amineptine
  • Naproxen
  • Amiodarone
  • Nepafenac
  • Amitriptyline
  • Nadroparin
  • Amitriptylinoxide
  • Naratriptan
  • Amobarbital
  • Nelfinavir
  • Amoxapine
  • Nafarelin
  • Amtolmetin Guacil
  • Nicomorphine
  • Anagrelide
  • Levomethadyl
  • Anileridine
  • Lorcainide
  • Apixaban
  • Levorphanol
  • Apomorphine
  • Lithium
  • Aprepitant
  • Levomilnacipran
  • Aprindine
  • Lidoflazine
  • Ardeparin
  • Lofepramine
  • Argatroban
  • Lopinavir
  • Aripiprazole
  • Lornoxicam
  • Arsenic Trioxide
  • Lorcaserin
  • Artemether
  • Sertindole
  • Asenapine
  • Salsalate
  • Aspirin
  • Sertraline
  • Astemizole
  • Selexipag
  • Atazanavir
  • Salmeterol
  • Azimilide
  • Secobarbital
  • Azithromycin
  • Isradipine
  • Bedaquiline
  • Sematilide
  • Bemiparin
  • Ivabradine
  • Bivalirudin
  • Imipramine
  • Bretylium
  • Iloprost
  • Bromazepam
  • Iloperidone
  • Bromfenac
  • Itraconazole
  • Bromopride
  • Indomethacin
  • Brompheniramine
  • Ibutilide
  • Bufexamac
  • Isoflurane
  • Buprenorphine
  • Ketazolam
  • Bupropion
  • Dolasetron
  • Midazolam
  • Buserelin
  • Mifepristone
  • Buspirone
  • Morniflumate
  • Butabarbital
  • Mizolastine
  • Butorphanol
  • Mirtazapine
  • Cangrelor
  • Moricizine
  • Carbamazepine
  • Morphine
  • Carbinoxamine
  • Milnacipran
  • Celecoxib
  • Solifenacin
  • Ceritinib
  • Sulfinpyrazone
  • Certoparin
  • Sulfamethoxazole
  • Chloral Hydrate
  • St John's Wort
  • Chlordiazepoxide
  • Sorafenib
  • Chloroquine
  • Sufentanil
  • Chlorpheniramine
  • Sotalol
  • Chlorpromazine
  • Spiramycin
  • Choline Salicylate
  • Sulindac
  • Cilostazol
  • Oxyphenbutazone
  • Ciprofloxacin
  • Panobinostat
  • Citalopram
  • Papaveretum
  • Clarithromycin
  • Paliperidone
  • Clomipramine
  • Oxymorphone
  • Clonazepam
  • Palonosetron
  • Clonixin
  • Papaverine
  • Clopidogrel
  • Paregoric
  • Clozapine
  • Parecoxib
  • Cocaine
  • Phenobarbital
  • Codeine
  • Pimavanserin
  • Conivaptan
  • Piroxicam
  • Crizotinib
  • Pirmenol
  • Cyclobenzaprine
  • Pipamperone
  • Cyclosporine
  • Piketoprofen
  • Dabigatran Etexilate
  • Phenytoin
  • Dabrafenib
  • Pitolisant
  • Dalteparin
  • Pixantrone
  • Danaparoid
  • Piritramide
  • Darunavir
  • Phenylbutazone
  • Dasatinib
  • Phenprocoumon
  • Degarelix
  • Ondansetron
  • Delamanid
  • Octreotide
  • Desipramine
  • Ofloxacin
  • Desirudin
  • Opipramol
  • Deslorelin
  • Olanzapine
  • Desvenlafaxine
  • Opium
  • Dexamethasone
  • Oxaprozin
  • Dexibuprofen
  • Pasireotide
  • Dexketoprofen
  • Paroxetine
  • Dexmedetomidine
  • Oxycodone
  • Dextromethorphan
  • Parnaparin
  • Diacetylmorphine
  • Pazopanib
  • Diazepam
  • Oxazepam
  • Dibenzepin
  • Ticagrelor
  • Diclofenac
  • Tirofiban
  • Difenoxin
  • Ticlopidine
  • Diflunisal
  • Tiotropium
  • Digoxin
  • Tinzaparin
  • Dihydrocodeine
  • Tizanidine
  • Dihydroergotamine
  • Tilidine
  • Diltiazem
  • Levofloxacin
  • Diphenhydramine
  • Lovastatin
  • Diphenoxylate
  • Loxoprofen
  • Dipyridamole
  • Meclizine
  • Dipyrone
  • Lepirudin
  • Disopyramide
  • Leuprolide
  • Dofetilide
  • Lapatinib
  • Domperidone
  • Lumefantrine
  • Donepezil
  • Lumiracoxib
  • Doxepin
  • Meclofenamate
  • Doxorubicin
  • Sultopride
  • Doxorubicin Hydrochloride Liposome
  • Tacrolimus
  • Doxylamine
  • Sulpiride
  • Droperidol
  • Tamoxifen
  • Drotrecogin Alfa
  • Tapentadol
  • Droxicam
  • Sunitinib
  • Duloxetine
  • Sumatriptan
  • Ebastine
  • Tedisamil
  • Edoxaban
  • Telaprevir
  • Efavirenz
  • Ketobemidone
  • Eletriptan
  • Ketorolac
  • Eliglustat
  • Mefenamic Acid
  • Encainide
  • Morphine Sulfate Liposome
  • Enflurane
  • Moxifloxacin
  • Enoxaparin
  • Niflumic Acid
  • Enzalutamide
  • Ketoconazole
  • Epoprostenol
  • Ketoprofen
  • Eptifibatide
  • Periciazine
  • Ergotamine
  • Posaconazole
  • Eribulin
  • Prasugrel
  • Erythromycin
  • Prajmaline
  • Escitalopram
  • Sodium Salicylate
  • Pranoprofen
  • Zolmitriptan
  • Eslicarbazepine Acetate
  • Zopiclone
  • Perphenazine
  • Zolpidem
  • Prazepam
  • Zaleplon
  • Estazolam
  • Vorapaxar
  • Phenindione
  • Zotepine
  • Eszopiclone
  • Ethchlorvynol
  • Probucol
  • Vinflunine
  • Ethylmorphine
  • Primidone
  • Zuclopenthixol
  • Etodolac
  • Procainamide
  • Etofenamate
  • Protein C
  • Etoricoxib
  • Propionic Acid
  • Famotidine
  • Propofol
  • Felbamate
  • Propyphenazone
  • Felbinac
  • Promethazine
  • Fenoprofen
  • Propoxyphene
  • Fepradinol
  • Procarbazine
  • Fentanyl
  • Propafenone
  • Feprazone
  • Prochlorperazine
  • Fingolimod
  • Proquazone
  • Flecainide
  • Proglumetacin
  • Flibanserin
  • Tramadol
  • Floctafenine
  • Temazepam
  • Fluconazole
  • Tetrabenazine
  • Flufenamic Acid
  • Tolmetin
  • Fluoxetine
  • Treprostinil
  • Flurazepam
  • Tiaprofenic Acid
  • Flurbiprofen
  • Tianeptine
  • Fluvoxamine
  • Telavancin
  • Fondaparinux
  • Topotecan
  • Formoterol
  • Tenoxicam
  • Fosaprepitant
  • Thioridazine
  • Foscarnet
  • Trazodone
  • Fosphenytoin
  • Toremifene
  • Fospropofol
  • Tolfenamic Acid
  • Frovatriptan
  • Tolterodine
  • Galantamine
  • Telithromycin
  • Gatifloxacin
  • Triazolam
  • Gemifloxacin
  • Vardenafil
  • Gonadorelin
  • Trimipramine
  • Goserelin
  • Trimethoprim
  • Granisetron
  • Trifluoperazine
  • Halazepam
  • Triptorelin
  • Halofantrine
  • Valdecoxib
  • Haloperidol
  • Vasopressin
  • Halothane
  • Vandetanib
  • Heparin
  • Rifapentine
  • Histrelin
  • Rivaroxaban
  • Hydrocodone
  • Rizatriptan
  • Hydromorphone
  • Risperidone
  • Clorazepate
  • Ritonavir
  • Hydroquinidine
  • Quinidine
  • Rofecoxib
  • Hydroxychloroquine
  • Quetiapine
  • Salicylic Acid
  • Hydroxytryptophan
  • Quazepam
  • Sevoflurane
  • Hydroxyzine
  • Rifabutin
  • Ibuprofen
  • Remifentanil
  • Quinine
  • Ibuprofen Lysine
  • Sibutramine
  • Nilotinib
  • Rifampin
  • Nimesulide
  • Ranolazine
  • Nimesulide Beta Cyclodextrin
  • Simeprevir
  • Nitrazepam
  • Reviparin
  • Norfloxacin
  • Ramelteon
  • Nortriptyline
  • Simvastatin
  • Vincristine Sulfate Liposome
  • Opium Alkaloids
  • Vemurafenib
  • Peginterferon Alfa-2b
  • Verapamil
  • Pentamidine
  • Vilazodone
  • Pentazocine
  • Vilanterol
  • Pentobarbital
  • Venetoclax
  • Perflutren Lipid Microsphere
  • Venlafaxine
  • Protriptyline
  • Vincristine
  • Sodium Oxybate
  • Warfarin
  • Sodium Phosphate
  • Voriconazole
  • Sodium Phosphate, Dibasic
  • Vorinostat
  • Sodium Phosphate, Monobasic
  • Ziprasidone

In some instances, however, doctors may feel it is in the patient's best interests to take Meclizine, Buclizine, and Cyclizine alongside one of the medicines listed above. If so, the patient's dose of medication may be reduced or they may be instructed to take the medication at a specific time.

Patients should also be aware that Meclizine, Buclizine, and Cyclizine can interact with other substances. Due to this, patients should not consume the following when taking this medication:

  • Grapefruit, grapefruit juice or any other products containing grapefruit

It is essential that patient's tell their physician if they are using any other medicines, vitamins or supplements before they start taking Meclizine, Buclizine, and Cyclizine. Similarly, patients will need to obtain medical advice before using any new medicines, supplements or vitamins, once they have started to take Meclizine, Buclizine, and Cyclizine.

Warnings

If patients have any other existing medical conditions or a history of certain conditions, it could affect their use of Meclizine, Buclizine, and Cyclizine. Due to this, patients should notify their physician of any health problems before they start taking this type of medication. The following conditions can be particularly relevant if treatment with Meclizine, Buclizine, and Cyclizine is being considered:

Although children of certain ages may be able to use some forms of Meclizine, Buclizine, and Cyclizine, medical advice should be sought before giving this medication to a child or infant. Often, pediatric patients are more sensitive to some of the side-effects of Meclizine, Buclizine, and Cyclizine, such as, dryness of the throat, nose and mouth.

Similarly, geriatric patients can use Meclizine, Buclizine, and Cyclizine, providing they do not have any existing health problems which would prevent the use of these medications. However, older patients may be more sensitive to some of the side-effects of Meclizine, Buclizine, and Cyclizine, such as difficult urination, constipation and/or dryness of the throat, nose and mouth.

As Meclizine, Buclizine, and Cyclizine add to the effects of other central nervous system depressants, they should not be taken in conjunction with the following substances:

  • Cold and flu remedies
  • Other antihistamines
  • Allergy medications
  • Seizure medications
  • Barbiturates
  • Sedatives
  • Muscle relaxants
  • Cough syrups
  • Narcotic pain medications
  • Tranquilizers
  • Anesthetics, including dental anesthetics

If patients are due to undergo any medical tests or procedures, they must inform the relevant healthcare practitioners that they are taking Meclizine, Buclizine, and Cyclizine. These medications can affect the way other drugs work and could interfere with anesthetics, for example.

In addition to this, patients must notify their doctor or nurse that they are taking Meclizine, Buclizine, and Cyclizine if they are due to undergo any skin testing for allergies. These medications could affect the results of allergy tests so modifications may need to be made.

When taking Meclizine, Buclizine, and Cyclizine, patients may experience dryness of the mouth. In order to relieve this side-effect, patients may want to suck sugarless candy, chew gum or use a saliva substitute. However, if dryness of the mouth persists, patients should consult their physician or dentist as it may increase the risk of developing dental disease.

Meclizine, Buclizine, and Cyclizine can cause patients to feel less alert than usual and/or drowsy. If affected in this way, patients should not operate machinery, drive or perform potentially dangerous tasks until the symptoms have passed.

If patients are pregnant, they must consult a physician before using any form of Meclizine, Buclizine, and Cyclizine. Whilst some types of medication may be considered acceptable for use during pregnancy, others could carry a significant risk.

If patients become pregnant whilst using Meclizine, Buclizine, and Cyclizine, they should consult their doctor straight away.

Meclizine, Buclizine, and Cyclizine can be present in breast milk but are not believed to cause problems to nursing infants. However, patients should obtain medical advice taking Meclizine, Buclizine, and Cyclizine if they are breastfeeding. Furthermore, Meclizine, Buclizine, and Cyclizine could reduce the flow of breast milk in some patients and may make breastfeeding more difficult.

Before using Meclizine, Buclizine, and Cyclizine, patients should tell their doctor if they have experienced any allergic reactions before. In rare cases, Meclizine, Buclizine, and Cyclizine could cause patients to exhibit an allergic reaction and if so, they will require emergency medical care. An allergic reaction may be characterized by the following symptoms:

  • Rash on the skin
  • Itching
  • Wheezing
  • Hoarseness
  • Difficulty swallowing
  • Hives
  • Difficulty breathing
  • Swelling, affecting the lips, tongue, mouth, throat, face or hands

Storage

When storing medicine at home, it's important that patients keep it in a safe location and prevent children and/or pets from gaining access to it. However, patients may carry Meclizine, Buclizine, and Cyclizine with them when they are out, particularly if they are using the medication to treat or prevent motion sickness. If so, patients must ensure that the medication is stored safely and that it cannot get lost or pose a risk to anyone else.

In order to store Meclizine, Buclizine, and Cyclizine properly, patients should follow the manufacturer's instructions. Generally, these medications can be stored at room temperature but should not be exposed to heat, light or moisture.

If patients are advised to stop taking Meclizine, Buclizine, and Cyclizine or if the medication reaches its expiry date, it should be disposed of carefully. Instead of throwing medication out with household waste, patients should contact their physician's office or pharmacist and access a safe disposal route.

Summary

Nausea and vomiting can be extremely debilitating, particularly if they occur regularly or are associated with certain activities, such as travelling. Similarly, dizziness and vertigo can prevent patients from performing any type of task and may even prevent patients from walking or moving around.

By affecting vestibular stimulation and the medullar area of the brain, Meclizine, Buclizine, and Cyclizine can help to prevent or treat nausea, dizziness and/or vomiting. As a result, these medications can enable patients to continue with their daily routine, without being affected by unpleasant symptoms.